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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CABYR-CABYR (FusionGDB2 ID:12265)

Fusion Gene Summary for CABYR-CABYR

check button Fusion gene summary
Fusion gene informationFusion gene name: CABYR-CABYR
Fusion gene ID: 12265
HgeneTgene
Gene symbol

CABYR

CABYR

Gene ID

26256

26256

Gene namecalcium binding tyrosine phosphorylation regulatedcalcium binding tyrosine phosphorylation regulated
SynonymsCABYRa|CABYRc|CABYRc/d|CABYRe|CBP86|CT88|FSP-2|FSP2CABYRa|CABYRc|CABYRc/d|CABYRe|CBP86|CT88|FSP-2|FSP2
Cytomap

18q11.2

18q11.2

Type of geneprotein-codingprotein-coding
Descriptioncalcium-binding tyrosine phosphorylation-regulated proteincalcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)calcium-binding protein 86cancer/testis antigen 88fibrousheathin IIfibrousheathin-2testis tissue sperm-binding proteincalcium-binding tyrosine phosphorylation-regulated proteincalcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)calcium-binding protein 86cancer/testis antigen 88fibrousheathin IIfibrousheathin-2testis tissue sperm-binding protein
Modification date2020031320200313
UniProtAcc

O75952

O75952

Ensembl transtripts involved in fusion geneENST00000327201, ENST00000399481, 
ENST00000399496, ENST00000399499, 
ENST00000415309, ENST00000581397, 
ENST00000327201, ENST00000399481, 
ENST00000399496, ENST00000399499, 
ENST00000415309, ENST00000581397, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 3=75
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CABYR [Title/Abstract] AND CABYR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCABYR(21739385)-CABYR(21739386), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CABYR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CABYR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF942049CABYRchr18

21739385

+CABYRchr18

21739386

-
ChiTaRS5.0N/ABF942175CABYRchr18

21739385

+CABYRchr18

21739386

-
ChiTaRS5.0N/ABF942322CABYRchr18

21739385

+CABYRchr18

21739386

-


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Fusion Gene ORF analysis for CABYR-CABYR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000327201ENST00000327201CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000327201ENST00000399481CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000327201ENST00000399496CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000327201ENST00000399499CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000327201ENST00000415309CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000327201ENST00000581397CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399481ENST00000327201CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399481ENST00000399481CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399481ENST00000399496CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399481ENST00000399499CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399481ENST00000415309CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399481ENST00000581397CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399496ENST00000327201CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399496ENST00000399481CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399496ENST00000399496CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399496ENST00000399499CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399496ENST00000415309CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399496ENST00000581397CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399499ENST00000327201CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399499ENST00000399481CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399499ENST00000399496CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399499ENST00000399499CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399499ENST00000415309CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000399499ENST00000581397CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000415309ENST00000327201CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000415309ENST00000399481CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000415309ENST00000399496CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000415309ENST00000399499CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000415309ENST00000415309CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000415309ENST00000581397CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000581397ENST00000327201CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000581397ENST00000399481CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000581397ENST00000399496CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000581397ENST00000399499CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000581397ENST00000415309CABYRchr18

21739385

+CABYRchr18

21739386

-
intron-intronENST00000581397ENST00000581397CABYRchr18

21739385

+CABYRchr18

21739386

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CABYR-CABYR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CABYR-CABYR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21739385/:21739386)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CABYR

O75952

CABYR

O75952

FUNCTION: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.FUNCTION: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CABYR-CABYR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CABYR-CABYR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CABYR-CABYR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CABYR-CABYR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource