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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CABIN1-CTNNBIP1 (FusionGDB2 ID:12227)

Fusion Gene Summary for CABIN1-CTNNBIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CABIN1-CTNNBIP1
Fusion gene ID: 12227
HgeneTgene
Gene symbol

CABIN1

CTNNBIP1

Gene ID

23523

56998

Gene namecalcineurin binding protein 1catenin beta interacting protein 1
SynonymsCAIN|KB-318B8.7|PPP3INICAT
Cytomap

22q11.23

1p36.22

Type of geneprotein-codingprotein-coding
Descriptioncalcineurin-binding protein cabin-1calcineurin binding protein cabin 1calcineurin inhibitorbeta-catenin-interacting protein 1beta-catenin-interacting protein ICATinhibitor of beta-catenin and Tcf-4
Modification date2020031320200313
UniProtAcc

Q9Y6J0

Q9NSA3

Ensembl transtripts involved in fusion geneENST00000263119, ENST00000398319, 
ENST00000405822, ENST00000337989, 
ENST00000485008, 		ENST00000377256, 
ENST00000377258, ENST00000400904, 
ENST00000537447, ENST00000377263, 
Fusion gene scores* DoF score16 X 15 X 8=19207 X 7 X 9=441
# samples 1813
** MAII scorelog2(18/1920*10)=-3.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/441*10)=-1.76226703252907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CABIN1 [Title/Abstract] AND CTNNBIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCABIN1(24509715)-CTNNBIP1(9910834), # samples:1
Anticipated loss of major functional domain due to fusion event.CABIN1-CTNNBIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CABIN1-CTNNBIP1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCABIN1

GO:0006336

DNA replication-independent nucleosome assembly

14718166

TgeneCTNNBIP1

GO:0032091

negative regulation of protein binding

12408825|18287330


check buttonFusion gene breakpoints across CABIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTNNBIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-0725-01ACABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-


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Fusion Gene ORF analysis for CABIN1-CTNNBIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263119ENST00000377256CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000263119ENST00000377258CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000263119ENST00000400904CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000263119ENST00000537447CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000398319ENST00000377256CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000398319ENST00000377258CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000398319ENST00000400904CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000398319ENST00000537447CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000405822ENST00000377256CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000405822ENST00000377258CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000405822ENST00000400904CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
Frame-shiftENST00000405822ENST00000537447CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
In-frameENST00000263119ENST00000377263CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
In-frameENST00000398319ENST00000377263CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
In-frameENST00000405822ENST00000377263CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000337989ENST00000377256CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000337989ENST00000377258CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000337989ENST00000377263CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000337989ENST00000400904CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000337989ENST00000537447CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000485008ENST00000377256CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000485008ENST00000377258CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000485008ENST00000377263CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000485008ENST00000400904CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-
intron-3CDSENST00000485008ENST00000537447CABIN1chr22

24509715

+CTNNBIP1chr1

9910834

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263119CABIN1chr2224509715+ENST00000377263CTNNBIP1chr19910834-6928442712144851454
ENST00000405822CABIN1chr2224509715+ENST00000377263CTNNBIP1chr19910834-665841578842151375
ENST00000398319CABIN1chr2224509715+ENST00000377263CTNNBIP1chr19910834-7186468537947431454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263119ENST00000377263CABIN1chr2224509715+CTNNBIP1chr19910834-0.0026519020.99734807
ENST00000405822ENST00000377263CABIN1chr2224509715+CTNNBIP1chr19910834-0.0017976340.9982023
ENST00000398319ENST00000377263CABIN1chr2224509715+CTNNBIP1chr19910834-0.0033555130.9966445

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Fusion Genomic Features for CABIN1-CTNNBIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CABIN1-CTNNBIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:24509715/chr1:9910834)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CABIN1

Q9Y6J0

CTNNBIP1

Q9NSA3

FUNCTION: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}.FUNCTION: Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:12408824}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCABIN1chr22:24509715chr1:9910834ENST00000263119+27371055_108814332221.0RepeatNote=TPR 5
HgeneCABIN1chr22:24509715chr1:9910834ENST00000263119+27371106_113914332221.0RepeatNote=TPR 6
HgeneCABIN1chr22:24509715chr1:9910834ENST00000263119+2737125_15714332221.0RepeatNote=TPR 3
HgeneCABIN1chr22:24509715chr1:9910834ENST00000263119+273736_6914332221.0RepeatNote=TPR 1
HgeneCABIN1chr22:24509715chr1:9910834ENST00000263119+2737615_64814332221.0RepeatNote=TPR 4
HgeneCABIN1chr22:24509715chr1:9910834ENST00000263119+273790_12314332221.0RepeatNote=TPR 2
HgeneCABIN1chr22:24509715chr1:9910834ENST00000398319+27371055_108814332221.0RepeatNote=TPR 5
HgeneCABIN1chr22:24509715chr1:9910834ENST00000398319+27371106_113914332221.0RepeatNote=TPR 6
HgeneCABIN1chr22:24509715chr1:9910834ENST00000398319+2737125_15714332221.0RepeatNote=TPR 3
HgeneCABIN1chr22:24509715chr1:9910834ENST00000398319+273736_6914332221.0RepeatNote=TPR 1
HgeneCABIN1chr22:24509715chr1:9910834ENST00000398319+2737615_64814332221.0RepeatNote=TPR 4
HgeneCABIN1chr22:24509715chr1:9910834ENST00000398319+273790_12314332221.0RepeatNote=TPR 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CABIN1-CTNNBIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12227_12227_1_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000263119_CTNNBIP1_chr1_9910834_ENST00000377263_length(transcript)=6928nt_BP=4427nt
AGCCGGACGGCGCGGTGGTCGGGACAGACTGGCCGTTGCTGTGGAGACGCCTGGAGAGTTGTGGACTGGGGCAACCTTTGCCAGTGATGA
GAAGTGATGCTCGTGGCAGTGCTGAATCTCTCTGAATATGATTCGAATTGCAGCCTTAAATGCCAGCTCCACCATTGAGGATGATCATGA
AGGAAGCTTTAAAAGTCACAAAACCCAGACAAAGGAGGCTCAGGAAGCAGAGGCTTTTGCATTGTACCACAAGGCCCTTGATCTGCAGAA
ACATGACCGGTTTGAGGAGTCTGCCAAAGCCTACCATGAGCTCTTGGAGGCGAGCCTGCTGCGGGAGGCAGTTTCATCCGGTGATGAGAA
AGAGGGGTTGAAACACCCTGGGCTGATACTGAAATATTCCACTTATAAGAACTTGGCCCAGCTGGCAGCCCAGCGGGAGGATCTGGAGAC
AGCCATGGAGTTCTACTTAGAGGCAGTGATGCTGGACTCCACAGATGTCAACCTCTGGTATAAGATTGGACATGTGGCCCTGAGGCTCAT
CCGGATCCCCCTGGCTCGCCATGCTTTTGAGGAAGGGCTGCGGTGCAATCCTGACCACTGGCCCTGTTTGGATAACCTAATCACTGTCCT
GTACACCCTCAGTGATTACACAACATGTCTGTACTTCATCTGCAAAGCTTTGGAGAAGGATTGCCGGTACAGCAAAGGGCTGGTCCTCAA
GGAGAAGATTTTTGAGGAGCAGCCTTGTCTCCGGAAGGACTCTCTCAGAATGTTCCTCAAATGTGACATGTCGATTCACGATGTTTCGGT
GAGTGCAGCTGAGACACAGGCGATTGTAGATGAGGCCTTGGGGCTGCGAAAAAAGAGGCAAGCGCTGATTGTGCGGGAGAAGGAGCCGGA
CCTGAAACTTGTGCAGCCCATTCCTTTCTTCACCTGGAAGTGCCTCGGAGAGAGCTTGCTGGCCATGTACAATCATCTCACCACCTGTGA
GCCCCCACGTCCCAGCCTTGGCAAAAGGATTGATTTGTCGGACTACCAGGACCCCAGCCAGCCTCTTGAGTCCTCCATGGTGGTGACGCC
AGTTAACGTGATCCAGCCAAGCACTGTCAGCACCAACCCAGCTGTGGCTGTCGCCGAGCCTGTGGTCTCCTACACCTCTGTGGCTACAAC
CAGCTTCCCACTGCACAGTCCTGGTCTGTTGGAGACAGGCGCTCCTGTGGGTGATATTTCTGGGGGAGATAAATCCAAGAAAGGGGTAAA
ACGGAAGAAGATTTCAGAAGAGAGTGGAGAAACAGCAAAGCGGCGGTCTGCCCGTGTCCGAAACACCAAGTGCAAAAAAGAAGAGAAAGT
AGACTTCCAGGAGCTTCTGATGAAGTTCTTGCCGTCCAGGTTAAGAAAGCTGGACCCTGAGGAGGAAGATGATTCCTTTAATAACTATGA
AGTCCAGTCAGAAGCCAAACTGGAAAGCTTCCCAAGCATTGGGCCTCAAAGGCTGTCATTTGACTCAGCCACATTCATGGAATCTGAAAA
GCAGGACGTGCATGAGTTCCTGCTGGAGAACCTAACCAACGGGGGCATCCTGGAGCTGATGATGCGCTACCTGAAAGCCATGGGCCACAA
GTTCTTGGTAAGGTGGCCTCCAGGCTTGGCGGAGGTCGTGCTCAGCGTCTACCACAGCTGGAGGAGGCACAGCACCAGCCTGCCCAACCC
GCTGCTGAGGGACTGCAGCAACAAGCACATCAAGGACATGATGCTGATGTCTCTCTCCTGCATGGAACTCCAGCTGGACCAGTGGCTGCT
GACCAAAGGCAGAAGCTCTGCAGTGTCTCCTCGGAACTGTCCTGCTGGTATGGTGAATGGCAGATTTGGACCTGACTTCCCAGGGACCCA
CTGCCTGGGTGACCTCCTACAGCTGTCATTTGCCTCGTCCCAGCGCGACCTGTTCGAGGATGGTTGGCTGGAGTTTGTGGTCCGTGTTTA
CTGGCTGAAGGCTCGCTTCCTGGCGCTGCAGGGAGACATGGAGCAGGCCCTGGAGAACTATGACATCTGCACAGAAATGCTCCAGAGTTC
CACCGCCATCCAGGTGGAGGCAGGGGCTGAACGAAGAGACATTGTCATCCGGCTGCCCAACCTCCATAATGACTCTGTGGTTTCCCTGGA
GGAGATTGATAAGAACCTGAAGTCGCTGGAGCGGTGCCAGTCCCTGGAGGAGATTCAGCGGCTGTATGAAGCAGGCGACTACAAGGCTGT
TGTGCATCTGCTCCGCCCCACTTTGTGCACCAGTGGGTTTGACCGGGCCAAACACCTGGAGTTTATGACTTCCATTCCTGAGAGGCCAGC
CCAGCTGCTTCTTCTGCAGGACTCCTTGCTCCGGCTGAAGGACTATCGGCAGTGTTTTGAGTGTTCCGATGTGGCTCTGAACGAGGCTGT
CCAGCAGATGGTGAACTCAGGTGAGGCTGCCGCCAAGGAGGAGTGGGTGGCCACAGTGACCCAACTGCTGATGGGCATCGAGCAGGCCCT
CTCTGCGGACAGCAGTGGTAGCATCCTGAAGGTATCATCCTCCACCACTGGCCTTGTGCGGCTCACCAACAACCTCATCCAGGTCATTGA
CTGCAGCATGGCTGTGCAGGAGGAGGCCAAGGAGCCCCACGTCTCTTCAGTGCTACCCTGGATCATTCTACACCGGATCATCTGGCAGGA
GGAAGACACCTTCCATTCTCTGTGCCACCAGCAGCAGCTCCAAAACCCAGCGGAGGAAGGGATGTCAGAGACGCCCATGCTCCCATCCTC
CCTCATGCTGCTGAACACAGCCCACGAGTATTTGGGCAGAAGGTCCTGGTGCTGCAATTCAGATGGGGCTCTGCTGCGATTCTATGTGCG
AGTACTCCAGAAGGAACTGGCTGCATCCACCTCTGAAGACACGCACCCTTACAAGGAGGAGCTGGAGACAGCCTTGGAGCAGTGCTTCTA
CTGCCTGTACAGCTTCCCCAGCAAGAAGAGTAAGGCCAGGTACCTGGAGGAACACTCGGCCCAGCAGGTGGATCTTATATGGGAGGATGC
ACTGTTCATGTTTGAGTATTTTAAGCCCAAGACCCTTCCTGAATTTGACAGCTATAAGACCAGCACCGTGTCTGCTGACTTGGCCAACCT
ACTGAAGAGAATTGCCACCATTGTGCCTCGCACAGAGAGGCCAGCCCTTAGCCTGGACAAAGTCTCTGCCTACATTGAGGGAACTTCAAC
TGAGGTACCCTGCCTCCCAGAGGGGGCTGACCCCTCCCCTCCAGTGGTGAACGAGCTTTACTACCTCCTGGCTGATTATCATTTCAAAAA
CAAGGAGCAGTCCAAGGCCATCAAGTTCTACATGCATGACATCTGCATCTGCCCCAATAGGTTTGATTCCTGGGCAGGCATGGCTCTGGC
CCGGGCCAGCCGCATTCAGGACAAGCTGAACTCCAATGAGCTGAAGAGTGATGGGCCCATTTGGAAGCATGCCACGCCCGTCTTGAACTG
CTTCCGTCGGGCCCTGGAGATTGACAGCTCCAACTTGTCCCTATGGATTGAGTATGGCACCATGTCCTATGCCTTGCACTCATTCGCCTC
ACGTCAATTGAAGCAGTGGAGAGGCGAGCTGCCCCCTGAGCTCGTGCAGCAGATGGAGGGCCGGCGCGACAGCATGCTAGAGACAGCCAA
GCACTGTTTCACATCAGCAGCCCGCTGCGAGGGTGATGGTGACGAGGAGGAGTGGCTCATCCACTACATGCTGGGCAAGGTGGCTGAGAA
GCAGCAGCAGCCACCCACCGTTTACTTGCTGCACTACAGGCAGGCTGGCCACTACCTGCACGAGGAGGCTGCCCGCTACCCCAAGAAGAT
CCACTACCACAACCCACCTGAGCTGGCCATGGAGGCCCTGGAGGTGTACTTTCGGCTCCATGCTTCCATCCTGAAGCTCCTGGGGAAGCC
CGATTCTGGGGTTGGTGCAGAGGTCCTGGTCAACTTTATGAAGGAGGCTGCAGAAGGACCCTTTGCCAGGGGCGAGGAGAAGAACACACC
CAAAGCTTCAGAAAAGGAGAAGGCCTGCCTGGTGGACGAGGACTCCCACTCTTCAGCTGGGACACTGCCGGGCCCCGGAGCCTCCCTCCC
CTCCTCCTCTGGCCCAGGTCTGACATCCCCACCTTACACAGCCACTCCGATTGACCACGATTACGTCAAATGTAAAAAACCCCACCAGCA
GGCAACGCCGGACGACCGAAGCCAGGACAGCACAGCCGTAGCACTCTCAGACTCTAGCTCAACGCAGGACTTCTTTAATGAGCCCACCAG
CTTACTGGAAGGCTCCAGGAAATCCTACACAGAGAAGAGGCTGCCCATTCTCAGTTCCCAAGCAGGAGCGACGGGTAAAGATCTTCAGGG
GGCCACAGAAGAAAGAGGTGCAGAGGACGTGGTGATGGCGTTTTCCAGGTCGGAGACGGAAGACCGGAGGCAGTAGCTGCAAAGCCCTTG
GAACACCCTGGATGCTGTTGAGGGCCAAGAGATCTGTGTGGCTCCTGGGCCGGCTGAGTGGCAGCAGCCCCCCTTGCCCCACCTCCCCCT
TCCCCTACCCAACCCTGCCCTGCCCCACCCCACCTCACAGCTACTCAGTGGGGCTGGCATCAAGGGAGACACCAGTGGTGCGTTTATAAT
TGGCTTAAAGGGATGGACTTGTGATTGGCTGCAGGAAGAAACTTTTTTATTTTTTAAATCTTGACCAACAGAAACCTTTTATTTTTATTT
CTGACTCTTATTTTTTAAAAAATTTGCGCCTCGGTATCTGGCTTCCCTGGAAGCTCTCCGAGCTCTGGTGCTTTAGTTAGGTCATTTTTT
TAGAAATGTGAAGAGGTCTGATTGGCTGCTTAAACTGGAAAGGATCTGTGATTGGCTGGTTAATGGGAAACGGTTTTTTTCTTTGGCTGC
AGGTGTTCTGCTGATATCAACAGCTTCCCTATTTTGAATGCAGAAAACAGGGTCTGGGACATTAGTCGTTATATTTGACTTGAAAAGAAA
GAAACCAAGTGCGCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGCCTTCACATTTGGGGTTTGTGTTTGATTGGCTTTCGATGCG
TGTGTTTGGTTTCCCATTGGTTCACCTGTGACTCCTGTTGCCATGGATTCACCCCCCTCTGCTGCCGGCTCTGGGCCTGAGGGTCCACCT
GGAGAGTACATTTGCTTTAATGAGTGCACCTGCCTCCACCAGCAAGGGGACCCCGAGAACCCTGAGCAGGGTCCACAGCTGGAAAGTTGG
GCCCCTGAGGAGCTTTGTGTCGTCTTGAACGAGCAGCCCAGGGCCTAGAGGTAACCGTTAGGCGGGATTTATGTGCACTGCCTGCATGAG
CTGGCAACCAGCCAGCGTCCCTTGGTGAGAAAGGGATTGCTGAGGCACCGTCCAGGCCCCACCGGCCAGGCCGCGCCCAGCAGAGGCGTA
CTACCCAGCTCTGTCCTCTTGGCCATCCTTCTGTGTACCACTTCCTGAGGCCTCATTTTGGGGGTCATCTTGGAAAGGGGAGGAGCTTCT
CCCAGTGTGAGACCCCAAAGACTCTGGAGGTCATCTGGCGGAGGTCTCTGGGAGCCCAGAACCCACATAAAAGCCCCAGCTTGGCTCACA
AGGCCCAGGAGACCTCCAGCTAAACACCAACCCCTGACCTACCCCAGCCAGGCTCCTACCTGTCTGCTGCCAGCACAGTAGGTCCCGGCC
AGCTCTGGAGTTCTCTCATCGGAGGCCCATGCCCTCCACTCCACTGCCTTTGGAAGGGTCTCTCTCCAGGTCAGCCTGGAAGGGACAGTA
TCGTTTGTTTATGAAATGCCACTGGGACAGCTGGCTGGGCCTTCACCAAGCAAGTCCCTTCAGACTGGCCCTTAAGCCAAACTCAGGCCC
AGAATTGCAGTTCAGAATGGCAGTCCTGGAGGCAGGGGGTGAGGGGCAGGTCTAGTGTTCCTGCACCAAACCTAAGTCCTTCCACCTGCC
ACCCCCTTCCCTGGGAGGGAGGTGGTCCTCCTATCTCCCTGGCTCACTGGCAGGTGTGGGATCTGGGGAGAGCGGCTGGAGAAAGATGCA
GTCCTCAGGAAGGGGGCCGCCACCCTCCCCTATGCTGGTAGATGCTGAGGCCCCTAGGTGCCCAGGGCCAGTGGGACCCTCTCAGAACCA
AATCTTTCCCCTTTCTCGGGGCTTGGGGCTCGGGCCGTAGGGGCTCCTGAGTGTCATGAAGTGCACAGGAGCCAAATGACCGAGCCCTGG
AGAGCCCCATGGTGGGTAGGTGGTTCGTGCTGTGCTCTGGCACCATCAGCCTGTTCCAGAAGGAGGATTCGAGCATCAGGCTAAGACCCT
GTGTCCTCCACCATGCACTCACCCCTAGCCCTGGTTAGCTGACAGTCAGCTGTGGGGAACACAGCTACAACCCTACCCTGGCAGGGACCT
GAGAGCATCTCAGGAGGGGCAGCGCATGTGTGCATGTGCTGTGTGAGTGAGCACACCCGTGTGCACACTCATACACATGTGCACACACAC
GCACTCTCCCCGCTCAGGGGCCTGGAGGTCTGGCTGAGCCCCTGGGGAAAGGTGAGTTCTTTCATCTCCCTCCTCCAGGTCGGAGTGCCT
GGAGTCAGGTGTCGAGGCCACATTGCTGGCTGCCCCCTCTTTGTAGCTCCTATAAAGGGCCCACACCTGGTGGATACCTGGTTGAGTGTG
TGGTCTCTGCCCCAGCCTGTCCTTGTCACGATCACAGGCCTTGCTTTTGTAACAATGATGACCCCGGCCTGTCTCATCTTCTGAAGAGGA

>12227_12227_1_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000263119_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=1454AA_BP=1435
MNMIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLIL
KYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL
YFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFF
TWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTPVNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLL
ETGAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKVDFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESF
PSIGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHKFLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHI
KDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQ
GDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLEEIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCT
SGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAVQQMVNSGEAAAKEEWVATVTQLLMGIEQALSADSSGSILK
VSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIWQEEDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEY
LGRRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPK
TLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVSAYIEGTSTEVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFY
MHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRGEL
PPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAM
EALEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSP
PYTATPIDHDYVKCKKPHQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQGATEERGAEDV

--------------------------------------------------------------
>12227_12227_2_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000398319_CTNNBIP1_chr1_9910834_ENST00000377263_length(transcript)=7186nt_BP=4685nt
CTCAGCAGAGCCCGGGGCACAGGCCGGAGGGGCTGCAGGCGCGAGGCTGGGTTACGTGAGGAAGCTGGGGGTTTCGCGGGCAGCTTTAGA
GCCCCAGTCAGGGAAACCGAGGCCGGGCTTCCTGGCTGCCTCGCGAGCCTCTTCATGGCTCTCGCCGCCGCCCTGAGGTGCCTAGAATGG
GTTCCGGCCTCCGGGGAGGTTCCCAGTAACCGCAGGAGCCACCATTGATTTGGCGTCTGCTGGGTGCAAAGCCCAGCGCGCTAACCCTTT
ACTCGCGACCTTTCGCTTCACCTTCACAGCAGCCCTGCGAGGAGAGTTGTGGACTGGGGCAACCTTTGCCAGTGATGAGAAGTGATGCTC
GTGGCAGTGCTGAATCTCTCTGAATATGATTCGAATTGCAGCCTTAAATGCCAGCTCCACCATTGAGGATGATCATGAAGGAAGCTTTAA
AAGTCACAAAACCCAGACAAAGGAGGCTCAGGAAGCAGAGGCTTTTGCATTGTACCACAAGGCCCTTGATCTGCAGAAACATGACCGGTT
TGAGGAGTCTGCCAAAGCCTACCATGAGCTCTTGGAGGCGAGCCTGCTGCGGGAGGCAGTTTCATCCGGTGATGAGAAAGAGGGGTTGAA
ACACCCTGGGCTGATACTGAAATATTCCACTTATAAGAACTTGGCCCAGCTGGCAGCCCAGCGGGAGGATCTGGAGACAGCCATGGAGTT
CTACTTAGAGGCAGTGATGCTGGACTCCACAGATGTCAACCTCTGGTATAAGATTGGACATGTGGCCCTGAGGCTCATCCGGATCCCCCT
GGCTCGCCATGCTTTTGAGGAAGGGCTGCGGTGCAATCCTGACCACTGGCCCTGTTTGGATAACCTAATCACTGTCCTGTACACCCTCAG
TGATTACACAACATGTCTGTACTTCATCTGCAAAGCTTTGGAGAAGGATTGCCGGTACAGCAAAGGGCTGGTCCTCAAGGAGAAGATTTT
TGAGGAGCAGCCTTGTCTCCGGAAGGACTCTCTCAGAATGTTCCTCAAATGTGACATGTCGATTCACGATGTTTCGGTGAGTGCAGCTGA
GACACAGGCGATTGTAGATGAGGCCTTGGGGCTGCGAAAAAAGAGGCAAGCGCTGATTGTGCGGGAGAAGGAGCCGGACCTGAAACTTGT
GCAGCCCATTCCTTTCTTCACCTGGAAGTGCCTCGGAGAGAGCTTGCTGGCCATGTACAATCATCTCACCACCTGTGAGCCCCCACGTCC
CAGCCTTGGCAAAAGGATTGATTTGTCGGACTACCAGGACCCCAGCCAGCCTCTTGAGTCCTCCATGGTGGTGACGCCAGTTAACGTGAT
CCAGCCAAGCACTGTCAGCACCAACCCAGCTGTGGCTGTCGCCGAGCCTGTGGTCTCCTACACCTCTGTGGCTACAACCAGCTTCCCACT
GCACAGTCCTGGTCTGTTGGAGACAGGCGCTCCTGTGGGTGATATTTCTGGGGGAGATAAATCCAAGAAAGGGGTAAAACGGAAGAAGAT
TTCAGAAGAGAGTGGAGAAACAGCAAAGCGGCGGTCTGCCCGTGTCCGAAACACCAAGTGCAAAAAAGAAGAGAAAGTAGACTTCCAGGA
GCTTCTGATGAAGTTCTTGCCGTCCAGGTTAAGAAAGCTGGACCCTGAGGAGGAAGATGATTCCTTTAATAACTATGAAGTCCAGTCAGA
AGCCAAACTGGAAAGCTTCCCAAGCATTGGGCCTCAAAGGCTGTCATTTGACTCAGCCACATTCATGGAATCTGAAAAGCAGGACGTGCA
TGAGTTCCTGCTGGAGAACCTAACCAACGGGGGCATCCTGGAGCTGATGATGCGCTACCTGAAAGCCATGGGCCACAAGTTCTTGGTAAG
GTGGCCTCCAGGCTTGGCGGAGGTCGTGCTCAGCGTCTACCACAGCTGGAGGAGGCACAGCACCAGCCTGCCCAACCCGCTGCTGAGGGA
CTGCAGCAACAAGCACATCAAGGACATGATGCTGATGTCTCTCTCCTGCATGGAACTCCAGCTGGACCAGTGGCTGCTGACCAAAGGCAG
AAGCTCTGCAGTGTCTCCTCGGAACTGTCCTGCTGGTATGGTGAATGGCAGATTTGGACCTGACTTCCCAGGGACCCACTGCCTGGGTGA
CCTCCTACAGCTGTCATTTGCCTCGTCCCAGCGCGACCTGTTCGAGGATGGTTGGCTGGAGTTTGTGGTCCGTGTTTACTGGCTGAAGGC
TCGCTTCCTGGCGCTGCAGGGAGACATGGAGCAGGCCCTGGAGAACTATGACATCTGCACAGAAATGCTCCAGAGTTCCACCGCCATCCA
GGTGGAGGCAGGGGCTGAACGAAGAGACATTGTCATCCGGCTGCCCAACCTCCATAATGACTCTGTGGTTTCCCTGGAGGAGATTGATAA
GAACCTGAAGTCGCTGGAGCGGTGCCAGTCCCTGGAGGAGATTCAGCGGCTGTATGAAGCAGGCGACTACAAGGCTGTTGTGCATCTGCT
CCGCCCCACTTTGTGCACCAGTGGGTTTGACCGGGCCAAACACCTGGAGTTTATGACTTCCATTCCTGAGAGGCCAGCCCAGCTGCTTCT
TCTGCAGGACTCCTTGCTCCGGCTGAAGGACTATCGGCAGTGTTTTGAGTGTTCCGATGTGGCTCTGAACGAGGCTGTCCAGCAGATGGT
GAACTCAGGTGAGGCTGCCGCCAAGGAGGAGTGGGTGGCCACAGTGACCCAACTGCTGATGGGCATCGAGCAGGCCCTCTCTGCGGACAG
CAGTGGTAGCATCCTGAAGGTATCATCCTCCACCACTGGCCTTGTGCGGCTCACCAACAACCTCATCCAGGTCATTGACTGCAGCATGGC
TGTGCAGGAGGAGGCCAAGGAGCCCCACGTCTCTTCAGTGCTACCCTGGATCATTCTACACCGGATCATCTGGCAGGAGGAAGACACCTT
CCATTCTCTGTGCCACCAGCAGCAGCTCCAAAACCCAGCGGAGGAAGGGATGTCAGAGACGCCCATGCTCCCATCCTCCCTCATGCTGCT
GAACACAGCCCACGAGTATTTGGGCAGAAGGTCCTGGTGCTGCAATTCAGATGGGGCTCTGCTGCGATTCTATGTGCGAGTACTCCAGAA
GGAACTGGCTGCATCCACCTCTGAAGACACGCACCCTTACAAGGAGGAGCTGGAGACAGCCTTGGAGCAGTGCTTCTACTGCCTGTACAG
CTTCCCCAGCAAGAAGAGTAAGGCCAGGTACCTGGAGGAACACTCGGCCCAGCAGGTGGATCTTATATGGGAGGATGCACTGTTCATGTT
TGAGTATTTTAAGCCCAAGACCCTTCCTGAATTTGACAGCTATAAGACCAGCACCGTGTCTGCTGACTTGGCCAACCTACTGAAGAGAAT
TGCCACCATTGTGCCTCGCACAGAGAGGCCAGCCCTTAGCCTGGACAAAGTCTCTGCCTACATTGAGGGAACTTCAACTGAGGTACCCTG
CCTCCCAGAGGGGGCTGACCCCTCCCCTCCAGTGGTGAACGAGCTTTACTACCTCCTGGCTGATTATCATTTCAAAAACAAGGAGCAGTC
CAAGGCCATCAAGTTCTACATGCATGACATCTGCATCTGCCCCAATAGGTTTGATTCCTGGGCAGGCATGGCTCTGGCCCGGGCCAGCCG
CATTCAGGACAAGCTGAACTCCAATGAGCTGAAGAGTGATGGGCCCATTTGGAAGCATGCCACGCCCGTCTTGAACTGCTTCCGTCGGGC
CCTGGAGATTGACAGCTCCAACTTGTCCCTATGGATTGAGTATGGCACCATGTCCTATGCCTTGCACTCATTCGCCTCACGTCAATTGAA
GCAGTGGAGAGGCGAGCTGCCCCCTGAGCTCGTGCAGCAGATGGAGGGCCGGCGCGACAGCATGCTAGAGACAGCCAAGCACTGTTTCAC
ATCAGCAGCCCGCTGCGAGGGTGATGGTGACGAGGAGGAGTGGCTCATCCACTACATGCTGGGCAAGGTGGCTGAGAAGCAGCAGCAGCC
ACCCACCGTTTACTTGCTGCACTACAGGCAGGCTGGCCACTACCTGCACGAGGAGGCTGCCCGCTACCCCAAGAAGATCCACTACCACAA
CCCACCTGAGCTGGCCATGGAGGCCCTGGAGGTGTACTTTCGGCTCCATGCTTCCATCCTGAAGCTCCTGGGGAAGCCCGATTCTGGGGT
TGGTGCAGAGGTCCTGGTCAACTTTATGAAGGAGGCTGCAGAAGGACCCTTTGCCAGGGGCGAGGAGAAGAACACACCCAAAGCTTCAGA
AAAGGAGAAGGCCTGCCTGGTGGACGAGGACTCCCACTCTTCAGCTGGGACACTGCCGGGCCCCGGAGCCTCCCTCCCCTCCTCCTCTGG
CCCAGGTCTGACATCCCCACCTTACACAGCCACTCCGATTGACCACGATTACGTCAAATGTAAAAAACCCCACCAGCAGGCAACGCCGGA
CGACCGAAGCCAGGACAGCACAGCCGTAGCACTCTCAGACTCTAGCTCAACGCAGGACTTCTTTAATGAGCCCACCAGCTTACTGGAAGG
CTCCAGGAAATCCTACACAGAGAAGAGGCTGCCCATTCTCAGTTCCCAAGCAGGAGCGACGGGTAAAGATCTTCAGGGGGCCACAGAAGA
AAGAGGTGCAGAGGACGTGGTGATGGCGTTTTCCAGGTCGGAGACGGAAGACCGGAGGCAGTAGCTGCAAAGCCCTTGGAACACCCTGGA
TGCTGTTGAGGGCCAAGAGATCTGTGTGGCTCCTGGGCCGGCTGAGTGGCAGCAGCCCCCCTTGCCCCACCTCCCCCTTCCCCTACCCAA
CCCTGCCCTGCCCCACCCCACCTCACAGCTACTCAGTGGGGCTGGCATCAAGGGAGACACCAGTGGTGCGTTTATAATTGGCTTAAAGGG
ATGGACTTGTGATTGGCTGCAGGAAGAAACTTTTTTATTTTTTAAATCTTGACCAACAGAAACCTTTTATTTTTATTTCTGACTCTTATT
TTTTAAAAAATTTGCGCCTCGGTATCTGGCTTCCCTGGAAGCTCTCCGAGCTCTGGTGCTTTAGTTAGGTCATTTTTTTAGAAATGTGAA
GAGGTCTGATTGGCTGCTTAAACTGGAAAGGATCTGTGATTGGCTGGTTAATGGGAAACGGTTTTTTTCTTTGGCTGCAGGTGTTCTGCT
GATATCAACAGCTTCCCTATTTTGAATGCAGAAAACAGGGTCTGGGACATTAGTCGTTATATTTGACTTGAAAAGAAAGAAACCAAGTGC
GCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGCCTTCACATTTGGGGTTTGTGTTTGATTGGCTTTCGATGCGTGTGTTTGGTTT
CCCATTGGTTCACCTGTGACTCCTGTTGCCATGGATTCACCCCCCTCTGCTGCCGGCTCTGGGCCTGAGGGTCCACCTGGAGAGTACATT
TGCTTTAATGAGTGCACCTGCCTCCACCAGCAAGGGGACCCCGAGAACCCTGAGCAGGGTCCACAGCTGGAAAGTTGGGCCCCTGAGGAG
CTTTGTGTCGTCTTGAACGAGCAGCCCAGGGCCTAGAGGTAACCGTTAGGCGGGATTTATGTGCACTGCCTGCATGAGCTGGCAACCAGC
CAGCGTCCCTTGGTGAGAAAGGGATTGCTGAGGCACCGTCCAGGCCCCACCGGCCAGGCCGCGCCCAGCAGAGGCGTACTACCCAGCTCT
GTCCTCTTGGCCATCCTTCTGTGTACCACTTCCTGAGGCCTCATTTTGGGGGTCATCTTGGAAAGGGGAGGAGCTTCTCCCAGTGTGAGA
CCCCAAAGACTCTGGAGGTCATCTGGCGGAGGTCTCTGGGAGCCCAGAACCCACATAAAAGCCCCAGCTTGGCTCACAAGGCCCAGGAGA
CCTCCAGCTAAACACCAACCCCTGACCTACCCCAGCCAGGCTCCTACCTGTCTGCTGCCAGCACAGTAGGTCCCGGCCAGCTCTGGAGTT
CTCTCATCGGAGGCCCATGCCCTCCACTCCACTGCCTTTGGAAGGGTCTCTCTCCAGGTCAGCCTGGAAGGGACAGTATCGTTTGTTTAT
GAAATGCCACTGGGACAGCTGGCTGGGCCTTCACCAAGCAAGTCCCTTCAGACTGGCCCTTAAGCCAAACTCAGGCCCAGAATTGCAGTT
CAGAATGGCAGTCCTGGAGGCAGGGGGTGAGGGGCAGGTCTAGTGTTCCTGCACCAAACCTAAGTCCTTCCACCTGCCACCCCCTTCCCT
GGGAGGGAGGTGGTCCTCCTATCTCCCTGGCTCACTGGCAGGTGTGGGATCTGGGGAGAGCGGCTGGAGAAAGATGCAGTCCTCAGGAAG
GGGGCCGCCACCCTCCCCTATGCTGGTAGATGCTGAGGCCCCTAGGTGCCCAGGGCCAGTGGGACCCTCTCAGAACCAAATCTTTCCCCT
TTCTCGGGGCTTGGGGCTCGGGCCGTAGGGGCTCCTGAGTGTCATGAAGTGCACAGGAGCCAAATGACCGAGCCCTGGAGAGCCCCATGG
TGGGTAGGTGGTTCGTGCTGTGCTCTGGCACCATCAGCCTGTTCCAGAAGGAGGATTCGAGCATCAGGCTAAGACCCTGTGTCCTCCACC
ATGCACTCACCCCTAGCCCTGGTTAGCTGACAGTCAGCTGTGGGGAACACAGCTACAACCCTACCCTGGCAGGGACCTGAGAGCATCTCA
GGAGGGGCAGCGCATGTGTGCATGTGCTGTGTGAGTGAGCACACCCGTGTGCACACTCATACACATGTGCACACACACGCACTCTCCCCG
CTCAGGGGCCTGGAGGTCTGGCTGAGCCCCTGGGGAAAGGTGAGTTCTTTCATCTCCCTCCTCCAGGTCGGAGTGCCTGGAGTCAGGTGT
CGAGGCCACATTGCTGGCTGCCCCCTCTTTGTAGCTCCTATAAAGGGCCCACACCTGGTGGATACCTGGTTGAGTGTGTGGTCTCTGCCC
CAGCCTGTCCTTGTCACGATCACAGGCCTTGCTTTTGTAACAATGATGACCCCGGCCTGTCTCATCTTCTGAAGAGGAAAAGTCAAAGTG

>12227_12227_2_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000398319_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=1454AA_BP=1435
MNMIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLIL
KYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL
YFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSIHDVSVSAAETQAIVDEALGLRKKRQALIVREKEPDLKLVQPIPFF
TWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTPVNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLL
ETGAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKVDFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESF
PSIGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHKFLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHI
KDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTHCLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQ
GDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLEEIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCT
SGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAVQQMVNSGEAAAKEEWVATVTQLLMGIEQALSADSSGSILK
VSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIWQEEDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEY
LGRRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFYCLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPK
TLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVSAYIEGTSTEVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFY
MHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRGEL
PPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAM
EALEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTPKASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPGLTSP
PYTATPIDHDYVKCKKPHQQATPDDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQGATEERGAEDV

--------------------------------------------------------------
>12227_12227_3_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000405822_CTNNBIP1_chr1_9910834_ENST00000377263_length(transcript)=6658nt_BP=4157nt
CGTTGCTGTGGAGACGCCTGGAGAGTTGTGGACTGGGGCAACCTTTGCCAGTGATGAGAAGTGATGCTCGTGGCAGTGCTGAATCTCTCT
GAATATGATTCGAATTGCAGCCTTAAATGCCAGCTCCACCATTGAGGATGATCATGAAGGAAGCTTTAAAAGTCACAAAACCCAGACAAA
GGAGGCTCAGGAAGCAGAGGCTTTTGCATTGTACCACAAGGCCCTTGATCTGCAGAAACATGACCGGTTTGAGGAGTCTGCCAAAGCCTA
CCATGAGCTCTTGGAGGCGAGCCTGCTGCGGGAGGCAGTTTCATCCGGTGATGAGAAAGAGGGGTTGAAACACCCTGGGCTGATACTGAA
ATATTCCACTTATAAGAACTTGGCCCAGCTGGCAGCCCAGCGGGAGGATCTGGAGACAGCCATGGAGTTCTACTTAGAGGCAGTGATGCT
GGACTCCACAGATGTCAACCTCTGGTATAAGATTGGACATGTGGCCCTGAGGCTCATCCGGATCCCCCTGGCTCGCCATGCTTTTGAGGA
AGGGCTGCGGTGCAATCCTGACCACTGGCCCTGTTTGGATAACCTAATCACTGTCCTGTACACCCTCAGTGATTACACAACATGTCTGTA
CTTCATCTGCAAAGCTTTGGAGAAGGATTGCCGGTACAGCAAAGGGCTGGTCCTCAAGGAGAAGATTTTTGAGGAGCAGCCTTGTCTCCG
GAAGGACTCTCTCAGAATGTTCCTCAAATGCTGGAAGTGCCTCGGAGAGAGCTTGCTGGCCATGTACAATCATCTCACCACCTGTGAGCC
CCCACGTCCCAGCCTTGGCAAAAGGATTGATTTGTCGGACTACCAGGACCCCAGCCAGCCTCTTGAGTCCTCCATGGTGGTGACGCCAGT
TAACGTGATCCAGCCAAGCACTGTCAGCACCAACCCAGCTGTGGCTGTCGCCGAGCCTGTGGTCTCCTACACCTCTGTGGCTACAACCAG
CTTCCCACTGCACAGTCCTGGTCTGTTGGAGACAGGCGCTCCTGTGGGTGATATTTCTGGGGGAGATAAATCCAAGAAAGGGGTAAAACG
GAAGAAGATTTCAGAAGAGAGTGGAGAAACAGCAAAGCGGCGGTCTGCCCGTGTCCGAAACACCAAGTGCAAAAAAGAAGAGAAAGTAGA
CTTCCAGGAGCTTCTGATGAAGTTCTTGCCGTCCAGGTTAAGAAAGCTGGACCCTGAGGAGGAAGATGATTCCTTTAATAACTATGAAGT
CCAGTCAGAAGCCAAACTGGAAAGCTTCCCAAGCATTGGGCCTCAAAGGCTGTCATTTGACTCAGCCACATTCATGGAATCTGAAAAGCA
GGACGTGCATGAGTTCCTGCTGGAGAACCTAACCAACGGGGGCATCCTGGAGCTGATGATGCGCTACCTGAAAGCCATGGGCCACAAGTT
CTTGGTAAGGTGGCCTCCAGGCTTGGCGGAGGTCGTGCTCAGCGTCTACCACAGCTGGAGGAGGCACAGCACCAGCCTGCCCAACCCGCT
GCTGAGGGACTGCAGCAACAAGCACATCAAGGACATGATGCTGATGTCTCTCTCCTGCATGGAACTCCAGCTGGACCAGTGGCTGCTGAC
CAAAGGCAGAAGCTCTGCAGTGTCTCCTCGGAACTGTCCTGCTGGTATGGTGAATGGCAGATTTGGACCTGACTTCCCAGGGACCCACTG
CCTGGGTGACCTCCTACAGCTGTCATTTGCCTCGTCCCAGCGCGACCTGTTCGAGGATGGTTGGCTGGAGTTTGTGGTCCGTGTTTACTG
GCTGAAGGCTCGCTTCCTGGCGCTGCAGGGAGACATGGAGCAGGCCCTGGAGAACTATGACATCTGCACAGAAATGCTCCAGAGTTCCAC
CGCCATCCAGGTGGAGGCAGGGGCTGAACGAAGAGACATTGTCATCCGGCTGCCCAACCTCCATAATGACTCTGTGGTTTCCCTGGAGGA
GATTGATAAGAACCTGAAGTCGCTGGAGCGGTGCCAGTCCCTGGAGGAGATTCAGCGGCTGTATGAAGCAGGCGACTACAAGGCTGTTGT
GCATCTGCTCCGCCCCACTTTGTGCACCAGTGGGTTTGACCGGGCCAAACACCTGGAGTTTATGACTTCCATTCCTGAGAGGCCAGCCCA
GCTGCTTCTTCTGCAGGACTCCTTGCTCCGGCTGAAGGACTATCGGCAGTGTTTTGAGTGTTCCGATGTGGCTCTGAACGAGGCTGTCCA
GCAGATGGTGAACTCAGGTGAGGCTGCCGCCAAGGAGGAGTGGGTGGCCACAGTGACCCAACTGCTGATGGGCATCGAGCAGGCCCTCTC
TGCGGACAGCAGTGGTAGCATCCTGAAGGTATCATCCTCCACCACTGGCCTTGTGCGGCTCACCAACAACCTCATCCAGGTCATTGACTG
CAGCATGGCTGTGCAGGAGGAGGCCAAGGAGCCCCACGTCTCTTCAGTGCTACCCTGGATCATTCTACACCGGATCATCTGGCAGGAGGA
AGACACCTTCCATTCTCTGTGCCACCAGCAGCAGCTCCAAAACCCAGCGGAGGAAGGGATGTCAGAGACGCCCATGCTCCCATCCTCCCT
CATGCTGCTGAACACAGCCCACGAGTATTTGGGCAGAAGGTCCTGGTGCTGCAATTCAGATGGGGCTCTGCTGCGATTCTATGTGCGAGT
ACTCCAGAAGGAACTGGCTGCATCCACCTCTGAAGACACGCACCCTTACAAGGAGGAGCTGGAGACAGCCTTGGAGCAGTGCTTCTACTG
CCTGTACAGCTTCCCCAGCAAGAAGAGTAAGGCCAGGTACCTGGAGGAACACTCGGCCCAGCAGGTGGATCTTATATGGGAGGATGCACT
GTTCATGTTTGAGTATTTTAAGCCCAAGACCCTTCCTGAATTTGACAGCTATAAGACCAGCACCGTGTCTGCTGACTTGGCCAACCTACT
GAAGAGAATTGCCACCATTGTGCCTCGCACAGAGAGGCCAGCCCTTAGCCTGGACAAAGTCTCTGCCTACATTGAGGGAACTTCAACTGA
GGTACCCTGCCTCCCAGAGGGGGCTGACCCCTCCCCTCCAGTGGTGAACGAGCTTTACTACCTCCTGGCTGATTATCATTTCAAAAACAA
GGAGCAGTCCAAGGCCATCAAGTTCTACATGCATGACATCTGCATCTGCCCCAATAGGTTTGATTCCTGGGCAGGCATGGCTCTGGCCCG
GGCCAGCCGCATTCAGGACAAGCTGAACTCCAATGAGCTGAAGAGTGATGGGCCCATTTGGAAGCATGCCACGCCCGTCTTGAACTGCTT
CCGTCGGGCCCTGGAGATTGACAGCTCCAACTTGTCCCTATGGATTGAGTATGGCACCATGTCCTATGCCTTGCACTCATTCGCCTCACG
TCAATTGAAGCAGTGGAGAGGCGAGCTGCCCCCTGAGCTCGTGCAGCAGATGGAGGGCCGGCGCGACAGCATGCTAGAGACAGCCAAGCA
CTGTTTCACATCAGCAGCCCGCTGCGAGGGTGATGGTGACGAGGAGGAGTGGCTCATCCACTACATGCTGGGCAAGGTGGCTGAGAAGCA
GCAGCAGCCACCCACCGTTTACTTGCTGCACTACAGGCAGGCTGGCCACTACCTGCACGAGGAGGCTGCCCGCTACCCCAAGAAGATCCA
CTACCACAACCCACCTGAGCTGGCCATGGAGGCCCTGGAGGTGTACTTTCGGCTCCATGCTTCCATCCTGAAGCTCCTGGGGAAGCCCGA
TTCTGGGGTTGGTGCAGAGGTCCTGGTCAACTTTATGAAGGAGGCTGCAGAAGGACCCTTTGCCAGGGGCGAGGAGAAGAACACACCCAA
AGCTTCAGAAAAGGAGAAGGCCTGCCTGGTGGACGAGGACTCCCACTCTTCAGCTGGGACACTGCCGGGCCCCGGAGCCTCCCTCCCCTC
CTCCTCTGGCCCAGACCGAAGCCAGGACAGCACAGCCGTAGCACTCTCAGACTCTAGCTCAACGCAGGACTTCTTTAATGAGCCCACCAG
CTTACTGGAAGGCTCCAGGAAATCCTACACAGAGAAGAGGCTGCCCATTCTCAGTTCCCAAGCAGGAGCGACGGGTAAAGATCTTCAGGG
GGCCACAGAAGAAAGAGGTGCAGAGGACGTGGTGATGGCGTTTTCCAGGTCGGAGACGGAAGACCGGAGGCAGTAGCTGCAAAGCCCTTG
GAACACCCTGGATGCTGTTGAGGGCCAAGAGATCTGTGTGGCTCCTGGGCCGGCTGAGTGGCAGCAGCCCCCCTTGCCCCACCTCCCCCT
TCCCCTACCCAACCCTGCCCTGCCCCACCCCACCTCACAGCTACTCAGTGGGGCTGGCATCAAGGGAGACACCAGTGGTGCGTTTATAAT
TGGCTTAAAGGGATGGACTTGTGATTGGCTGCAGGAAGAAACTTTTTTATTTTTTAAATCTTGACCAACAGAAACCTTTTATTTTTATTT
CTGACTCTTATTTTTTAAAAAATTTGCGCCTCGGTATCTGGCTTCCCTGGAAGCTCTCCGAGCTCTGGTGCTTTAGTTAGGTCATTTTTT
TAGAAATGTGAAGAGGTCTGATTGGCTGCTTAAACTGGAAAGGATCTGTGATTGGCTGGTTAATGGGAAACGGTTTTTTTCTTTGGCTGC
AGGTGTTCTGCTGATATCAACAGCTTCCCTATTTTGAATGCAGAAAACAGGGTCTGGGACATTAGTCGTTATATTTGACTTGAAAAGAAA
GAAACCAAGTGCGCTTTGCAATATTTATTACACAAAGAACTTGCTGCTGCCTTCACATTTGGGGTTTGTGTTTGATTGGCTTTCGATGCG
TGTGTTTGGTTTCCCATTGGTTCACCTGTGACTCCTGTTGCCATGGATTCACCCCCCTCTGCTGCCGGCTCTGGGCCTGAGGGTCCACCT
GGAGAGTACATTTGCTTTAATGAGTGCACCTGCCTCCACCAGCAAGGGGACCCCGAGAACCCTGAGCAGGGTCCACAGCTGGAAAGTTGG
GCCCCTGAGGAGCTTTGTGTCGTCTTGAACGAGCAGCCCAGGGCCTAGAGGTAACCGTTAGGCGGGATTTATGTGCACTGCCTGCATGAG
CTGGCAACCAGCCAGCGTCCCTTGGTGAGAAAGGGATTGCTGAGGCACCGTCCAGGCCCCACCGGCCAGGCCGCGCCCAGCAGAGGCGTA
CTACCCAGCTCTGTCCTCTTGGCCATCCTTCTGTGTACCACTTCCTGAGGCCTCATTTTGGGGGTCATCTTGGAAAGGGGAGGAGCTTCT
CCCAGTGTGAGACCCCAAAGACTCTGGAGGTCATCTGGCGGAGGTCTCTGGGAGCCCAGAACCCACATAAAAGCCCCAGCTTGGCTCACA
AGGCCCAGGAGACCTCCAGCTAAACACCAACCCCTGACCTACCCCAGCCAGGCTCCTACCTGTCTGCTGCCAGCACAGTAGGTCCCGGCC
AGCTCTGGAGTTCTCTCATCGGAGGCCCATGCCCTCCACTCCACTGCCTTTGGAAGGGTCTCTCTCCAGGTCAGCCTGGAAGGGACAGTA
TCGTTTGTTTATGAAATGCCACTGGGACAGCTGGCTGGGCCTTCACCAAGCAAGTCCCTTCAGACTGGCCCTTAAGCCAAACTCAGGCCC
AGAATTGCAGTTCAGAATGGCAGTCCTGGAGGCAGGGGGTGAGGGGCAGGTCTAGTGTTCCTGCACCAAACCTAAGTCCTTCCACCTGCC
ACCCCCTTCCCTGGGAGGGAGGTGGTCCTCCTATCTCCCTGGCTCACTGGCAGGTGTGGGATCTGGGGAGAGCGGCTGGAGAAAGATGCA
GTCCTCAGGAAGGGGGCCGCCACCCTCCCCTATGCTGGTAGATGCTGAGGCCCCTAGGTGCCCAGGGCCAGTGGGACCCTCTCAGAACCA
AATCTTTCCCCTTTCTCGGGGCTTGGGGCTCGGGCCGTAGGGGCTCCTGAGTGTCATGAAGTGCACAGGAGCCAAATGACCGAGCCCTGG
AGAGCCCCATGGTGGGTAGGTGGTTCGTGCTGTGCTCTGGCACCATCAGCCTGTTCCAGAAGGAGGATTCGAGCATCAGGCTAAGACCCT
GTGTCCTCCACCATGCACTCACCCCTAGCCCTGGTTAGCTGACAGTCAGCTGTGGGGAACACAGCTACAACCCTACCCTGGCAGGGACCT
GAGAGCATCTCAGGAGGGGCAGCGCATGTGTGCATGTGCTGTGTGAGTGAGCACACCCGTGTGCACACTCATACACATGTGCACACACAC
GCACTCTCCCCGCTCAGGGGCCTGGAGGTCTGGCTGAGCCCCTGGGGAAAGGTGAGTTCTTTCATCTCCCTCCTCCAGGTCGGAGTGCCT
GGAGTCAGGTGTCGAGGCCACATTGCTGGCTGCCCCCTCTTTGTAGCTCCTATAAAGGGCCCACACCTGGTGGATACCTGGTTGAGTGTG
TGGTCTCTGCCCCAGCCTGTCCTTGTCACGATCACAGGCCTTGCTTTTGTAACAATGATGACCCCGGCCTGTCTCATCTTCTGAAGAGGA

>12227_12227_3_CABIN1-CTNNBIP1_CABIN1_chr22_24509715_ENST00000405822_CTNNBIP1_chr1_9910834_ENST00000377263_length(amino acids)=1375AA_BP=1356
MNMIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYHELLEASLLREAVSSGDEKEGLKHPGLIL
KYSTYKNLAQLAAQREDLETAMEFYLEAVMLDSTDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCL
YFICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCWKCLGESLLAMYNHLTTCEPPRPSLGKRIDLSDYQDPSQPLESSMVVTP
VNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLLETGAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKV
DFQELLMKFLPSRLRKLDPEEEDDSFNNYEVQSEAKLESFPSIGPQRLSFDSATFMESEKQDVHEFLLENLTNGGILELMMRYLKAMGHK
FLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKDMMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTH
CLGDLLQLSFASSQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEMLQSSTAIQVEAGAERRDIVIRLPNLHNDSVVSLE
EIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCTSGFDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAV
QQMVNSGEAAAKEEWVATVTQLLMGIEQALSADSSGSILKVSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEPHVSSVLPWIILHRIIWQE
EDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEYLGRRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFY
CLYSFPSKKSKARYLEEHSAQQVDLIWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTERPALSLDKVSAYIEGTST
EVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFYMHDICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNC
FRRALEIDSSNLSLWIEYGTMSYALHSFASRQLKQWRGELPPELVQQMEGRRDSMLETAKHCFTSAARCEGDGDEEEWLIHYMLGKVAEK
QQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEALEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTP
KASEKEKACLVDEDSHSSAGTLPGPGASLPSSSGPDRSQDSTAVALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQ

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Fusion Gene PPI Analysis for CABIN1-CTNNBIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CABIN1-CTNNBIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CABIN1-CTNNBIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource