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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CABLES1-HLA-DQA1 (FusionGDB2 ID:12247)

Fusion Gene Summary for CABLES1-HLA-DQA1

Fusion gene summary

Fusion gene information	Fusion gene name: CABLES1-HLA-DQA1
	Fusion gene ID: 12247
		Hgene	Tgene
	Gene symbol	CABLES1	HLA-DQA1
	Gene ID	91768	3117
	Gene name	Cdk5 and Abl enzyme substrate 1	major histocompatibility complex, class II, DQ alpha 1
	Synonyms	CABL1\|CABLES\|HsT2563\|IK3-1	CELIAC1\|DQ-A1\|DQA1\|HLA-DQA
	Cytomap	18q11.2	6p21.32
	Type of gene	protein-coding	protein-coding
	Description	CDK5 and ABL1 enzyme substrate 1interactor with CDK3 1	HLA class II histocompatibility antigen, DQ alpha 1 chainDC-1 alpha chainDC-alphaHLA-DCAMHC HLA-DQ alphaMHC class II DQ alpha chainMHC class II DQA1MHC class II HLA-DQ-alpha-1MHC class II antigen DQA1truncated MHC class II antigen
	Modification date	20200313	20200323
	UniProtAcc	Q8TDN4	P01909
	Ensembl transtripts involved in fusion gene	ENST00000256925, ENST00000400473, ENST00000420687, ENST00000585061,	ENST00000343139, ENST00000374949, ENST00000383251, ENST00000395363, ENST00000399675, ENST00000399678, ENST00000416403, ENST00000418023, ENST00000420385, ENST00000441297, ENST00000442315, ENST00000442680, ENST00000443320, ENST00000444296, ENST00000450614, ENST00000450960, ENST00000451947, ENST00000453504, ENST00000456258, ENST00000457246, ENST00000463379, ENST00000466849, ENST00000498769, ENST00000547425, ENST00000548014, ENST00000548597, ENST00000550158, ENST00000552932,
Fusion gene scores	* DoF score	16 X 13 X 3=624	3 X 2 X 1=6
	# samples	21	3
	** MAII score	log2(21/624*10)=-1.57115670119613 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/6*10)=2.32192809488736
Context	PubMed: CABLES1 [Title/Abstract] AND HLA-DQA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CABLES1(20823550)-HLA-DQA1(32611038), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CABLES1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLA-DQA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AA165510	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-

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Fusion Gene ORF analysis for CABLES1-HLA-DQA1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000256925	ENST00000343139	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-3UTR	ENST00000400473	ENST00000343139	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-3UTR	ENST00000420687	ENST00000343139	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-3UTR	ENST00000585061	ENST00000343139	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000374949	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000383251	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000395363	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000399675	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000399678	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000416403	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000418023	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000420385	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000441297	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000442315	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000442680	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000443320	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000444296	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000450614	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000450960	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000451947	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000453504	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000456258	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000457246	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000463379	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000466849	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000498769	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000547425	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000548014	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000548597	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000550158	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000256925	ENST00000552932	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000374949	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000383251	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000395363	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000399675	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000399678	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000416403	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000418023	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000420385	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000441297	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000442315	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000442680	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000443320	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000444296	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000450614	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000450960	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000451947	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000453504	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000456258	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000457246	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000463379	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000466849	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000498769	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000547425	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000548014	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000548597	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000550158	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000400473	ENST00000552932	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000374949	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000383251	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000395363	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000399675	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000399678	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000416403	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000418023	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000420385	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000441297	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000442315	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000442680	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000443320	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000444296	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000450614	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000450960	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000451947	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000453504	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000456258	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000457246	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000463379	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000466849	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000498769	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000547425	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000548014	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000548597	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000550158	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000420687	ENST00000552932	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000374949	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000383251	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000395363	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000399675	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000399678	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000416403	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000418023	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000420385	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000441297	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000442315	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000442680	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000443320	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000444296	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000450614	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000450960	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000451947	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000453504	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000456258	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000457246	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000463379	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000466849	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000498769	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000547425	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000548014	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000548597	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000550158	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-
intron-intron	ENST00000585061	ENST00000552932	CABLES1	chr18	20823550	+	HLA-DQA1	chr6	32611038	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CABLES1-HLA-DQA1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CABLES1-HLA-DQA1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:20823550/:32611038)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CABLES1 Q8TDN4	HLA-DQA1 P01909
FUNCTION: Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). {ECO:0000250}.	FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CABLES1-HLA-DQA1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CABLES1-HLA-DQA1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CABLES1-HLA-DQA1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CABLES1-HLA-DQA1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source