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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CACHD1-CLIC4 (FusionGDB2 ID:12269)

Fusion Gene Summary for CACHD1-CLIC4

Fusion gene summary

Fusion gene information	Fusion gene name: CACHD1-CLIC4
	Fusion gene ID: 12269
		Hgene	Tgene
	Gene symbol	CACHD1	CLIC4
	Gene ID	57685	25932
	Gene name	cache domain containing 1	chloride intracellular channel 4
	Synonyms	-	CLIC4L\|H1\|MTCLIC\|huH1\|p64H1
	Cytomap	1p31.3	1p36.11
	Type of gene	protein-coding	protein-coding
	Description	VWFA and cache domain-containing protein 1cache domain-containing protein 1von Willebrand factor type A and cache domain containing 1	chloride intracellular channel protein 4chloride intracellular channel 4 likeepididymis secretory sperm binding proteinintracellular chloride ion channel protein p64H1
	Modification date	20200320	20200313
	UniProtAcc	Q5VU97	Q9Y696
	Ensembl transtripts involved in fusion gene	ENST00000290039, ENST00000371073, ENST00000495994,	ENST00000497755, ENST00000374379,
Fusion gene scores	* DoF score	6 X 5 X 4=120	12 X 10 X 5=600
	# samples	6	12
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/600*10)=-2.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CACHD1 [Title/Abstract] AND CLIC4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CACHD1(64936625)-CLIC4(25124233), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CLIC4	GO:0030336	negative regulation of cell migration	12163372

Fusion gene breakpoints across CACHD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CLIC4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A1FC-01A	CACHD1	chr1	64936625	-	CLIC4	chr1	25124233	+
ChimerDB4	BRCA	TCGA-BH-A1FC-01A	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+

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Fusion Gene ORF analysis for CACHD1-CLIC4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000290039	ENST00000497755	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+
5CDS-3UTR	ENST00000371073	ENST00000497755	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+
In-frame	ENST00000290039	ENST00000374379	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+
In-frame	ENST00000371073	ENST00000374379	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+
intron-3CDS	ENST00000495994	ENST00000374379	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+
intron-3UTR	ENST00000495994	ENST00000497755	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000371073

CACHD1

chr1

64936625

ENST00000374379

CLIC4

chr1

25124233

4275

198

916

305

ENST00000290039

CACHD1

chr1

64936625

ENST00000374379

CLIC4

chr1

25124233

4228

151

869

290

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000371073	ENST00000374379	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+	0.000446144	0.99955386
ENST00000290039	ENST00000374379	CACHD1	chr1	64936625	+	CLIC4	chr1	25124233	+	0.000586498	0.9994135

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Fusion Genomic Features for CACHD1-CLIC4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CACHD1	chr1	64936625	+	CLIC4	chr1	25124232	+	1.75E-07	0.9999999
CACHD1	chr1	64936625	+	CLIC4	chr1	25124232	+	1.75E-07	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CACHD1-CLIC4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:64936625/chr1:25124233)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CACHD1 Q5VU97	CLIC4 Q9Y696
FUNCTION: May regulate voltage-dependent calcium channels. {ECO:0000250}.	FUNCTION: Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269\|PubMed:12163372, ECO:0000269\|PubMed:14569596, ECO:0000269\|PubMed:16176272, ECO:0000269\|PubMed:16239224, ECO:0000269\|PubMed:18302930, ECO:0000269\|PubMed:19247789}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CLIC4

chr1:64936625

chr1:25124233

ENST00000374379

104_244

254.0

Domain

Note=GST C-terminal

Tgene

CLIC4

chr1:64936625

chr1:25124233

ENST00000374379

37_57

254.0

Transmembrane

Helical%3B Note%3DAfter insertion into the membrane

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

1243_1260

1275.0

Compositional bias

Note=His-rich

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

943_982

1275.0

Compositional bias

Note=Cys-rich

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

228_443

1275.0

Domain

VWFA

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

453_532

1275.0

Domain

Note=Cache 1

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

772_853

1275.0

Domain

Note=Cache 2

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

1117_1274

1275.0

Topological domain

Cytoplasmic

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

36_1095

1275.0

Topological domain

Extracellular

Hgene

CACHD1

chr1:64936625

chr1:25124233

ENST00000371073

1096_1116

1275.0

Transmembrane

Helical

Tgene

CLIC4

chr1:64936625

chr1:25124233

ENST00000374379

2_101

254.0

Region

Required for insertion into the membrane

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Fusion Gene Sequence for CACHD1-CLIC4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>12269_12269_1_CACHD1-CLIC4_CACHD1_chr1_64936625_ENST00000290039_CLIC4_chr1_25124233_ENST00000374379_length(transcript)=4228nt_BP=151nt
GCGGCCGCCCCTCTGGCTGCTCTGCCTGGTCGCGTGCTGGCTCCTGGGCGCCGGGGCCGAAGCCGACTTCTCCATCCTGGACGAGGCGCA
AGTGCTGGCGAGCCAGATGCGGAGGCTGGCGGCCGAGGAGCTGGGGGTCGTCACCATGCAGGCTGGCAGTGATGGTGAAAGCATAGGAAA
CTGCCCCTTTTCCCAGAGGCTCTTCATGATTCTTTGGCTCAAAGGAGTTGTATTTAGTGTGACGACTGTTGACCTGAAAAGGAAGCCAGC
AGACCTGCAGAACTTGGCTCCCGGGACCCACCCACCATTTATAACTTTCAACAGTGAAGTCAAAACGGATGTAAATAAGATTGAGGAATT
TCTTGAAGAAGTCTTATGCCCTCCCAAGTACTTAAAGCTTTCACCAAAACACCCAGAATCAAATACTGCTGGAATGGACATCTTTGCCAA
ATTCTCTGCATATATCAAGAATTCAAGGCCAGAGGCTAATGAAGCACTGGAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATA
TCTGAATTCTCCTCTCCCTGATGAAATTGATGAAAATAGTATGGAGGACATAAAGTTTTCTACACGTAAATTTCTGGATGGCAATGAAAT
GACATTAGCTGATTGCAACCTGCTGCCCAAACTGCATATTGTCAAGGTGGTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAAT
GACTGGCATCTGGAGATACCTAACTAATGCATACAGTAGGGACGAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTTGAAATAGCATA
TAGTGATGTAGCCAAAAGACTCACCAAGTAAAATCGCGTTTGTAAAAGAGATGTCTTCATGTCTTCCCCTAAGAATACGCTTTTCCTAAC
AGGCTACTCCTTCCTGTAGAGCAGAAATTGTATTTTGCACGAACATGCAGTTATTGAAGATTAGGATCAAGGATAGACAAGGTATAGTAG
TTATCTTAAAATATACACTCCTAAGCAGTATTATTTTAAAATCCTTTACCCTGGCTACCTCCCCTACCCGGGTTCCCCTCTCTTTAATTT
GGAGACACTCCACCACAAACTTTTCACTTTAGAGGTAGCTTGCCATCTCTCAGGAGCCCTCACCATTGTGTCCATTCACTGTGTATAGAT
GGCAGAACTTTTGAGGTGCAATGTTTAATTGTTAAAAATAGTAGCCACGACTTTATCAGGCAGCCCCAAACTGGTGCATAATGCATGGTA
CAAGAAATATTTATGTATTTTTTGGAATTTTGTAATATTTAGTAAGAGTATATGAAAGGATTGCTACTGTATCAGAAATATTGTTTCAAT
TTAGTCTATCCTGGATATGTACTAACGAATATTACCACCAGAGAAGAGAGCTTTCTACAAAAGTCACTACAGATTTTGCTATATTGCTTT
GTAGATAGATTTTTACTTTTGCCTAAAAGCATTTATCCTTCATACCAATTGTAACATCTGACACCATGTAGAAGCTAAAAGTTTAGAGGG
AGTGAGGGTTTTCTCAAGACCTTCCTCAAGCATTTTATCTTTAGAAGAGAAACTGATGGGCACCTGATACTCTGTCTAAATACGTTTGTT
ATATGTGTTTTGCCCTGTGCCATTCATTTGGAACTTTATTGCATTCTTTATTTTAAAAAGCTTGTTTTTACGTAATCATAGAGCTTGCTA
TTTGTACATCTGTTGAGCAACACTACATAACTGATTTTTAGTTGACTTAGCTATAGCAGTACAATGATTAGTAATGTAAAAATTAACACA
GAAATTAACCTAAGGAATGAAGGGTGGGTTTGTCAAAATATCAAGTAAATTTTTGTTTCTAAAGTACATTTAATGTAGATGACCTAAAGA
ATGCGTTATCCATCCTATATAAAAGAAAGATAAAACACAGGTCACCAATTTTCTCATTTCACCCCATTTACCTTGTATAGAGGATTGTTC
ATTCCTTTGGGACTAAGTTATAGTTATGGTGAGTGTGTATTTACTGTAGTTTTGCCTGATCTCACTCATTGCACTTCCTGGAGTTAAATT
TTCCAACAGCCATGTTGAGGAATAGCACTCTGCATGTTTTTGTTTTGTTTTTCGGGGTTTTTTTTAATTGAAGCCCTAAACCAGGAATTA
TTTGTGTTCTAACAGGAGGATGAACTTGCTGAAAATAAAACTTTGCTATGTATTTACTCTTTTTTAAAAGACAAAAGCAAAACCAGACTT
TCTACGTACTACTCCAAAGACTGTGATTGTGACTATAATACATTTTTGGTAATTTTTTTATACCTAATTTGTATAGGAAGTGCTATTTCT
CATAGGCTGTTTCTTGAAATTTTAAGTTTATTGCTTTAAAATGGCAGTGTTTCTCCCACTTTGATATGCTAACATTTAGTAAGCACTGGC
TTTATGAAAGCGGCTTTTTATAAGTATACTGCATTTTTTGAGCCTATCATTAATTAGCTTAGTATGAAAGATAAGAAAATCTCCATGTTG
TATCCATTTGGCTCAGGAAGATTCTTTGCCTTACCTTTCTTAGAACTCTTTATTGCTTATCAAAAGTTTGAGTACCCGCTTGGTTTTTTT
TTGGTAATTAAATATTGTATGATTTATCTGGTTCAAGGAAGATGCACTATTCAGTTATCTATTGAGAAATTATTTTGCAGTGGTTTTAGT
GGGTGAAAATGTCCCATCTGCACCAGTACACAGGCAGGCATTATCATTCTTCACCTACTTTTTAAATAGTGGCAACTTGGGATTCATTCT
GGTGATTCTGAACCTTGCCTCATAGCTTAAAGTATAAAAAAGATTCAAGAGCAGTGAGGTTTGTTCTTTCCAGTGAATGGTGGACTGAGT
GGTGCGAGGTGGAGGGCTAACAAGAGGAAAGAACTACATTCTTCAGAATACAGTGATGAAAATTCATTTTGAAACTCAAATATTTTCATT
TTGGATATTCTCCTGTTTTTATTAAACCAGTGATTACACCTGGCCATCCCTCTAAATGTTCTAGGAAGGCATGTCTATTGTGATTTTGAT
GAAGACAGAATTATTTTTCTCTGTAGAAACACAGATACCACTTTATCAGGGAAGTTAGTCAAATGAAATGGAAATTGGTAAATGGACAAA
AGCTAGCTAGTAAAAAGGACGACCCAGCAACATGCTTTAACCCCATTGTATGTTTGTGGAAAGAGCATAGTTTAACATCTTGAGAAATTT
GGGACATAAAGTTTTCATGGTAGACAGTTCATGCAGTATATGAATTGCCATAATGGAAATAATCTGATTTTATTTTTACAACTAACATCC
ATTCCCCTTCATTTAAACACCTTTTGTGTTTTACTTCAGTGAGGAGATTGGAGTCTGAATGGATCTGTTTTCCAAGAGATTCTGAGAAAT
TTTTGTATTCAGCAGTTGGAAAGCTCTCTATTCTAGTTGATAAAACTTCCCTTTTTTGATGTAGATGCAGATATTCTATACAGTTCTGTT
GTCTTTTACTAGGACTGTAAACTTTTGTGATAAAATTCAAATAAGATTTTATTTCTTGGTAATTTTGGCTTTCACAATTTATCTTTAAAT
CCTTGAGCAATCTGTATACAATTAAGAGATTTCTGACATTTATTCTTACACTAAATGGATCAACTCTAGGATTTAGGCATGTTAACTTCT
GTTGTGTTTTGAATCTCTCCAGAGTTGCATGTAGATAGCATTTATTTCTGTGCCCTTAAACCCATTTAGAAAATAACTACAAAGTAAAAA
TGTAGAGGAAATAGAAATGTATTTTTTCATGAACATTTTGATACAAATTTCATCATTTAATGATTCACCAATTTCTTGCATTAATTTGAA
TTTAAGCATTTAATTCAAAGAGAGGGGAGCATCCATTATTGATACATGTGGGCTTTTAAAAACTCCATCCTTTATAAATAGTCAAGGTTT
GGGCCACACAAAGTATATTTTTATCATGGAAAAATTTCAACTCCTCAAGCCGTAATGTTGAACAGAATTGGAGTATTTTCTTTATAATTT
CTTGAACAGGCAAATGAAAGCTTATTATAGAATGCATGTATTTTCTTTTATCTTTGGAACATCAGCACCAGTATATTGCTGGCAGCTATT

>12269_12269_1_CACHD1-CLIC4_CACHD1_chr1_64936625_ENST00000290039_CLIC4_chr1_25124233_ENST00000374379_length(amino acids)=290AA_BP=0
MKTSLLQTRFYLVSLLATSLYAISTSLSLGQVLVNSSLLYALVRYLQMPVISFGISKLRYFLATTLTICSLGSRLQSANVISLPSRNLRV
ENFMSSILFSSISSGRGEFRYSSSFCRVFRRPLSSASLASGLEFLIYAENLAKMSIPAVFDSGCFGESFKYLGGHKTSSRNSSILFTSVL
TSLLKVINGGWVPGAKFCRSAGFLFRSTVVTLNTTPLSQRIMKSLWEKGQFPMLSPSLPACMVTTPSSSAASLRIWLASTCASSRMEKSA

--------------------------------------------------------------
>12269_12269_2_CACHD1-CLIC4_CACHD1_chr1_64936625_ENST00000371073_CLIC4_chr1_25124233_ENST00000374379_length(transcript)=4275nt_BP=198nt
ATGGCCCGCCAGCCGGAGGAAGAGGAGACGGCCGTGGCCCGGGCGCGGCGGCCGCCCCTCTGGCTGCTCTGCCTGGTCGCGTGCTGGCTC
CTGGGCGCCGGGGCCGAAGCCGACTTCTCCATCCTGGACGAGGCGCAAGTGCTGGCGAGCCAGATGCGGAGGCTGGCGGCCGAGGAGCTG
GGGGTCGTCACCATGCAGGCTGGCAGTGATGGTGAAAGCATAGGAAACTGCCCCTTTTCCCAGAGGCTCTTCATGATTCTTTGGCTCAAA
GGAGTTGTATTTAGTGTGACGACTGTTGACCTGAAAAGGAAGCCAGCAGACCTGCAGAACTTGGCTCCCGGGACCCACCCACCATTTATA
ACTTTCAACAGTGAAGTCAAAACGGATGTAAATAAGATTGAGGAATTTCTTGAAGAAGTCTTATGCCCTCCCAAGTACTTAAAGCTTTCA
CCAAAACACCCAGAATCAAATACTGCTGGAATGGACATCTTTGCCAAATTCTCTGCATATATCAAGAATTCAAGGCCAGAGGCTAATGAA
GCACTGGAGAGGGGTCTCCTGAAAACCCTGCAGAAACTGGATGAATATCTGAATTCTCCTCTCCCTGATGAAATTGATGAAAATAGTATG
GAGGACATAAAGTTTTCTACACGTAAATTTCTGGATGGCAATGAAATGACATTAGCTGATTGCAACCTGCTGCCCAAACTGCATATTGTC
AAGGTGGTGGCCAAAAAATATCGCAACTTTGATATTCCAAAAGAAATGACTGGCATCTGGAGATACCTAACTAATGCATACAGTAGGGAC
GAGTTCACCAATACCTGTCCCAGTGATAAGGAGGTTGAAATAGCATATAGTGATGTAGCCAAAAGACTCACCAAGTAAAATCGCGTTTGT
AAAAGAGATGTCTTCATGTCTTCCCCTAAGAATACGCTTTTCCTAACAGGCTACTCCTTCCTGTAGAGCAGAAATTGTATTTTGCACGAA
CATGCAGTTATTGAAGATTAGGATCAAGGATAGACAAGGTATAGTAGTTATCTTAAAATATACACTCCTAAGCAGTATTATTTTAAAATC
CTTTACCCTGGCTACCTCCCCTACCCGGGTTCCCCTCTCTTTAATTTGGAGACACTCCACCACAAACTTTTCACTTTAGAGGTAGCTTGC
CATCTCTCAGGAGCCCTCACCATTGTGTCCATTCACTGTGTATAGATGGCAGAACTTTTGAGGTGCAATGTTTAATTGTTAAAAATAGTA
GCCACGACTTTATCAGGCAGCCCCAAACTGGTGCATAATGCATGGTACAAGAAATATTTATGTATTTTTTGGAATTTTGTAATATTTAGT
AAGAGTATATGAAAGGATTGCTACTGTATCAGAAATATTGTTTCAATTTAGTCTATCCTGGATATGTACTAACGAATATTACCACCAGAG
AAGAGAGCTTTCTACAAAAGTCACTACAGATTTTGCTATATTGCTTTGTAGATAGATTTTTACTTTTGCCTAAAAGCATTTATCCTTCAT
ACCAATTGTAACATCTGACACCATGTAGAAGCTAAAAGTTTAGAGGGAGTGAGGGTTTTCTCAAGACCTTCCTCAAGCATTTTATCTTTA
GAAGAGAAACTGATGGGCACCTGATACTCTGTCTAAATACGTTTGTTATATGTGTTTTGCCCTGTGCCATTCATTTGGAACTTTATTGCA
TTCTTTATTTTAAAAAGCTTGTTTTTACGTAATCATAGAGCTTGCTATTTGTACATCTGTTGAGCAACACTACATAACTGATTTTTAGTT
GACTTAGCTATAGCAGTACAATGATTAGTAATGTAAAAATTAACACAGAAATTAACCTAAGGAATGAAGGGTGGGTTTGTCAAAATATCA
AGTAAATTTTTGTTTCTAAAGTACATTTAATGTAGATGACCTAAAGAATGCGTTATCCATCCTATATAAAAGAAAGATAAAACACAGGTC
ACCAATTTTCTCATTTCACCCCATTTACCTTGTATAGAGGATTGTTCATTCCTTTGGGACTAAGTTATAGTTATGGTGAGTGTGTATTTA
CTGTAGTTTTGCCTGATCTCACTCATTGCACTTCCTGGAGTTAAATTTTCCAACAGCCATGTTGAGGAATAGCACTCTGCATGTTTTTGT
TTTGTTTTTCGGGGTTTTTTTTAATTGAAGCCCTAAACCAGGAATTATTTGTGTTCTAACAGGAGGATGAACTTGCTGAAAATAAAACTT
TGCTATGTATTTACTCTTTTTTAAAAGACAAAAGCAAAACCAGACTTTCTACGTACTACTCCAAAGACTGTGATTGTGACTATAATACAT
TTTTGGTAATTTTTTTATACCTAATTTGTATAGGAAGTGCTATTTCTCATAGGCTGTTTCTTGAAATTTTAAGTTTATTGCTTTAAAATG
GCAGTGTTTCTCCCACTTTGATATGCTAACATTTAGTAAGCACTGGCTTTATGAAAGCGGCTTTTTATAAGTATACTGCATTTTTTGAGC
CTATCATTAATTAGCTTAGTATGAAAGATAAGAAAATCTCCATGTTGTATCCATTTGGCTCAGGAAGATTCTTTGCCTTACCTTTCTTAG
AACTCTTTATTGCTTATCAAAAGTTTGAGTACCCGCTTGGTTTTTTTTTGGTAATTAAATATTGTATGATTTATCTGGTTCAAGGAAGAT
GCACTATTCAGTTATCTATTGAGAAATTATTTTGCAGTGGTTTTAGTGGGTGAAAATGTCCCATCTGCACCAGTACACAGGCAGGCATTA
TCATTCTTCACCTACTTTTTAAATAGTGGCAACTTGGGATTCATTCTGGTGATTCTGAACCTTGCCTCATAGCTTAAAGTATAAAAAAGA
TTCAAGAGCAGTGAGGTTTGTTCTTTCCAGTGAATGGTGGACTGAGTGGTGCGAGGTGGAGGGCTAACAAGAGGAAAGAACTACATTCTT
CAGAATACAGTGATGAAAATTCATTTTGAAACTCAAATATTTTCATTTTGGATATTCTCCTGTTTTTATTAAACCAGTGATTACACCTGG
CCATCCCTCTAAATGTTCTAGGAAGGCATGTCTATTGTGATTTTGATGAAGACAGAATTATTTTTCTCTGTAGAAACACAGATACCACTT
TATCAGGGAAGTTAGTCAAATGAAATGGAAATTGGTAAATGGACAAAAGCTAGCTAGTAAAAAGGACGACCCAGCAACATGCTTTAACCC
CATTGTATGTTTGTGGAAAGAGCATAGTTTAACATCTTGAGAAATTTGGGACATAAAGTTTTCATGGTAGACAGTTCATGCAGTATATGA
ATTGCCATAATGGAAATAATCTGATTTTATTTTTACAACTAACATCCATTCCCCTTCATTTAAACACCTTTTGTGTTTTACTTCAGTGAG
GAGATTGGAGTCTGAATGGATCTGTTTTCCAAGAGATTCTGAGAAATTTTTGTATTCAGCAGTTGGAAAGCTCTCTATTCTAGTTGATAA
AACTTCCCTTTTTTGATGTAGATGCAGATATTCTATACAGTTCTGTTGTCTTTTACTAGGACTGTAAACTTTTGTGATAAAATTCAAATA
AGATTTTATTTCTTGGTAATTTTGGCTTTCACAATTTATCTTTAAATCCTTGAGCAATCTGTATACAATTAAGAGATTTCTGACATTTAT
TCTTACACTAAATGGATCAACTCTAGGATTTAGGCATGTTAACTTCTGTTGTGTTTTGAATCTCTCCAGAGTTGCATGTAGATAGCATTT
ATTTCTGTGCCCTTAAACCCATTTAGAAAATAACTACAAAGTAAAAATGTAGAGGAAATAGAAATGTATTTTTTCATGAACATTTTGATA
CAAATTTCATCATTTAATGATTCACCAATTTCTTGCATTAATTTGAATTTAAGCATTTAATTCAAAGAGAGGGGAGCATCCATTATTGAT
ACATGTGGGCTTTTAAAAACTCCATCCTTTATAAATAGTCAAGGTTTGGGCCACACAAAGTATATTTTTATCATGGAAAAATTTCAACTC
CTCAAGCCGTAATGTTGAACAGAATTGGAGTATTTTCTTTATAATTTCTTGAACAGGCAAATGAAAGCTTATTATAGAATGCATGTATTT
TCTTTTATCTTTGGAACATCAGCACCAGTATATTGCTGGCAGCTATTGTATTAAAAAATAAAGTATATTTTCACTATCATAAAGGATTCT

>12269_12269_2_CACHD1-CLIC4_CACHD1_chr1_64936625_ENST00000371073_CLIC4_chr1_25124233_ENST00000374379_length(amino acids)=305AA_BP=0
MKTSLLQTRFYLVSLLATSLYAISTSLSLGQVLVNSSLLYALVRYLQMPVISFGISKLRYFLATTLTICSLGSRLQSANVISLPSRNLRV
ENFMSSILFSSISSGRGEFRYSSSFCRVFRRPLSSASLASGLEFLIYAENLAKMSIPAVFDSGCFGESFKYLGGHKTSSRNSSILFTSVL
TSLLKVINGGWVPGAKFCRSAGFLFRSTVVTLNTTPLSQRIMKSLWEKGQFPMLSPSLPACMVTTPSSSAASLRIWLASTCASSRMEKSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CACHD1-CLIC4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CACHD1-CLIC4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CACHD1-CLIC4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source