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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CACNA2D3-INTS4 (FusionGDB2 ID:12365)

Fusion Gene Summary for CACNA2D3-INTS4

check button Fusion gene summary
Fusion gene informationFusion gene name: CACNA2D3-INTS4
Fusion gene ID: 12365
HgeneTgene
Gene symbol

CACNA2D3

INTS4

Gene ID

55799

92105

Gene namecalcium voltage-gated channel auxiliary subunit alpha2delta 3integrator complex subunit 4
SynonymsHSA272268INT4|MST093
Cytomap

3p21.1-p14.3

11q14.1

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent calcium channel subunit alpha-2/delta-3calcium channel alpha2-delta3 subunitcalcium channel, voltage-dependent, alpha 2/delta 3 subunitcalcium channel, voltage-dependent, alpha 2/delta subunit 3voltage-gated calcium channel subunit aintegrator complex subunit 4MSTP093
Modification date2020031320200313
UniProtAcc.

Q96HW7

Ensembl transtripts involved in fusion geneENST00000288197, ENST00000415676, 
ENST00000474759, ENST00000490478, 
ENST00000478261, 		ENST00000525931, 
ENST00000527522, ENST00000529807, 
ENST00000535943, ENST00000534064, 
Fusion gene scores* DoF score14 X 12 X 6=100813 X 9 X 8=936
# samples 1516
** MAII scorelog2(15/1008*10)=-2.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/936*10)=-2.54843662469604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CACNA2D3 [Title/Abstract] AND INTS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCACNA2D3(54157621)-INTS4(77692622), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINTS4

GO:0016180

snRNA processing

16239144


check buttonFusion gene breakpoints across CACNA2D3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across INTS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-CG-5722-11ACACNA2D3chr3

54157621

+INTS4chr11

77692622

-


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Fusion Gene ORF analysis for CACNA2D3-INTS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000288197ENST00000525931CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000288197ENST00000527522CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000288197ENST00000529807CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000288197ENST00000535943CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000415676ENST00000525931CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000415676ENST00000527522CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000415676ENST00000529807CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000415676ENST00000535943CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000474759ENST00000525931CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000474759ENST00000527522CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000474759ENST00000529807CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5CDS-intronENST00000474759ENST00000535943CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5UTR-3CDSENST00000490478ENST00000534064CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5UTR-intronENST00000490478ENST00000525931CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5UTR-intronENST00000490478ENST00000527522CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5UTR-intronENST00000490478ENST00000529807CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
5UTR-intronENST00000490478ENST00000535943CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
In-frameENST00000288197ENST00000534064CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
In-frameENST00000415676ENST00000534064CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
In-frameENST00000474759ENST00000534064CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
intron-3CDSENST00000478261ENST00000534064CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
intron-intronENST00000478261ENST00000525931CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
intron-intronENST00000478261ENST00000527522CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
intron-intronENST00000478261ENST00000529807CACNA2D3chr3

54157621

+INTS4chr11

77692622

-
intron-intronENST00000478261ENST00000535943CACNA2D3chr3

54157621

+INTS4chr11

77692622

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415676CACNA2D3chr354157621+ENST00000534064INTS4chr1177692622-31973221182967949
ENST00000288197CACNA2D3chr354157621+ENST00000534064INTS4chr1177692622-3127252482897949
ENST00000474759CACNA2D3chr354157621+ENST00000534064INTS4chr1177692622-3127252482897949

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415676ENST00000534064CACNA2D3chr354157621+INTS4chr1177692622-0.001428020.998572
ENST00000288197ENST00000534064CACNA2D3chr354157621+INTS4chr1177692622-0.0013706150.99862945
ENST00000474759ENST00000534064CACNA2D3chr354157621+INTS4chr1177692622-0.0013706150.99862945

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Fusion Genomic Features for CACNA2D3-INTS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CACNA2D3-INTS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:54157621/chr11:77692622)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INTS4

Q96HW7

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:16239144}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneINTS4chr3:54157621chr11:77692622ENST00000529807112145_18382506.0RepeatNote=HEAT 2
TgeneINTS4chr3:54157621chr11:77692622ENST00000529807112190_22882506.0RepeatNote=HEAT 3
TgeneINTS4chr3:54157621chr11:77692622ENST00000529807112229_26382506.0RepeatNote=HEAT 4
TgeneINTS4chr3:54157621chr11:77692622ENST00000529807112277_31382506.0RepeatNote=HEAT 5
TgeneINTS4chr3:54157621chr11:77692622ENST00000529807112369_40582506.0RepeatNote=HEAT 6
TgeneINTS4chr3:54157621chr11:77692622ENST00000529807112406_44482506.0RepeatNote=HEAT 7
TgeneINTS4chr3:54157621chr11:77692622ENST00000529807112446_48482506.0RepeatNote=HEAT 8
TgeneINTS4chr3:54157621chr11:77692622ENST00000534064123145_18382964.0RepeatNote=HEAT 2
TgeneINTS4chr3:54157621chr11:77692622ENST00000534064123190_22882964.0RepeatNote=HEAT 3
TgeneINTS4chr3:54157621chr11:77692622ENST00000534064123229_26382964.0RepeatNote=HEAT 4
TgeneINTS4chr3:54157621chr11:77692622ENST00000534064123277_31382964.0RepeatNote=HEAT 5
TgeneINTS4chr3:54157621chr11:77692622ENST00000534064123369_40582964.0RepeatNote=HEAT 6
TgeneINTS4chr3:54157621chr11:77692622ENST00000534064123406_44482964.0RepeatNote=HEAT 7
TgeneINTS4chr3:54157621chr11:77692622ENST00000534064123446_48482964.0RepeatNote=HEAT 8
TgeneINTS4chr3:54157621chr11:77692622ENST0000053594309145_1830339.0RepeatNote=HEAT 2
TgeneINTS4chr3:54157621chr11:77692622ENST0000053594309190_2280339.0RepeatNote=HEAT 3
TgeneINTS4chr3:54157621chr11:77692622ENST0000053594309229_2630339.0RepeatNote=HEAT 4
TgeneINTS4chr3:54157621chr11:77692622ENST0000053594309277_3130339.0RepeatNote=HEAT 5
TgeneINTS4chr3:54157621chr11:77692622ENST0000053594309369_4050339.0RepeatNote=HEAT 6
TgeneINTS4chr3:54157621chr11:77692622ENST0000053594309406_4440339.0RepeatNote=HEAT 7
TgeneINTS4chr3:54157621chr11:77692622ENST0000053594309446_4840339.0RepeatNote=HEAT 8
TgeneINTS4chr3:54157621chr11:77692622ENST000005359430966_1050339.0RepeatNote=HEAT 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000288197+238256_438681092.0DomainVWFA
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000288197+238452_549681092.0DomainNote=Cache
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000415676+339256_438681092.0DomainVWFA
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000415676+339452_549681092.0DomainNote=Cache
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000474759+238256_438681092.0DomainVWFA
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000474759+238452_549681092.0DomainNote=Cache
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000490478+137256_4380998.0DomainVWFA
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000490478+137452_5490998.0DomainNote=Cache
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000288197+238262_266681092.0MotifNote=MIDAS-like motif
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000415676+339262_266681092.0MotifNote=MIDAS-like motif
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000474759+238262_266681092.0MotifNote=MIDAS-like motif
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000490478+137262_2660998.0MotifNote=MIDAS-like motif
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000288197+2381090_1091681092.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000288197+23829_1068681092.0Topological domainExtracellular
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000415676+3391090_1091681092.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000415676+33929_1068681092.0Topological domainExtracellular
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000474759+2381090_1091681092.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000474759+23829_1068681092.0Topological domainExtracellular
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000490478+1371090_10910998.0Topological domainCytoplasmic
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000490478+13729_10680998.0Topological domainExtracellular
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000288197+2381069_1089681092.0TransmembraneHelical
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000415676+3391069_1089681092.0TransmembraneHelical
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000474759+2381069_1089681092.0TransmembraneHelical
HgeneCACNA2D3chr3:54157621chr11:77692622ENST00000490478+1371069_10890998.0TransmembraneHelical
TgeneINTS4chr3:54157621chr11:77692622ENST0000052980711266_10582506.0RepeatNote=HEAT 1
TgeneINTS4chr3:54157621chr11:77692622ENST0000053406412366_10582964.0RepeatNote=HEAT 1


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Fusion Gene Sequence for CACNA2D3-INTS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12365_12365_1_CACNA2D3-INTS4_CACNA2D3_chr3_54157621_ENST00000288197_INTS4_chr11_77692622_ENST00000534064_length(transcript)=3127nt_BP=252nt
CGGCCGCTCTCGTCGCCGCCGCAGCGGGCGCGTCGGAGGGAGCCCAGCATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCC
TCGGCGCTTCTCGCTGCCGCGCTTCTCTACGCCGCGCTGGGGGACGTGGTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTC
TGGGCCTCGGCTTTTGGTGGGGAGATAAAATCCATTGCTGCTAAGTACTCCGGTTCCCAGCTTCTGCAAAAGGAGAATGATCCATCTGTG
AGACTGAAAATTGCATCATTGTTGGGTTTATTATCAAAGACAGCAGGATTTTCACCAGACTGCATTATGGATGATGCCATCAACATCCTG
CAGAATGAAAAGTCTCATCAAGTCCTAGCTCAACTGCTGGATACTTTGCTTGCAATTGGCACTAAGCTACCAGAGAATCAAGCTATCCAA
ATGCGATTAGTTGATGTGGCCTGCAAGCATCTGACAGATACGTCTCATGGTGTAAGAAATAAGTGCCTGCAGTTACTTGGCAATCTTGGC
TCTTTGGAGAAAAGTGTCACAAAAGATGCAGAAGGCCTAGCTGCCAGAGATGTCCAGAAGATTATAGGGGATTACTTCAGTGACCAAGAC
CCACGTGTCAGAACAGCAGCTATAAAAGCCATGTTGCAGCTCCATGAAAGAGGACTGAAATTACACCAAACAATTTATAATCAGGCCTGT
AAATTACTCTCTGATGACTATGAACAAGTGCGCAGTGCTGCAGTCCAGCTTATCTGGGTCGTCAGTCAGCTCTATCCTGAAAGCATTGTC
CCAATTCCTTCTTCTAATGAAGAAATACGCTTAGTTGATGATGCGTTTGGCAAAATTTGTCACATGGTCAGTGATGGCTCTTGGGTGGTT
CGTGTTCAGGCAGCAAAACTGTTGGGCTCTATGGAGCAAGTCAGTTCTCATTTCTTGGAGCAGACCCTTGACAAGAAGCTGATGTCAGAT
CTGAGGAGGAAACGTACTGCACATGAGCGTGCCAAGGAACTTTACAGTTCGGGGGAGTTTTCCAGTGGCAGAAAGTGGGGAGATGATGCT
CCCAAGGAAGAAGTAGATACCGGGGCTGTGAACTTGATTGAGTCAGGAGCTTGTGGAGCTTTTGTTCATGGGTTGGAAGATGAGATGTAT
GAGGTTCGTATTGCTGCTGTGGAGGCCCTCTGCATGTTGGCCCAGTCTTCACCCTCTTTTGCTGAGAAGTGCCTTGATTTCCTAGTTGAC
ATGTTCAACGATGAAATTGAGGAAGTACGTCTGCAGTCTATACATACCATGAGAAAAATCTCTAACAACATCACCCTCCGAGAAGATCAG
CTTGACACTGTCCTGGCTGTGCTAGAGGATTCATCCAGAGATATTCGAGAGGCTCTTCATGAACTCTTATGCTGTACTAATGTTTCAACC
AAAGAAGGGATTCATCTTGCATTGGTGGAGCTGCTGAAAAATTTAACCAAGTACCCTACTGATAGGGACTCCATATGGAAGTGCTTGAAG
TTTCTGGGAAGTCGGCATCCAACCCTGGTGCTTCCCTTGGTGCCAGAGCTTCTGAGCACCCACCCATTTTTTGACACAGCTGAACCAGAC
ATGGATGATCCAGCTTATATTGCAGTTTTGGTACTTATTTTCAATGCTGCTAAAACCTGTCCAACAATGCCAGCATTGTTCTCAGATCAC
ACCTTCAGGCACTATGCCTACCTCCGAGACAGTCTTTCTCATCTTGTTCCTGCCTTGAGGTTACCAGGTAGAAAACTGGTGTCATCAGCT
GTTTCTCCCAGCATCATACCTCAAGAGGATCCTTCCCAGCAGTTCCTGCAGCAGAGCCTTGAAAGAGTGTATAGTCTTCAGCACTTGGAC
CCTCAGGGAGCCCAGGAGCTGCTGGAATTCACCATCAGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGAT
TTCTCTGCCACCTATCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAG
CAGAGTGATTTGGCCTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAG
GTGGTGATTATACATCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTT
GGGATGTGTGAAAAATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGAC
AAACTCCTTGACCTTATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTT
CTGCATCTCCCGCTTCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACC
TCTGGGTTGGTGGTTGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCA
GATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTC
TCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCATTCCAAAATGCCCCTGG
ATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAAAGTTTATATAATGCCC
AAACCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTTAGGTGTCAGAATGAGCCAAGCCTGAAGCA
CTTCACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTATCAAACACAGGATAAATTGTTTCTTCATT

>12365_12365_1_CACNA2D3-INTS4_CACNA2D3_chr3_54157621_ENST00000288197_INTS4_chr11_77692622_ENST00000534064_length(amino acids)=949AA_BP=653
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKENDPSVRLKIASLLGLLSKTAG
FSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAAR
DVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAF
GKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESG
ACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIR
EALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNA
AKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQ
RLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQL
IVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATI
IEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLL

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>12365_12365_2_CACNA2D3-INTS4_CACNA2D3_chr3_54157621_ENST00000415676_INTS4_chr11_77692622_ENST00000534064_length(transcript)=3197nt_BP=322nt
CACCCGCTCCTTTTTCTGCTCCCCAAGTGAGCCGGGCGCTCGCCCACCGCCCGCTCCGCGCAGCTCCCCGCGGCCGCTCTCGTCGCCGCC
GCAGCGGGCGCGTCGGAGGGAGCCCAGCATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCCTCGGCGCTTCTCGCTGCCGC
GCTTCTCTACGCCGCGCTGGGGGACGTGGTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTCTGGGCCTCGGCTTTTGGTGG
GGAGATAAAATCCATTGCTGCTAAGTACTCCGGTTCCCAGCTTCTGCAAAAGGAGAATGATCCATCTGTGAGACTGAAAATTGCATCATT
GTTGGGTTTATTATCAAAGACAGCAGGATTTTCACCAGACTGCATTATGGATGATGCCATCAACATCCTGCAGAATGAAAAGTCTCATCA
AGTCCTAGCTCAACTGCTGGATACTTTGCTTGCAATTGGCACTAAGCTACCAGAGAATCAAGCTATCCAAATGCGATTAGTTGATGTGGC
CTGCAAGCATCTGACAGATACGTCTCATGGTGTAAGAAATAAGTGCCTGCAGTTACTTGGCAATCTTGGCTCTTTGGAGAAAAGTGTCAC
AAAAGATGCAGAAGGCCTAGCTGCCAGAGATGTCCAGAAGATTATAGGGGATTACTTCAGTGACCAAGACCCACGTGTCAGAACAGCAGC
TATAAAAGCCATGTTGCAGCTCCATGAAAGAGGACTGAAATTACACCAAACAATTTATAATCAGGCCTGTAAATTACTCTCTGATGACTA
TGAACAAGTGCGCAGTGCTGCAGTCCAGCTTATCTGGGTCGTCAGTCAGCTCTATCCTGAAAGCATTGTCCCAATTCCTTCTTCTAATGA
AGAAATACGCTTAGTTGATGATGCGTTTGGCAAAATTTGTCACATGGTCAGTGATGGCTCTTGGGTGGTTCGTGTTCAGGCAGCAAAACT
GTTGGGCTCTATGGAGCAAGTCAGTTCTCATTTCTTGGAGCAGACCCTTGACAAGAAGCTGATGTCAGATCTGAGGAGGAAACGTACTGC
ACATGAGCGTGCCAAGGAACTTTACAGTTCGGGGGAGTTTTCCAGTGGCAGAAAGTGGGGAGATGATGCTCCCAAGGAAGAAGTAGATAC
CGGGGCTGTGAACTTGATTGAGTCAGGAGCTTGTGGAGCTTTTGTTCATGGGTTGGAAGATGAGATGTATGAGGTTCGTATTGCTGCTGT
GGAGGCCCTCTGCATGTTGGCCCAGTCTTCACCCTCTTTTGCTGAGAAGTGCCTTGATTTCCTAGTTGACATGTTCAACGATGAAATTGA
GGAAGTACGTCTGCAGTCTATACATACCATGAGAAAAATCTCTAACAACATCACCCTCCGAGAAGATCAGCTTGACACTGTCCTGGCTGT
GCTAGAGGATTCATCCAGAGATATTCGAGAGGCTCTTCATGAACTCTTATGCTGTACTAATGTTTCAACCAAAGAAGGGATTCATCTTGC
ATTGGTGGAGCTGCTGAAAAATTTAACCAAGTACCCTACTGATAGGGACTCCATATGGAAGTGCTTGAAGTTTCTGGGAAGTCGGCATCC
AACCCTGGTGCTTCCCTTGGTGCCAGAGCTTCTGAGCACCCACCCATTTTTTGACACAGCTGAACCAGACATGGATGATCCAGCTTATAT
TGCAGTTTTGGTACTTATTTTCAATGCTGCTAAAACCTGTCCAACAATGCCAGCATTGTTCTCAGATCACACCTTCAGGCACTATGCCTA
CCTCCGAGACAGTCTTTCTCATCTTGTTCCTGCCTTGAGGTTACCAGGTAGAAAACTGGTGTCATCAGCTGTTTCTCCCAGCATCATACC
TCAAGAGGATCCTTCCCAGCAGTTCCTGCAGCAGAGCCTTGAAAGAGTGTATAGTCTTCAGCACTTGGACCCTCAGGGAGCCCAGGAGCT
GCTGGAATTCACCATCAGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGATTTCTCTGCCACCTATCTTCG
CTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAGCAGAGTGATTTGGCCTCAGC
AGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAGGTGGTGATTATACATCACAT
GAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTTGGGATGTGTGAAAAATTTTT
ACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGACAAACTCCTTGACCTTATGCC
CCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTTCTGCATCTCCCGCTTCCAGA
GCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACCTCTGGGTTGGTGGTTGCCCT
GGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCAGATGGCCAGGCTCAGATGAT
TCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTCTCCCACACCGCTTGGACAGA
GGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCATTCCAAAATGCCCCTGGATGGAGGGTGGTGAGATGTC
ACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAAAGTTTATATAATGCCCAAACCTGCACGGCGCTAAGG
CAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTTAGGTGTCAGAATGAGCCAAGCCTGAAGCACTTCACCTGGAATTGATGTG
TAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTATCAAACACAGGATAAATTGTTTCTTCATTAAAAAATAAAAAACCTTCAA

>12365_12365_2_CACNA2D3-INTS4_CACNA2D3_chr3_54157621_ENST00000415676_INTS4_chr11_77692622_ENST00000534064_length(amino acids)=949AA_BP=653
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKENDPSVRLKIASLLGLLSKTAG
FSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAAR
DVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAF
GKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESG
ACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIR
EALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNA
AKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQ
RLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQL
IVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATI
IEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLL

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>12365_12365_3_CACNA2D3-INTS4_CACNA2D3_chr3_54157621_ENST00000474759_INTS4_chr11_77692622_ENST00000534064_length(transcript)=3127nt_BP=252nt
CGGCCGCTCTCGTCGCCGCCGCAGCGGGCGCGTCGGAGGGAGCCCAGCATGGCCGGGCCGGGCTCGCCGCGCCGCGCGTCCCGGGGGGCC
TCGGCGCTTCTCGCTGCCGCGCTTCTCTACGCCGCGCTGGGGGACGTGGTGCGCTCGGAGCAGCAGATACCGCTCTCCGTGGTGAAGCTC
TGGGCCTCGGCTTTTGGTGGGGAGATAAAATCCATTGCTGCTAAGTACTCCGGTTCCCAGCTTCTGCAAAAGGAGAATGATCCATCTGTG
AGACTGAAAATTGCATCATTGTTGGGTTTATTATCAAAGACAGCAGGATTTTCACCAGACTGCATTATGGATGATGCCATCAACATCCTG
CAGAATGAAAAGTCTCATCAAGTCCTAGCTCAACTGCTGGATACTTTGCTTGCAATTGGCACTAAGCTACCAGAGAATCAAGCTATCCAA
ATGCGATTAGTTGATGTGGCCTGCAAGCATCTGACAGATACGTCTCATGGTGTAAGAAATAAGTGCCTGCAGTTACTTGGCAATCTTGGC
TCTTTGGAGAAAAGTGTCACAAAAGATGCAGAAGGCCTAGCTGCCAGAGATGTCCAGAAGATTATAGGGGATTACTTCAGTGACCAAGAC
CCACGTGTCAGAACAGCAGCTATAAAAGCCATGTTGCAGCTCCATGAAAGAGGACTGAAATTACACCAAACAATTTATAATCAGGCCTGT
AAATTACTCTCTGATGACTATGAACAAGTGCGCAGTGCTGCAGTCCAGCTTATCTGGGTCGTCAGTCAGCTCTATCCTGAAAGCATTGTC
CCAATTCCTTCTTCTAATGAAGAAATACGCTTAGTTGATGATGCGTTTGGCAAAATTTGTCACATGGTCAGTGATGGCTCTTGGGTGGTT
CGTGTTCAGGCAGCAAAACTGTTGGGCTCTATGGAGCAAGTCAGTTCTCATTTCTTGGAGCAGACCCTTGACAAGAAGCTGATGTCAGAT
CTGAGGAGGAAACGTACTGCACATGAGCGTGCCAAGGAACTTTACAGTTCGGGGGAGTTTTCCAGTGGCAGAAAGTGGGGAGATGATGCT
CCCAAGGAAGAAGTAGATACCGGGGCTGTGAACTTGATTGAGTCAGGAGCTTGTGGAGCTTTTGTTCATGGGTTGGAAGATGAGATGTAT
GAGGTTCGTATTGCTGCTGTGGAGGCCCTCTGCATGTTGGCCCAGTCTTCACCCTCTTTTGCTGAGAAGTGCCTTGATTTCCTAGTTGAC
ATGTTCAACGATGAAATTGAGGAAGTACGTCTGCAGTCTATACATACCATGAGAAAAATCTCTAACAACATCACCCTCCGAGAAGATCAG
CTTGACACTGTCCTGGCTGTGCTAGAGGATTCATCCAGAGATATTCGAGAGGCTCTTCATGAACTCTTATGCTGTACTAATGTTTCAACC
AAAGAAGGGATTCATCTTGCATTGGTGGAGCTGCTGAAAAATTTAACCAAGTACCCTACTGATAGGGACTCCATATGGAAGTGCTTGAAG
TTTCTGGGAAGTCGGCATCCAACCCTGGTGCTTCCCTTGGTGCCAGAGCTTCTGAGCACCCACCCATTTTTTGACACAGCTGAACCAGAC
ATGGATGATCCAGCTTATATTGCAGTTTTGGTACTTATTTTCAATGCTGCTAAAACCTGTCCAACAATGCCAGCATTGTTCTCAGATCAC
ACCTTCAGGCACTATGCCTACCTCCGAGACAGTCTTTCTCATCTTGTTCCTGCCTTGAGGTTACCAGGTAGAAAACTGGTGTCATCAGCT
GTTTCTCCCAGCATCATACCTCAAGAGGATCCTTCCCAGCAGTTCCTGCAGCAGAGCCTTGAAAGAGTGTATAGTCTTCAGCACTTGGAC
CCTCAGGGAGCCCAGGAGCTGCTGGAATTCACCATCAGGGATCTGCAAAGACTTGGAGAACTTCAATCTGAATTGGCAGGAGTAGCTGAT
TTCTCTGCCACCTATCTTCGCTGTCAACTACTTCTCATCAAGGCCTTGCAGGAAAAGTTGTGGAATGTAGCTGCCCCTTTGTATTTGAAG
CAGAGTGATTTGGCCTCAGCAGCAGCGAAACAGATTATGGAAGAGACCTACAAAATGGAATTCATGTACAGTGGTGTGGAGAATAAGCAG
GTGGTGATTATACATCACATGAGGCTGCAGGCCAAAGCTTTGCAACTTATAGTAACAGCACGAACTACACGAGGACTTGACCCCTTATTT
GGGATGTGTGAAAAATTTTTACAGGAAGTAGACTTTTTTCAGAGGTATTTCATCGCTGATTTGCCCCACTTGCAGGACAGCTTTGTGGAC
AAACTCCTTGACCTTATGCCCCGACTCATGACATCCAAACCTGCAGAAGTGGTCAAAATTCTACAGACCATGCTGCGACAGAGTGCCTTT
CTGCATCTCCCGCTTCCAGAGCAGATCCACAAAGCCTCAGCCACCATCATCGAGCCAGCGGGCGAGTCAGACAACCCTTTGCGGTTTACC
TCTGGGTTGGTGGTTGCCCTGGATGTTGATGCAACCCTGGAGCATGTGCAGGATCCTCAGAACACTGTTAAGGTCCAGGTCTTATATCCA
GATGGCCAGGCTCAGATGATTCACCCCAAGCCTGCAGACTTCCGGAATCCTGGCCCAGGGCGGCACCGGCTCATCACTCAGGTTTATCTC
TCCCACACCGCTTGGACAGAGGCATGCCAGGTGGAAGTGAGGCTGCTGCTGGCCTACAACTCCAGTGCTCGCATTCCAAAATGCCCCTGG
ATGGAGGGTGGTGAGATGTCACCACAGGTGGAAACCAGCATCGAGGGCACCATTCCCTTCAGCAAGCCTGTAAAAGTTTATATAATGCCC
AAACCTGCACGGCGCTAAGGCAAAAACAGTCTTCCCAACCGTGGCCTAGAGGGCCCTTCTTAGGTGTCAGAATGAGCCAAGCCTGAAGCA
CTTCACCTGGAATTGATGTGTAGGCTTAAGGAGTATGTGACCCTTACAGTCTCATCTGGTATCAAACACAGGATAAATTGTTTCTTCATT

>12365_12365_3_CACNA2D3-INTS4_CACNA2D3_chr3_54157621_ENST00000474759_INTS4_chr11_77692622_ENST00000534064_length(amino acids)=949AA_BP=653
MAGPGSPRRASRGASALLAAALLYAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKENDPSVRLKIASLLGLLSKTAG
FSPDCIMDDAINILQNEKSHQVLAQLLDTLLAIGTKLPENQAIQMRLVDVACKHLTDTSHGVRNKCLQLLGNLGSLEKSVTKDAEGLAAR
DVQKIIGDYFSDQDPRVRTAAIKAMLQLHERGLKLHQTIYNQACKLLSDDYEQVRSAAVQLIWVVSQLYPESIVPIPSSNEEIRLVDDAF
GKICHMVSDGSWVVRVQAAKLLGSMEQVSSHFLEQTLDKKLMSDLRRKRTAHERAKELYSSGEFSSGRKWGDDAPKEEVDTGAVNLIESG
ACGAFVHGLEDEMYEVRIAAVEALCMLAQSSPSFAEKCLDFLVDMFNDEIEEVRLQSIHTMRKISNNITLREDQLDTVLAVLEDSSRDIR
EALHELLCCTNVSTKEGIHLALVELLKNLTKYPTDRDSIWKCLKFLGSRHPTLVLPLVPELLSTHPFFDTAEPDMDDPAYIAVLVLIFNA
AKTCPTMPALFSDHTFRHYAYLRDSLSHLVPALRLPGRKLVSSAVSPSIIPQEDPSQQFLQQSLERVYSLQHLDPQGAQELLEFTIRDLQ
RLGELQSELAGVADFSATYLRCQLLLIKALQEKLWNVAAPLYLKQSDLASAAAKQIMEETYKMEFMYSGVENKQVVIIHHMRLQAKALQL
IVTARTTRGLDPLFGMCEKFLQEVDFFQRYFIADLPHLQDSFVDKLLDLMPRLMTSKPAEVVKILQTMLRQSAFLHLPLPEQIHKASATI
IEPAGESDNPLRFTSGLVVALDVDATLEHVQDPQNTVKVQVLYPDGQAQMIHPKPADFRNPGPGRHRLITQVYLSHTAWTEACQVEVRLL

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Fusion Gene PPI Analysis for CACNA2D3-INTS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CACNA2D3-INTS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CACNA2D3-INTS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource