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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACBD4-LRRC37A (FusionGDB2 ID:1253)

Fusion Gene Summary for ACBD4-LRRC37A

check button Fusion gene summary
Fusion gene informationFusion gene name: ACBD4-LRRC37A
Fusion gene ID: 1253
HgeneTgene
Gene symbol

ACBD4

LRRC37A

Gene ID

79777

105376839

Gene nameacyl-CoA binding domain containing 4uncharacterized LOC105376839
SynonymsHMFT0700LRRC37A
Cytomap

17q21.31

17q21.31

Type of geneprotein-codingncRNA
Descriptionacyl-CoA-binding domain-containing protein 4acyl-Coenzyme A binding domain containing 4leucine rich repeat containing 37A
Modification date2020032020200313
UniProtAcc

Q8NC06

O60309

Ensembl transtripts involved in fusion geneENST00000376955, ENST00000431281, 
ENST00000586346, ENST00000591859, 
ENST00000321854, ENST00000398322, 
ENST00000591136, ENST00000592162, 
ENST00000320254, ENST00000393465, 
ENST00000496930, 
Fusion gene scores* DoF score4 X 2 X 2=167 X 7 X 6=294
# samples 27
** MAII scorelog2(2/16*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACBD4 [Title/Abstract] AND LRRC37A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACBD4(43216527)-LRRC37A(44412911), # samples:2
Anticipated loss of major functional domain due to fusion event.ACBD4-LRRC37A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACBD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LRRC37A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A8EJ-01AACBD4chr17

43216527

+LRRC37Achr17

44412911

+


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Fusion Gene ORF analysis for ACBD4-LRRC37A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000376955ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000376955ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000376955ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000431281ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000431281ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000431281ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000586346ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000586346ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000586346ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000591859ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000591859ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
Frame-shiftENST00000591859ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
In-frameENST00000321854ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
In-frameENST00000321854ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
In-frameENST00000321854ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
In-frameENST00000398322ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
In-frameENST00000398322ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
In-frameENST00000398322ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
intron-3CDSENST00000591136ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
intron-3CDSENST00000591136ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
intron-3CDSENST00000591136ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
intron-3CDSENST00000592162ENST00000320254ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
intron-3CDSENST00000592162ENST00000393465ACBD4chr17

43216527

+LRRC37Achr17

44412911

+
intron-3CDSENST00000592162ENST00000496930ACBD4chr17

43216527

+LRRC37Achr17

44412911

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398322ACBD4chr1743216527+ENST00000496930LRRC37Achr1744412911+161012474581540360
ENST00000398322ACBD4chr1743216527+ENST00000393465LRRC37Achr1744412911+140012474581345295
ENST00000398322ACBD4chr1743216527+ENST00000320254LRRC37Achr1744412911+161212474581540360
ENST00000321854ACBD4chr1743216527+ENST00000496930LRRC37Achr1744412911+143510722831365360
ENST00000321854ACBD4chr1743216527+ENST00000393465LRRC37Achr1744412911+122510722831170295
ENST00000321854ACBD4chr1743216527+ENST00000320254LRRC37Achr1744412911+143710722831365360

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398322ENST00000496930ACBD4chr1743216527+LRRC37Achr1744412911+0.0079714990.99202853
ENST00000398322ENST00000393465ACBD4chr1743216527+LRRC37Achr1744412911+0.0086289340.99137104
ENST00000398322ENST00000320254ACBD4chr1743216527+LRRC37Achr1744412911+0.0081971470.9918029
ENST00000321854ENST00000496930ACBD4chr1743216527+LRRC37Achr1744412911+0.008372560.99162745
ENST00000321854ENST00000393465ACBD4chr1743216527+LRRC37Achr1744412911+0.0100180530.98998195
ENST00000321854ENST00000320254ACBD4chr1743216527+LRRC37Achr1744412911+0.0085722280.9914278

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Fusion Genomic Features for ACBD4-LRRC37A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACBD4chr1743216527+LRRC37Achr1744412910+8.86E-050.9999113
ACBD4chr1743216527+LRRC37Achr1744412910+8.86E-050.9999113

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACBD4-LRRC37A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:43216527/chr17:44412911)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACBD4

Q8NC06

LRRC37A

O60309

FUNCTION: Binds medium- and long-chain acyl-CoA esters and may function as an intracellular carrier of acyl-CoA esters.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACBD4chr17:43216527chr17:44412911ENST00000321854+91012_101263306.0DomainACB
HgeneACBD4chr17:43216527chr17:44412911ENST00000376955+91012_101259269.0DomainACB
HgeneACBD4chr17:43216527chr17:44412911ENST00000398322+8912_101263306.0DomainACB
HgeneACBD4chr17:43216527chr17:44412911ENST00000431281+111212_101275342.0DomainACB
HgeneACBD4chr17:43216527chr17:44412911ENST00000586346+91012_101275342.0DomainACB
HgeneACBD4chr17:43216527chr17:44412911ENST00000591859+111212_101275342.0DomainACB
HgeneACBD4chr17:43216527chr17:44412911ENST00000321854+91023_32263306.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000321854+91043_47263306.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000376955+91023_32259269.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000376955+91043_47259269.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000398322+8923_32263306.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000398322+8943_47263306.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000431281+111223_32275342.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000431281+111243_47275342.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000586346+91023_32275342.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000586346+91043_47275342.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000591859+111223_32275342.0RegionNote=Acyl-CoA binding
HgeneACBD4chr17:43216527chr17:44412911ENST00000591859+111243_47275342.0RegionNote=Acyl-CoA binding
TgeneLRRC37Achr17:43216527chr17:44412911ENST000003202549141604_170016031701.0Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLRRC37Achr17:43216527chr17:44412911ENST00000320254914866_88716031701.0RepeatNote=LRR 1
TgeneLRRC37Achr17:43216527chr17:44412911ENST00000320254914890_91116031701.0RepeatNote=LRR 2
TgeneLRRC37Achr17:43216527chr17:44412911ENST00000320254914914_93516031701.0RepeatNote=LRR 3
TgeneLRRC37Achr17:43216527chr17:44412911ENST00000320254914938_95916031701.0RepeatNote=LRR 4
TgeneLRRC37Achr17:43216527chr17:44412911ENST00000320254914965_98616031701.0RepeatNote=LRR 5
TgeneLRRC37Achr17:43216527chr17:44412911ENST0000032025491436_158216031701.0Topological domainExtracellular
TgeneLRRC37Achr17:43216527chr17:44412911ENST000003202549141583_160316031701.0TransmembraneHelical


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Fusion Gene Sequence for ACBD4-LRRC37A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1253_1253_1_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000321854_LRRC37A_chr17_44412911_ENST00000320254_length(transcript)=1437nt_BP=1072nt
GGCGAGAGAGGACCCAGGTGTCCTGGCAGTGGGCGCCGCGGGGCACACGCTGGGCCAAGGTGCAGGCGGCCAGGGTGGGAGACTGTTCGC
CCCGCCCTGAGTACTCCTATCTTGTTTCTCCACCTGTTCGGGAGTTGGAGATGTGCACCTAAAGGAGGCGCATCTGGGGACGGACACATC
TGGCACTGAGGCCCTCGCCACCTGCCTCGCCACCTGGCGACCCTGACCCCACCACACTGCCTTGAGAGTCGCTCAAAAGTAGGGCCCCAG
GGCTCGCAGCAGCATGGGCACCGAGAAAGAAAGCCCAGAGCCCGACTGCCAGAAACAGTTCCAGGCTGCAGTGAGCGTCATCCAGAACCT
GCCCAAGAACGGTTCTTACCGCCCCTCCTATGAAGAGATGCTGCGATTCTACAGTTACTACAAGCAGGCCACCATGGGGCCCTGCCTGGT
CCCCCGGCCCGGGTTCTGGGACCCCATTGGACGATATAAGTGGGACGCCTGGAACAGTCTGGGCAAGATGAGCAGGGAGGAGGCCATGTC
TGCCTACATCACTGAAATGAAACTGGTGGCACAGAAGGTGATCGACACAGTGCCCCTGGGTGAGGTGGCAGAGGACATGTTTGGTTACTT
CGAGCCCCTGTACCAGGTGATCCCTGACATGCCGAGGCCCCCAGAGACCTTCCTGAGAAGGGTCACAGGTTGGAAAGAGCAGGTTGTGAA
TGGAGATGTTGGGGCTGTTTCAGAGCCTCCCTGCCTCCCCAAGGAACCGGCACCCCCAAGCCCAGAGTCCCATTCACCCAGGGACCTGGA
CTCCGAGGTTTTCTGTGATTCCCTGGAGCAGCTGGAGCCTGAGCTGGTTTGGACAGAGCAGCGGGCAGCATCTGGAGGAAAGCGTGATCC
CAGGAACAGCCCCGTGCCCCCCACAAAGAAAGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGAC
AGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGATATGTTG
TCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGGCATTTTCAGATTTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGA
GAGTCAGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTTAAAGATCTGTACAAACCTCTCAGTGCCACAAGAATAAATAATCATGC
ATGGAAGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTCAACAGGGACCCTGGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAG

>1253_1253_1_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000321854_LRRC37A_chr17_44412911_ENST00000320254_length(amino acids)=360AA_BP=0
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYIT
EMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVF
CDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEGLRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQICCHRRS
LQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP

--------------------------------------------------------------
>1253_1253_2_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000321854_LRRC37A_chr17_44412911_ENST00000393465_length(transcript)=1225nt_BP=1072nt
GGCGAGAGAGGACCCAGGTGTCCTGGCAGTGGGCGCCGCGGGGCACACGCTGGGCCAAGGTGCAGGCGGCCAGGGTGGGAGACTGTTCGC
CCCGCCCTGAGTACTCCTATCTTGTTTCTCCACCTGTTCGGGAGTTGGAGATGTGCACCTAAAGGAGGCGCATCTGGGGACGGACACATC
TGGCACTGAGGCCCTCGCCACCTGCCTCGCCACCTGGCGACCCTGACCCCACCACACTGCCTTGAGAGTCGCTCAAAAGTAGGGCCCCAG
GGCTCGCAGCAGCATGGGCACCGAGAAAGAAAGCCCAGAGCCCGACTGCCAGAAACAGTTCCAGGCTGCAGTGAGCGTCATCCAGAACCT
GCCCAAGAACGGTTCTTACCGCCCCTCCTATGAAGAGATGCTGCGATTCTACAGTTACTACAAGCAGGCCACCATGGGGCCCTGCCTGGT
CCCCCGGCCCGGGTTCTGGGACCCCATTGGACGATATAAGTGGGACGCCTGGAACAGTCTGGGCAAGATGAGCAGGGAGGAGGCCATGTC
TGCCTACATCACTGAAATGAAACTGGTGGCACAGAAGGTGATCGACACAGTGCCCCTGGGTGAGGTGGCAGAGGACATGTTTGGTTACTT
CGAGCCCCTGTACCAGGTGATCCCTGACATGCCGAGGCCCCCAGAGACCTTCCTGAGAAGGGTCACAGGTTGGAAAGAGCAGGTTGTGAA
TGGAGATGTTGGGGCTGTTTCAGAGCCTCCCTGCCTCCCCAAGGAACCGGCACCCCCAAGCCCAGAGTCCCATTCACCCAGGGACCTGGA
CTCCGAGGTTTTCTGTGATTCCCTGGAGCAGCTGGAGCCTGAGCTGGTTTGGACAGAGCAGCGGGCAGCATCTGGAGGAAAGCGTGATCC
CAGGAACAGCCCCGTGCCCCCCACAAAGAAAGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGAC
AGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGATATGTTG
TCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAGCCCTGCCATA

>1253_1253_2_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000321854_LRRC37A_chr17_44412911_ENST00000393465_length(amino acids)=295AA_BP=262
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYIT
EMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVF
CDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEGLRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQICCHRRS

--------------------------------------------------------------
>1253_1253_3_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000321854_LRRC37A_chr17_44412911_ENST00000496930_length(transcript)=1435nt_BP=1072nt
GGCGAGAGAGGACCCAGGTGTCCTGGCAGTGGGCGCCGCGGGGCACACGCTGGGCCAAGGTGCAGGCGGCCAGGGTGGGAGACTGTTCGC
CCCGCCCTGAGTACTCCTATCTTGTTTCTCCACCTGTTCGGGAGTTGGAGATGTGCACCTAAAGGAGGCGCATCTGGGGACGGACACATC
TGGCACTGAGGCCCTCGCCACCTGCCTCGCCACCTGGCGACCCTGACCCCACCACACTGCCTTGAGAGTCGCTCAAAAGTAGGGCCCCAG
GGCTCGCAGCAGCATGGGCACCGAGAAAGAAAGCCCAGAGCCCGACTGCCAGAAACAGTTCCAGGCTGCAGTGAGCGTCATCCAGAACCT
GCCCAAGAACGGTTCTTACCGCCCCTCCTATGAAGAGATGCTGCGATTCTACAGTTACTACAAGCAGGCCACCATGGGGCCCTGCCTGGT
CCCCCGGCCCGGGTTCTGGGACCCCATTGGACGATATAAGTGGGACGCCTGGAACAGTCTGGGCAAGATGAGCAGGGAGGAGGCCATGTC
TGCCTACATCACTGAAATGAAACTGGTGGCACAGAAGGTGATCGACACAGTGCCCCTGGGTGAGGTGGCAGAGGACATGTTTGGTTACTT
CGAGCCCCTGTACCAGGTGATCCCTGACATGCCGAGGCCCCCAGAGACCTTCCTGAGAAGGGTCACAGGTTGGAAAGAGCAGGTTGTGAA
TGGAGATGTTGGGGCTGTTTCAGAGCCTCCCTGCCTCCCCAAGGAACCGGCACCCCCAAGCCCAGAGTCCCATTCACCCAGGGACCTGGA
CTCCGAGGTTTTCTGTGATTCCCTGGAGCAGCTGGAGCCTGAGCTGGTTTGGACAGAGCAGCGGGCAGCATCTGGAGGAAAGCGTGATCC
CAGGAACAGCCCCGTGCCCCCCACAAAGAAAGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGAC
AGTTCGAGCACTACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGATATGTTG
TCACCGAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGGCATTTTCAGATTTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGA
GAGTCAGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTTAAAGATCTGTACAAACCTCTCAGTGCCACAAGAATAAATAATCATGC
ATGGAAGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTCAACAGGGACCCTGGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAG

>1253_1253_3_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000321854_LRRC37A_chr17_44412911_ENST00000496930_length(amino acids)=360AA_BP=0
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYIT
EMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVF
CDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEGLRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQICCHRRS
LQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP

--------------------------------------------------------------
>1253_1253_4_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000398322_LRRC37A_chr17_44412911_ENST00000320254_length(transcript)=1612nt_BP=1247nt
AGTAGGAAGCCGCGGGGTGGTGGCGAGAGAGGACCCAGGTGTCCTGGCAGTGGGCGCCGCGGGGCACACGCTGGGCCAAGGTGCAGGCGG
CCAGGGTGGGAGACTGTTCGCCCCGCCCTGAGTACTCCTATCTTGTTTCTCCACCTGTTCGGGAGTTGGAGATGTGCACCTAAAGGAGGC
GCATCTGGGGACGGACACATCTGGCACTGAGGCCCTCGCCACCTGCCTCGCCACCTGGCGACCCTGACCCCACCACACTGCCTTGAGGTA
GGAAAAGGAGGCTCCTCAACCACAACTTCTGACCTCCCAGGGTGTCTGAGGCCTCTAAAGAGCTTAGTTTGCCCCTCTGGGAAGTGAATC
CTTGGCTTATGGTGCCGGGGGGACCCTGGAGGCCCCCTCACACGAAGGCTGCTTCTTGCAGAGTCGCTCAAAAGTAGGGCCCCAGGGCTC
GCAGCAGCATGGGCACCGAGAAAGAAAGCCCAGAGCCCGACTGCCAGAAACAGTTCCAGGCTGCAGTGAGCGTCATCCAGAACCTGCCCA
AGAACGGTTCTTACCGCCCCTCCTATGAAGAGATGCTGCGATTCTACAGTTACTACAAGCAGGCCACCATGGGGCCCTGCCTGGTCCCCC
GGCCCGGGTTCTGGGACCCCATTGGACGATATAAGTGGGACGCCTGGAACAGTCTGGGCAAGATGAGCAGGGAGGAGGCCATGTCTGCCT
ACATCACTGAAATGAAACTGGTGGCACAGAAGGTGATCGACACAGTGCCCCTGGGTGAGGTGGCAGAGGACATGTTTGGTTACTTCGAGC
CCCTGTACCAGGTGATCCCTGACATGCCGAGGCCCCCAGAGACCTTCCTGAGAAGGGTCACAGGTTGGAAAGAGCAGGTTGTGAATGGAG
ATGTTGGGGCTGTTTCAGAGCCTCCCTGCCTCCCCAAGGAACCGGCACCCCCAAGCCCAGAGTCCCATTCACCCAGGGACCTGGACTCCG
AGGTTTTCTGTGATTCCCTGGAGCAGCTGGAGCCTGAGCTGGTTTGGACAGAGCAGCGGGCAGCATCTGGAGGAAAGCGTGATCCCAGGA
ACAGCCCCGTGCCCCCCACAAAGAAAGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTC
GAGCACTACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGATATGTTGTCACC
GAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGGCATTTTCAGATTTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGAGAGTC
AGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTTAAAGATCTGTACAAACCTCTCAGTGCCACAAGAATAAATAATCATGCATGGA
AGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTCAACAGGGACCCTGGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAG

>1253_1253_4_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000398322_LRRC37A_chr17_44412911_ENST00000320254_length(amino acids)=360AA_BP=0
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYIT
EMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVF
CDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEGLRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQICCHRRS
LQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP

--------------------------------------------------------------
>1253_1253_5_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000398322_LRRC37A_chr17_44412911_ENST00000393465_length(transcript)=1400nt_BP=1247nt
AGTAGGAAGCCGCGGGGTGGTGGCGAGAGAGGACCCAGGTGTCCTGGCAGTGGGCGCCGCGGGGCACACGCTGGGCCAAGGTGCAGGCGG
CCAGGGTGGGAGACTGTTCGCCCCGCCCTGAGTACTCCTATCTTGTTTCTCCACCTGTTCGGGAGTTGGAGATGTGCACCTAAAGGAGGC
GCATCTGGGGACGGACACATCTGGCACTGAGGCCCTCGCCACCTGCCTCGCCACCTGGCGACCCTGACCCCACCACACTGCCTTGAGGTA
GGAAAAGGAGGCTCCTCAACCACAACTTCTGACCTCCCAGGGTGTCTGAGGCCTCTAAAGAGCTTAGTTTGCCCCTCTGGGAAGTGAATC
CTTGGCTTATGGTGCCGGGGGGACCCTGGAGGCCCCCTCACACGAAGGCTGCTTCTTGCAGAGTCGCTCAAAAGTAGGGCCCCAGGGCTC
GCAGCAGCATGGGCACCGAGAAAGAAAGCCCAGAGCCCGACTGCCAGAAACAGTTCCAGGCTGCAGTGAGCGTCATCCAGAACCTGCCCA
AGAACGGTTCTTACCGCCCCTCCTATGAAGAGATGCTGCGATTCTACAGTTACTACAAGCAGGCCACCATGGGGCCCTGCCTGGTCCCCC
GGCCCGGGTTCTGGGACCCCATTGGACGATATAAGTGGGACGCCTGGAACAGTCTGGGCAAGATGAGCAGGGAGGAGGCCATGTCTGCCT
ACATCACTGAAATGAAACTGGTGGCACAGAAGGTGATCGACACAGTGCCCCTGGGTGAGGTGGCAGAGGACATGTTTGGTTACTTCGAGC
CCCTGTACCAGGTGATCCCTGACATGCCGAGGCCCCCAGAGACCTTCCTGAGAAGGGTCACAGGTTGGAAAGAGCAGGTTGTGAATGGAG
ATGTTGGGGCTGTTTCAGAGCCTCCCTGCCTCCCCAAGGAACCGGCACCCCCAAGCCCAGAGTCCCATTCACCCAGGGACCTGGACTCCG
AGGTTTTCTGTGATTCCCTGGAGCAGCTGGAGCCTGAGCTGGTTTGGACAGAGCAGCGGGCAGCATCTGGAGGAAAGCGTGATCCCAGGA
ACAGCCCCGTGCCCCCCACAAAGAAAGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTC
GAGCACTACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGATATGTTGTCACC
GAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAGCCCTGCCATAGGAGG

>1253_1253_5_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000398322_LRRC37A_chr17_44412911_ENST00000393465_length(amino acids)=295AA_BP=262
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYIT
EMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVF
CDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEGLRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQICCHRRS

--------------------------------------------------------------
>1253_1253_6_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000398322_LRRC37A_chr17_44412911_ENST00000496930_length(transcript)=1610nt_BP=1247nt
AGTAGGAAGCCGCGGGGTGGTGGCGAGAGAGGACCCAGGTGTCCTGGCAGTGGGCGCCGCGGGGCACACGCTGGGCCAAGGTGCAGGCGG
CCAGGGTGGGAGACTGTTCGCCCCGCCCTGAGTACTCCTATCTTGTTTCTCCACCTGTTCGGGAGTTGGAGATGTGCACCTAAAGGAGGC
GCATCTGGGGACGGACACATCTGGCACTGAGGCCCTCGCCACCTGCCTCGCCACCTGGCGACCCTGACCCCACCACACTGCCTTGAGGTA
GGAAAAGGAGGCTCCTCAACCACAACTTCTGACCTCCCAGGGTGTCTGAGGCCTCTAAAGAGCTTAGTTTGCCCCTCTGGGAAGTGAATC
CTTGGCTTATGGTGCCGGGGGGACCCTGGAGGCCCCCTCACACGAAGGCTGCTTCTTGCAGAGTCGCTCAAAAGTAGGGCCCCAGGGCTC
GCAGCAGCATGGGCACCGAGAAAGAAAGCCCAGAGCCCGACTGCCAGAAACAGTTCCAGGCTGCAGTGAGCGTCATCCAGAACCTGCCCA
AGAACGGTTCTTACCGCCCCTCCTATGAAGAGATGCTGCGATTCTACAGTTACTACAAGCAGGCCACCATGGGGCCCTGCCTGGTCCCCC
GGCCCGGGTTCTGGGACCCCATTGGACGATATAAGTGGGACGCCTGGAACAGTCTGGGCAAGATGAGCAGGGAGGAGGCCATGTCTGCCT
ACATCACTGAAATGAAACTGGTGGCACAGAAGGTGATCGACACAGTGCCCCTGGGTGAGGTGGCAGAGGACATGTTTGGTTACTTCGAGC
CCCTGTACCAGGTGATCCCTGACATGCCGAGGCCCCCAGAGACCTTCCTGAGAAGGGTCACAGGTTGGAAAGAGCAGGTTGTGAATGGAG
ATGTTGGGGCTGTTTCAGAGCCTCCCTGCCTCCCCAAGGAACCGGCACCCCCAAGCCCAGAGTCCCATTCACCCAGGGACCTGGACTCCG
AGGTTTTCTGTGATTCCCTGGAGCAGCTGGAGCCTGAGCTGGTTTGGACAGAGCAGCGGGCAGCATCTGGAGGAAAGCGTGATCCCAGGA
ACAGCCCCGTGCCCCCCACAAAGAAAGAGGGGTTGCGGGGCAGCCCGCCGGGGCCCCAGGAGTTGGACGTGTGGCTGCTGGGGACAGTTC
GAGCACTACAGGAGAGCATGCAGGAGGTGCAGGCGAGGGTGCAGAGCCTGGAGAGCATGCCCCGGCCCCCTGAGCAGATATGTTGTCACC
GAAGGTCATTACAAGAAGATGAAGAAGGATTCTCAAGGGGCATTTTCAGATTTCTGCCATGGAGGGGATGCTCTTCGCGAAGGGAGAGTC
AGGATGGACTTTCCTCATTTGGACAGCCGCTCTGGTTTAAAGATCTGTACAAACCTCTCAGTGCCACAAGAATAAATAATCATGCATGGA
AGCTGCACAAGAAGTCATCTAATGAGGACAAGATCCTCAACAGGGACCCTGGGGACAGCGAAGCCCCAACGGAGGAGGAGGAGAGTGAAG

>1253_1253_6_ACBD4-LRRC37A_ACBD4_chr17_43216527_ENST00000398322_LRRC37A_chr17_44412911_ENST00000496930_length(amino acids)=360AA_BP=0
MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYSYYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYIT
EMKLVAQKVIDTVPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPKEPAPPSPESHSPRDLDSEVF
CDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEGLRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQICCHRRS
LQEDEEGFSRGIFRFLPWRGCSSRRESQDGLSSFGQPLWFKDLYKPLSATRINNHAWKLHKKSSNEDKILNRDPGDSEAPTEEEESEALP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACBD4-LRRC37A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACBD4-LRRC37A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACBD4-LRRC37A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource