|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:C8orf76-PDE3A (FusionGDB2 ID:12091) |
Fusion Gene Summary for C8orf76-PDE3A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: C8orf76-PDE3A | Fusion gene ID: 12091 | Hgene | Tgene | Gene symbol | C8orf76 | PDE3A | Gene ID | 84933 | 5139 |
| Gene name | chromosome 8 open reading frame 76 | phosphodiesterase 3A | |
| Synonyms | - | CGI-PDE|CGI-PDE A|CGI-PDE-A|HTNB | |
| Cytomap | 8q24.13 | 12p12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | uncharacterized protein C8orf76 | cGMP-inhibited 3',5'-cyclic phosphodiesterase AcAMP phosphodiesterase, myocardial cGMP-inhibitedcyclic GMP-inhibited phosphodiesterase Aphosphodiesterase 3A, cGMP-inhibited | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000276704, ENST00000521310, | ENST00000544307, ENST00000359062, | |
| Fusion gene scores | * DoF score | 4 X 5 X 6=120 | 9 X 12 X 6=648 |
| # samples | 7 | 13 | |
| ** MAII score | log2(7/120*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/648*10)=-2.31748218985617 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: C8orf76 [Title/Abstract] AND PDE3A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | C8orf76(124238740)-PDE3A(20709594), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PDE3A | GO:0071321 | cellular response to cGMP | 17704206 |
| Fusion gene breakpoints across C8orf76 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across PDE3A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-CG-5721-01A | C8orf76 | chr8 | 124238740 | - | PDE3A | chr12 | 20709594 | + |
Top |
Fusion Gene ORF analysis for C8orf76-PDE3A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000276704 | ENST00000544307 | C8orf76 | chr8 | 124238740 | - | PDE3A | chr12 | 20709594 | + |
| 5CDS-intron | ENST00000521310 | ENST00000544307 | C8orf76 | chr8 | 124238740 | - | PDE3A | chr12 | 20709594 | + |
| In-frame | ENST00000276704 | ENST00000359062 | C8orf76 | chr8 | 124238740 | - | PDE3A | chr12 | 20709594 | + |
| In-frame | ENST00000521310 | ENST00000359062 | C8orf76 | chr8 | 124238740 | - | PDE3A | chr12 | 20709594 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000276704 | C8orf76 | chr8 | 124238740 | - | ENST00000359062 | PDE3A | chr12 | 20709594 | + | 7576 | 1000 | 52 | 3465 | 1137 |
| ENST00000521310 | C8orf76 | chr8 | 124238740 | - | ENST00000359062 | PDE3A | chr12 | 20709594 | + | 7524 | 948 | 951 | 3413 | 820 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000276704 | ENST00000359062 | C8orf76 | chr8 | 124238740 | - | PDE3A | chr12 | 20709594 | + | 0.000293068 | 0.9997069 |
| ENST00000521310 | ENST00000359062 | C8orf76 | chr8 | 124238740 | - | PDE3A | chr12 | 20709594 | + | 0.000367354 | 0.9996326 |
Top |
Fusion Genomic Features for C8orf76-PDE3A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| C8orf76 | chr8 | 124238737 | - | PDE3A | chr12 | 20709593 | + | 1.95E-08 | 1 |
| C8orf76 | chr8 | 124238737 | - | PDE3A | chr12 | 20709593 | + | 1.95E-08 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
 |
Top |
Fusion Protein Features for C8orf76-PDE3A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:124238740/chr12:20709594) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 1040_1045 | 320 | 1142.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 1121_1125 | 320 | 1142.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 440_445 | 320 | 1142.0 | Compositional bias | Note=Poly-Thr | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 870_873 | 320 | 1142.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 674_1093 | 320 | 1142.0 | Domain | PDEase |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 288_291 | 320 | 1142.0 | Compositional bias | Note=Poly-Arg | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 95_98 | 320 | 1142.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 99_102 | 320 | 1142.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 130_150 | 320 | 1142.0 | Transmembrane | Helical | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 160_180 | 320 | 1142.0 | Transmembrane | Helical | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 185_205 | 320 | 1142.0 | Transmembrane | Helical | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 210_230 | 320 | 1142.0 | Transmembrane | Helical | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 232_252 | 320 | 1142.0 | Transmembrane | Helical | |
| Tgene | PDE3A | chr8:124238740 | chr12:20709594 | ENST00000359062 | 0 | 16 | 61_81 | 320 | 1142.0 | Transmembrane | Helical |
Top |
Fusion Gene Sequence for C8orf76-PDE3A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >12091_12091_1_C8orf76-PDE3A_C8orf76_chr8_124238740_ENST00000276704_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=7576nt_BP=1000nt CCGCCTTTTCCGGCGGGCCCCGCTTCCTCGTTGCCCCCGCCGCGGGCGCGAGATGGATTCCGGGTGCTGGTTGTTCGGCGGCGAGTTCGA GGACTCGGTGTTCGAGGAGAGGCCGGAGCGGCGGTCAGGACCGCCCGCGTCCTACTGCGCCAAGCTCTGCGAGCCGCAGTGGTTTTATGA AGAAACAGAAAGCAGTGATGATGTTGAAGTGCTGACTCTCAAGAAATTCAAAGGAGACCTGGCCTACAGACGACAAGAGTATCAGAAAGC ACTGCAGGAGTATTCCAGTATCTCTGAAAAATTGTCATCAACCAATTTTGCCATGAAAAGGGATGTCCAGGAAGGTCAGGCTCGGTGTCT GGCTCACCTGGGTAGGCATATGGAGGCGCTGGAGATTGCTGCAAACTTGGAAAATAAAGCAACCAACACAGACCATTTAACCACGGTACT CTACCTCCAGCTTGCTATTTGTTCAAGTTTGCAGAACTTGGAGAAAACAATTTTCTGCCTGCAGAAACTGATTTCTTTGCATCCTTTTAA TCCTTGGAACTGGGGCAAATTGGCAGAGGCTTACCTGAATCTGGGGCCAGCTCTTTCAGCAGCACTTGCGTCATCTCAGAAACAGCACAG TTTCACCTCAAGTGACAAAACTATCAAATCCTTCTTTCCACACTCAGGAAAAGACTGTCTTTTGTGTTTTCCTGAAACCTTGCCTGAGAG CTCTTTATTTTCTGTGGAAGCGAATAGCAGTAATAGCCAGAAAAATGAGAAAGCTCTGACAAATATCCAAAACTGTATGGCAGAAAAGAG AGAAACAGTGTTGATAGAGACTCAGCTGAAAGCATGTGCCTCTTTTATACGAACCAGGCTTCTGCTTCAGTTTACCCAACCTCAGCAAAC ATCGTTTGCTTTGGAGAGGAACTTAAGGACTCAGCAGGAAATTGAAGATAAAATGAAAGGGTTCAGCTTCAAAGAAGACACTTTGCTGTT GATAGCTGAGCTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGAGGATCACAGTCTTCAGGAACCAGTATTACTGTGGACAT CGCCGTCATGGGCGAGGCCCACGGCCTCATTACCGACCTCCTGGCAGACCCTTCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGT GAGCAACTTGCTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGAGTGAATCCCGTCACTTCGCTCAGTGAAAACTATACCTG TTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCTATTCCAAAGCGCCTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGT TTCTTCCACTTGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAGCCTGCACCAGTACGGAGAGACCGCAGCACCAGCATCAA ACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAATAATCCAGTGATGATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTA TGCTATTTCTGCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGTGCCCTCGCTAAAATTTCACCTCTTTCATCGCCCTGCTC CTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGCAAAATTTCTGCAGTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACA AAGCCTAGGTTCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTATCCCCTCAAATCCTGACTCCACCTGTTATATGTAGCAG CTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAGCCCCTGGAGAGAAGTGGGGTAGCCACTCGGACACCAAGTAGAACAGATGA CACTGCTCAAGTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGTGACATTGTACAGAATGAAGATGAAACAGAGTGCCTGAG AGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCTCCTGAGACCATGATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCT TGTCATGGATAACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTTCCAATTTTTGATTTAGTGGAAAATATAGGAAGAAAATG TGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAAGACATGGGCCTCTTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAA TTATTTTCATGCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGAATCCATGCCACTGATGTTTTACATGCTGTTTGGTATCT TACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAATGATCATGGTTCAACCAGTGATTCAGATTCTGACAGTGGATTTACACATGG ACATATGGGATATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATACGGATGTCTGTCTGGGAATATCCCTGCCTTGGAGTTGAT GGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCATCCAGGAAGGACTAATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGT GCTATATAACGATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGGAATCTTTTCATGTCCCGGCCAGAGTATAACTTCTTAAT TAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTTGTCATTGAAGCAATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGT AGCCAAATTTAATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAATGAAAATGATCGTCTACTGGTTTGTCAAATGTGTATAAA GTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTCCATCTTCAGTGGACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGA TGAAGAGGCCAGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCTCCTCAGCTGGCCAACCTTCAGGAATCCTTCATCTCTCA CATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGACTAATGCCTGGAAAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGA TGACCCAGAAGAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACCTGTGAAAATAATGAATCTCCAAAAAAGAAGACTTTCAA AAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTACAGAACCACAAGATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGC AGGCATAGAAAATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAACAGATCCAGGCTATCAAGGAAGAAGAAGAAGAGAAAGG GAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGACCAGTGACAATGGATAGAATGGGCTGTGTTTCCAAACAGATTGACTTGTCA AAGACTCTCTTCAAGCCAGCACAACATTTAGACACAACACTGTAGAAATTTGAGATGGGCAAATGGCTATTGCATTTTGGGATTCTTCGC ATTTTGTGTGTATATTTTTACAGTGAGGTACATTGTTAAAAACTTTTTGCTCAAAGAAGCTTTCACATTGCAACACCAGCTTCTAAGGAT TTTTTAAGGAGGGAATATATATGTGTGTGTGTATATAAGCTCCCACATAGATACATGTAAAACATATTCACACCCATGCACGCACACACA TACACACTGAAGGCCACGATTGCTGGCTCCACAATTTAGTAACATTTATATTAAGATATATATATAGTGGTCACTGTGATATAATAAATC ATAAAGGAAACCAAATCACAAAGGAGATGGTGTGGCTTAGCAAGGAAACAGTGCAGGAAATGTAGGTTACCAACTAAGCAGCTTTTGCTC TTAGTACTGAGGGATGAAAGTTCCAGAGCATTATTTGAATTCTGATACATCCTGCCAACACTGTGTGTGTGTGTGTGTGTGTGTGTGTGT GTGTGTGTGTGTGTGAAAGAGAGACAGAAGGGAATGGTTTGAGAGGGTGCTTGTGTGCATGTGTGTGCATATGTAAAGAGATTTTTGTGG TTTAAGTAACTCAGAATAGCTGTAGCAAATGACTGAATACATGTGAACAAACAGAAGGAAGTTCACTCTGGAGTGTCTTTGGGAGGCAGC CATTCCAAATGCCCTCCTCCATTTAGCTTCAATAAAGGGCCTTTTGCTGATGGAGGGCACTCAAGGGCTGGGTGAGAGGGCCACGTGTTT GGTATTACATTACTGCTATGCACCACTTGAAGGAGCTCTATCACCAGCCTCAAACCCGAAAGACTGAGGCATTTTCCAGTCTACTTGCCT AATGAATGTATAGGAACTGTCTATGAGTATGGATGTCACTCAACTAAGATCAAATCACCATTTAAGGGGATGGCATTCTTTATACCTAAA CACCTAAGAGCTGAAGTCAGGTCTTTTAATCAGGTTAGAATTCTAAATGATGCCAGAGAAGGCTTGGGAAATTGTACTTCAGCGTGATAG CCTGTGTCTTCTTAATTTGCTGCAAAATATGTGGTAGAGAAAGAAAAGGAAACAGAAAAATCACTCTGGGTTATATAGCAAGAGATGAAG GAGAATATTTCAACACAGGGTTTTTGTGTTGACATAGGAAAAGCCTGATTCTTGGCAACTGTTGTAGTTTGTCTTTCAGGGGTGAAGGTC CCACTGACAACCCCTGTTGTGGTGTTCCACACGCTGTTTGTTGGGGTAGCTTCCATCGGCAGTCTGGCCCATTGTCAGTCATGCTTCTTC TGGCCGGGGAGATTATAGAGAGATTGTTTGAAGATTGGGTTATTATTGAAAGTCTTTTTTTTTGTTTGTTTTGTTTTGGTTTGTTTGTTT ATCTACACTTGTTTATGCTGTGAGCCAAACCTCTATTTAAAAAGTTGATACTCACTTTCAATATTTTATTTCATATTATTATATATGTCA TGATAGTTATCTTGATGTAAATATGAAGATTTTTTTGTTTCTGTAGATAGTAAACTCTTTTTTTAAAAAAGGAAAAGGGAAACATTTTTA TAAAGTTATATTTTAATCACCATTTTTATACATTGTAGTTCTCTCCAAGCCCAGTAAGAGAATGATGATTCATTTGCATGGAGGTCGATG GACAACCAATCATCTACCTTTTCTAATTTAAATGATAATCTGATATAGTTTTATTGCCAGTTAAATGAGGATGCTGCAAAGCATGTTTTT TCACTAGTAACTTTTGCTAACTGAATGAATTCTGGGTCCATATCTCCCAGATGAAAAACTGTTAACCAATACCATATTTTATAGTTGGTG TCCATTTCTTTCCAACACTGTTTGTTATGATTCTTCCTTGAGTACTTATATACAGACCTGCTCATTATCTAAACAATCTTACCTTCTAAG TAAACCTTGATTGTGATTTCCAGTTTTTATTTTCTCTGACGTAGTAGAAAGGAATGTTTACATTAAAAATACTTTTGTTTCTCATAAATG GATATTGTACTCCCCCCTTTCAAAGCATTATTTTACAATAATTCATGGCATTTTAAAAAATAAGGCAAAGATAATACGACAAAAAATATA CATGGTTTCAAGGCAAATTCTCCAATAAGTTGGAAAATGTAAAAAGGATCAAGTGGATGCAGCCTCTACCTAAATAATTAAAATATATTT CAGTATATTTCTGAATTAACACCAGGTCTTCATTATTTAGAACTTACTAAATTGTTTTCATTTTCTTAGTTTTACCTGTGTATCTCCATG TTTGCAAAAATTACTATAAGTCAAATTTTGCCAGTGAATTTAACTATTTTTCTTTCCTTGCAATTAAGGGGAAAAAAGCATTTATCTTAT CTTCTCATACCCCTTGCATCTAAGTACTTAGCAAAGTCAATATTTTCCCATTTTCCAAATGCGTCCATCTCTAACATAAATATTAATTGA ACATAGAGCTATGTTTGGAGTGAGTGGACTGGCAGGACAGTTGGAAGTCCATCACAGTCTATTGACAGTTTCATCAAAGCTGTATAGTCC AACTAGTGGGGCAGCTTGGCTACTATGGTGGAAGTCTCAGCAAACTGCCTGGTTTTGTTTGTTTGTTTTGTTTTAAGGTACAGGAAATAA GAGGAATAATAGTGGCCAAAGCAATTAGAACATCTTCATTCCAGAACTGTGTTCAGCAATCCAGGCAGATTGATACATTTTTCTTTAAAA ATAAATTGCTATTACAGCTAGACGTCAATTGGGATAAATAAAGGGATGAAGATCCACTAAGTTTGTGACTTTCATACACACCCAGTACAT CTCAAAGGATGCTAAGGGACATTTTCTGCCAGTAGAGTTCTCCCCCTTTTTGGTGACAGCAATATTATTATGTTCACATCTAACTCCAGA GCTTACTTCCTGTGGTGCCAATGTATTTGTTGCAATTTACTACATTTTTATATGAGCCTATTTATAGGTGCCATTAAACTCAGGTCTTTC AAATGAAAGAGTTTCTAGCCCACTTAGGGAAAAAGATAATTGTTTAGAAAACCATAAAATCAATGGTAGGAAAAGTTGGAACTGGTTACC TGGATGCCATGGTTCTCTGTTAAATAAAGTAAGAGACCAGGTGTATTCTGAGTGTCATCAGTGTTATTTTCAGCATGCTAATAAATGTCT TTCCGGTTATATATCTATCTAAATTAACCTTTAAAATATTGGTTTCCTTGATAAAAGCACCACTTTTGCTTTTGTTAGCTGTAATATTTT TTGTCATTTAGATAAGACCTGGTTTGGCTCTCAATAAAAGATGAAGACAGTAGCTCTGTACAGGGATATATCTATATTAGTCTTCATCTG ATGAATGAAGAAATTTTCTCATATTATGTTCAAGAAAGTATTTACTTCCTAAAAATAGAATTCCCGATTCTGTCTATTTTGGTTGAATAC CAGAACAAATCTTTCCGTTGCAATCCCAGTAAAACGAAAGAAAAGGAATATCTTACAGACTGTTCATATTAGATGTATGTAGACTGTTAA TTTGCAATTTCCCCATATTTCCTGCCTATCTTACCCAGATAACTTTCTTTGAAGGTAAAAGCTGTGCAAAAGGCATGAGACTCAGGCCTA CTCTTTGTTTAAATGATGGAAAAATATAAATTATTTTCTAAGTAATAAAAGTATAAAAATTATCATTATAAATAAAGTCTAAAGTTTGAA ATTATTAATTTATAAAAGTGAACTAATTGTGTGATTATCAAATCCTGATTAATGAGAAGTGAATAATCTAAAAATCATTTATATTCTACT GTGGGAGGTATTCTTGGTGCTTCCATGTCAGTATCGGGCTCTCCATTGTCCTCATCATTTATAGTACTTCTAAAATAATAATGGAAACCT CAATAAGGGTCTTGTCCTCTTCTGTCATCCTAACCCTGATTCTAGTTTAATGCCTTTCCTGACTTATATGCCATTTGTAAATAAACTTCC >12091_12091_1_C8orf76-PDE3A_C8orf76_chr8_124238740_ENST00000276704_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=1137AA_BP=316 MDSGCWLFGGEFEDSVFEERPERRSGPPASYCAKLCEPQWFYEETESSDDVEVLTLKKFKGDLAYRRQEYQKALQEYSSISEKLSSTNFA MKRDVQEGQARCLAHLGRHMEALEIAANLENKATNTDHLTTVLYLQLAICSSLQNLEKTIFCLQKLISLHPFNPWNWGKLAEAYLNLGPA LSAALASSQKQHSFTSSDKTIKSFFPHSGKDCLLCFPETLPESSLFSVEANSSNSQKNEKALTNIQNCMAEKRETVLIETQLKACASFIR TRLLLQFTQPQQTSFALERNLRTQQEIEDKMKGFSFKEDTLLLIAELMGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADP SLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSEESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLE PAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISAANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISA VQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRPYSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSS DIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDNLDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGL FEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKY GCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEA ILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSA PQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEEEEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHK -------------------------------------------------------------- >12091_12091_2_C8orf76-PDE3A_C8orf76_chr8_124238740_ENST00000521310_PDE3A_chr12_20709594_ENST00000359062_length(transcript)=7524nt_BP=948nt GGATTCCGGGTGCTGGTTGTTCGGCGGCGAGTTCGAGGACTCGGTGTTCGAGGAGAGGCCGGAGCGGCGGTCAGGACCGCCCGCGTCCTA CTGCGCCAAGCTCTGCGAGCCGCAGTGGTTTTATGAAGAAACAGAAAGCAGTGATGATGTTGAAGTGCTGACTCTCAAGAAATTCAAAGG AGACCTGGCCTACAGACGACAAGAGTATCAGAAAGCACTGCAGGAGTATTCCAGTATCTCTGAAAAATTGTCATCAACCAATTTTGCCAT GAAAAGGGATGTCCAGGAAGGTCAGGCTCGGTGTCTGGCTCACCTGGGTAGGCATATGGAGGCGCTGGAGATTGCTGCAAACTTGGAAAA TAAAGCAACCAACACAGACCATTTAACCACGGTACTCTACCTCCAGCTTGCTATTTGTTCAAGTTTGCAGAACTTGGAGAAAACAATTTT CTGCCTGCAGAAACTGATTTCTTTGCATCCTTTTAATCCTTGGAACTGGGGCAAATTGGCAGAGGCTTACCTGAATCTGGGGCCAGCTCT TTCAGCAGCACTTGCGTCATCTCAGAAACAGCACAGTTTCACCTCAAGTGACAAAACTATCAAATCCTTCTTTCCACACTCAGGAAAAGA CTGTCTTTTGTGTTTTCCTGAAACCTTGCCTGAGAGCTCTTTATTTTCTGTGGAAGCGAATAGCAGTAATAGCCAGAAAAATGAGAAAGC TCTGACAAATATCCAAAACTGTATGGCAGAAAAGAGAGAAACAGTGTTGATAGAGACTCAGCTGAAAGCATGTGCCTCTTTTATACGAAC CAGGCTTCTGCTTCAGTTTACCCAACCTCAGCAAACATCGTTTGCTTTGGAGAGGAACTTAAGGACTCAGCAGGAAATTGAAGATAAAAT GAAAGGGTTCAGCTTCAAAGAAGACACTTTGCTGTTGATAGCTGAGGTCTCATGGGGCATTCAGAATGGGACCACAAACGAGGGCCAAGA GGATCACAGTCTTCAGGAACCAGTATTACTGTGGACATCGCCGTCATGGGCGAGGCCCACGGCCTCATTACCGACCTCCTGGCAGACCCT TCTCTTCCACCAAACGTGTGCACATCCTTGAGAGCCGTGAGCAACTTGCTCAGCACACAGCTCACCTTCCAGGCCATTCACAAGCCCAGA GTGAATCCCGTCACTTCGCTCAGTGAAAACTATACCTGTTCTGACTCTGAAGAGAGCTCTGAAAAAGACAAGCTTGCTATTCCAAAGCGC CTGAGAAGGAGTTTGCCTCCTGGCTTGTTGAGACGAGTTTCTTCCACTTGGACCACCACCACCTCGGCCACAGGTCTACCCACCTTGGAG CCTGCACCAGTACGGAGAGACCGCAGCACCAGCATCAAACTGCAGGAAGCACCTTCATCCAGTCCTGATTCTTGGAATAATCCAGTGATG ATGACCCTCACCAAAAGCAGATCCTTTACTTCATCCTATGCTATTTCTGCAGCTAACCATGTAAAGGCTAAAAAGCAAAGTCGACCAGGT GCCCTCGCTAAAATTTCACCTCTTTCATCGCCCTGCTCCTCACCTCTCCAAGGGACTCCTGCCAGCAGCCTGGTCAGCAAAATTTCTGCA GTGCAGTTTCCAGAATCTGCTGACACAACTGCCAAACAAAGCCTAGGTTCTCACAGGGCCTTAACTTACACTCAGAGTGCCCCAGACCTA TCCCCTCAAATCCTGACTCCACCTGTTATATGTAGCAGCTGTGGCAGACCATATTCCCAAGGGAATCCTGCTGATGAGCCCCTGGAGAGA AGTGGGGTAGCCACTCGGACACCAAGTAGAACAGATGACACTGCTCAAGTTACCTCTGATTATGAAACCAATAACAACAGTGACAGCAGT GACATTGTACAGAATGAAGATGAAACAGAGTGCCTGAGAGAGCCTCTGAGGAAAGCATCGGCTTGCAGCACCTATGCTCCTGAGACCATG ATGTTTCTGGACAAACCAATTCTTGCTCCCGAACCTCTTGTCATGGATAACCTGGACTCAATTATGGAGCAGCTAAATACTTGGAATTTT CCAATTTTTGATTTAGTGGAAAATATAGGAAGAAAATGTGGCCGTATTCTTAGTCAGGTATCTTACAGACTTTTTGAAGACATGGGCCTC TTTGAAGCTTTTAAAATTCCAATTAGGGAATTTATGAATTATTTTCATGCTTTGGAGATTGGATATAGGGATATTCCTTATCATAACAGA ATCCATGCCACTGATGTTTTACATGCTGTTTGGTATCTTACTACACAGCCTATTCCAGGCCTCTCAACTGTGATTAATGATCATGGTTCA ACCAGTGATTCAGATTCTGACAGTGGATTTACACATGGACATATGGGATATGTATTCTCAAAAACGTATAATGTGACAGATGATAAATAC GGATGTCTGTCTGGGAATATCCCTGCCTTGGAGTTGATGGCGCTGTATGTGGCTGCAGCCATGCACGATTATGATCATCCAGGAAGGACT AATGCTTTCCTGGTTGCAACTAGTGCTCCTCAGGCGGTGCTATATAACGATCGTTCAGTTTTGGAGAATCATCACGCAGCTGCTGCATGG AATCTTTTCATGTCCCGGCCAGAGTATAACTTCTTAATTAACCTTGACCATGTGGAATTTAAGCATTTCCGTTTCCTTGTCATTGAAGCA ATTTTGGCCACTGACCTGAAGAAACACTTTGACTTCGTAGCCAAATTTAATGGCAAGGTAAATGATGATGTTGGAATAGATTGGACCAAT GAAAATGATCGTCTACTGGTTTGTCAAATGTGTATAAAGTTGGCTGATATCAATGGTCCAGCTAAATGTAAAGAACTCCATCTTCAGTGG ACAGATGGTATTGTCAATGAATTTTATGAACAGGGTGATGAAGAGGCCAGCCTTGGATTACCCATAAGCCCCTTCATGGATCGTTCTGCT CCTCAGCTGGCCAACCTTCAGGAATCCTTCATCTCTCACATTGTGGGGCCTCTGTGCAACTCCTATGATTCAGCAGGACTAATGCCTGGA AAATGGGTGGAAGACAGCGATGAGTCAGGAGATACTGATGACCCAGAAGAAGAGGAGGAAGAAGCACCAGCACCAAATGAAGAGGAAACC TGTGAAAATAATGAATCTCCAAAAAAGAAGACTTTCAAAAGGAGAAAAATCTACTGCCAAATAACTCAGCACCTCTTACAGAACCACAAG ATGTGGAAGAAAGTCATTGAAGAGGAGCAACGGTTGGCAGGCATAGAAAATCAATCCCTGGACCAGACCCCTCAGTCGCACTCTTCAGAA CAGATCCAGGCTATCAAGGAAGAAGAAGAAGAGAAAGGGAAACCAAGAGGCGAGGAGATACCAACCCAAAAGCCAGACCAGTGACAATGG ATAGAATGGGCTGTGTTTCCAAACAGATTGACTTGTCAAAGACTCTCTTCAAGCCAGCACAACATTTAGACACAACACTGTAGAAATTTG AGATGGGCAAATGGCTATTGCATTTTGGGATTCTTCGCATTTTGTGTGTATATTTTTACAGTGAGGTACATTGTTAAAAACTTTTTGCTC AAAGAAGCTTTCACATTGCAACACCAGCTTCTAAGGATTTTTTAAGGAGGGAATATATATGTGTGTGTGTATATAAGCTCCCACATAGAT ACATGTAAAACATATTCACACCCATGCACGCACACACATACACACTGAAGGCCACGATTGCTGGCTCCACAATTTAGTAACATTTATATT AAGATATATATATAGTGGTCACTGTGATATAATAAATCATAAAGGAAACCAAATCACAAAGGAGATGGTGTGGCTTAGCAAGGAAACAGT GCAGGAAATGTAGGTTACCAACTAAGCAGCTTTTGCTCTTAGTACTGAGGGATGAAAGTTCCAGAGCATTATTTGAATTCTGATACATCC TGCCAACACTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGAAAGAGAGACAGAAGGGAATGGTTTGAGAGGGTGCTT GTGTGCATGTGTGTGCATATGTAAAGAGATTTTTGTGGTTTAAGTAACTCAGAATAGCTGTAGCAAATGACTGAATACATGTGAACAAAC AGAAGGAAGTTCACTCTGGAGTGTCTTTGGGAGGCAGCCATTCCAAATGCCCTCCTCCATTTAGCTTCAATAAAGGGCCTTTTGCTGATG GAGGGCACTCAAGGGCTGGGTGAGAGGGCCACGTGTTTGGTATTACATTACTGCTATGCACCACTTGAAGGAGCTCTATCACCAGCCTCA AACCCGAAAGACTGAGGCATTTTCCAGTCTACTTGCCTAATGAATGTATAGGAACTGTCTATGAGTATGGATGTCACTCAACTAAGATCA AATCACCATTTAAGGGGATGGCATTCTTTATACCTAAACACCTAAGAGCTGAAGTCAGGTCTTTTAATCAGGTTAGAATTCTAAATGATG CCAGAGAAGGCTTGGGAAATTGTACTTCAGCGTGATAGCCTGTGTCTTCTTAATTTGCTGCAAAATATGTGGTAGAGAAAGAAAAGGAAA CAGAAAAATCACTCTGGGTTATATAGCAAGAGATGAAGGAGAATATTTCAACACAGGGTTTTTGTGTTGACATAGGAAAAGCCTGATTCT TGGCAACTGTTGTAGTTTGTCTTTCAGGGGTGAAGGTCCCACTGACAACCCCTGTTGTGGTGTTCCACACGCTGTTTGTTGGGGTAGCTT CCATCGGCAGTCTGGCCCATTGTCAGTCATGCTTCTTCTGGCCGGGGAGATTATAGAGAGATTGTTTGAAGATTGGGTTATTATTGAAAG TCTTTTTTTTTGTTTGTTTTGTTTTGGTTTGTTTGTTTATCTACACTTGTTTATGCTGTGAGCCAAACCTCTATTTAAAAAGTTGATACT CACTTTCAATATTTTATTTCATATTATTATATATGTCATGATAGTTATCTTGATGTAAATATGAAGATTTTTTTGTTTCTGTAGATAGTA AACTCTTTTTTTAAAAAAGGAAAAGGGAAACATTTTTATAAAGTTATATTTTAATCACCATTTTTATACATTGTAGTTCTCTCCAAGCCC AGTAAGAGAATGATGATTCATTTGCATGGAGGTCGATGGACAACCAATCATCTACCTTTTCTAATTTAAATGATAATCTGATATAGTTTT ATTGCCAGTTAAATGAGGATGCTGCAAAGCATGTTTTTTCACTAGTAACTTTTGCTAACTGAATGAATTCTGGGTCCATATCTCCCAGAT GAAAAACTGTTAACCAATACCATATTTTATAGTTGGTGTCCATTTCTTTCCAACACTGTTTGTTATGATTCTTCCTTGAGTACTTATATA CAGACCTGCTCATTATCTAAACAATCTTACCTTCTAAGTAAACCTTGATTGTGATTTCCAGTTTTTATTTTCTCTGACGTAGTAGAAAGG AATGTTTACATTAAAAATACTTTTGTTTCTCATAAATGGATATTGTACTCCCCCCTTTCAAAGCATTATTTTACAATAATTCATGGCATT TTAAAAAATAAGGCAAAGATAATACGACAAAAAATATACATGGTTTCAAGGCAAATTCTCCAATAAGTTGGAAAATGTAAAAAGGATCAA GTGGATGCAGCCTCTACCTAAATAATTAAAATATATTTCAGTATATTTCTGAATTAACACCAGGTCTTCATTATTTAGAACTTACTAAAT TGTTTTCATTTTCTTAGTTTTACCTGTGTATCTCCATGTTTGCAAAAATTACTATAAGTCAAATTTTGCCAGTGAATTTAACTATTTTTC TTTCCTTGCAATTAAGGGGAAAAAAGCATTTATCTTATCTTCTCATACCCCTTGCATCTAAGTACTTAGCAAAGTCAATATTTTCCCATT TTCCAAATGCGTCCATCTCTAACATAAATATTAATTGAACATAGAGCTATGTTTGGAGTGAGTGGACTGGCAGGACAGTTGGAAGTCCAT CACAGTCTATTGACAGTTTCATCAAAGCTGTATAGTCCAACTAGTGGGGCAGCTTGGCTACTATGGTGGAAGTCTCAGCAAACTGCCTGG TTTTGTTTGTTTGTTTTGTTTTAAGGTACAGGAAATAAGAGGAATAATAGTGGCCAAAGCAATTAGAACATCTTCATTCCAGAACTGTGT TCAGCAATCCAGGCAGATTGATACATTTTTCTTTAAAAATAAATTGCTATTACAGCTAGACGTCAATTGGGATAAATAAAGGGATGAAGA TCCACTAAGTTTGTGACTTTCATACACACCCAGTACATCTCAAAGGATGCTAAGGGACATTTTCTGCCAGTAGAGTTCTCCCCCTTTTTG GTGACAGCAATATTATTATGTTCACATCTAACTCCAGAGCTTACTTCCTGTGGTGCCAATGTATTTGTTGCAATTTACTACATTTTTATA TGAGCCTATTTATAGGTGCCATTAAACTCAGGTCTTTCAAATGAAAGAGTTTCTAGCCCACTTAGGGAAAAAGATAATTGTTTAGAAAAC CATAAAATCAATGGTAGGAAAAGTTGGAACTGGTTACCTGGATGCCATGGTTCTCTGTTAAATAAAGTAAGAGACCAGGTGTATTCTGAG TGTCATCAGTGTTATTTTCAGCATGCTAATAAATGTCTTTCCGGTTATATATCTATCTAAATTAACCTTTAAAATATTGGTTTCCTTGAT AAAAGCACCACTTTTGCTTTTGTTAGCTGTAATATTTTTTGTCATTTAGATAAGACCTGGTTTGGCTCTCAATAAAAGATGAAGACAGTA GCTCTGTACAGGGATATATCTATATTAGTCTTCATCTGATGAATGAAGAAATTTTCTCATATTATGTTCAAGAAAGTATTTACTTCCTAA AAATAGAATTCCCGATTCTGTCTATTTTGGTTGAATACCAGAACAAATCTTTCCGTTGCAATCCCAGTAAAACGAAAGAAAAGGAATATC TTACAGACTGTTCATATTAGATGTATGTAGACTGTTAATTTGCAATTTCCCCATATTTCCTGCCTATCTTACCCAGATAACTTTCTTTGA AGGTAAAAGCTGTGCAAAAGGCATGAGACTCAGGCCTACTCTTTGTTTAAATGATGGAAAAATATAAATTATTTTCTAAGTAATAAAAGT ATAAAAATTATCATTATAAATAAAGTCTAAAGTTTGAAATTATTAATTTATAAAAGTGAACTAATTGTGTGATTATCAAATCCTGATTAA TGAGAAGTGAATAATCTAAAAATCATTTATATTCTACTGTGGGAGGTATTCTTGGTGCTTCCATGTCAGTATCGGGCTCTCCATTGTCCT CATCATTTATAGTACTTCTAAAATAATAATGGAAACCTCAATAAGGGTCTTGTCCTCTTCTGTCATCCTAACCCTGATTCTAGTTTAATG >12091_12091_2_C8orf76-PDE3A_C8orf76_chr8_124238740_ENST00000521310_PDE3A_chr12_20709594_ENST00000359062_length(amino acids)=820AA_BP=0 MGHSEWDHKRGPRGSQSSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPVTSLSENYTCSDSE ESSEKDKLAIPKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSTSIKLQEAPSSSPDSWNNPVMMTLTKSRSFTSSYAISA ANHVKAKKQSRPGALAKISPLSSPCSSPLQGTPASSLVSKISAVQFPESADTTAKQSLGSHRALTYTQSAPDLSPQILTPPVICSSCGRP YSQGNPADEPLERSGVATRTPSRTDDTAQVTSDYETNNNSDSSDIVQNEDETECLREPLRKASACSTYAPETMMFLDKPILAPEPLVMDN LDSIMEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQP IPGLSTVINDHGSTSDSDSDSGFTHGHMGYVFSKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYND RSVLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGKVNDDVGIDWTNENDRLLVCQMCIKLADI NGPAKCKELHLQWTDGIVNEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCNSYDSAGLMPGKWVEDSDESGDTDDPEE EEEEAPAPNEEETCENNESPKKKTFKRRKIYCQITQHLLQNHKMWKKVIEEEQRLAGIENQSLDQTPQSHSSEQIQAIKEEEEEKGKPRG -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for C8orf76-PDE3A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for C8orf76-PDE3A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for C8orf76-PDE3A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies