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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CAAP1-COG5 (FusionGDB2 ID:12201) |
Fusion Gene Summary for CAAP1-COG5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CAAP1-COG5 | Fusion gene ID: 12201 | Hgene | Tgene | Gene symbol | CAAP1 | COG5 | Gene ID | 79886 | 10466 |
| Gene name | caspase activity and apoptosis inhibitor 1 | component of oligomeric golgi complex 5 | |
| Synonyms | C9orf82|CAAP | CDG2I|GOLTC1|GTC90 | |
| Cytomap | 9p21.2 | 7q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | caspase activity and apoptosis inhibitor 1conserved anti-apoptotic protein | conserved oligomeric Golgi complex subunit 513S golgi transport complex 1 90 kDa subunitCOG complex subunit 5conserved oligomeric Golgi complex protein 5 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9H8G2 | Q9UP83 | |
| Ensembl transtripts involved in fusion gene | ENST00000333916, ENST00000535437, ENST00000495958, ENST00000520187, | ENST00000475638, ENST00000297135, ENST00000347053, ENST00000393603, | |
| Fusion gene scores | * DoF score | 5 X 4 X 5=100 | 14 X 10 X 8=1120 |
| # samples | 6 | 13 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/1120*10)=-3.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CAAP1 [Title/Abstract] AND COG5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CAAP1(26861063)-COG5(107053077), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | COG5 | GO:0048219 | inter-Golgi cisterna vesicle-mediated transport | 9792665 |
| Fusion gene breakpoints across CAAP1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across COG5 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | READ | TCGA-AH-6547 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
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Fusion Gene ORF analysis for CAAP1-COG5 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000333916 | ENST00000475638 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| 5CDS-5UTR | ENST00000535437 | ENST00000475638 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| Frame-shift | ENST00000535437 | ENST00000297135 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| Frame-shift | ENST00000535437 | ENST00000347053 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| Frame-shift | ENST00000535437 | ENST00000393603 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| In-frame | ENST00000333916 | ENST00000297135 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| In-frame | ENST00000333916 | ENST00000347053 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| In-frame | ENST00000333916 | ENST00000393603 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-3CDS | ENST00000495958 | ENST00000297135 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-3CDS | ENST00000495958 | ENST00000347053 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-3CDS | ENST00000495958 | ENST00000393603 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-3CDS | ENST00000520187 | ENST00000297135 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-3CDS | ENST00000520187 | ENST00000347053 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-3CDS | ENST00000520187 | ENST00000393603 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-5UTR | ENST00000495958 | ENST00000475638 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| intron-5UTR | ENST00000520187 | ENST00000475638 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000333916 | CAAP1 | chr9 | 26861063 | - | ENST00000347053 | COG5 | chr7 | 107053077 | - | 4678 | 828 | 89 | 2716 | 875 |
| ENST00000333916 | CAAP1 | chr9 | 26861063 | - | ENST00000297135 | COG5 | chr7 | 107053077 | - | 3732 | 828 | 89 | 2779 | 896 |
| ENST00000333916 | CAAP1 | chr9 | 26861063 | - | ENST00000393603 | COG5 | chr7 | 107053077 | - | 5343 | 828 | 89 | 2668 | 859 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000333916 | ENST00000347053 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - | 0.001198638 | 0.99880135 |
| ENST00000333916 | ENST00000297135 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - | 0.001237293 | 0.9987627 |
| ENST00000333916 | ENST00000393603 | CAAP1 | chr9 | 26861063 | - | COG5 | chr7 | 107053077 | - | 0.001514338 | 0.99848574 |
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Fusion Genomic Features for CAAP1-COG5 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CAAP1-COG5 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:26861063/chr7:107053077) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CAAP1 | COG5 |
| FUNCTION: Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}. | FUNCTION: Required for normal Golgi function. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CAAP1 | chr9:26861063 | chr7:107053077 | ENST00000333916 | - | 5 | 6 | 19_25 | 246 | 362.0 | Compositional bias | Note=Poly-Ala |
| Hgene | CAAP1 | chr9:26861063 | chr7:107053077 | ENST00000535437 | - | 5 | 6 | 19_25 | 101 | 217.0 | Compositional bias | Note=Poly-Ala |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CAAP1 | chr9:26861063 | chr7:107053077 | ENST00000333916 | - | 5 | 6 | 281_311 | 246 | 362.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | CAAP1 | chr9:26861063 | chr7:107053077 | ENST00000535437 | - | 5 | 6 | 281_311 | 101 | 217.0 | Coiled coil | Ontology_term=ECO:0000255 |
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Fusion Gene Sequence for CAAP1-COG5 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >12201_12201_1_CAAP1-COG5_CAAP1_chr9_26861063_ENST00000333916_COG5_chr7_107053077_ENST00000297135_length(transcript)=3732nt_BP=828nt CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAG GTTTGGAATTAAAACAAGATTATCTTTCTCAAGGAATAGATCTTTCTGGAATAGAAGTGATAGAAAATGATCTACTTTTTATTGCAAGAG CCCGACTTGAAGTGGAAAATCAAGCTAAGCGCCTACTAGAGCAGGGTTTGGAGACTCAGAATCCAACTCAAGTCGGAACAGCTCTTCAGG TTTTCTATAATCTTGGAACTTTGAAGGATACTATTACCAGTGTTGTGGATGGATATTGTGCTACTTTAGAAGAAAATATCAACAGTGCAT TAGACATAAAAGTTTTGACTCAGCCTTCCCAGTCAGCTGTGAGAGGGGGACCTGGACGATCTACCATGCCAACCCCAGGAAATACTGCAG CTTTGCGTGCCTCATTCTGGACCAATATGGAGAAACTTATGGATCATATTTATGCTGTTTGTGGACAGGTACAACATCTACAAAAAGTAT TGGCCAAGAAGAGAGATCCTGTTTCTCACATTTGTTTCATTGAAGAAATAGTTAAGGATGGACAACCGGAAATTTTCTACACATTTTGGA ATTCAGTTACTCAGGCACTTTCTTCTCAATTTCATATGGCAACAAACTCTTCGATGTTTTTGAAGCAGGCATTTGAAGGAGAATACCCTA AATTATTACGTCTTTATAATGACTTATGGAAGCGTCTTCAACAATACAGTCAGCATATCCAAGGGAATTTTAATGCAAGTGGAACTACAG ACCTCTATGTTGACCTACAACACATGGAAGATGATGCACAAGATATATTCATACCAAAAAAGCCAGATTATGATCCAGAAAAGGCTTTGA AAGACTCACTACAACCCTATGAGGCTGCTTATCTATCAAAATCCTTATCTCGACTCTTCGATCCTATCAACTTGGTTTTTCCCCCGGGTG GTCGTAATCCTCCTTCCTCTGATGAACTTGATGGTATTATTAAAACTATAGCAAGTGAACTAAATGTTGCTGCTGTTGATACAAACCTCA CATTAGCTGTGTCAAAAAATGTGGCAAAGACCATCCAGTTATACAGTGTAAAATCAGAGCAGCTTCTCTCCACACAAGGAGATGCAAGTC AGGTGATTGGGCCTCTTACTGAAGGACAGAGAAGAAATGTGGCAGTAGTGAATTCATTGTATAAGTTGCACCAATCAGTAACAAAGGTTG TTTCCAGTCAGAGCTCATTCCCACTGGCAGCTGAGCAAACTATAATTTCAGCTCTAAAGGCTATTCATGCTCTTATGGAAAATGCTGTGC AACCCTTACTCACTTCTGTGGGAGATGCTATAGAGGCCATAATCATCACCATGCATCAAGAAGACTTTTCTGGGTCATTATCCAGCTCAG GAAAACCTGATGTTCCTTGTTCTCTGTACATGAAGGAGCTACAAGGTTTCATTGCCAGAGTTATGAGTGACTATTTTAAACACTTTGAAT GCTTGGATTTTGTCTTTGACAACACTGAGGCTATTGCCCAAAGAGCTGTTGAACTTTTTATCCGCCATGCCAGTCTCATAAGACCTCTTG GTGAAGGTGGGAAAATGCGACTTGCTGCTGATTTTGCACAGATGGAGTTGGCTGTGGGTCCATTCTGTAGACGAGTATCTGATTTAGGAA AGTCCTATCGGATGCTGAGATCATTCAGACCTCTGCTCTTCCAGGCAAGTGAACATGTAGCCAGTAGTCCTGCATTGGGGGATGTGATTC CGTTCAGCATCATTATTCAGTTTTTGTTCACGAGAGCACCCGCTGAACTGAAATCTCCTTTCCAGAGGGCAGAGTGGTCCCACACACGCT TCTCTCAGTGGCTGGATGACCATCCATCTGAAAAGGACAGGCTCCTCCTCATCAGGGGAGCCCTGGAAGCTTATGTTCAATCAGTGAGAA GTAGAGAAGGCAAAGAATTTGCACCAGTTTATCCCATAATGGTTCAGCTGCTTCAAAAGGCTATGTCTGCTCTTCAGTAATGACATGAAA TCTTTGTTCATCTCCACTTTGTGCTAACCCATTCATAGTTGGCAGTTAAACACATACTCCAAAAGACTGCTACTATCTACTATTTTAAGA ATGTAATTGATTGTTCGGTATTTCCTATCGACGTTTATTTACCTCTTTAGCACTTATACTTTAGCATAAAAAATGTTGAGTTATCACCAC CTTTCAATTCCATGGACCTGATTTTTCCAGAAAGATGTTTTCCTCTTTCAGATTTTTGTACAAGGCTAAAATGTCTTTCCCATCCATAAC CAAGTCCTCCTATGGGTACATAAACCCAAAGTCCCCACTTCTTTTAAAGGGATATGATCAAGTTATAACATGTACCCTGCTTCCCCCAAC CCTGCCTTCTTCACTAAATAAGCATGTAGCTCAGTGGTTTCCAAATTTGGCTGCACATTCATACCAATCACCAGGGGATTTTTTTAAAAT CCTGATGCCCAACTTGCACTCCACATTAATTAACATGTCTAGGAGTGGGAGCCTGACAGACACCACTATTAAAAAAAAAAAAAATCCCCA AAATGATTCCAATAGACAACAAAGTTGAGGAACCACTGGCACATCCCAAGCTAAGATACAAGGTTAAATGGCCTTTTTAAGTATGTCATA CTGGATCTTTAAATAAAGCAAGGCTTTTGTTACACTTTGTCATGTTATTAAAAGCAGACCTTTGGGCTGTTTAACCGTGTAACAAAAATG CCACGTGAAAAATAAAAATTTTTATTGTATAGCAATTCTCTATAAATAGTAGATAATCTAAGTCCTTATTTTCTGATGGCTCTTGTTCCA CTATTAACATTGTTTTTAATTTTTAAAATCCTATCAGCAGCCTCCTAATTAGCAGTGTTAGGAATTTGCCTTATGTTTTCCATCTCATCT >12201_12201_1_CAAP1-COG5_CAAP1_chr9_26861063_ENST00000333916_COG5_chr7_107053077_ENST00000297135_length(amino acids)=896AA_BP=246 MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQDYLSQGIDLSGIEVIENDLLFIAR ARLEVENQAKRLLEQGLETQNPTQVGTALQVFYNLGTLKDTITSVVDGYCATLEENINSALDIKVLTQPSQSAVRGGPGRSTMPTPGNTA ALRASFWTNMEKLMDHIYAVCGQVQHLQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTFWNSVTQALSSQFHMATNSSMFLKQAFEGEYP KLLRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDLQHMEDDAQDIFIPKKPDYDPEKALKDSLQPYEAAYLSKSLSRLFDPINLVFPPG GRNPPSSDELDGIIKTIASELNVAAVDTNLTLAVSKNVAKTIQLYSVKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNSLYKLHQSVTKV VSSQSSFPLAAEQTIISALKAIHALMENAVQPLLTSVGDAIEAIIITMHQEDFSGSLSSSGKPDVPCSLYMKELQGFIARVMSDYFKHFE CLDFVFDNTEAIAQRAVELFIRHASLIRPLGEGGKMRLAADFAQMELAVGPFCRRVSDLGKSYRMLRSFRPLLFQASEHVASSPALGDVI -------------------------------------------------------------- >12201_12201_2_CAAP1-COG5_CAAP1_chr9_26861063_ENST00000333916_COG5_chr7_107053077_ENST00000347053_length(transcript)=4678nt_BP=828nt CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAG GTTTGGAATTAAAACAAGATTATCTTTCTCAAGGAATAGATCTTTCTGGAATAGAAGTGATAGAAAATGATCTACTTTTTATTGCAAGAG CCCGACTTGAAGTGGAAAATCAAGCTAAGCGCCTACTAGAGCAGGGTTTGGAGACTCAGAATCCAACTCAAGTCGGAACAGCTCTTCAGG TTTTCTATAATCTTGGAACTTTGAAGGATACTATTACCAGTGTTGTGGATGGATATTGTGCTACTTTAGAAGAAAATATCAACAGTGCAT TAGACATAAAAGTTTTGACTCAGCCTTCCCAGTCAGCTGTGAGAGGGGGACCTGGACGATCTACCATGCCAACCCCAGGAAATACTGCAG CTTTGCGTGCCTCATTCTGGACCAATATGGAGAAACTTATGGATCATATTTATGCTGTTTGTGGACAGGTACAACATCTACAAAAAGTAT TGGCCAAGAAGAGAGATCCTGTTTCTCACATTTGTTTCATTGAAGAAATAGTTAAGGATGGACAACCGGAAATTTTCTACACATTTTGGA ATTCAGTTACTCAGGCACTTTCTTCTCAATTTCATATGGCAACAAACTCTTCGATGTTTTTGAAGCAGGCATTTGAAGGAGAATACCCTA AATTATTACGTCTTTATAATGACTTATGGAAGCGTCTTCAACAATACAGTCAGCATATCCAAGGGAATTTTAATGCAAGTGGAACTACAG ACCTCTATGTTGACCTACAACACATGGAAGATGATGCACAAGATATATTCATACCAAAAAAGCCAGATTATGATCCAGAAAAGGCTTTGA AAGACTCACTACAACCCTATGAGGCTGCTTATCTATCAAAATCCTTATCTCGACTCTTCGATCCTATCAACTTGGTTTTTCCCCCGGGTG GTCGTAATCCTCCTTCCTCTGATGAACTTGATGGTATTATTAAAACTATAGCAAGTGAACTAAATGTTGCTGCTGTTGATACAAACCTCA CATTAGCTGTGTCAAAAAATGTGGCAAAGACCATCCAGTTATACAGTGTAAAATCAGAGCAGCTTCTCTCCACACAAGGAGATGCAAGTC AGGTGATTGGGCCTCTTACTGAAGGACAGAGAAGAAATGTGGCAGTAGTGAATTCATTGTATAAGTTGCACCAATCAGTAACAAAGGCTA TTCATGCTCTTATGGAAAATGCTGTGCAACCCTTACTCACTTCTGTGGGAGATGCTATAGAGGCCATAATCATCACCATGCATCAAGAAG ACTTTTCTGGGTCATTATCCAGCTCAGGAAAACCTGATGTTCCTTGTTCTCTGTACATGAAGGAGCTACAAGGTTTCATTGCCAGAGTTA TGAGTGACTATTTTAAACACTTTGAATGCTTGGATTTTGTCTTTGACAACACTGAGGCTATTGCCCAAAGAGCTGTTGAACTTTTTATCC GCCATGCCAGTCTCATAAGACCTCTTGGTGAAGGTGGGAAAATGCGACTTGCTGCTGATTTTGCACAGATGGAGTTGGCTGTGGGTCCAT TCTGTAGACGAGTATCTGATTTAGGAAAGTCCTATCGGATGCTGAGATCATTCAGACCTCTGCTCTTCCAGGCAAGTGAACATGTAGCCA GTAGTCCTGCATTGGGGGATGTGATTCCGTTCAGCATCATTATTCAGTTTTTGTTCACGAGAGCACCCGCTGAACTGAAATCTCCTTTCC AGAGGGCAGAGTGGTCCCACACACGCTTCTCTCAGTGGCTGGATGACCATCCATCTGAAAAGGACAGGCTCCTCCTCATCAGGGGAGCCC TGGAAGCTTATGTTCAATCAGTGAGAAGTAGAGAAGGCAAAGAATTTGCACCAGTTTATCCCATAATGGTTCAGCTGCTTCAAAAGGCTA TGTCTGCTCTTCAGTAATGACATGAAATCTTTGTTCATCTCCACTTTGTGCTAACCCATTCATAGTTGGCAGTTAAACACATACTCCAAA AGACTGCTACTATCTACTATTTTAAGAATGTAATTGATTGTTCGGTATTTCCTATCGACGTTTATTTACCTCTTTAGCACTTATACTTTA GCATAAAAAATGTTGAGTTATCACCACCTTTCAATTCCATGGACCTGATTTTTCCAGAAAGATGTTTTCCTCTTTCAGATTTTTGTACAA GGCTAAAATGTCTTTCCCATCCATAACCAAGTCCTCCTATGGGTACATAAACCCAAAGTCCCCACTTCTTTTAAAGGGATATGATCAAGT TATAACATGTACCCTGCTTCCCCCAACCCTGCCTTCTTCACTAAATAAGCATGTAGCTCAGTGGTTTCCAAATTTGGCTGCACATTCATA CCAATCACCAGGGGATTTTTTTAAAATCCTGATGCCCAACTTGCACTCCACATTAATTAACATGTCTAGGAGTGGGAGCCTGACAGACAC CACTATTAAAAAAAAAAAAAATCCCCAAAATGATTCCAATAGACAACAAAGTTGAGGAACCACTGGCACATCCCAAGCTAAGATACAAGG TTAAATGGCCTTTTTAAGTATGTCATACTGGATCTTTAAATAAAGCAAGGCTTTTGTTACACTTTGTCATGTTATTAAAAGCAGACCTTT GGGCTGTTTAACCGTGTAACAAAAATGCCACGTGAAAAATAAAAATTTTTATTGTATAGCAATTCTCTATAAATAGTAGATAATCTAAGT CCTTATTTTCTGATGGCTCTTGTTCCACTATTAACATTGTTTTTAATTTTTAAAATCCTATCAGCAGCCTCCTAATTAGCAGTGTTAGGA ATTTGCCTTATGTTTTCCATCTCATCTCCTGAACCTGTTATTCTGAGAACTCATAAATAAAATTCAGCCAAGATTAATCAATCAATCAAT CAATCAGTAGACGTCAGAGATAAGCAACTTTTTTTTCCATTTATTTGAAATAATATACAAGAATATAGTGTGCAAAATTTAGGGGCAACA TCATGAAGAAGTGTGATGAACTGAAATCAATTTTACAGCTGTGATTCCTAACCAGAAACACCACTTGGTAAGTAACATGAAAAGCCATGA TTGTAGCTCAGAGCAAAAGCAGCTGTATTGCCAATGTATTTGCTCTAATTTTAGACAGTTGGAGGAAAATTAAAGTGCAAGTGTTGCACT GCAGTAAGTGCAAAGTCTGCCCCCACCATAAAGATTATGATGACAAAATATATTTAAGATACATGGCTGAGGAGATACAGAACACGAAGT TAAAAAATACAATGGTGTTGACTGTTTGTTAATAGCACCATTACAGTGACTATATCCCAATGCTATTAACTAACTTTACCTTGGCCTGGG CTAGGTCTCCATTGGAAATAATAACGGATGGCTGCTGCCACCTGGTGCATCAACTCAGCATGCCATGGTAACTGCAGCAGGTGGCTCTTA GGCTGGGACACCAACACCAGCCACCTGCCCCATGTTCTGGTAGCCTCTTGGCACTGACCAGACTAGGAGCGCCTATGTTTGGCACAGATG CTGAGCCATGTGGTGGTTACTAGAGGAAAGGCCGACTCCCAGCTTCTGCTTCATTTCATCATGTGTACAATACAGATTAATAAGCAGTAA GGAGCCAATGTATAAACAGCAGTTACATATTTTTTAAATTCCCCTTTCGTACAATTTAAAATAAAACATGTATACACTTCTCCTCTCTTT CTACTGTACTTTAGCACCACAGGATATCAATTTTCAAGCCTATTATTACCTGATAGACATATATGAAGTTTGGAAGAAAAATAAGGCAAT >12201_12201_2_CAAP1-COG5_CAAP1_chr9_26861063_ENST00000333916_COG5_chr7_107053077_ENST00000347053_length(amino acids)=875AA_BP=246 MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQDYLSQGIDLSGIEVIENDLLFIAR ARLEVENQAKRLLEQGLETQNPTQVGTALQVFYNLGTLKDTITSVVDGYCATLEENINSALDIKVLTQPSQSAVRGGPGRSTMPTPGNTA ALRASFWTNMEKLMDHIYAVCGQVQHLQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTFWNSVTQALSSQFHMATNSSMFLKQAFEGEYP KLLRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDLQHMEDDAQDIFIPKKPDYDPEKALKDSLQPYEAAYLSKSLSRLFDPINLVFPPG GRNPPSSDELDGIIKTIASELNVAAVDTNLTLAVSKNVAKTIQLYSVKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNSLYKLHQSVTKA IHALMENAVQPLLTSVGDAIEAIIITMHQEDFSGSLSSSGKPDVPCSLYMKELQGFIARVMSDYFKHFECLDFVFDNTEAIAQRAVELFI RHASLIRPLGEGGKMRLAADFAQMELAVGPFCRRVSDLGKSYRMLRSFRPLLFQASEHVASSPALGDVIPFSIIIQFLFTRAPAELKSPF -------------------------------------------------------------- >12201_12201_3_CAAP1-COG5_CAAP1_chr9_26861063_ENST00000333916_COG5_chr7_107053077_ENST00000393603_length(transcript)=5343nt_BP=828nt CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGCAAGACATCTGTATAGATTCTGCTTCATCCGTGAGAGAGAATAAGCAACCTGAAG GTTTGGAATTAAAACAAGATTATCTTTCTCAAGGAATAGATCTTTCTGGAATAGAAGTGATAGAAAATGATCTACTTTTTATTGCAAGAG CCCGACTTGAAGTGGAAAATCAAGCTAAGCGCCTACTAGAGCAGGGTTTGGAGACTCAGAATCCAACTCAAGTCGGAACAGCTCTTCAGG TTTTCTATAATCTTGGAACTTTGAAGGATACTATTACCAGTGTTGTGGATGGATATTGTGCTACTTTAGAAGAAAATATCAACAGTGCAT TAGACATAAAAGTTTTGACTCAGCCTTCCCAGTCAGCTGTGAGAGGGGGACCTGGACGATCTACCATGCCAACCCCAGGAAATACTGCAG CTTTGCGTGCCTCATTCTGGACCAATATGGAGAAACTTATGGATCATATTTATGCTGTTTGTGGACAGGTACAACATCTACAAAAAGTAT TGGCCAAGAAGAGAGATCCTGTTTCTCACATTTGTTTCATTGAAGAAATAGTTAAGGATGGACAACCGGAAATTTTCTACACATTTTGGA ATTCAGTTACTCAGGCACTTTCTTCTCAATTTCATATGGCAACAAACTCTTCGATGTTTTTGAAGCAGGCATTTGAAGGAGAATACCCTA AATTATTACGTCTTTATAATGACTTATGGAAGCGTCTTCAACAATACAGTCAGCATATCCAAGGGAATTTTAATGCAAGTGGAACTACAG ACCTCTATGTTGACCTACAACACATGGAAGATGATGCACAAGATATATTCATACCAAAAAAGCCAGATTATGATCCAGAAAAGGCTTTGA AAGACTCACTACAACCCTATGAGGCTGCTTATCTATCAAAATCCTTATCTCGACTCTTCGATCCTATCAACTTGGTTTTTCCCCCGGGTG GTCGTAATCCTCCTTCCTCTGATGAACTTGATGGTATTATTAAAACTATAGCAAGTGAACTAAATGTTGCTGCTGTTGATACAAACCTCA CATTAGCTGTGTCAAAAAATGTGGCAAAGACCATCCAGTTATACAGTGTAAAATCAGAGCAGCTTCTCTCCACACAAGGAGATGCAAGTC AGGTGATTGGGCCTCTTACTGAAGGACAGAGAAGAAATGTGGCAGTAGTGAATTCATTGTATAAGTTGCACCAATCAGTAACAAAGGTTG TTTCCAGTCAGAGCTCATTCCCACTGGCAGCTGAGCAAACTATAATTTCAGCTCTAAAGGCTATTCATGCTCTTATGGAAAATGCTGTGC AACCCTTACTCACTTCTGTGGGAGATGCTATAGAGGCCATAATCATCACCATGCATCAAGAAGACTTTTCTGGGTCATTATCCAGCTCAG GAAAACCTGATGTTCCTTGTTCTCTGTACATGAAGGAGCTACAAGGTTTCATTGCCAGAGTTATGAGTGACTATTTTAAACACTTTGAAT GCTTGGATTTTGTCTTTGACAACACTGAGGCTATTGCCCAAAGAGCTGTTGAACTTTTTATCCGCCATGCCAGTCTCATAAGACCTCTTG GTGAAGGTGGGAAAATGCGACTTGCTGCTGATTTTGCACAGATGGAGTTGGCTGTGGGTCCATTCTGTAGACGAGTATCTGATTTAGGAA AGTCCTATCGGATGCTGAGATCATTCAGACCTCTGCTCTTCCAGGCAAGTGAACATGTAGCCAGTAGTCCTGCATTGGGGGATGTGATTC CGTTCAGCATCATTATTCAGTTTTTGTTCACGAGAGCACCCGCTGAACTGAAATCTCCTTTCCAGAGGGCAGAGTGGTCCCACACACGCT TCTCTCAGTGGCTGGATGACCATCCATCTGAAAAGGACAGGCTCCTCCTCATCAGGTAAAGCCAGGTGCTCTGGGGGCACCCATCTGGTC TGGAAGCCCAAGGAGGGTGGGGATGCAAGAGAGGATGAAGGAGCAGTGCCTGGGGGCATGGACATGTGACTGCACCTTCCAGTGGCGGGC CACCTCACTGCCTAGGCACGGGTGCTGGAGCAACCAGCAGTTGGAAATGTTGGCCACAACATCTTTTGCTTTCTTTCATTCCAAACCTTC ATATCCCTGATGTGCAATCCTGTGTCCCATGCAACCCTAAGGACCATGCATTTGTACCTTTGAAAATCATCATTTGCTATGAAAAGTTTT GCCCTAGCTCCGCATCTTTTACTTCATTTTTATGTGCTGCAGTTACTGAATTGGTGGAACACAGATGTGAGTGAATTTTTAAAAATACCC AAGTGCGAAACAGTTCTGAGGAGGAAACAAGAACAACCCAGCAGCCACTTGGATACCATGGCCCTCCAGTAGTGCCCCATGAATGCATTC ACATACATACGCATGTGCTCTTGCCCACACGTGCACACACCCCCATGTACCCCAACCATGCCCAGGGTGGGGTGCTTTAACTGTCATACA TGGCTTATTAAGCAACACTCTTCCCTGCAACTGCTCTCACCATCACCAGAGACCTCTCAGCCACCAAACATTCCCATTTTTACCTTACCA CTCTGTAGCTTTAGCTACAGTTGACCGCCATTTCCTTCTGTAAACTCATAAACTGGGACTCAGCACATTTTTATTGATGCTGAGCTCACA TTTTATCAGCATGGTAGGCCCTGGGCCAGGAACCGAGGATACGAAGTAAGCCGAGATATGGCCCTGTCCTCTCAGAGCTTGCATTACACC ACAGCCATCTGTTTCTGTTCTAACTTCTCTGGCCATTTTTTTTTGTGTGTCATTTGCTGAATTATCTTCTTCTAGCCATTCCTTAAATGC TATCATTTCCCATATTTTCTTCTTCTCATCCTGCCTCTGCCTTGGTTCCCAGGTGAGCTTGTCCAGACCCATGCCTCTAGTGCCCCTTCT ATACTTAAGAGCCCTCAGGTCTGTGACTGCCTCTGGATGGGGCCTTGGCCCAGTAAACTTGCTATCATATGTCACCACCCACAGAAATCT CAACCCCAGAATGGTCAAAATAATTCTAATCTTTTCTCTCAAACCTTCTCATTCTCTTATACTCCCTGTCTTGGTTGGGAGGTCACAATC ACCTAACTAGCCAAGCCGGAAAACCTTTACATCATCATTCAACTCCTCTGTCATCCTTATTCCTCAAACCCACTCTGTTGCGTCTCTAAA ATAGCTCTTGAAGTCATTCTCAACTCTCCCAGGGGATCCCAATTCTGTTGGTCTGGGCCCACTGCACCCAGTGATCCTTTGTTAGCCTGT GTCAGGTGATGAGTTGAGTTCCCTAAAGCCAGAGTGGGGCTGACATGATGAGGTGGTTCTAAACCACATGTGCACACAAGAATCATTTAC ATAGCTTGGAAAATTCCTAGTGCCCAGGTCTCTCACCCTTGCCTACCTCAGAATCTCCAGGGTAGGCCTGCTATCAGGATTTCTCTATAG CTCCCCAAGAAGGTCCAGGGTGCAGCCAAGGGCGTGAACCCCTGCCATAGTGGGTCATATTTCAGTTAGGATGAAAGACTGCTGAGGAAG CTATGACAGGTCAGTAAGAACCATCAGCCTGTCAGCTTTGTTTCCAGAAGTGACCCTGAGCCCTCAAGCTTGGTACCCACATCCCACATG AGCCACTGGCCCTCTGGGCGTATGTGTGGATAAAGATTAGCTCGGACCCTGCTCTTTTTCCTTGCTTATCTGTTACTCAGCTATGAACAT CTGACACAGAAATGGGAGAGGTTACCAGCCCCGGTGAATGTTCCTGGTAAAATCTGCCCTCGGGAAAGGCTTTGGATTTGGGTGAGGAGT TTGGGCCTGGGCTAACACAGGGATTTGCAATGTCTGTGTGGATTATTTTTCCCGAGTCCCAAAGATTCACTCAGCTGCAACACACTCAGT CGTCTTAAAAAGAGGATTCAGTTAATTGAACACGTTCATTTTTCTCATCTTAACAAGTTGGTCATTTTTGTCGTCTTAACAAGTTGGAAT GAGTTCATCCAAAACAGTTGTCCTGCTGTGTGTACATCACAAATCTGTTTTCTTTTGCTTCTCTTTAAAAATGTCTCCTGAGTGATTTCA TCAGCAGTGCTGTTGCTAAGCCTATATTTAGCAACTGAAAATCATGCTCAGAAATACTGTCATGCTTTTTTAAAAAGGCATATCCATCCC TCCACACATGGCTGATTCCAGAACCTTCATGCCCTTAGCAAAAAATTGAGCTGTCCTTCAGGGTTTCAAAAAAAGTACTGTACTCCTGCT GCACCCCAGGCTCTTGGCAAGGAGGGGACTTTTGTCCTAGAGAATGTTCTTTCTTATGTATTATTGCAAAACAATTTTGTTCTTGCATAC TGAAGCATCACTGGATGAATTTCTTTCCCCTGTAGACAAACCGAGGGTGAGTATTGCTCTTTAAATGTCAGTAAATTTGTTTTAGCTTCT GGGGCAAACCTTGTTGTATACTCATTCTGTTCCTCCCAGCATAATATGTTAGGTTGTCATAAAATAGGGCAAATTGAGGATAGTGTAACT >12201_12201_3_CAAP1-COG5_CAAP1_chr9_26861063_ENST00000333916_COG5_chr7_107053077_ENST00000393603_length(amino acids)=859AA_BP=246 MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQQDICIDSASSVRENKQPEGLELKQDYLSQGIDLSGIEVIENDLLFIAR ARLEVENQAKRLLEQGLETQNPTQVGTALQVFYNLGTLKDTITSVVDGYCATLEENINSALDIKVLTQPSQSAVRGGPGRSTMPTPGNTA ALRASFWTNMEKLMDHIYAVCGQVQHLQKVLAKKRDPVSHICFIEEIVKDGQPEIFYTFWNSVTQALSSQFHMATNSSMFLKQAFEGEYP KLLRLYNDLWKRLQQYSQHIQGNFNASGTTDLYVDLQHMEDDAQDIFIPKKPDYDPEKALKDSLQPYEAAYLSKSLSRLFDPINLVFPPG GRNPPSSDELDGIIKTIASELNVAAVDTNLTLAVSKNVAKTIQLYSVKSEQLLSTQGDASQVIGPLTEGQRRNVAVVNSLYKLHQSVTKV VSSQSSFPLAAEQTIISALKAIHALMENAVQPLLTSVGDAIEAIIITMHQEDFSGSLSSSGKPDVPCSLYMKELQGFIARVMSDYFKHFE CLDFVFDNTEAIAQRAVELFIRHASLIRPLGEGGKMRLAADFAQMELAVGPFCRRVSDLGKSYRMLRSFRPLLFQASEHVASSPALGDVI -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CAAP1-COG5 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CAAP1-COG5 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CAAP1-COG5 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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