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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CALD1-BRWD1 (FusionGDB2 ID:12510)

Fusion Gene Summary for CALD1-BRWD1

check button Fusion gene summary
Fusion gene informationFusion gene name: CALD1-BRWD1
Fusion gene ID: 12510
HgeneTgene
Gene symbol

CALD1

BRWD1

Gene ID

800

54014

Gene namecaldesmon 1bromodomain and WD repeat domain containing 1
SynonymsCDM|H-CAD|HCAD|L-CAD|LCAD|NAG22C21orf107|DCAF19|N143|WDR9|WRD9
Cytomap

7q33

21q22.2

Type of geneprotein-codingprotein-coding
Descriptioncaldesmontestis secretory sperm-binding protein Li 227nbromodomain and WD repeat-containing protein 1WD repeat protein WDR9-form2WD repeat-containing protein 9transcriptional unit N143
Modification date2020031320200313
UniProtAcc

Q05682

Q9NSI6

Ensembl transtripts involved in fusion geneENST00000466704, ENST00000361388, 
ENST00000361675, ENST00000361901, 
ENST00000393118, ENST00000417172, 
ENST00000422748, ENST00000424922, 
ENST00000495522, ENST00000543443, 
ENST00000333229, ENST00000341322, 
ENST00000342449, ENST00000380800, 
ENST00000470108, 
Fusion gene scores* DoF score20 X 22 X 11=484012 X 12 X 3=432
# samples 2912
** MAII scorelog2(29/4840*10)=-4.06088224214702
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/432*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALD1 [Title/Abstract] AND BRWD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCALD1(134635143)-BRWD1(40664869), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CALD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across BRWD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG980424CALD1chr7

134635143

-BRWD1chr21

40664869

+


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Fusion Gene ORF analysis for CALD1-BRWD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000466704ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
3UTR-intronENST00000466704ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361388ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361675ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000361901ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000393118ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000417172ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000422748ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000424922ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000495522ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000333229CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000341322CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000342449CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000380800CALD1chr7

134635143

-BRWD1chr21

40664869

+
5CDS-intronENST00000543443ENST00000470108CALD1chr7

134635143

-BRWD1chr21

40664869

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CALD1-BRWD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CALD1-BRWD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:134635143/:40664869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALD1

Q05682

BRWD1

Q9NSI6

FUNCTION: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269|PubMed:8227296}.FUNCTION: May be a transcriptional activator. May be involved in chromatin remodeling (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000250, ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CALD1-BRWD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CALD1-BRWD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CALD1-BRWD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CALD1-BRWD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource