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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CACNA1G-CDK18 (FusionGDB2 ID:12333)

Fusion Gene Summary for CACNA1G-CDK18

check button Fusion gene summary
Fusion gene informationFusion gene name: CACNA1G-CDK18
Fusion gene ID: 12333
HgeneTgene
Gene symbol

CACNA1G

CDK18

Gene ID

8913

5129

Gene namecalcium voltage-gated channel subunit alpha1 Gcyclin dependent kinase 18
SynonymsCa(V)T.1|Cav3.1|NBR13|SCA42|SCA42NDPCTAIRE|PCTAIRE3|PCTK3
Cytomap

17q21.33

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent T-type calcium channel subunit alpha-1Gcalcium channel, voltage-dependent, T type, alpha 1G subunitcav3.1cvoltage-dependent T-type calcium channel alpha 1G subunitvoltage-dependent calcium channel alpha 1G subunitvoltage-gated calcicyclin-dependent kinase 18PCTAIRE protein kinase 3PCTAIRE-motif protein kinase 3cell division protein kinase 18serine/threonine-protein kinase PCTAIRE-3
Modification date2020031320200313
UniProtAcc

O43497

Q07002

Ensembl transtripts involved in fusion geneENST00000352832, ENST00000354983, 
ENST00000358244, ENST00000359106, 
ENST00000360761, ENST00000416767, 
ENST00000429973, ENST00000442258, 
ENST00000502264, ENST00000503485, 
ENST00000505165, ENST00000507336, 
ENST00000507510, ENST00000507609, 
ENST00000507896, ENST00000510115, 
ENST00000510366, ENST00000512389, 
ENST00000513689, ENST00000513964, 
ENST00000514079, ENST00000514181, 
ENST00000514717, ENST00000515165, 
ENST00000515411, ENST00000515765, 
ENST00000360066, ENST00000509056, 
ENST00000429964, ENST00000506784, 
Fusion gene scores* DoF score7 X 6 X 4=1685 X 5 X 3=75
# samples 65
** MAII scorelog2(6/168*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CACNA1G [Title/Abstract] AND CDK18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCACNA1G(48703210)-CDK18(205500934), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCACNA1G

GO:0042391

regulation of membrane potential

21084288

HgeneCACNA1G

GO:0070509

calcium ion import

21084288

HgeneCACNA1G

GO:0070588

calcium ion transmembrane transport

26456284|26715324


check buttonFusion gene breakpoints across CACNA1G (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CDK18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF928811CACNA1Gchr17

48703210

+CDK18chr1

205500934

-


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Fusion Gene ORF analysis for CACNA1G-CDK18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000352832ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000352832ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000354983ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000354983ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000358244ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000358244ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000359106ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000359106ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000360761ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000360761ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000416767ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000416767ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000429973ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000429973ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000442258ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000442258ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000502264ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000502264ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000503485ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000503485ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000505165ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000505165ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507336ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507336ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507510ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507510ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507609ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507609ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507896ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000507896ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000510115ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000510115ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000510366ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000510366ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000512389ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000512389ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000513689ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000513689ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000513964ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000513964ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000514079ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000514079ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000514181ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000514181ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000514717ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000514717ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000515165ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000515165ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000515411ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000515411ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000515765ENST00000360066CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-3UTRENST00000515765ENST00000509056CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000352832ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000352832ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000354983ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000354983ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000358244ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000358244ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000359106ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000359106ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000360761ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000360761ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000416767ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000416767ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000429973ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000429973ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000442258ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000442258ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000502264ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000502264ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000503485ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000503485ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000505165ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000505165ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507336ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507336ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507510ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507510ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507609ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507609ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507896ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000507896ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000510115ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000510115ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000510366ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000510366ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000512389ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000512389ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000513689ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000513689ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000513964ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000513964ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000514079ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000514079ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000514181ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000514181ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000514717ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000514717ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000515165ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000515165ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000515411ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000515411ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000515765ENST00000429964CACNA1Gchr17

48703210

+CDK18chr1

205500934

-
intron-intronENST00000515765ENST00000506784CACNA1Gchr17

48703210

+CDK18chr1

205500934

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CACNA1G-CDK18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CACNA1G-CDK18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48703210/:205500934)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CACNA1G

O43497

CDK18

Q07002

FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. {ECO:0000269|PubMed:10648811, ECO:0000269|PubMed:10692398, ECO:0000269|PubMed:26456284, ECO:0000269|PubMed:26715324, ECO:0000269|PubMed:29878067}.FUNCTION: May play a role in signal transduction cascades in terminally differentiated cells.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CACNA1G-CDK18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CACNA1G-CDK18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CACNA1G-CDK18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CACNA1G-CDK18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource