FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CACNG7-PARK2 (FusionGDB2 ID:12421)

Fusion Gene Summary for CACNG7-PARK2

check button Fusion gene summary
Fusion gene informationFusion gene name: CACNG7-PARK2
Fusion gene ID: 12421
HgeneTgene
Gene symbol

CACNG7

PARK2

Gene ID

59284

5071

Gene namecalcium voltage-gated channel auxiliary subunit gamma 7parkin RBR E3 ubiquitin protein ligase
Synonyms-AR-JP|LPRS2|PARK2|PDJ
Cytomap

19q13.42

6q26

Type of geneprotein-codingprotein-coding
Descriptionvoltage-dependent calcium channel gamma-7 subunitTARP gamma-7calcium channel, voltage-dependent, gamma subunit 7neuronal voltage-gated calcium channel gamma-7 subunittransmembrane AMPAR regulatory protein gamma-7E3 ubiquitin-protein ligase parkinParkinson disease (autosomal recessive, juvenile) 2, parkinparkinson juvenile disease protein 2parkinson protein 2 E3 ubiquitin protein ligaseparkinson protein 2, E3 ubiquitin protein ligase (parkin)
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000222212, ENST00000391766, 
ENST00000391767, ENST00000468076, 
ENST00000338468, ENST00000366892, 
ENST00000366894, ENST00000366896, 
ENST00000366897, ENST00000366898, 
Fusion gene scores* DoF score2 X 2 X 1=420 X 16 X 5=1600
# samples 321
** MAII scorelog2(3/4*10)=2.90689059560852log2(21/1600*10)=-2.9296106721086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CACNG7 [Title/Abstract] AND PARK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCACNG7(54439037)-PARK2(161930886), # samples:1
CACNG7(54439037)-PARK2(162992331), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCACNG7

GO:2000311

regulation of AMPA receptor activity

21172611

TgenePARK2

GO:0000209

protein polyubiquitination

12150907|16227987|18541373|19880420

TgenePARK2

GO:0000422

autophagy of mitochondrion

25621951

TgenePARK2

GO:0001933

negative regulation of protein phosphorylation

17512523

TgenePARK2

GO:0006511

ubiquitin-dependent protein catabolic process

12925569|17097639

TgenePARK2

GO:0006513

protein monoubiquitination

20889974

TgenePARK2

GO:0010506

regulation of autophagy

20889974

TgenePARK2

GO:0010821

regulation of mitochondrion organization

21113145

TgenePARK2

GO:0016567

protein ubiquitination

10973942|11439185|12628165|17314283

TgenePARK2

GO:0031648

protein destabilization

19591802|29311685

TgenePARK2

GO:0032232

negative regulation of actin filament bundle assembly

17512523

TgenePARK2

GO:0033132

negative regulation of glucokinase activity

24187134

TgenePARK2

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

17314283|19880420

TgenePARK2

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

11439185|21376232

TgenePARK2

GO:0043388

positive regulation of DNA binding

17314283

TgenePARK2

GO:0043524

negative regulation of neuron apoptotic process

12628165|22511790|23985028

TgenePARK2

GO:0044828

negative regulation by host of viral genome replication

25244949

TgenePARK2

GO:0045944

positive regulation of transcription by RNA polymerase II

23453807

TgenePARK2

GO:0046676

negative regulation of insulin secretion

24187134

TgenePARK2

GO:0051865

protein autoubiquitination

12628165|15728840|16352719|17512523

TgenePARK2

GO:0060548

negative regulation of cell death

15603737

TgenePARK2

GO:0061734

parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization

19029340

TgenePARK2

GO:0070534

protein K63-linked ubiquitination

15728840|17314283|19880420|25621951

TgenePARK2

GO:0070936

protein K48-linked ubiquitination

21376232|23858059

TgenePARK2

GO:0070979

protein K11-linked ubiquitination

25621951

TgenePARK2

GO:0085020

protein K6-linked ubiquitination

25621951

TgenePARK2

GO:0090090

negative regulation of canonical Wnt signaling pathway

19591802

TgenePARK2

GO:0090201

negative regulation of release of cytochrome c from mitochondria

19880420|23453807

TgenePARK2

GO:0098779

positive regulation of mitophagy in response to mitochondrial depolarization

20457763

TgenePARK2

GO:0099074

mitochondrion to lysosome transport

24446486

TgenePARK2

GO:1900407

regulation of cellular response to oxidative stress

24446486

TgenePARK2

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

11439185|12150907|23453807

TgenePARK2

GO:1903265

positive regulation of tumor necrosis factor-mediated signaling pathway

23453807

TgenePARK2

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

17314283

TgenePARK2

GO:1903599

positive regulation of autophagy of mitochondrion

26310625


check buttonFusion gene breakpoints across CACNG7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across PARK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AKC357594CACNG7chr19

54439037

+PARK2chr6

161930886

-
ChiTaRS5.0N/AKC774171CACNG7chr19

54439037

+PARK2chr6

162992331

-


Top

Fusion Gene ORF analysis for CACNG7-PARK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000222212ENST00000338468CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000222212ENST00000338468CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000222212ENST00000366892CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000222212ENST00000366892CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000222212ENST00000366894CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000222212ENST00000366894CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000222212ENST00000366896CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000222212ENST00000366896CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000222212ENST00000366897CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000222212ENST00000366897CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000222212ENST00000366898CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000222212ENST00000366898CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391766ENST00000338468CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391766ENST00000338468CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391766ENST00000366892CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391766ENST00000366892CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391766ENST00000366894CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391766ENST00000366894CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391766ENST00000366896CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391766ENST00000366896CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391766ENST00000366897CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391766ENST00000366897CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391766ENST00000366898CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391766ENST00000366898CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391767ENST00000338468CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391767ENST00000338468CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391767ENST00000366892CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391767ENST00000366892CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391767ENST00000366894CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391767ENST00000366894CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391767ENST00000366896CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391767ENST00000366896CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391767ENST00000366897CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391767ENST00000366897CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000391767ENST00000366898CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000391767ENST00000366898CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000468076ENST00000338468CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000468076ENST00000338468CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000468076ENST00000366892CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000468076ENST00000366892CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000468076ENST00000366894CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000468076ENST00000366894CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000468076ENST00000366896CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000468076ENST00000366896CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000468076ENST00000366897CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000468076ENST00000366897CACNG7chr19

54439037

+PARK2chr6

162992331

-
intron-intronENST00000468076ENST00000366898CACNG7chr19

54439037

+PARK2chr6

161930886

-
intron-intronENST00000468076ENST00000366898CACNG7chr19

54439037

+PARK2chr6

162992331

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for CACNG7-PARK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CACNG7-PARK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:54439037/:161930886)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CACNG7-PARK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CACNG7-PARK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CACNG7-PARK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CACNG7-PARK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource