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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACAP2-ATP13A3 (FusionGDB2 ID:1213)

Fusion Gene Summary for ACAP2-ATP13A3

Fusion gene summary

Fusion gene information	Fusion gene name: ACAP2-ATP13A3
	Fusion gene ID: 1213
		Hgene	Tgene
	Gene symbol	ACAP2	ATP13A3
	Gene ID	23527	79572
	Gene name	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	ATPase 13A3
	Synonyms	CENTB2\|CNT-B2	AFURS1
	Cytomap	3q29	3q29
	Type of gene	protein-coding	protein-coding
	Description	arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2Arf GAP with coiled coil, ANK repeat and PH domains 2centaurin-beta-2	probable cation-transporting ATPase 13A3ATPase family homolog up-regulated in senescence cells 1ATPase type 13A3
	Modification date	20200313	20200313
	UniProtAcc	Q15057	Q9H7F0
	Ensembl transtripts involved in fusion gene	ENST00000326793, ENST00000472860,	ENST00000256031, ENST00000439040,
Fusion gene scores	* DoF score	16 X 14 X 11=2464	7 X 9 X 5=315
	# samples	22	11
	** MAII score	log2(22/2464*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/315*10)=-1.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ACAP2 [Title/Abstract] AND ATP13A3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACAP2(195101738)-ATP13A3(194134568), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACAP2	GO:0030029	actin filament-based process	11062263

Fusion gene breakpoints across ACAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP13A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8277	ACAP2	chr3	195101738	-	ATP13A3	chr3	194134568	-

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Fusion Gene ORF analysis for ACAP2-ATP13A3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000326793	ENST00000256031	ACAP2	chr3	195101738	-	ATP13A3	chr3	194134568	-
In-frame	ENST00000326793	ENST00000439040	ACAP2	chr3	195101738	-	ATP13A3	chr3	194134568	-
intron-3CDS	ENST00000472860	ENST00000256031	ACAP2	chr3	195101738	-	ATP13A3	chr3	194134568	-
intron-3CDS	ENST00000472860	ENST00000439040	ACAP2	chr3	195101738	-	ATP13A3	chr3	194134568	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000326793	ACAP2	chr3	195101738	-	ENST00000439040	ATP13A3	chr3	194134568	-	4042	516	213	794	193
ENST00000326793	ACAP2	chr3	195101738	-	ENST00000256031	ATP13A3	chr3	194134568	-	4034	516	213	794	193

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000326793	ENST00000439040	ACAP2	chr3	195101738	-	ATP13A3	chr3	194134568	-	0.000863201	0.99913687
ENST00000326793	ENST00000256031	ACAP2	chr3	195101738	-	ATP13A3	chr3	194134568	-	0.000886539	0.9991135

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Fusion Genomic Features for ACAP2-ATP13A3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACAP2-ATP13A3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:195101738/chr3:194134568)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACAP2 Q15057	ATP13A3 Q9H7F0
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). {ECO:0000269\|PubMed:11062263}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

1144_1164

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

1144_1164

1134

1227.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACAP2

chr3:195101738

chr3:194134568

ENST00000326793

1_226

779.0

Domain

Note=BAR

Hgene

ACAP2

chr3:195101738

chr3:194134568

ENST00000326793

266_361

779.0

Domain

Hgene

ACAP2

chr3:195101738

chr3:194134568

ENST00000326793

399_520

779.0

Domain

Arf-GAP

Hgene

ACAP2

chr3:195101738

chr3:194134568

ENST00000326793

640_669

779.0

Repeat

Note=ANK 1

Hgene

ACAP2

chr3:195101738

chr3:194134568

ENST00000326793

673_702

779.0

Repeat

Note=ANK 2

Hgene

ACAP2

chr3:195101738

chr3:194134568

ENST00000326793

706_735

779.0

Repeat

Note=ANK 3

Hgene

ACAP2

chr3:195101738

chr3:194134568

ENST00000326793

414_437

779.0

Zinc finger

C4-type

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

231_234

1134

1227.0

Compositional bias

Note=Poly-Tyr

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

231_234

1134

1227.0

Compositional bias

Note=Poly-Tyr

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

1000_1020

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

1074_1094

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

1106_1126

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

206_226

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

233_253

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

29_49

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

410_430

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

449_469

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

941_961

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000256031

963_983

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

1000_1020

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

1074_1094

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

1106_1126

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

206_226

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

233_253

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

29_49

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

410_430

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

449_469

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

941_961

1134

1227.0

Transmembrane

Helical

Tgene

ATP13A3

chr3:195101738

chr3:194134568

ENST00000439040

963_983

1134

1227.0

Transmembrane

Helical

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Fusion Gene Sequence for ACAP2-ATP13A3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1213_1213_1_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000256031_length(transcript)=4034nt_BP=516nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATAGTGTGTGTACCATATCAGTGG
CGTGTAACTATGCTCATCATTGTTCTTGTCAATGCCTTTGTGTCTATCACAGTGGAGGAGTCAGTGGATCGGTGGGGAAAATGCTGCTTA
CCCTGGGCCCTGGGCTGTAGAAAGAAGACACCAAAGGCAAAGTACATGTATCTGGCGCAGGAGCTCTTGGTTGATCCAGAATGGCCACCA
AAACCTCAGACAACCACAGAAGCTAAAGCTTTAGTTAAGGAGAATGGATCATGTCAAATCATCACCATAACATAGCAGTGAATCAGTCTC
AGTGGTATTGCTGATAGCAGTATTCAGGAATATGTGATTTTAGGAGTTTCTGATCCTGTGTGTCAGAATGGCACTAGTTCAGTTTATGTC
CCTTCTGATATAGTAGCTTATTTGACAGCTTTGCTCTTCCTTAAAATAAAAACAGAAAAATATATCGTCCTAACAGTTAAATTAACAATC
AATCCATAAAGTCCTATATCTTCATTCAGCAACCCAAATATTACATACATTTCCAGAATTTTCTTGATTGTTACTTTCAGTGATATTCTT
TATATTGGGTACAGGAGAAGTTTGGTGTTTGGTAGGTTTTTCAACATTAGTTTTTGAGACTAGTTTACCTCTTCACATTTATGCTCACAA
CCCTCTTGTTAGAAAAGTCTGTGTTTATATACAGGCTGTAAGTTTGTGATTGATAAAAAGAAGATGAGTGTTAATTAGCCTCCAGTGAAA
ATATACTGAAAGCCTGTTTTCATTTGATTCCAATGTTTCTTCCAAAGAATTCTGTATAAACATATGCCAATTCCCTATGATGGTCTAGAG
TTAGGAATGAGTGTTTATGGTGTTGCTTATAGAACAACTCAGGTAATCTCCATTTCTGGTTTTATATTTTCTGTACAAACTGCCTGGGTT
TTATTTTTCTAATCAGCAAGGTGCTTCACTGCCTTCTTGAGACGCCTCTCAAAGCTCTTAAATGGCTCCTGTGCTATGTGTGGTGTTGGC
AGTCTAATTTGCTTCTGTTAAATGTTGTAGAACCTTTTTCACTAGGAAATAAGATTCATTTCTTTCGGCAGTAGATGTAGATTCATCTTT
TAACGTTTCTTCAAATTTGTTTCTGTCAGGCTTTGTGTTATTTTAAATGGTTTTTTAAAATTTTCTTCTATGTTTTCAATTACCTAAAGA
CATAGGATAATAGTTTTTTTTAAGTTAGAATTTTACCTCATAAAATTTTTTGAGGTTTGATGTATGTCTCTGTCTTATCAATAATGAGGC
TTAAAAAATACTGGATTTGAATGGCTGCCGTTTTTTCAAAGCAATATGAATTTGATGAGTTTGTTTTATGCCATTAGGTGGCGCCAGAGG
TCAGAACATGTCTATTTTGAATTGGATCGTTACAAATGAGCATATTTGATGCGGAAATTTCTGGGAGAAAAAAAATTGAGGAAATAAAGT
TAAAAAATTGACATTCATTGAGCCAAAAGAGATGTGGAGAAACATTTTTCACCTTTCTGTTTGGCCTGATTAACATTTAAATTCTTGCCA
AAATTAAGGTAACTTTTAAAAAACACCTTTTATAGGTGGATCCAGCAGTCTGGCAACGCCCACAGTTACCACAACACAGAAAACTGATCG
TGCTATAAAATGGACGCTAAACTATGAAAACAGTGTGACATTGTTCTCTGTTCTTCCAGAGCCAGTAACATGCTTGCTCGTGCTTTCTAC
TTCTAGCTGATCATTCTTTTCCCAACATATATTTACAAATTTACCAAATTTTACCTAGAATTTTAGGACCAAATGGTTCTCACTCTTTAT
GCTGCAAAGACCTGGATGATGTTTGGTAACTATAGAAAAATAGAAATTACACTCAGGATCACTGTTACTGCTATTGCCACTGATGATTCC
TGCAAAAATATAATCGAAGTTTTCCATCAAATGTATAATATGCTATTAATACACATTAGATGATAACAGTTGTTCCATGAATGATTCTAT
GAAGCTATGCATCTTAGACCTCTTGAGCTGTGAATTAGCACTATTTTCTATAGTTACTTATTCTCTGGATCATTTTATAATTTCCATATT
AATTTCAAATATGCTCGTGTTATTCTTCAGTGATTTCCACAATTGTGCATTTTATTCTTTGGTTTAAGTACTGAAGCATATAATGAAAGT
AATTGCTAAGTAGCAGCTTAAAAATTCAATTATCCGATTGTATTTAACATCTTTAAGAGCATGATCATAAAGAGCTATTTTTGACACCCC
CCCCCCACTTTTTTAACATTTAGAGTTAGTAAGGGTTTTATATCTCTTCTGTCCATATTGTTTTCAAAGGAATGAGGTGTTTAGGTGGCT
GGAAAAGCATTTGTAGGAAGTTAGATTTGAATATAGACAAGGTGGGTTATTCACGTTGAGAATGTTATTTGAAGAATGCCTGTGAAGCCA
GGTGTGGGTTCTACTCAGTGCCATAGATAGACTGAGTCTTCTCTCGTAGGTTACCATTACATAGTAATTTTGATTCTGAATTTCACATTA
AATTATTTGAGTTTATACAGACCTAAATTTTAAAATCTGTACATATATTATTTTGATGTATTAAGATGAATATTGCTGATTTAAATTTTA
TTTATGCACATACTTAAAGGACAGAAATGTCTGGGAAAGTAATTGTTAAATAATGATATGTAACTTTTTAACTTTTTAAATAAATAACAA
GATTTTTAATGTGTGTCTCCCTCAGGGTTGTTTAAAGTTTTTTTTCTCCCTCAAGTATAAATAGTGGTAACTATATGTTTTGTATCTTCT
AGCACCAACTGCTGTAAAGCAATGCTGCAAATAATGCTTGAATACAAGTGGCTAAGCCAACAACAGAATAAATACTTTTATAGTAGTTTT
ATAATCCTGAAATTCGAAAGCTTTCCCAATTGCACTTGCATCTAAACAAAACTGTTGCAGTTTTTACTCTATTTATTTTGTTCCCCATGT
TTATGAAAGTCCTGCACAGTTTCAAAGGCATGGTAAATAATATATCAATGTTTATGTAGTCTGTTACAGAAACAGCTATAGATAACATTA
TCCAGTGAAGAGCAAAATTCAAGCTTTAGAAAATATTCATGCATGCAATTTTGACATATCTAAAAATAGGTTTTTGTATATTTATGGTGG
GAGGTGGTTGGGAACTTTTAACAAAATGGGGTGTTAATTTTTGTACAGTCTGTGGGCATTTACACATTTTTAATGTATTAAAATTTGGTA
ATTATGTGTACATTAAATTAATAAAAGTTACTTCTAGTTATGATTTGTGAATTCCCTAAGACCTTGGATTTTTTTAAGTAACTTTATATC
AGAAATGATACTGCATCTTTATATTTTTAAAATTGTATTGCTGCTCAAGAATGGTACCCTCTTGTCAAAAAGGCATACATTCATAATTGT

>1213_1213_1_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000256031_length(amino acids)=193AA_BP=101
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTIVCVPYQWRVTMLIIVLVNAFVSITVEESVDRWGKCCLPWALGCRKKTPKAKYMYLAQELLVDPEWPPKPQTTTEAKAL

--------------------------------------------------------------
>1213_1213_2_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000439040_length(transcript)=4042nt_BP=516nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATAGTGTGTGTACCATATCAGTGG
CGTGTAACTATGCTCATCATTGTTCTTGTCAATGCCTTTGTGTCTATCACAGTGGAGGAGTCAGTGGATCGGTGGGGAAAATGCTGCTTA
CCCTGGGCCCTGGGCTGTAGAAAGAAGACACCAAAGGCAAAGTACATGTATCTGGCGCAGGAGCTCTTGGTTGATCCAGAATGGCCACCA
AAACCTCAGACAACCACAGAAGCTAAAGCTTTAGTTAAGGAGAATGGATCATGTCAAATCATCACCATAACATAGCAGTGAATCAGTCTC
AGTGGTATTGCTGATAGCAGTATTCAGGAATATGTGATTTTAGGAGTTTCTGATCCTGTGTGTCAGAATGGCACTAGTTCAGTTTATGTC
CCTTCTGATATAGTAGCTTATTTGACAGCTTTGCTCTTCCTTAAAATAAAAACAGAAAAATATATCGTCCTAACAGTTAAATTAACAATC
AATCCATAAAGTCCTATATCTTCATTCAGCAACCCAAATATTACATACATTTCCAGAATTTTCTTGATTGTTACTTTCAGTGATATTCTT
TATATTGGGTACAGGAGAAGTTTGGTGTTTGGTAGGTTTTTCAACATTAGTTTTTGAGACTAGTTTACCTCTTCACATTTATGCTCACAA
CCCTCTTGTTAGAAAAGTCTGTGTTTATATACAGGCTGTAAGTTTGTGATTGATAAAAAGAAGATGAGTGTTAATTAGCCTCCAGTGAAA
ATATACTGAAAGCCTGTTTTCATTTGATTCCAATGTTTCTTCCAAAGAATTCTGTATAAACATATGCCAATTCCCTATGATGGTCTAGAG
TTAGGAATGAGTGTTTATGGTGTTGCTTATAGAACAACTCAGGTAATCTCCATTTCTGGTTTTATATTTTCTGTACAAACTGCCTGGGTT
TTATTTTTCTAATCAGCAAGGTGCTTCACTGCCTTCTTGAGACGCCTCTCAAAGCTCTTAAATGGCTCCTGTGCTATGTGTGGTGTTGGC
AGTCTAATTTGCTTCTGTTAAATGTTGTAGAACCTTTTTCACTAGGAAATAAGATTCATTTCTTTCGGCAGTAGATGTAGATTCATCTTT
TAACGTTTCTTCAAATTTGTTTCTGTCAGGCTTTGTGTTATTTTAAATGGTTTTTTAAAATTTTCTTCTATGTTTTCAATTACCTAAAGA
CATAGGATAATAGTTTTTTTTAAGTTAGAATTTTACCTCATAAAATTTTTTGAGGTTTGATGTATGTCTCTGTCTTATCAATAATGAGGC
TTAAAAAATACTGGATTTGAATGGCTGCCGTTTTTTCAAAGCAATATGAATTTGATGAGTTTGTTTTATGCCATTAGGTGGCGCCAGAGG
TCAGAACATGTCTATTTTGAATTGGATCGTTACAAATGAGCATATTTGATGCGGAAATTTCTGGGAGAAAAAAAATTGAGGAAATAAAGT
TAAAAAATTGACATTCATTGAGCCAAAAGAGATGTGGAGAAACATTTTTCACCTTTCTGTTTGGCCTGATTAACATTTAAATTCTTGCCA
AAATTAAGGTAACTTTTAAAAAACACCTTTTATAGGTGGATCCAGCAGTCTGGCAACGCCCACAGTTACCACAACACAGAAAACTGATCG
TGCTATAAAATGGACGCTAAACTATGAAAACAGTGTGACATTGTTCTCTGTTCTTCCAGAGCCAGTAACATGCTTGCTCGTGCTTTCTAC
TTCTAGCTGATCATTCTTTTCCCAACATATATTTACAAATTTACCAAATTTTACCTAGAATTTTAGGACCAAATGGTTCTCACTCTTTAT
GCTGCAAAGACCTGGATGATGTTTGGTAACTATAGAAAAATAGAAATTACACTCAGGATCACTGTTACTGCTATTGCCACTGATGATTCC
TGCAAAAATATAATCGAAGTTTTCCATCAAATGTATAATATGCTATTAATACACATTAGATGATAACAGTTGTTCCATGAATGATTCTAT
GAAGCTATGCATCTTAGACCTCTTGAGCTGTGAATTAGCACTATTTTCTATAGTTACTTATTCTCTGGATCATTTTATAATTTCCATATT
AATTTCAAATATGCTCGTGTTATTCTTCAGTGATTTCCACAATTGTGCATTTTATTCTTTGGTTTAAGTACTGAAGCATATAATGAAAGT
AATTGCTAAGTAGCAGCTTAAAAATTCAATTATCCGATTGTATTTAACATCTTTAAGAGCATGATCATAAAGAGCTATTTTTGACACCCC
CCCCCCACTTTTTTAACATTTAGAGTTAGTAAGGGTTTTATATCTCTTCTGTCCATATTGTTTTCAAAGGAATGAGGTGTTTAGGTGGCT
GGAAAAGCATTTGTAGGAAGTTAGATTTGAATATAGACAAGGTGGGTTATTCACGTTGAGAATGTTATTTGAAGAATGCCTGTGAAGCCA
GGTGTGGGTTCTACTCAGTGCCATAGATAGACTGAGTCTTCTCTCGTAGGTTACCATTACATAGTAATTTTGATTCTGAATTTCACATTA
AATTATTTGAGTTTATACAGACCTAAATTTTAAAATCTGTACATATATTATTTTGATGTATTAAGATGAATATTGCTGATTTAAATTTTA
TTTATGCACATACTTAAAGGACAGAAATGTCTGGGAAAGTAATTGTTAAATAATGATATGTAACTTTTTAACTTTTTAAATAAATAACAA
GATTTTTAATGTGTGTCTCCCTCAGGGTTGTTTAAAGTTTTTTTTCTCCCTCAAGTATAAATAGTGGTAACTATATGTTTTGTATCTTCT
AGCACCAACTGCTGTAAAGCAATGCTGCAAATAATGCTTGAATACAAGTGGCTAAGCCAACAACAGAATAAATACTTTTATAGTAGTTTT
ATAATCCTGAAATTCGAAAGCTTTCCCAATTGCACTTGCATCTAAACAAAACTGTTGCAGTTTTTACTCTATTTATTTTGTTCCCCATGT
TTATGAAAGTCCTGCACAGTTTCAAAGGCATGGTAAATAATATATCAATGTTTATGTAGTCTGTTACAGAAACAGCTATAGATAACATTA
TCCAGTGAAGAGCAAAATTCAAGCTTTAGAAAATATTCATGCATGCAATTTTGACATATCTAAAAATAGGTTTTTGTATATTTATGGTGG
GAGGTGGTTGGGAACTTTTAACAAAATGGGGTGTTAATTTTTGTACAGTCTGTGGGCATTTACACATTTTTAATGTATTAAAATTTGGTA
ATTATGTGTACATTAAATTAATAAAAGTTACTTCTAGTTATGATTTGTGAATTCCCTAAGACCTTGGATTTTTTTAAGTAACTTTATATC
AGAAATGATACTGCATCTTTATATTTTTAAAATTGTATTGCTGCTCAAGAATGGTACCCTCTTGTCAAAAAGGCATACATTCATAATTGT

>1213_1213_2_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000439040_length(amino acids)=193AA_BP=101
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTIVCVPYQWRVTMLIIVLVNAFVSITVEESVDRWGKCCLPWALGCRKKTPKAKYMYLAQELLVDPEWPPKPQTTTEAKAL

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Fusion Gene PPI Analysis for ACAP2-ATP13A3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ACAP2-ATP13A3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ACAP2-ATP13A3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source