Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CALD1-LRGUK (FusionGDB2 ID:12518)

Fusion Gene Summary for CALD1-LRGUK

Fusion gene summary

Fusion gene information	Fusion gene name: CALD1-LRGUK
	Fusion gene ID: 12518
		Hgene	Tgene
	Gene symbol	CALD1	LRGUK
	Gene ID	800	136332
	Gene name	caldesmon 1	leucine rich repeats and guanylate kinase domain containing
	Synonyms	CDM\|H-CAD\|HCAD\|L-CAD\|LCAD\|NAG22	CFAP246
	Cytomap	7q33	7q33
	Type of gene	protein-coding	protein-coding
	Description	caldesmontestis secretory sperm-binding protein Li 227n	leucine-rich repeat and guanylate kinase domain-containing protein
	Modification date	20200313	20200322
	UniProtAcc	Q05682	Q96M69
	Ensembl transtripts involved in fusion gene	ENST00000361388, ENST00000361675, ENST00000361901, ENST00000422748, ENST00000393118, ENST00000417172, ENST00000424922, ENST00000466704, ENST00000495522, ENST00000543443,	ENST00000285928, ENST00000473068,
Fusion gene scores	* DoF score	20 X 22 X 11=4840	3 X 6 X 3=54
	# samples	29	5
	** MAII score	log2(29/4840*10)=-4.06088224214702 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/54*10)=-0.111031312388744 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CALD1 [Title/Abstract] AND LRGUK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CALD1(134464500)-LRGUK(133932308), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CALD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRGUK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A244-01A	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
ChimerDB4	BRCA	TCGA-E9-A244-01A	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
ChimerDB4	BRCA	TCGA-E9-A244-01A	CALD1	chr7	134464500	-	LRGUK	chr7	133932308	+
ChimerDB4	BRCA	TCGA-E9-A244-01A	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
ChimerDB4	BRCA	TCGA-E9-A244-01A	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
ChimerDB4	BRCA	TCGA-E9-A244	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
ChimerDB4	BRCA	TCGA-E9-A244	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+

Top

Fusion Gene ORF analysis for CALD1-LRGUK

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000361388	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000361388	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-3CDS	ENST00000361388	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-3CDS	ENST00000361388	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-3CDS	ENST00000361388	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000361388	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
5UTR-3CDS	ENST00000361675	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000361675	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-3CDS	ENST00000361675	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-3CDS	ENST00000361675	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-3CDS	ENST00000361675	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000361675	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
5UTR-3CDS	ENST00000361901	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000361901	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-3CDS	ENST00000361901	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-3CDS	ENST00000361901	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-3CDS	ENST00000361901	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000361901	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
5UTR-3CDS	ENST00000422748	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000422748	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-3CDS	ENST00000422748	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-3CDS	ENST00000422748	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-3CDS	ENST00000422748	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-3CDS	ENST00000422748	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000361388	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000361388	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000361388	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-intron	ENST00000361388	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-intron	ENST00000361388	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000361388	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000361675	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000361675	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000361675	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-intron	ENST00000361675	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-intron	ENST00000361675	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000361675	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000361901	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000361901	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000361901	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-intron	ENST00000361901	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-intron	ENST00000361901	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000361901	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000422748	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000422748	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
5UTR-intron	ENST00000422748	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
5UTR-intron	ENST00000422748	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
5UTR-intron	ENST00000422748	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
5UTR-intron	ENST00000422748	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000393118	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000393118	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000393118	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-3CDS	ENST00000393118	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-3CDS	ENST00000393118	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000393118	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000417172	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000417172	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000417172	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-3CDS	ENST00000417172	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-3CDS	ENST00000417172	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000417172	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000424922	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000424922	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000424922	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-3CDS	ENST00000424922	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-3CDS	ENST00000424922	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000424922	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000466704	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000466704	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000466704	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-3CDS	ENST00000466704	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-3CDS	ENST00000466704	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000466704	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000495522	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000495522	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000495522	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-3CDS	ENST00000495522	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-3CDS	ENST00000495522	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000495522	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000543443	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000543443	ENST00000285928	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-3CDS	ENST00000543443	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-3CDS	ENST00000543443	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-3CDS	ENST00000543443	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-3CDS	ENST00000543443	ENST00000285928	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000393118	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000393118	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000393118	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-intron	ENST00000393118	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-intron	ENST00000393118	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000393118	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000417172	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000417172	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000417172	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-intron	ENST00000417172	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-intron	ENST00000417172	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000417172	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000424922	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000424922	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000424922	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-intron	ENST00000424922	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-intron	ENST00000424922	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000424922	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000466704	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000466704	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000466704	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-intron	ENST00000466704	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-intron	ENST00000466704	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000466704	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000495522	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000495522	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000495522	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-intron	ENST00000495522	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-intron	ENST00000495522	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000495522	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000543443	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000543443	ENST00000473068	CALD1	chr7	134464499	+	LRGUK	chr7	133933702	+
intron-intron	ENST00000543443	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932308	+
intron-intron	ENST00000543443	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933703	+
intron-intron	ENST00000543443	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+
intron-intron	ENST00000543443	ENST00000473068	CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for CALD1-LRGUK

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+	0.92029303	0.07970697
CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+	0.92029303	0.07970697
CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+	0.003793445	0.9962065
CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+	0.003793445	0.9962065
CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+	0.92029303	0.07970697
CALD1	chr7	134464500	+	LRGUK	chr7	133932307	+	0.92029303	0.07970697
CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+	0.003793445	0.9962065
CALD1	chr7	134464500	+	LRGUK	chr7	133933702	+	0.003793445	0.9962065

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CALD1-LRGUK

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:134464500/:133932308)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CALD1 Q05682	LRGUK Q96M69
FUNCTION: Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250, ECO:0000269\|PubMed:8227296}.	FUNCTION: Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. {ECO:0000250\|UniProtKB:Q9D5S7}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for CALD1-LRGUK

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CALD1-LRGUK

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CALD1-LRGUK

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CALD1-LRGUK

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source