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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CADPS-FHIT (FusionGDB2 ID:12483)

Fusion Gene Summary for CADPS-FHIT

Fusion gene summary

Fusion gene information	Fusion gene name: CADPS-FHIT
	Fusion gene ID: 12483
		Hgene	Tgene
	Gene symbol	CADPS	FHIT
	Gene ID	8618	2272
	Gene name	calcium dependent secretion activator	fragile histidine triad diadenosine triphosphatase
	Synonyms	CADPS1\|CAPS\|CAPS1\|UNC-31	AP3Aase\|FRA3B
	Cytomap	3p14.2	3p14.2
	Type of gene	protein-coding	protein-coding
	Description	calcium-dependent secretion activator 1CAPS-1Ca++-dependent secretion activatorCa2+ dependent secretion activatorCa2+-dependent activator protein for secretionCa2+-regulated cytoskeletal proteincalcium-dependent activator protein for secretion 1	bis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatase
	Modification date	20200313	20200313
	UniProtAcc	Q9ULU8	P49789
	Ensembl transtripts involved in fusion gene	ENST00000283269, ENST00000357948, ENST00000383710, ENST00000490353, ENST00000462768,	ENST00000341848, ENST00000466788, ENST00000468189, ENST00000476844, ENST00000492590,
Fusion gene scores	* DoF score	3 X 3 X 3=27	27 X 20 X 11=5940
	# samples	3	32
	** MAII score	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(32/5940*10)=-4.21431912080077 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CADPS [Title/Abstract] AND FHIT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CADPS(62860264)-FHIT(59908140), # samples:1 FHIT(61027719)-CADPS(62484943), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FHIT	GO:0006163	purine nucleotide metabolic process	9323207

Fusion gene breakpoints across CADPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FHIT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A22E-01A	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-

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Fusion Gene ORF analysis for CADPS-FHIT

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000283269	ENST00000341848	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000283269	ENST00000466788	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000283269	ENST00000468189	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000357948	ENST00000341848	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000357948	ENST00000466788	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000357948	ENST00000468189	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000383710	ENST00000341848	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000383710	ENST00000466788	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000383710	ENST00000468189	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000490353	ENST00000341848	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000490353	ENST00000466788	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
5CDS-5UTR	ENST00000490353	ENST00000468189	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000283269	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000283269	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000357948	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000357948	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000383710	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000383710	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000490353	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
In-frame	ENST00000490353	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
intron-3CDS	ENST00000462768	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
intron-3CDS	ENST00000462768	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
intron-5UTR	ENST00000462768	ENST00000341848	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
intron-5UTR	ENST00000462768	ENST00000466788	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-
intron-5UTR	ENST00000462768	ENST00000468189	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000383710	CADPS	chr3	62860264	-	ENST00000476844	FHIT	chr3	59908140	-	1220	791	871	41	276
ENST00000383710	CADPS	chr3	62860264	-	ENST00000492590	FHIT	chr3	59908140	-	1231	791	278	955	225
ENST00000357948	CADPS	chr3	62860264	-	ENST00000476844	FHIT	chr3	59908140	-	1179	750	830	0	276
ENST00000357948	CADPS	chr3	62860264	-	ENST00000492590	FHIT	chr3	59908140	-	1190	750	237	914	225
ENST00000283269	CADPS	chr3	62860264	-	ENST00000476844	FHIT	chr3	59908140	-	1082	653	733	2	244
ENST00000283269	CADPS	chr3	62860264	-	ENST00000492590	FHIT	chr3	59908140	-	1093	653	140	817	225
ENST00000490353	CADPS	chr3	62860264	-	ENST00000476844	FHIT	chr3	59908140	-	870	441	0	605	201
ENST00000490353	CADPS	chr3	62860264	-	ENST00000492590	FHIT	chr3	59908140	-	881	441	0	605	201

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000383710	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.002684913	0.9973151
ENST00000383710	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.002579735	0.9974203
ENST00000357948	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.003773011	0.996227
ENST00000357948	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.003299749	0.9967002
ENST00000283269	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.003689748	0.9963103
ENST00000283269	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.003597081	0.996403
ENST00000490353	ENST00000476844	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.002611053	0.997389
ENST00000490353	ENST00000492590	CADPS	chr3	62860264	-	FHIT	chr3	59908140	-	0.002443738	0.9975562

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Fusion Genomic Features for CADPS-FHIT

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CADPS-FHIT

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:62860264/chr3:59908140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CADPS Q9ULU8	FHIT P49789
FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering (By similarity). {ECO:0000250}.	FUNCTION: Possesses dinucleoside triphosphate hydrolase activity (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (PubMed:8794732). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (PubMed:18694747). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:18694747). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (PubMed:26181368). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (PubMed:26181368). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (PubMed:18077326). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (PubMed:16407838). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (PubMed:15313915). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake (PubMed:12574506, PubMed:19622739). Functions as tumor suppressor (By similarity). {ECO:0000250\|UniProtKB:O89106, ECO:0000269\|PubMed:12574506, ECO:0000269\|PubMed:15313915, ECO:0000269\|PubMed:16407838, ECO:0000269\|PubMed:18077326, ECO:0000269\|PubMed:18694747, ECO:0000269\|PubMed:19622739, ECO:0000269\|PubMed:26181368, ECO:0000269\|PubMed:8794732, ECO:0000269\|PubMed:9323207, ECO:0000269\|PubMed:9543008}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000341848

94_98

148.0

Motif

Histidine triad motif

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000468189

94_98

148.0

Motif

Histidine triad motif

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000476844

94_98

214.0

Motif

Histidine triad motif

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000492590

94_98

205.33333333333334

Motif

Histidine triad motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000283269

380_495

147

1315.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000283269

521_624

147

1315.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000283269

931_1111

147

1315.0

Domain

MHD1

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000357948

380_495

147

1275.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000357948

521_624

147

1275.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000357948

931_1111

147

1275.0

Domain

MHD1

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000383710

380_495

147

1354.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000383710

521_624

147

1354.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000383710

931_1111

147

1354.0

Domain

MHD1

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000490353

380_495

147

458.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000490353

521_624

147

458.0

Domain

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000490353

931_1111

147

458.0

Domain

MHD1

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000283269

1177_1353

147

1315.0

Region

Mediates targeting and association with DCVs

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000357948

1177_1353

147

1275.0

Region

Mediates targeting and association with DCVs

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000383710

1177_1353

147

1354.0

Region

Mediates targeting and association with DCVs

Hgene

CADPS

chr3:62860264

chr3:59908140

ENST00000490353

1177_1353

147

458.0

Region

Mediates targeting and association with DCVs

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000341848

2_109

148.0

Domain

HIT

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000468189

2_109

148.0

Domain

HIT

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000476844

2_109

214.0

Domain

HIT

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000492590

2_109

205.33333333333334

Domain

HIT

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000341848

89_92

148.0

Nucleotide binding

Substrate

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000468189

89_92

148.0

Nucleotide binding

Substrate

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000476844

89_92

214.0

Nucleotide binding

Substrate

Tgene

FHIT

chr3:62860264

chr3:59908140

ENST00000492590

89_92

205.33333333333334

Nucleotide binding

Substrate

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Fusion Gene Sequence for CADPS-FHIT

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>12483_12483_1_CADPS-FHIT_CADPS_chr3_62860264_ENST00000283269_FHIT_chr3_59908140_ENST00000476844_length(transcript)=1082nt_BP=653nt
CTCCTCCCTTCGCGCTTCTGGGTCTGAGCCCAGCTCGCGACCGCCGGGCAGAGGATCAGTCGCGGCGGCCGAGGCTGAGCAGCAGCGCTC
TCGCTCCCTGACCTGGGGAGAAGCGCCCACCCGGGAGAGCTGATCCCCGGCTGCCTCCAGCGCCCCCCACCTTTTGCACTCCAAGCCGGG
GGCTCCAGAGACCCCGCTCCCCAGGCGCCACTATGCTGGACCCTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAGGAGAGCG
GCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGCGCGCGCCTGTCTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGGCTGGGGG
GCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGTGCAGGCGGCGGCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGGCTGCAAC
CCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCCAGCCCCAGCCCGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGGCTGCAGA
AAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAGCTGTATGTGTTCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAGCCCACCG
ACATGGCTCGCCGGCAGCAGAAGCACGTTCACGTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGG
AGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACT
TTCAGTGACACAGATCCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAAT
CAGCATGAAAATGCAGTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATAC
CTAGACCTAAACGGCTCAGACAGGCAGATTTGAGGTTTCCCCCTGTCTCCTTATTCGGCAGCCTTATGATTAAACTTCCTTCTCTGCTGC

>12483_12483_1_CADPS-FHIT_CADPS_chr3_62860264_ENST00000283269_FHIT_chr3_59908140_ENST00000476844_length(amino acids)=244AA_BP=4
MFLELLIDAVIPVKVSSLPGKNMDVNVLLLPASHVGGLLGIKGVGDAAHHEHIQLQPLLPLLLLFLQPLQLFLLLLAHHRRAGAGGPAAA
SAAAGLQPPGPAAAARAAAPAAACTHPGSGAGAAAPQPGAAGRALAGTAGRQARAGRGRAEHLLAALLLHDLIRFFFAGRRVQHSGAWGA

--------------------------------------------------------------
>12483_12483_2_CADPS-FHIT_CADPS_chr3_62860264_ENST00000283269_FHIT_chr3_59908140_ENST00000492590_length(transcript)=1093nt_BP=653nt
CTCCTCCCTTCGCGCTTCTGGGTCTGAGCCCAGCTCGCGACCGCCGGGCAGAGGATCAGTCGCGGCGGCCGAGGCTGAGCAGCAGCGCTC
TCGCTCCCTGACCTGGGGAGAAGCGCCCACCCGGGAGAGCTGATCCCCGGCTGCCTCCAGCGCCCCCCACCTTTTGCACTCCAAGCCGGG
GGCTCCAGAGACCCCGCTCCCCAGGCGCCACTATGCTGGACCCTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAGGAGAGCG
GCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGCGCGCGCCTGTCTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGGCTGGGGG
GCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGTGCAGGCGGCGGCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGGCTGCAAC
CCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCCAGCCCCAGCCCGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGGCTGCAGA
AAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAGCTGTATGTGTTCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAGCCCACCG
ACATGGCTCGCCGGCAGCAGAAGCACGTTCACGTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGG
AGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACT
TTCAGTGACACAGATGTTTTTCAGATCCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAG
AGGAACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTC
CCTTAAAATACCTAGACCTAAACGGCTCAGACAGGCAGATTTGAGGTTTCCCCCTGTCTCCTTATTCGGCAGCCTTATGATTAAACTTCC

>12483_12483_2_CADPS-FHIT_CADPS_chr3_62860264_ENST00000283269_FHIT_chr3_59908140_ENST00000492590_length(amino acids)=225AA_BP=171
MPPAPPTFCTPSRGLQRPRSPGATMLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVGAGGGGG
SGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKHVHVHVLPR

--------------------------------------------------------------
>12483_12483_3_CADPS-FHIT_CADPS_chr3_62860264_ENST00000357948_FHIT_chr3_59908140_ENST00000476844_length(transcript)=1179nt_BP=750nt
TCAGCAGCCGCAGATGGCATCCGGCTGCGGGCTCGGGGCTCGCAATTGATTCTCCCCCTTGCCCACCTCGAGTCCACGGACGCACCTCTC
CCTTCCCCTCCTCCCTTCGCGCTTCTGGGTCTGAGCCCAGCTCGCGACCGCCGGGCAGAGGATCAGTCGCGGCGGCCGAGGCTGAGCAGC
AGCGCTCTCGCTCCCTGACCTGGGGAGAAGCGCCCACCCGGGAGAGCTGATCCCCGGCTGCCTCCAGCGCCCCCCACCTTTTGCACTCCA
AGCCGGGGGCTCCAGAGACCCCGCTCCCCAGGCGCCACTATGCTGGACCCTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAG
GAGAGCGGCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGCGCGCGCCTGTCTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGG
CTGGGGGGCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGTGCAGGCGGCGGCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGG
CTGCAACCCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCCAGCCCCAGCCCGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGG
CTGCAGAAAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAGCTGTATGTGTTCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAG
CCCACCGACATGGCTCGCCGGCAGCAGAAGCACGTTCACGTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATC
TATGAGGAGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGG
GTCTACTTTCAGTGACACAGATCCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGA
ACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTT
AAAATACCTAGACCTAAACGGCTCAGACAGGCAGATTTGAGGTTTCCCCCTGTCTCCTTATTCGGCAGCCTTATGATTAAACTTCCTTCT

>12483_12483_3_CADPS-FHIT_CADPS_chr3_62860264_ENST00000357948_FHIT_chr3_59908140_ENST00000476844_length(amino acids)=276AA_BP=4
MFLELLIDAVIPVKVSSLPGKNMDVNVLLLPASHVGGLLGIKGVGDAAHHEHIQLQPLLPLLLLFLQPLQLFLLLLAHHRRAGAGGPAAA
SAAAGLQPPGPAAAARAAAPAAACTHPGSGAGAAAPQPGAAGRALAGTAGRQARAGRGRAEHLLAALLLHDLIRFFFAGRRVQHSGAWGA
GSLEPPAWSAKGGGRWRQPGISSPGWALLPRSGSESAAAQPRPPRLILCPAVASWAQTQKREGRRGRERCVRGLEVGKGENQLRAPSPQP

--------------------------------------------------------------
>12483_12483_4_CADPS-FHIT_CADPS_chr3_62860264_ENST00000357948_FHIT_chr3_59908140_ENST00000492590_length(transcript)=1190nt_BP=750nt
TCAGCAGCCGCAGATGGCATCCGGCTGCGGGCTCGGGGCTCGCAATTGATTCTCCCCCTTGCCCACCTCGAGTCCACGGACGCACCTCTC
CCTTCCCCTCCTCCCTTCGCGCTTCTGGGTCTGAGCCCAGCTCGCGACCGCCGGGCAGAGGATCAGTCGCGGCGGCCGAGGCTGAGCAGC
AGCGCTCTCGCTCCCTGACCTGGGGAGAAGCGCCCACCCGGGAGAGCTGATCCCCGGCTGCCTCCAGCGCCCCCCACCTTTTGCACTCCA
AGCCGGGGGCTCCAGAGACCCCGCTCCCCAGGCGCCACTATGCTGGACCCTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAG
GAGAGCGGCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGCGCGCGCCTGTCTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGG
CTGGGGGGCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGTGCAGGCGGCGGCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGG
CTGCAACCCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCCAGCCCCAGCCCGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGG
CTGCAGAAAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAGCTGTATGTGTTCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAG
CCCACCGACATGGCTCGCCGGCAGCAGAAGCACGTTCACGTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATC
TATGAGGAGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGG
GTCTACTTTCAGTGACACAGATGTTTTTCAGATCCTGAATTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCT
CCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACT
CCAACTCCCTTAAAATACCTAGACCTAAACGGCTCAGACAGGCAGATTTGAGGTTTCCCCCTGTCTCCTTATTCGGCAGCCTTATGATTA

>12483_12483_4_CADPS-FHIT_CADPS_chr3_62860264_ENST00000357948_FHIT_chr3_59908140_ENST00000492590_length(amino acids)=225AA_BP=171
MPPAPPTFCTPSRGLQRPRSPGATMLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVGAGGGGG
SGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKHVHVHVLPR

--------------------------------------------------------------
>12483_12483_5_CADPS-FHIT_CADPS_chr3_62860264_ENST00000383710_FHIT_chr3_59908140_ENST00000476844_length(transcript)=1220nt_BP=791nt
ACAGCTTGCAACACTCGGCATCTTTTCTGGAGGCGCCTCCTTCAGCAGCCGCAGATGGCATCCGGCTGCGGGCTCGGGGCTCGCAATTGA
TTCTCCCCCTTGCCCACCTCGAGTCCACGGACGCACCTCTCCCTTCCCCTCCTCCCTTCGCGCTTCTGGGTCTGAGCCCAGCTCGCGACC
GCCGGGCAGAGGATCAGTCGCGGCGGCCGAGGCTGAGCAGCAGCGCTCTCGCTCCCTGACCTGGGGAGAAGCGCCCACCCGGGAGAGCTG
ATCCCCGGCTGCCTCCAGCGCCCCCCACCTTTTGCACTCCAAGCCGGGGGCTCCAGAGACCCCGCTCCCCAGGCGCCACTATGCTGGACC
CTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAGGAGAGCGGCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGCGCGCGCCTGT
CTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGGCTGGGGGGCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGTGCAGGCGGCG
GCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGGCTGCAACCCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCCAGCCCCAGCC
CGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGGCTGCAGAAAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAGCTGTATGTGT
TCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAGCCCACCGACATGGCTCGCCGGCAGCAGAAGCACGTTCACGTCCATGTTC
TTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGA
GATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATCCTGAATTCCAGCAAAAGAGCTATTGC
CAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCACCATCCTGTATTC
TTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCAGACAGGCAGATTTGAGGTTTCCCC

>12483_12483_5_CADPS-FHIT_CADPS_chr3_62860264_ENST00000383710_FHIT_chr3_59908140_ENST00000476844_length(amino acids)=276AA_BP=4
MFLELLIDAVIPVKVSSLPGKNMDVNVLLLPASHVGGLLGIKGVGDAAHHEHIQLQPLLPLLLLFLQPLQLFLLLLAHHRRAGAGGPAAA
SAAAGLQPPGPAAAARAAAPAAACTHPGSGAGAAAPQPGAAGRALAGTAGRQARAGRGRAEHLLAALLLHDLIRFFFAGRRVQHSGAWGA
GSLEPPAWSAKGGGRWRQPGISSPGWALLPRSGSESAAAQPRPPRLILCPAVASWAQTQKREGRRGRERCVRGLEVGKGENQLRAPSPQP

--------------------------------------------------------------
>12483_12483_6_CADPS-FHIT_CADPS_chr3_62860264_ENST00000383710_FHIT_chr3_59908140_ENST00000492590_length(transcript)=1231nt_BP=791nt
ACAGCTTGCAACACTCGGCATCTTTTCTGGAGGCGCCTCCTTCAGCAGCCGCAGATGGCATCCGGCTGCGGGCTCGGGGCTCGCAATTGA
TTCTCCCCCTTGCCCACCTCGAGTCCACGGACGCACCTCTCCCTTCCCCTCCTCCCTTCGCGCTTCTGGGTCTGAGCCCAGCTCGCGACC
GCCGGGCAGAGGATCAGTCGCGGCGGCCGAGGCTGAGCAGCAGCGCTCTCGCTCCCTGACCTGGGGAGAAGCGCCCACCCGGGAGAGCTG
ATCCCCGGCTGCCTCCAGCGCCCCCCACCTTTTGCACTCCAAGCCGGGGGCTCCAGAGACCCCGCTCCCCAGGCGCCACTATGCTGGACC
CTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAGGAGAGCGGCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGCGCGCGCCTGT
CTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGGCTGGGGGGCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGTGCAGGCGGCG
GCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGGCTGCAACCCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCCAGCCCCAGCC
CGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGGCTGCAGAAAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAGCTGTATGTGT
TCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAGCCCACCGACATGGCTCGCCGGCAGCAGAAGCACGTTCACGTCCATGTTC
TTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACATGACAAGGAGGACTTTCCTGCCTCTTGGA
GATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATGTTTTTCAGATCCTGAATTCCAGCAAA
AGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCACC
ATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCAGACAGGCAGATTT

>12483_12483_6_CADPS-FHIT_CADPS_chr3_62860264_ENST00000383710_FHIT_chr3_59908140_ENST00000492590_length(amino acids)=225AA_BP=171
MPPAPPTFCTPSRGLQRPRSPGATMLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVGAGGGGG
SGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKHVHVHVLPR

--------------------------------------------------------------
>12483_12483_7_CADPS-FHIT_CADPS_chr3_62860264_ENST00000490353_FHIT_chr3_59908140_ENST00000476844_length(transcript)=870nt_BP=441nt
ATGCTGGACCCTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAGGAGAGCGGCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGC
GCGCGCCTGTCTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGGCTGGGGGGCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGT
GCAGGCGGCGGCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGGCTGCAACCCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCC
AGCCCCAGCCCGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGGCTGCAGAAAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAG
CTGTATGTGTTCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAGCCCACCGACATGGCTCGCCGGCAGCAGAAGCACGTTCAC
GTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACATGACAAGGAGGACTTTCCT
GCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATCCTGAATTCCAGCAAAA
GAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTTTCTTCATCTCACCA
TCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCAGACAGGCAGATTTG

>12483_12483_7_CADPS-FHIT_CADPS_chr3_62860264_ENST00000490353_FHIT_chr3_59908140_ENST00000476844_length(amino acids)=201AA_BP=147
MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPS
SPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFP

--------------------------------------------------------------
>12483_12483_8_CADPS-FHIT_CADPS_chr3_62860264_ENST00000490353_FHIT_chr3_59908140_ENST00000492590_length(transcript)=881nt_BP=441nt
ATGCTGGACCCTTCGTCCAGCGAAGAAGAATCGGATGAGATCGTGGAGGAGGAGAGCGGCAAGGAGGTGCTCGGCTCGGCCCCGTCCGGC
GCGCGCCTGTCTCCCAGCCGTACCAGCGAGGGCTCGGCCGGCAGCGCCGGGCTGGGGGGCGGCGGCGCCGGCGCCGGAGCCGGGGTGGGT
GCAGGCGGCGGCGGGGGCAGCGGCGCGAGCAGCGGCGGCGGGGCCGGGGGGCTGCAACCCAGCAGCCGCGCTGGCGGCGGCCGGCCCTCC
AGCCCCAGCCCGTCGGTGGTGAGCGAGAAGGAGAAGGAAGAGTTGGAGCGGCTGCAGAAAGAGGAGGAGGAGAGGAAGAAGAGGCTGCAG
CTGTATGTGTTCGTGATGCGCTGCATCGCCTACCCCTTTAATGCCAAGCAGCCCACCGACATGGCTCGCCGGCAGCAGAAGCACGTTCAC
GTCCATGTTCTTCCCAGGAAGGCTGGAGACTTTCACAGGAATGACAGCATCTATGAGGAGCTCCAGAAACATGACAAGGAGGACTTTCCT
GCCTCTTGGAGATCAGAGGAGGAAATGGCAGCAGAAGCCGCAGCTCTGCGGGTCTACTTTCAGTGACACAGATGTTTTTCAGATCCTGAA
TTCCAGCAAAAGAGCTATTGCCAACCAGTTTGAAGACCGCCCCCCGCCTCTCCCCAAGAGGAACTGAATCAGCATGAAAATGCAGTTTCT
TCATCTCACCATCCTGTATTCTTCAACCAGTGATCCCCCACCTCGGTCACTCCAACTCCCTTAAAATACCTAGACCTAAACGGCTCAGAC

>12483_12483_8_CADPS-FHIT_CADPS_chr3_62860264_ENST00000490353_FHIT_chr3_59908140_ENST00000492590_length(amino acids)=201AA_BP=147
MLDPSSSEEESDEIVEEESGKEVLGSAPSGARLSPSRTSEGSAGSAGLGGGGAGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPS
SPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRQQKHVHVHVLPRKAGDFHRNDSIYEELQKHDKEDFP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CADPS-FHIT

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CADPS	chr3:62860264	chr3:59908140	ENST00000283269	-	1	28	790_1129	147.0	1315.0	DRD2
Hgene	CADPS	chr3:62860264	chr3:59908140	ENST00000357948	-	1	27	790_1129	147.0	1275.0	DRD2
Hgene	CADPS	chr3:62860264	chr3:59908140	ENST00000383710	-	1	30	790_1129	147.0	1354.0	DRD2
Hgene	CADPS	chr3:62860264	chr3:59908140	ENST00000490353	-	1	7	790_1129	147.0	458.0	DRD2

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CADPS-FHIT

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CADPS-FHIT

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source