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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CABIN1-MAFF (FusionGDB2 ID:12235)

Fusion Gene Summary for CABIN1-MAFF

check button Fusion gene summary
Fusion gene informationFusion gene name: CABIN1-MAFF
Fusion gene ID: 12235
HgeneTgene
Gene symbol

CABIN1

MAFF

Gene ID

23523

23764

Gene namecalcineurin binding protein 1MAF bZIP transcription factor F
SynonymsCAIN|KB-318B8.7|PPP3INU-MAF|hMafF
Cytomap

22q11.23

22q13.1

Type of geneprotein-codingprotein-coding
Descriptioncalcineurin-binding protein cabin-1calcineurin binding protein cabin 1calcineurin inhibitortranscription factor MafFv-maf avian musculoaponeurotic fibrosarcoma oncogene family protein Fv-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
Modification date2020031320200313
UniProtAcc

Q9Y6J0

MIP

Ensembl transtripts involved in fusion geneENST00000263119, ENST00000398319, 
ENST00000405822, ENST00000337989, 
ENST00000485008, 		ENST00000338483, 
ENST00000407965, ENST00000426621, 
ENST00000538320, ENST00000538999, 
Fusion gene scores* DoF score16 X 15 X 8=19207 X 4 X 6=168
# samples 188
** MAII scorelog2(18/1920*10)=-3.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CABIN1 [Title/Abstract] AND MAFF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCABIN1(24434909)-MAFF(38609830), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCABIN1

GO:0006336

DNA replication-independent nucleosome assembly

14718166

TgeneMAFF

GO:0045944

positive regulation of transcription by RNA polymerase II

12490281


check buttonFusion gene breakpoints across CABIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAFF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01ACABIN1chr22

24434909

+MAFFchr22

38609830

+


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Fusion Gene ORF analysis for CABIN1-MAFF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000263119ENST00000338483CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000263119ENST00000407965CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000263119ENST00000426621CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000263119ENST00000538320CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000398319ENST00000338483CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000398319ENST00000407965CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000398319ENST00000426621CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000398319ENST00000538320CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000405822ENST00000338483CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000405822ENST00000407965CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000405822ENST00000426621CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-5UTRENST00000405822ENST00000538320CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-intronENST00000263119ENST00000538999CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-intronENST00000398319ENST00000538999CABIN1chr22

24434909

+MAFFchr22

38609830

+
5CDS-intronENST00000405822ENST00000538999CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000337989ENST00000338483CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000337989ENST00000407965CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000337989ENST00000426621CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000337989ENST00000538320CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000485008ENST00000338483CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000485008ENST00000407965CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000485008ENST00000426621CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-5UTRENST00000485008ENST00000538320CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-intronENST00000337989ENST00000538999CABIN1chr22

24434909

+MAFFchr22

38609830

+
intron-intronENST00000485008ENST00000538999CABIN1chr22

24434909

+MAFFchr22

38609830

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CABIN1-MAFF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CABIN1chr2224434909+MAFFchr2238609829+2.44E-070.99999976
CABIN1chr2224434909+MAFFchr2238609829+2.44E-070.99999976

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CABIN1-MAFF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:24434909/:38609830)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CABIN1

Q9Y6J0

MAFF

MIP

FUNCTION: May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. {ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:9655484}.626

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CABIN1-MAFF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CABIN1-MAFF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CABIN1-MAFF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CABIN1-MAFF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource