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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAAP1-IFT74 (FusionGDB2 ID:12202)

Fusion Gene Summary for CAAP1-IFT74

check button Fusion gene summary
Fusion gene informationFusion gene name: CAAP1-IFT74
Fusion gene ID: 12202
HgeneTgene
Gene symbol

CAAP1

IFT74

Gene ID

79886

80173

Gene namecaspase activity and apoptosis inhibitor 1intraflagellar transport 74
SynonymsC9orf82|CAAPCCDC2|CMG-1|CMG1
Cytomap

9p21.2

9p21.2

Type of geneprotein-codingprotein-coding
Descriptioncaspase activity and apoptosis inhibitor 1conserved anti-apoptotic proteinintraflagellar transport protein 74 homologcapillary morphogenesis gene 1 proteincapillary morphogenesis protein 1coiled-coil domain containing 2coiled-coil domain-containing protein 2intraflagellar transport 74 homolog
Modification date2020031320200326
UniProtAcc

Q9H8G2

Q96LB3

Ensembl transtripts involved in fusion geneENST00000495958, ENST00000535437, 
ENST00000333916, ENST00000520187, 
ENST00000380062, ENST00000429045, 
ENST00000433700, ENST00000443698, 
Fusion gene scores* DoF score5 X 4 X 5=1009 X 4 X 5=180
# samples 69
** MAII scorelog2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/180*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAAP1 [Title/Abstract] AND IFT74 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIFT74(26990193)-CAAP1(26861137), # samples:1
CAAP1(26884808)-IFT74(27009018), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IFT74 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6709-01ACAAP1chr9

26884808

-IFT74chr9

27009018

+


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Fusion Gene ORF analysis for CAAP1-IFT74

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000495958ENST00000380062CAAP1chr9

26884808

-IFT74chr9

27009018

+
5UTR-3CDSENST00000495958ENST00000429045CAAP1chr9

26884808

-IFT74chr9

27009018

+
5UTR-3CDSENST00000495958ENST00000433700CAAP1chr9

26884808

-IFT74chr9

27009018

+
5UTR-3CDSENST00000495958ENST00000443698CAAP1chr9

26884808

-IFT74chr9

27009018

+
Frame-shiftENST00000535437ENST00000380062CAAP1chr9

26884808

-IFT74chr9

27009018

+
Frame-shiftENST00000535437ENST00000429045CAAP1chr9

26884808

-IFT74chr9

27009018

+
Frame-shiftENST00000535437ENST00000433700CAAP1chr9

26884808

-IFT74chr9

27009018

+
Frame-shiftENST00000535437ENST00000443698CAAP1chr9

26884808

-IFT74chr9

27009018

+
In-frameENST00000333916ENST00000380062CAAP1chr9

26884808

-IFT74chr9

27009018

+
In-frameENST00000333916ENST00000429045CAAP1chr9

26884808

-IFT74chr9

27009018

+
In-frameENST00000333916ENST00000433700CAAP1chr9

26884808

-IFT74chr9

27009018

+
In-frameENST00000333916ENST00000443698CAAP1chr9

26884808

-IFT74chr9

27009018

+
intron-3CDSENST00000520187ENST00000380062CAAP1chr9

26884808

-IFT74chr9

27009018

+
intron-3CDSENST00000520187ENST00000429045CAAP1chr9

26884808

-IFT74chr9

27009018

+
intron-3CDSENST00000520187ENST00000433700CAAP1chr9

26884808

-IFT74chr9

27009018

+
intron-3CDSENST00000520187ENST00000443698CAAP1chr9

26884808

-IFT74chr9

27009018

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000333916CAAP1chr926884808-ENST00000433700IFT74chr927009018+2159754891969626
ENST00000333916CAAP1chr926884808-ENST00000443698IFT74chr927009018+2159754891969626
ENST00000333916CAAP1chr926884808-ENST00000380062IFT74chr927009018+2164754891969626
ENST00000333916CAAP1chr926884808-ENST00000429045IFT74chr927009018+1572754891285398

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000333916ENST00000433700CAAP1chr926884808-IFT74chr927009018+0.0073326320.9926674
ENST00000333916ENST00000443698CAAP1chr926884808-IFT74chr927009018+0.0073326320.9926674
ENST00000333916ENST00000380062CAAP1chr926884808-IFT74chr927009018+0.0071847450.99281526
ENST00000333916ENST00000429045CAAP1chr926884808-IFT74chr927009018+0.0044309370.99556905

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Fusion Genomic Features for CAAP1-IFT74


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CAAP1chr926884807-IFT74chr927009017+1.80E-091
CAAP1chr926884807-IFT74chr927009017+1.80E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CAAP1-IFT74


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:26990193/chr9:26861137)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAAP1

Q9H8G2

IFT74

Q96LB3

FUNCTION: Anti-apoptotic protein that modulates a caspase-10 dependent mitochondrial caspase-3/9 feedback amplification loop. {ECO:0000269|PubMed:21980415}.FUNCTION: Component of the intraflagellar transport (IFT) complex B: together with IFT81, forms a tubulin-binding module that specifically mediates transport of tubulin within the cilium. Binds beta-tubulin via its basic region. Required for ciliogenesis. {ECO:0000269|PubMed:23990561}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAAP1chr9:26884808chr9:27009018ENST00000333916-4619_25221362.0Compositional biasNote=Poly-Ala
HgeneCAAP1chr9:26884808chr9:27009018ENST00000535437-4619_2576217.0Compositional biasNote=Poly-Ala

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAAP1chr9:26884808chr9:27009018ENST00000333916-46281_311221362.0Coiled coilOntology_term=ECO:0000255
HgeneCAAP1chr9:26884808chr9:27009018ENST00000535437-46281_31176217.0Coiled coilOntology_term=ECO:0000255
TgeneIFT74chr9:26884808chr9:27009018ENST0000038006272098_482195601.0Coiled coilOntology_term=ECO:0000255
TgeneIFT74chr9:26884808chr9:27009018ENST0000042904571498_482195373.0Coiled coilOntology_term=ECO:0000255
TgeneIFT74chr9:26884808chr9:27009018ENST0000043370072098_482195601.0Coiled coilOntology_term=ECO:0000255
TgeneIFT74chr9:26884808chr9:27009018ENST0000044369872098_482195601.0Coiled coilOntology_term=ECO:0000255
TgeneIFT74chr9:26884808chr9:27009018ENST000003800627201_90195601.0RegionNote=Basic region
TgeneIFT74chr9:26884808chr9:27009018ENST000004290457141_90195373.0RegionNote=Basic region
TgeneIFT74chr9:26884808chr9:27009018ENST000004337007201_90195601.0RegionNote=Basic region
TgeneIFT74chr9:26884808chr9:27009018ENST000004436987201_90195601.0RegionNote=Basic region


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Fusion Gene Sequence for CAAP1-IFT74


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12202_12202_1_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000380062_length(transcript)=2164nt_BP=754nt
CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA
TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG
CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA
GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG
ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG
ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT
TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG
AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG
ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGAAAGAAAAACAAATCAGAAGTGTCGAAGAAGAAATTGAACAGGAAAAACAAGCAA
CAGATGACATTATCAAAAATATGTCTTTTGAAAACCAAGTCAAGTACCTAGAGATGAAAACCACAAATGAGAAACTGTTACAGGAATTAG
ATACACTTCAACAACAATTGGATTCACAGAACATGAAAAAAGAGAGCCTGGAAGCAGAAATAGCTCACTCCCAGGTGAAACAGGAGGCGG
TATTGCTGCATGAAAAACTTTATGAGTTGGAGTCCCATCGAGATCAAATGATTGCAGAAGACAAAAGCATAGGATCTCCAATGGAAGAGA
GAGAGAAATTACTTAAGCAGATTAAAGATGATAATCAGGAAATAGCCAGCATGGAAAGACAGTTAACAGATACAAAAGAAAAGATAAATC
AGTTTATTGAAGAAATTAGACAACTTGACATGGATTTAGAGGAACACCAAGGTGAAATGAACCAGAAATACAAGGAGCTAAAGAAAAGGG
AGGAACATATGGACACTTTTATTGAGACTTTTGAGGAAACAAAGAATCAGGAACTGAAACGAAAGGCACAGATAGAAGCCAACATTGTTG
CACTCTTGGAGCACTGCAGTCGAAATATAAATCGTATAGAACAGATATCCTCTATCACCAATCAAGAGCTAAAGATGATGCAGGATGACC
TCAATTTTAAATCTACTGAAGTGCAGAAATCACAAAGTACAGCTCAGAATTTGACTTCAGACATTCAACGTCTGCAGTTGGATCTGCAGA
AAATGGAGCTTCTAGAAAGTAAGATGACTGAAGAACAGCATTCTCTAAAAAGCAAAATTAAGCAAATGACAACTGATCTGGAGATATATA
ATGATTTGCCAGCTTTAAAATCATCAGGTGAAGAAAAGATAAAGAAATTACATCAGGAGAGAATGATATTATCAACCCACAGAAATGCCT
TTAAGAAAATAATGGAGAAGCAAAACATAGAGTATGAGGCACTAAAAACACAATTGCAAGAAAATGAGACACATTCTCAGCTTACAAATT
TGGAGAGAAAGTGGCAACACCTTGAGCAAAATAATTTTGCGATGAAAGAATTCATAGCAACCAAGAGTCAAGAGAGTGATTACCAGCCAA
TTAAGAAAAATGTGACCAAGCAGATTGCAGAGTACAATAAAACCATCGTGGATGCTTTACATAGCACCAGCGGAAACTGAGTTTAAGTCC
ACTGAAAGTCTCTAAGGAAGTATCCTCTTGCTGCTAAACTTGGTACAAGTTGACTACCAAAAAAAAAAAAAGCTTACTTTTGGAGTTTAC
CTAAAATTTCTGAATGTTATAATTTTTGTGGCCTCTTTTAAGAATGATATTTTAAAATAGTAAATAGTTCAATAAATGGTTTGCATATTA

>12202_12202_1_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000380062_length(amino acids)=626AA_BP=222
MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST
DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ
EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQEL
DTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN
QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDD
LNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNA

--------------------------------------------------------------
>12202_12202_2_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000429045_length(transcript)=1572nt_BP=754nt
CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA
TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG
CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA
GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG
ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG
ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT
TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG
AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG
ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGAAAGAAAAACAAATCAGAAGTGTCGAAGAAGAAATTGAACAGGAAAAACAAGCAA
CAGATGACATTATCAAAAATATGTCTTTTGAAAACCAAGTCAAGTACCTAGAGATGAAAACCACAAATGAGAAACTGTTACAGGAATTAG
ATACACTTCAACAACAATTGGATTCACAGAACATGAAAAAAGAGAGCCTGGAAGCAGAAATAGCTCACTCCCAGGTGAAACAGGAGGCGG
TATTGCTGCATGAAAAACTTTATGAGTTGGAGTCCCATCGAGATCAAATGATTGCAGAAGACAAAAGCATAGGATCTCCAATGGAAGAGA
GAGAGAAATTACTTAAGCAGATTAAAGATGATAATCAGGAAATAGCCAGCATGGAAAGACAGTTAACAGATACAAAAGAAAAGATAAATC
AGTTTATTGAAGAAATTAGACAACTTGACATGGATTTAGAGGAACACCAAGATCCTACCAACTATGGATGGAAAATACTTGAAAAAAATA
CAGGAAGTTTCAAAAAGCAAGTTTGAACCTGCCATGTGCTAAGCACTATGCTGAATCCATTTGAACTGAAGAATACCCTGCTATAGCCTC
CCATTGTTTCACAGATCTTCAGTCTCTCTCTAGCACCCACTGTTTGAGCAGTGTTCATCTGGCATTTTATTCATTGGCTACTTGTGTTCA
CTCTTTGCTTCTGTGAAAAAAAAAAGACTCCTAAAAATCAATTATATGGTGAAAGAAATCCCTTACAGACTAAGAGAGAGCGTAAAGTGC

>12202_12202_2_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000429045_length(amino acids)=398AA_BP=222
MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST
DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ
EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQEL
DTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN

--------------------------------------------------------------
>12202_12202_3_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000433700_length(transcript)=2159nt_BP=754nt
CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA
TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG
CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA
GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG
ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG
ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT
TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG
AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG
ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGAAAGAAAAACAAATCAGAAGTGTCGAAGAAGAAATTGAACAGGAAAAACAAGCAA
CAGATGACATTATCAAAAATATGTCTTTTGAAAACCAAGTCAAGTACCTAGAGATGAAAACCACAAATGAGAAACTGTTACAGGAATTAG
ATACACTTCAACAACAATTGGATTCACAGAACATGAAAAAAGAGAGCCTGGAAGCAGAAATAGCTCACTCCCAGGTGAAACAGGAGGCGG
TATTGCTGCATGAAAAACTTTATGAGTTGGAGTCCCATCGAGATCAAATGATTGCAGAAGACAAAAGCATAGGATCTCCAATGGAAGAGA
GAGAGAAATTACTTAAGCAGATTAAAGATGATAATCAGGAAATAGCCAGCATGGAAAGACAGTTAACAGATACAAAAGAAAAGATAAATC
AGTTTATTGAAGAAATTAGACAACTTGACATGGATTTAGAGGAACACCAAGGTGAAATGAACCAGAAATACAAGGAGCTAAAGAAAAGGG
AGGAACATATGGACACTTTTATTGAGACTTTTGAGGAAACAAAGAATCAGGAACTGAAACGAAAGGCACAGATAGAAGCCAACATTGTTG
CACTCTTGGAGCACTGCAGTCGAAATATAAATCGTATAGAACAGATATCCTCTATCACCAATCAAGAGCTAAAGATGATGCAGGATGACC
TCAATTTTAAATCTACTGAAGTGCAGAAATCACAAAGTACAGCTCAGAATTTGACTTCAGACATTCAACGTCTGCAGTTGGATCTGCAGA
AAATGGAGCTTCTAGAAAGTAAGATGACTGAAGAACAGCATTCTCTAAAAAGCAAAATTAAGCAAATGACAACTGATCTGGAGATATATA
ATGATTTGCCAGCTTTAAAATCATCAGGTGAAGAAAAGATAAAGAAATTACATCAGGAGAGAATGATATTATCAACCCACAGAAATGCCT
TTAAGAAAATAATGGAGAAGCAAAACATAGAGTATGAGGCACTAAAAACACAATTGCAAGAAAATGAGACACATTCTCAGCTTACAAATT
TGGAGAGAAAGTGGCAACACCTTGAGCAAAATAATTTTGCGATGAAAGAATTCATAGCAACCAAGAGTCAAGAGAGTGATTACCAGCCAA
TTAAGAAAAATGTGACCAAGCAGATTGCAGAGTACAATAAAACCATCGTGGATGCTTTACATAGCACCAGCGGAAACTGAGTTTAAGTCC
ACTGAAAGTCTCTAAGGAAGTATCCTCTTGCTGCTAAACTTGGTACAAGTTGACTACCAAAAAAAAAAAAAGCTTACTTTTGGAGTTTAC

>12202_12202_3_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000433700_length(amino acids)=626AA_BP=222
MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST
DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ
EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQEL
DTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN
QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDD
LNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNA

--------------------------------------------------------------
>12202_12202_4_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000443698_length(transcript)=2159nt_BP=754nt
CCAGTGCCTGCCGCCCACGGCCGCAGGAGTCGGGCTTCGGTCGCACCAGAGACAGCGGACTTTCCTCCGATGGTTGCAGCAGAGGGATCA
TGACGGGGAAAAAGTCCTCCCGGGAGAAACGGCGCAAACGTAGCAGTCAGGAGGCGGCCGCAGCGCTCGCGGCCCCGGACATCGTACCCG
CGTTGGCCAGCGGCAGCAGTGGAAGCACTAGCGGCTGCGGGAGCGCCGGGGGCTGCGGGAGCGTCAGCTGCTGTGGGAACGCCAATTTTA
GTGGAAGTGTCACCGGCGGTGGGAGCGGCGGCAGCTGTTGGGGCGGGAGCAGCGTGGAGCGCAGCGAGCGCCGGAAGCGGAGGAGTACCG
ACTCTTCCAGCGTCTCGGGCTCCTTGCAGCAGGAAACTAAATATATTTTGCCAACTTTGGAAAAAGAATTATTCTTGGCAGAGCACAGTG
ACCTTGAAGAAGGTGGACTGGACCTGACTGTGTCATTGAAACCAGTTAGTTTCTATATATCAGACAAAAAAGAAATGCTTCAGCAGTGCT
TCTGTATTATAGGAGAGAAAAAGTTACAGAAGATGCTTCCTGATGTGTTAAAGAACTGTTCAATAGAAGAAATTAAAAAACTATGCCAGG
AACAGTTAGAGCTCCTGTCTGAAAAAAAAATTTTGAAGATTCTTGAGGGTGACAATGGAATGGACTCTGATATGGAAGAGGAAGCAGATG
ATGGTTCTAAGATGGGATCTGATTTAGTCAGTCAGAAAGAAAAACAAATCAGAAGTGTCGAAGAAGAAATTGAACAGGAAAAACAAGCAA
CAGATGACATTATCAAAAATATGTCTTTTGAAAACCAAGTCAAGTACCTAGAGATGAAAACCACAAATGAGAAACTGTTACAGGAATTAG
ATACACTTCAACAACAATTGGATTCACAGAACATGAAAAAAGAGAGCCTGGAAGCAGAAATAGCTCACTCCCAGGTGAAACAGGAGGCGG
TATTGCTGCATGAAAAACTTTATGAGTTGGAGTCCCATCGAGATCAAATGATTGCAGAAGACAAAAGCATAGGATCTCCAATGGAAGAGA
GAGAGAAATTACTTAAGCAGATTAAAGATGATAATCAGGAAATAGCCAGCATGGAAAGACAGTTAACAGATACAAAAGAAAAGATAAATC
AGTTTATTGAAGAAATTAGACAACTTGACATGGATTTAGAGGAACACCAAGGTGAAATGAACCAGAAATACAAGGAGCTAAAGAAAAGGG
AGGAACATATGGACACTTTTATTGAGACTTTTGAGGAAACAAAGAATCAGGAACTGAAACGAAAGGCACAGATAGAAGCCAACATTGTTG
CACTCTTGGAGCACTGCAGTCGAAATATAAATCGTATAGAACAGATATCCTCTATCACCAATCAAGAGCTAAAGATGATGCAGGATGACC
TCAATTTTAAATCTACTGAAGTGCAGAAATCACAAAGTACAGCTCAGAATTTGACTTCAGACATTCAACGTCTGCAGTTGGATCTGCAGA
AAATGGAGCTTCTAGAAAGTAAGATGACTGAAGAACAGCATTCTCTAAAAAGCAAAATTAAGCAAATGACAACTGATCTGGAGATATATA
ATGATTTGCCAGCTTTAAAATCATCAGGTGAAGAAAAGATAAAGAAATTACATCAGGAGAGAATGATATTATCAACCCACAGAAATGCCT
TTAAGAAAATAATGGAGAAGCAAAACATAGAGTATGAGGCACTAAAAACACAATTGCAAGAAAATGAGACACATTCTCAGCTTACAAATT
TGGAGAGAAAGTGGCAACACCTTGAGCAAAATAATTTTGCGATGAAAGAATTCATAGCAACCAAGAGTCAAGAGAGTGATTACCAGCCAA
TTAAGAAAAATGTGACCAAGCAGATTGCAGAGTACAATAAAACCATCGTGGATGCTTTACATAGCACCAGCGGAAACTGAGTTTAAGTCC
ACTGAAAGTCTCTAAGGAAGTATCCTCTTGCTGCTAAACTTGGTACAAGTTGACTACCAAAAAAAAAAAAAGCTTACTTTTGGAGTTTAC

>12202_12202_4_CAAP1-IFT74_CAAP1_chr9_26884808_ENST00000333916_IFT74_chr9_27009018_ENST00000443698_length(amino acids)=626AA_BP=222
MTGKKSSREKRRKRSSQEAAAALAAPDIVPALASGSSGSTSGCGSAGGCGSVSCCGNANFSGSVTGGGSGGSCWGGSSVERSERRKRRST
DSSSVSGSLQQETKYILPTLEKELFLAEHSDLEEGGLDLTVSLKPVSFYISDKKEMLQQCFCIIGEKKLQKMLPDVLKNCSIEEIKKLCQ
EQLELLSEKKILKILEGDNGMDSDMEEEADDGSKMGSDLVSQKEKQIRSVEEEIEQEKQATDDIIKNMSFENQVKYLEMKTTNEKLLQEL
DTLQQQLDSQNMKKESLEAEIAHSQVKQEAVLLHEKLYELESHRDQMIAEDKSIGSPMEEREKLLKQIKDDNQEIASMERQLTDTKEKIN
QFIEEIRQLDMDLEEHQGEMNQKYKELKKREEHMDTFIETFEETKNQELKRKAQIEANIVALLEHCSRNINRIEQISSITNQELKMMQDD
LNFKSTEVQKSQSTAQNLTSDIQRLQLDLQKMELLESKMTEEQHSLKSKIKQMTTDLEIYNDLPALKSSGEEKIKKLHQERMILSTHRNA

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Fusion Gene PPI Analysis for CAAP1-IFT74


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAAP1-IFT74


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAAP1-IFT74


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource