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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CABIN1-GRIN2A (FusionGDB2 ID:12229) |
Fusion Gene Summary for CABIN1-GRIN2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CABIN1-GRIN2A | Fusion gene ID: 12229 | Hgene | Tgene | Gene symbol | CABIN1 | GRIN2A | Gene ID | 23523 | 2903 |
| Gene name | calcineurin binding protein 1 | glutamate ionotropic receptor NMDA type subunit 2A | |
| Synonyms | CAIN|KB-318B8.7|PPP3IN | EPND|FESD|GluN2A|LKS|NMDAR2A|NR2A | |
| Cytomap | 22q11.23 | 16p13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calcineurin-binding protein cabin-1calcineurin binding protein cabin 1calcineurin inhibitor | glutamate receptor ionotropic, NMDA 2AN-methyl D-aspartate receptor subtype 2AN-methyl-D-aspartate receptor channel, subunit epsilon-1N-methyl-D-aspartate receptor subunit 2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9Y6J0 | Q12879 | |
| Ensembl transtripts involved in fusion gene | ENST00000263119, ENST00000398319, ENST00000405822, ENST00000337989, ENST00000485008, | ENST00000566670, ENST00000330684, ENST00000396573, ENST00000396575, ENST00000404927, ENST00000535259, ENST00000562109, | |
| Fusion gene scores | * DoF score | 16 X 15 X 8=1920 | 8 X 7 X 5=280 |
| # samples | 18 | 8 | |
| ** MAII score | log2(18/1920*10)=-3.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/280*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CABIN1 [Title/Abstract] AND GRIN2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CABIN1(24515665)-GRIN2A(9984957), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | CABIN1-GRIN2A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CABIN1-GRIN2A seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CABIN1-GRIN2A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CABIN1-GRIN2A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CABIN1-GRIN2A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CABIN1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Tgene | GRIN2A | GO:0045471 | response to ethanol | 18445116 |
| Tgene | GRIN2A | GO:0097553 | calcium ion transmembrane import into cytosol | 26875626 |
| Fusion gene breakpoints across CABIN1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across GRIN2A (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BLCA | TCGA-DK-A3IN-01A | CABIN1 | chr22 | 24515665 | - | GRIN2A | chr16 | 9984957 | - |
| ChimerDB4 | BLCA | TCGA-DK-A3IN-01A | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
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Fusion Gene ORF analysis for CABIN1-GRIN2A |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000263119 | ENST00000566670 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| 5CDS-intron | ENST00000398319 | ENST00000566670 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| 5CDS-intron | ENST00000405822 | ENST00000566670 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000263119 | ENST00000330684 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000263119 | ENST00000396573 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000263119 | ENST00000396575 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000263119 | ENST00000404927 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000263119 | ENST00000535259 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000263119 | ENST00000562109 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000398319 | ENST00000330684 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000398319 | ENST00000396573 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000398319 | ENST00000396575 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000398319 | ENST00000404927 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000398319 | ENST00000535259 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000398319 | ENST00000562109 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000405822 | ENST00000330684 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000405822 | ENST00000396573 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000405822 | ENST00000396575 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000405822 | ENST00000404927 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000405822 | ENST00000535259 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| Frame-shift | ENST00000405822 | ENST00000562109 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000337989 | ENST00000330684 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000337989 | ENST00000396573 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000337989 | ENST00000396575 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000337989 | ENST00000404927 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000337989 | ENST00000535259 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000337989 | ENST00000562109 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000485008 | ENST00000330684 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000485008 | ENST00000396573 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000485008 | ENST00000396575 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000485008 | ENST00000404927 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000485008 | ENST00000535259 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-3CDS | ENST00000485008 | ENST00000562109 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-intron | ENST00000337989 | ENST00000566670 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| intron-intron | ENST00000485008 | ENST00000566670 | CABIN1 | chr22 | 24515665 | + | GRIN2A | chr16 | 9984957 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CABIN1-GRIN2A |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CABIN1-GRIN2A |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24515665/:9984957) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CABIN1 | GRIN2A |
| FUNCTION: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}. | FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have lower sensitivity to glutamate and faster deactivation kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761, PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:Q00959, ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:8768735}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CABIN1-GRIN2A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CABIN1-GRIN2A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CABIN1-GRIN2A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CABIN1-GRIN2A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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