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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CACNA2D1-NAALADL2 (FusionGDB2 ID:12355)

Fusion Gene Summary for CACNA2D1-NAALADL2

Fusion gene summary

Fusion gene information	Fusion gene name: CACNA2D1-NAALADL2
	Fusion gene ID: 12355
		Hgene	Tgene
	Gene symbol	CACNA2D1	NAALADL2
	Gene ID	781	254827
	Gene name	calcium voltage-gated channel auxiliary subunit alpha2delta 1	N-acetylated alpha-linked acidic dipeptidase like 2
	Synonyms	CACNA2\|CACNL2A\|CCHL2A\|LINC01112\|lncRNA-N3	-
	Cytomap	7q21.11	3q26.31
	Type of gene	protein-coding	protein-coding
	Description	voltage-dependent calcium channel subunit alpha-2/delta-1calcium channel, L type, alpha 2 polypeptidecalcium channel, voltage-dependent, alpha 2/delta subunit 1dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunitvoltage-gated calciu	inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue
	Modification date	20200313	20200313
	UniProtAcc	P54289	Q58DX5
	Ensembl transtripts involved in fusion gene	ENST00000356253, ENST00000356860, ENST00000423588, ENST00000464354, ENST00000535308,	ENST00000473253, ENST00000454872,
Fusion gene scores	* DoF score	6 X 8 X 4=192	21 X 16 X 9=3024
	# samples	9	24
	** MAII score	log2(9/192*10)=-1.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/3024*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CACNA2D1 [Title/Abstract] AND NAALADL2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CACNA2D1(81964451)-NAALADL2(175455094), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CACNA2D1	GO:0006816	calcium ion transport	1309651\|11160515
Hgene	CACNA2D1	GO:0051924	regulation of calcium ion transport	1309651

Fusion gene breakpoints across CACNA2D1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NAALADL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CN-4723-01A	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
ChimerDB4	HNSC	TCGA-CN-4723	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+

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Fusion Gene ORF analysis for CACNA2D1-NAALADL2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000356253	ENST00000473253	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
5CDS-intron	ENST00000356860	ENST00000473253	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
5CDS-intron	ENST00000423588	ENST00000473253	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
In-frame	ENST00000356253	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
In-frame	ENST00000356860	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
In-frame	ENST00000423588	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
intron-3CDS	ENST00000464354	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
intron-3CDS	ENST00000535308	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
intron-intron	ENST00000464354	ENST00000473253	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+
intron-intron	ENST00000535308	ENST00000473253	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356860	CACNA2D1	chr7	81964451	-	ENST00000454872	NAALADL2	chr3	175455094	+	3562	633	339	1124	261
ENST00000356253	CACNA2D1	chr7	81964451	-	ENST00000454872	NAALADL2	chr3	175455094	+	3479	550	256	1041	261
ENST00000423588	CACNA2D1	chr7	81964451	-	ENST00000454872	NAALADL2	chr3	175455094	+	3480	551	257	1042	261

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356860	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+	0.000458339	0.99954164
ENST00000356253	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+	0.000417262	0.9995827
ENST00000423588	ENST00000454872	CACNA2D1	chr7	81964451	-	NAALADL2	chr3	175455094	+	0.00041797	0.999582

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Fusion Genomic Features for CACNA2D1-NAALADL2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CACNA2D1	chr7	81964450	-	NAALADL2	chr3	175455093	+	3.36E-08	1
CACNA2D1	chr7	81964450	-	NAALADL2	chr3	175455093	+	3.36E-08	1
CACNA2D1	chr7	81964450	-	NAALADL2	chr3	175455093	+	3.36E-08	1
CACNA2D1	chr7	81964450	-	NAALADL2	chr3	175455093	+	3.36E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CACNA2D1-NAALADL2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:81964451/chr3:175455094)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CACNA2D1 P54289	NAALADL2 Q58DX5
FUNCTION: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). {ECO:0000250}.	FUNCTION: May be catalytically inactive.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356253

253_430

1104.0

Domain

VWFA

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356253

446_556

1104.0

Domain

Note=Cache

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356860

253_430

1092.0

Domain

VWFA

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356860

446_556

1092.0

Domain

Note=Cache

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356253

259_263

1104.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356860

259_263

1092.0

Motif

Note=MIDAS-like motif

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356253

1095_1103

1104.0

Topological domain

Cytoplasmic

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356253

25_1073

1104.0

Topological domain

Extracellular

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356860

1095_1103

1092.0

Topological domain

Cytoplasmic

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356860

25_1073

1092.0

Topological domain

Extracellular

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356253

1074_1094

1104.0

Transmembrane

Helical

Hgene

CACNA2D1

chr7:81964451

chr3:175455094

ENST00000356860

1074_1094

1092.0

Transmembrane

Helical

Tgene

NAALADL2

chr7:81964451

chr3:175455094

ENST00000454872

143_795

632

796.0

Topological domain

Extracellular

Tgene

NAALADL2

chr7:81964451

chr3:175455094

ENST00000454872

1_121

632

796.0

Topological domain

Cytoplasmic

Tgene

NAALADL2

chr7:81964451

chr3:175455094

ENST00000454872

122_142

632

796.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for CACNA2D1-NAALADL2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>12355_12355_1_CACNA2D1-NAALADL2_CACNA2D1_chr7_81964451_ENST00000356253_NAALADL2_chr3_175455094_ENST00000454872_length(transcript)=3479nt_BP=550nt
CGGCGGAGGCAAGGCGGCCGCGGCGCGGAGCAGCCGACGCACGCTAGTGGGTCCGCCCGCCACCGCCCCTTCCTCGGCGTCCGCTCCCGC
CCTTGCCGTCCCCCGCGCGGCTCCGCGCCTCGGGCCCCGGGCGCAGCCAGCCCTCCAGACGCCCGCGGTCCCGGCGGCGTGTGCTGCTCT
TCCTCCGCCCGCGGTTTCCAGCGCCGCTCCTTCCCCCGCTTGGGCAGGGAGGGGGCATTGATCTTCGATCGCGAAGATGGCTGCTGGCTG
CCTGCTGGCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCCGTCACTATCAAATC
ATGGGTGGATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATTTATGAGAAATATCA
AGATTTGTATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTGAGCAACAGATCTAA
AGCCCTGGTGCTCTCAGGAGAAGTGATTTTGCAAATTGCCAACGAACCTGTTCTGCCCTTTAATGCACTTGATATAGCTTTAGAAGTTCA
AAACAACCTTAAAGGTGATCAACCCAACACTCATCAACTGTTAGCCATGGCGTTACGCCTGCGGGAGAGTGCTGAACTTTTTCAGTCTGA
TGAGATGCGACCTGCTAATGATCCCAAGGAGAGAGCACCCATCCGCATCCGGATGCTGAATGACATTCTCCAAGACATGGAGAAAAGCTT
TCTGGTAAAGCAGGCACCACCAGGTTTTTATAGAAACATCCTCTACCACCTTGATGAAAAGACAAGCCGGTTTTCAATACTTATAGAGGC
TTGGGAACACTGCAAACCCCTTGCATCAAATGAGACCCTTCAAGAAGCCCTGTCAGAGGTGTTGAACAGCATTAATTCAGCTCAGGTTTA
CTTCAAAGCAGGACTTGATGTGTTCAAGAGTGTCTTGGATGGGAAGAATTGAGAAAACTCTGAGCATTTTTAAAAGTTTGTTTACAATTC
CACAAGCAAAAGCTCTAATTTAACCAGATTTTCTGACATTGAAGGCTTATTTTCCCCAATGGCTTTTTGACAAGTATAAAGCTATTATTA
CATTGTATTTTTTAAATGTAAATATAGAAAGAACATTTTGCACATTTAATATTTTTCTTATATCTACATTTCTGAATATGTAAAGCAAGT
TATTGAAATAGGACTTAAGAATTACCTATTAAAAAGAAATCTGATATATAAAAATATGTACTATTTTAAGGAAAAATTTCCAAGAAGTTC
TGGACTATCTTTGTTCCTATGGGGAGGGCATATAGGAACACAGTTTATTCTCTCTGATAGAGCTATTAATGACTTAGTTTCTGTAAAAGA
AATGGAGAGTTGATATGGTTCAGATTAACTTCACTATTAAGTGTTCAATATGAAGAATTCAAGTATTCTGACTGAGTGATTGGTTGACCT
AAACCACTTTGAATGTTTCTATTTTATGAAATGAAGTTTCTCTTCTTAACACAACTAGATGTAGTAATACACTGGTTATGAAATTGTATT
TTTTTAAGTATTAATGAAAAAAGAGCCATAAGCATTCCAGGAGAAAATCTCAAGGGAGCTACATAGAGCAATTTAAATGCAAATTTTTTT
CCTAACAACTTACAAGGTGACTAGCTTTGAAACCCCTAATTTGCCTCAGTTGATTTTCTAAGAATTTCAGGAGTGATGTATGTCTTAAGA
GGGAGAAAAAAATATTTCTTATTACTTTTTCTCTTGTTTCTGTTGGAAACACTGAAGCAGGGACTCTAAAATGAAAGCATCTCACATTGG
TTTTCTTTCTTGTATCTTTTCTGAAACTCCTTGCTGTAAGGCAGCTTTCTCAGAGTACTATATATTTTCAACAGTAAAGTAGCAGAGTTT
CTCTTTGAAACCCAAAATGTCTTCTAAAGAATCAAATTTCTATTTCTGCCTCTGACAAAAAGAACTTACTATGAAAGAAATAGTTGTTTT
ATCAATAAAAGCCCCTTAATATTATGAAGAAACTTTTCATATTTTTTCTTCTTTATCCTTAATTGTGACTAAGATGGAAATCTAGAAAAT
ATTCATGCTTCTAAGTTTCTGCAGTGTTACTGTAAGAGAGTGTCTCGTCTACACTTCAGTTCTTCTCTCATGTGGAAAACTAAGCTTTTT
ATATTGACATTGCCATTGAATAGCTCTAGCAACTATTATTATTCCCCCAAACCCTAAAATTCTACCTATTAGGTGTCAGGTTAAAGTTCT
AATTTATCTTTAGAAATTTATGTGAAAAATGGTTTTCCTATACTGGATAAAGCAATTCCCCTTAGGAAACATAGCCTCAGAGTATTTCAT
ATAAATTTTCTCTATCTAATTCAAACATATCTCCCCATGATACACCGCCAGAGTGACATTGCAGACAGTCTGTGTATGTTTAAATTTTCA
CTTTTTATGGATGAGCATAAACCTAGTCTTAGTTTAAAGGCAAACTAAAGTTGAGGGGAAATAATTAATCAATACTGATTAATTGATTTA
TAAGGTTCAACACTGTCTACCCTAAATAATTTTTATATGCTCAAGGCAAAGCAGGGAATAGAGGCAATTAGCTAGATAATTCAAGCAGAA
ATCCATTTTCATCGAAATTGCCTGTGTGCACATATTTTTAGATGAAAAATGAAACTACCTTACAATATTATTTTTTTAACCAATGTATTT
GTTTGCAAACATTTGCCATGTTGAAGAGTGTGTATAGGAAAGGTCTAGAAATAAATAGGCTTGTGCATACCTAGGCATTCATGCTCTTTC
TTCCTCTTCAGAGATCATCAGAAAAGAGGTGGGAATACACAAGCAGGTGCATGTAAGCCCAAAAGCTAGAAAGCCTTATATTTAACCAAA
GGTTGATGTGTTCATTCCAGTTATTCACTTACAGATGAAACTAAAACAAATAAAGGCAAGCTATTATCAGTTTGGTAGTTCATTATTTTA
GAACAAATTTCTAAATTAATTTATTCCCATAACCTACAATAGCACTGAGAACAGAAAACATGTTTCTTCTTCATTTTGTTTAAAGATTGC
GTACCTAGGTAAGTCACACTGTATAGATAAAAACCTTCTTCTGTATTCCTCACCTCTAAATTATATGTTATTTGCTATTTGAAAACTGTA
GTTAACTATGGTTTTTTATTAGTCTATTAAAAGATACGTGGAGATATTAAATTATACCTAAAGCAGACGTCCAACAAATTCTGTACATGC
TGCTTTACATCTTTGCAACAAACCTCTTAACTAGCAGCATTATTTCTATAGTGTGATTACCTGAGGGTGCCTCCAAATGTATATCATTTC

>12355_12355_1_CACNA2D1-NAALADL2_CACNA2D1_chr7_81964451_ENST00000356253_NAALADL2_chr3_175455094_ENST00000454872_length(amino acids)=261AA_BP=93
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLL
SNRSKALVLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQD

--------------------------------------------------------------
>12355_12355_2_CACNA2D1-NAALADL2_CACNA2D1_chr7_81964451_ENST00000356860_NAALADL2_chr3_175455094_ENST00000454872_length(transcript)=3562nt_BP=633nt
AGGGAGGAAACCGAGAGGGAGAGCGAGAGCGCGCGAGCGCCGGCGGGCTCGCCGAGGTCTGTTTCCAAAGTCGCCCTTGATGGCGGCGGA
GGCAAGGCGGCCGCGGCGCGGAGCAGCCGACGCACGCTAGTGGGTCCGCCCGCCACCGCCCCTTCCTCGGCGTCCGCTCCCGCCCTTGCC
GTCCCCCGCGCGGCTCCGCGCCTCGGGCCCCGGGCGCAGCCAGCCCTCCAGACGCCCGCGGTCCCGGCGGCGTGTGCTGCTCTTCCTCCG
CCCGCGGTTTCCAGCGCCGCTCCTTCCCCCGCTTGGGCAGGGAGGGGGCATTGATCTTCGATCGCGAAGATGGCTGCTGGCTGCCTGCTG
GCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCCGTCACTATCAAATCATGGGTG
GATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATTTATGAGAAATATCAAGATTTG
TATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTGAGCAACAGATCTAAAGCCCTG
GTGCTCTCAGGAGAAGTGATTTTGCAAATTGCCAACGAACCTGTTCTGCCCTTTAATGCACTTGATATAGCTTTAGAAGTTCAAAACAAC
CTTAAAGGTGATCAACCCAACACTCATCAACTGTTAGCCATGGCGTTACGCCTGCGGGAGAGTGCTGAACTTTTTCAGTCTGATGAGATG
CGACCTGCTAATGATCCCAAGGAGAGAGCACCCATCCGCATCCGGATGCTGAATGACATTCTCCAAGACATGGAGAAAAGCTTTCTGGTA
AAGCAGGCACCACCAGGTTTTTATAGAAACATCCTCTACCACCTTGATGAAAAGACAAGCCGGTTTTCAATACTTATAGAGGCTTGGGAA
CACTGCAAACCCCTTGCATCAAATGAGACCCTTCAAGAAGCCCTGTCAGAGGTGTTGAACAGCATTAATTCAGCTCAGGTTTACTTCAAA
GCAGGACTTGATGTGTTCAAGAGTGTCTTGGATGGGAAGAATTGAGAAAACTCTGAGCATTTTTAAAAGTTTGTTTACAATTCCACAAGC
AAAAGCTCTAATTTAACCAGATTTTCTGACATTGAAGGCTTATTTTCCCCAATGGCTTTTTGACAAGTATAAAGCTATTATTACATTGTA
TTTTTTAAATGTAAATATAGAAAGAACATTTTGCACATTTAATATTTTTCTTATATCTACATTTCTGAATATGTAAAGCAAGTTATTGAA
ATAGGACTTAAGAATTACCTATTAAAAAGAAATCTGATATATAAAAATATGTACTATTTTAAGGAAAAATTTCCAAGAAGTTCTGGACTA
TCTTTGTTCCTATGGGGAGGGCATATAGGAACACAGTTTATTCTCTCTGATAGAGCTATTAATGACTTAGTTTCTGTAAAAGAAATGGAG
AGTTGATATGGTTCAGATTAACTTCACTATTAAGTGTTCAATATGAAGAATTCAAGTATTCTGACTGAGTGATTGGTTGACCTAAACCAC
TTTGAATGTTTCTATTTTATGAAATGAAGTTTCTCTTCTTAACACAACTAGATGTAGTAATACACTGGTTATGAAATTGTATTTTTTTAA
GTATTAATGAAAAAAGAGCCATAAGCATTCCAGGAGAAAATCTCAAGGGAGCTACATAGAGCAATTTAAATGCAAATTTTTTTCCTAACA
ACTTACAAGGTGACTAGCTTTGAAACCCCTAATTTGCCTCAGTTGATTTTCTAAGAATTTCAGGAGTGATGTATGTCTTAAGAGGGAGAA
AAAAATATTTCTTATTACTTTTTCTCTTGTTTCTGTTGGAAACACTGAAGCAGGGACTCTAAAATGAAAGCATCTCACATTGGTTTTCTT
TCTTGTATCTTTTCTGAAACTCCTTGCTGTAAGGCAGCTTTCTCAGAGTACTATATATTTTCAACAGTAAAGTAGCAGAGTTTCTCTTTG
AAACCCAAAATGTCTTCTAAAGAATCAAATTTCTATTTCTGCCTCTGACAAAAAGAACTTACTATGAAAGAAATAGTTGTTTTATCAATA
AAAGCCCCTTAATATTATGAAGAAACTTTTCATATTTTTTCTTCTTTATCCTTAATTGTGACTAAGATGGAAATCTAGAAAATATTCATG
CTTCTAAGTTTCTGCAGTGTTACTGTAAGAGAGTGTCTCGTCTACACTTCAGTTCTTCTCTCATGTGGAAAACTAAGCTTTTTATATTGA
CATTGCCATTGAATAGCTCTAGCAACTATTATTATTCCCCCAAACCCTAAAATTCTACCTATTAGGTGTCAGGTTAAAGTTCTAATTTAT
CTTTAGAAATTTATGTGAAAAATGGTTTTCCTATACTGGATAAAGCAATTCCCCTTAGGAAACATAGCCTCAGAGTATTTCATATAAATT
TTCTCTATCTAATTCAAACATATCTCCCCATGATACACCGCCAGAGTGACATTGCAGACAGTCTGTGTATGTTTAAATTTTCACTTTTTA
TGGATGAGCATAAACCTAGTCTTAGTTTAAAGGCAAACTAAAGTTGAGGGGAAATAATTAATCAATACTGATTAATTGATTTATAAGGTT
CAACACTGTCTACCCTAAATAATTTTTATATGCTCAAGGCAAAGCAGGGAATAGAGGCAATTAGCTAGATAATTCAAGCAGAAATCCATT
TTCATCGAAATTGCCTGTGTGCACATATTTTTAGATGAAAAATGAAACTACCTTACAATATTATTTTTTTAACCAATGTATTTGTTTGCA
AACATTTGCCATGTTGAAGAGTGTGTATAGGAAAGGTCTAGAAATAAATAGGCTTGTGCATACCTAGGCATTCATGCTCTTTCTTCCTCT
TCAGAGATCATCAGAAAAGAGGTGGGAATACACAAGCAGGTGCATGTAAGCCCAAAAGCTAGAAAGCCTTATATTTAACCAAAGGTTGAT
GTGTTCATTCCAGTTATTCACTTACAGATGAAACTAAAACAAATAAAGGCAAGCTATTATCAGTTTGGTAGTTCATTATTTTAGAACAAA
TTTCTAAATTAATTTATTCCCATAACCTACAATAGCACTGAGAACAGAAAACATGTTTCTTCTTCATTTTGTTTAAAGATTGCGTACCTA
GGTAAGTCACACTGTATAGATAAAAACCTTCTTCTGTATTCCTCACCTCTAAATTATATGTTATTTGCTATTTGAAAACTGTAGTTAACT
ATGGTTTTTTATTAGTCTATTAAAAGATACGTGGAGATATTAAATTATACCTAAAGCAGACGTCCAACAAATTCTGTACATGCTGCTTTA
CATCTTTGCAACAAACCTCTTAACTAGCAGCATTATTTCTATAGTGTGATTACCTGAGGGTGCCTCCAAATGTATATCATTTCACTCCCC

>12355_12355_2_CACNA2D1-NAALADL2_CACNA2D1_chr7_81964451_ENST00000356860_NAALADL2_chr3_175455094_ENST00000454872_length(amino acids)=261AA_BP=93
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLL
SNRSKALVLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQD

--------------------------------------------------------------
>12355_12355_3_CACNA2D1-NAALADL2_CACNA2D1_chr7_81964451_ENST00000423588_NAALADL2_chr3_175455094_ENST00000454872_length(transcript)=3480nt_BP=551nt
GCGGCGGAGGCAAGGCGGCCGCGGCGCGGAGCAGCCGACGCACGCTAGTGGGTCCGCCCGCCACCGCCCCTTCCTCGGCGTCCGCTCCCG
CCCTTGCCGTCCCCCGCGCGGCTCCGCGCCTCGGGCCCCGGGCGCAGCCAGCCCTCCAGACGCCCGCGGTCCCGGCGGCGTGTGCTGCTC
TTCCTCCGCCCGCGGTTTCCAGCGCCGCTCCTTCCCCCGCTTGGGCAGGGAGGGGGCATTGATCTTCGATCGCGAAGATGGCTGCTGGCT
GCCTGCTGGCCTTGACTCTGACACTTTTCCAATCTTTGCTCATCGGCCCCTCGTCGGAGGAGCCGTTCCCTTCGGCCGTCACTATCAAAT
CATGGGTGGATAAGATGCAAGAAGACCTTGTCACACTGGCAAAAACAGCAAGTGGAGTCAATCAGCTTGTTGATATTTATGAGAAATATC
AAGATTTGTATACTGTGGAACCAAATAATGCACGCCAGCTGGTAGAAATTGCAGCCAGGGATATTGAGAAACTTCTGAGCAACAGATCTA
AAGCCCTGGTGCTCTCAGGAGAAGTGATTTTGCAAATTGCCAACGAACCTGTTCTGCCCTTTAATGCACTTGATATAGCTTTAGAAGTTC
AAAACAACCTTAAAGGTGATCAACCCAACACTCATCAACTGTTAGCCATGGCGTTACGCCTGCGGGAGAGTGCTGAACTTTTTCAGTCTG
ATGAGATGCGACCTGCTAATGATCCCAAGGAGAGAGCACCCATCCGCATCCGGATGCTGAATGACATTCTCCAAGACATGGAGAAAAGCT
TTCTGGTAAAGCAGGCACCACCAGGTTTTTATAGAAACATCCTCTACCACCTTGATGAAAAGACAAGCCGGTTTTCAATACTTATAGAGG
CTTGGGAACACTGCAAACCCCTTGCATCAAATGAGACCCTTCAAGAAGCCCTGTCAGAGGTGTTGAACAGCATTAATTCAGCTCAGGTTT
ACTTCAAAGCAGGACTTGATGTGTTCAAGAGTGTCTTGGATGGGAAGAATTGAGAAAACTCTGAGCATTTTTAAAAGTTTGTTTACAATT
CCACAAGCAAAAGCTCTAATTTAACCAGATTTTCTGACATTGAAGGCTTATTTTCCCCAATGGCTTTTTGACAAGTATAAAGCTATTATT
ACATTGTATTTTTTAAATGTAAATATAGAAAGAACATTTTGCACATTTAATATTTTTCTTATATCTACATTTCTGAATATGTAAAGCAAG
TTATTGAAATAGGACTTAAGAATTACCTATTAAAAAGAAATCTGATATATAAAAATATGTACTATTTTAAGGAAAAATTTCCAAGAAGTT
CTGGACTATCTTTGTTCCTATGGGGAGGGCATATAGGAACACAGTTTATTCTCTCTGATAGAGCTATTAATGACTTAGTTTCTGTAAAAG
AAATGGAGAGTTGATATGGTTCAGATTAACTTCACTATTAAGTGTTCAATATGAAGAATTCAAGTATTCTGACTGAGTGATTGGTTGACC
TAAACCACTTTGAATGTTTCTATTTTATGAAATGAAGTTTCTCTTCTTAACACAACTAGATGTAGTAATACACTGGTTATGAAATTGTAT
TTTTTTAAGTATTAATGAAAAAAGAGCCATAAGCATTCCAGGAGAAAATCTCAAGGGAGCTACATAGAGCAATTTAAATGCAAATTTTTT
TCCTAACAACTTACAAGGTGACTAGCTTTGAAACCCCTAATTTGCCTCAGTTGATTTTCTAAGAATTTCAGGAGTGATGTATGTCTTAAG
AGGGAGAAAAAAATATTTCTTATTACTTTTTCTCTTGTTTCTGTTGGAAACACTGAAGCAGGGACTCTAAAATGAAAGCATCTCACATTG
GTTTTCTTTCTTGTATCTTTTCTGAAACTCCTTGCTGTAAGGCAGCTTTCTCAGAGTACTATATATTTTCAACAGTAAAGTAGCAGAGTT
TCTCTTTGAAACCCAAAATGTCTTCTAAAGAATCAAATTTCTATTTCTGCCTCTGACAAAAAGAACTTACTATGAAAGAAATAGTTGTTT
TATCAATAAAAGCCCCTTAATATTATGAAGAAACTTTTCATATTTTTTCTTCTTTATCCTTAATTGTGACTAAGATGGAAATCTAGAAAA
TATTCATGCTTCTAAGTTTCTGCAGTGTTACTGTAAGAGAGTGTCTCGTCTACACTTCAGTTCTTCTCTCATGTGGAAAACTAAGCTTTT
TATATTGACATTGCCATTGAATAGCTCTAGCAACTATTATTATTCCCCCAAACCCTAAAATTCTACCTATTAGGTGTCAGGTTAAAGTTC
TAATTTATCTTTAGAAATTTATGTGAAAAATGGTTTTCCTATACTGGATAAAGCAATTCCCCTTAGGAAACATAGCCTCAGAGTATTTCA
TATAAATTTTCTCTATCTAATTCAAACATATCTCCCCATGATACACCGCCAGAGTGACATTGCAGACAGTCTGTGTATGTTTAAATTTTC
ACTTTTTATGGATGAGCATAAACCTAGTCTTAGTTTAAAGGCAAACTAAAGTTGAGGGGAAATAATTAATCAATACTGATTAATTGATTT
ATAAGGTTCAACACTGTCTACCCTAAATAATTTTTATATGCTCAAGGCAAAGCAGGGAATAGAGGCAATTAGCTAGATAATTCAAGCAGA
AATCCATTTTCATCGAAATTGCCTGTGTGCACATATTTTTAGATGAAAAATGAAACTACCTTACAATATTATTTTTTTAACCAATGTATT
TGTTTGCAAACATTTGCCATGTTGAAGAGTGTGTATAGGAAAGGTCTAGAAATAAATAGGCTTGTGCATACCTAGGCATTCATGCTCTTT
CTTCCTCTTCAGAGATCATCAGAAAAGAGGTGGGAATACACAAGCAGGTGCATGTAAGCCCAAAAGCTAGAAAGCCTTATATTTAACCAA
AGGTTGATGTGTTCATTCCAGTTATTCACTTACAGATGAAACTAAAACAAATAAAGGCAAGCTATTATCAGTTTGGTAGTTCATTATTTT
AGAACAAATTTCTAAATTAATTTATTCCCATAACCTACAATAGCACTGAGAACAGAAAACATGTTTCTTCTTCATTTTGTTTAAAGATTG
CGTACCTAGGTAAGTCACACTGTATAGATAAAAACCTTCTTCTGTATTCCTCACCTCTAAATTATATGTTATTTGCTATTTGAAAACTGT
AGTTAACTATGGTTTTTTATTAGTCTATTAAAAGATACGTGGAGATATTAAATTATACCTAAAGCAGACGTCCAACAAATTCTGTACATG
CTGCTTTACATCTTTGCAACAAACCTCTTAACTAGCAGCATTATTTCTATAGTGTGATTACCTGAGGGTGCCTCCAAATGTATATCATTT

>12355_12355_3_CACNA2D1-NAALADL2_CACNA2D1_chr7_81964451_ENST00000423588_NAALADL2_chr3_175455094_ENST00000454872_length(amino acids)=261AA_BP=93
MAAGCLLALTLTLFQSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLL
SNRSKALVLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CACNA2D1-NAALADL2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CACNA2D1-NAALADL2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CACNA2D1-NAALADL2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source