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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CALML4-ITGA11 (FusionGDB2 ID:12579)

Fusion Gene Summary for CALML4-ITGA11

check button Fusion gene summary
Fusion gene informationFusion gene name: CALML4-ITGA11
Fusion gene ID: 12579
HgeneTgene
Gene symbol

CALML4

ITGA11

Gene ID

91860

22801

Gene namecalmodulin like 4integrin subunit alpha 11
SynonymsNY-BR-20HsT18964
Cytomap

15q23

15q23

Type of geneprotein-codingprotein-coding
Descriptioncalmodulin-like protein 4serologically defined breast cancer antigen NY-BR-20integrin alpha-11
Modification date2020031320200313
UniProtAcc.

Q9UKX5

Ensembl transtripts involved in fusion geneENST00000448060, ENST00000467889, 
ENST00000540479, ENST00000395465, 
ENST00000562826, ENST00000315757, 
ENST00000423218, 
Fusion gene scores* DoF score3 X 3 X 3=274 X 5 X 3=60
# samples 35
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALML4 [Title/Abstract] AND ITGA11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCALML4(68489778)-ITGA11(68613841), # samples:2
Anticipated loss of major functional domain due to fusion event.CALML4-ITGA11 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
CALML4-ITGA11 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CALML4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGA11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-0970-01BCALML4chr15

68489778

-ITGA11chr15

68613841

-


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Fusion Gene ORF analysis for CALML4-ITGA11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000448060ENST00000562826CALML4chr15

68489778

-ITGA11chr15

68613841

-
5CDS-intronENST00000467889ENST00000562826CALML4chr15

68489778

-ITGA11chr15

68613841

-
5CDS-intronENST00000540479ENST00000562826CALML4chr15

68489778

-ITGA11chr15

68613841

-
Frame-shiftENST00000448060ENST00000315757CALML4chr15

68489778

-ITGA11chr15

68613841

-
Frame-shiftENST00000448060ENST00000423218CALML4chr15

68489778

-ITGA11chr15

68613841

-
Frame-shiftENST00000467889ENST00000315757CALML4chr15

68489778

-ITGA11chr15

68613841

-
Frame-shiftENST00000467889ENST00000423218CALML4chr15

68489778

-ITGA11chr15

68613841

-
In-frameENST00000540479ENST00000315757CALML4chr15

68489778

-ITGA11chr15

68613841

-
In-frameENST00000540479ENST00000423218CALML4chr15

68489778

-ITGA11chr15

68613841

-
intron-3CDSENST00000395465ENST00000315757CALML4chr15

68489778

-ITGA11chr15

68613841

-
intron-3CDSENST00000395465ENST00000423218CALML4chr15

68489778

-ITGA11chr15

68613841

-
intron-intronENST00000395465ENST00000562826CALML4chr15

68489778

-ITGA11chr15

68613841

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000540479CALML4chr1568489778-ENST00000315757ITGA11chr1568613841-3727113511892379396
ENST00000540479CALML4chr1568489778-ENST00000423218ITGA11chr1568613841-3730113511892382397

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000540479ENST00000315757CALML4chr1568489778-ITGA11chr1568613841-0.0052068830.9947931
ENST00000540479ENST00000423218CALML4chr1568489778-ITGA11chr1568613841-0.004458790.99554116

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Fusion Genomic Features for CALML4-ITGA11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CALML4-ITGA11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:68489778/chr15:68613841)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ITGA11

Q9UKX5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Integrin alpha-11/beta-1 is a receptor for collagen.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALML4chr15:68489778chr15:68613841ENST00000448060-3451_86117150.0DomainEF-hand 1
HgeneCALML4chr15:68489778chr15:68613841ENST00000467889-45124_159164197.0DomainEF-hand 3
HgeneCALML4chr15:68489778chr15:68613841ENST00000467889-4551_86164197.0DomainEF-hand 1
HgeneCALML4chr15:68489778chr15:68613841ENST00000467889-4587_122164197.0DomainEF-hand 2
HgeneCALML4chr15:68489778chr15:68613841ENST00000540479-3451_8688121.0DomainEF-hand 1
TgeneITGA11chr15:68489778chr15:68613841ENST0000031575717301153_11617741189.0Compositional biasNote=Poly-Leu
TgeneITGA11chr15:68489778chr15:68613841ENST0000031575717301173_11767741189.0Compositional biasNote=Poly-Arg
TgeneITGA11chr15:68489778chr15:68613841ENST0000042321817301153_11617741190.0Compositional biasNote=Poly-Leu
TgeneITGA11chr15:68489778chr15:68613841ENST0000042321817301173_11767741190.0Compositional biasNote=Poly-Arg
TgeneITGA11chr15:68489778chr15:68613841ENST0000031575717301165_11887741189.0Topological domainCytoplasmic
TgeneITGA11chr15:68489778chr15:68613841ENST0000042321817301165_11887741190.0Topological domainCytoplasmic
TgeneITGA11chr15:68489778chr15:68613841ENST0000031575717301142_11647741189.0TransmembraneHelical
TgeneITGA11chr15:68489778chr15:68613841ENST0000042321817301142_11647741190.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALML4chr15:68489778chr15:68613841ENST00000448060-34124_159117150.0DomainEF-hand 3
HgeneCALML4chr15:68489778chr15:68613841ENST00000448060-34160_195117150.0DomainEF-hand 4
HgeneCALML4chr15:68489778chr15:68613841ENST00000448060-3487_122117150.0DomainEF-hand 2
HgeneCALML4chr15:68489778chr15:68613841ENST00000467889-45160_195164197.0DomainEF-hand 4
HgeneCALML4chr15:68489778chr15:68613841ENST00000540479-34124_15988121.0DomainEF-hand 3
HgeneCALML4chr15:68489778chr15:68613841ENST00000540479-34160_19588121.0DomainEF-hand 4
HgeneCALML4chr15:68489778chr15:68613841ENST00000540479-3487_12288121.0DomainEF-hand 2
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730488_4967741189.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730551_5597741189.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730613_6217741189.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730488_4967741190.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730551_5597741190.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730613_6217741190.0Calcium bindingOntology_term=ECO:0000255
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730164_3457741189.0DomainVWFA
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730164_3457741190.0DomainVWFA
TgeneITGA11chr15:68489778chr15:68613841ENST00000315757173024_857741189.0RepeatFG-GAP 1
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730355_4067741189.0RepeatFG-GAP 3
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730411_4617741189.0RepeatFG-GAP 4
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730462_5277741189.0RepeatFG-GAP 5
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730528_5867741189.0RepeatFG-GAP 6
TgeneITGA11chr15:68489778chr15:68613841ENST000003157571730590_6507741189.0RepeatFG-GAP 7
TgeneITGA11chr15:68489778chr15:68613841ENST00000315757173091_1517741189.0RepeatFG-GAP 2
TgeneITGA11chr15:68489778chr15:68613841ENST00000423218173024_857741190.0RepeatFG-GAP 1
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730355_4067741190.0RepeatFG-GAP 3
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730411_4617741190.0RepeatFG-GAP 4
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730462_5277741190.0RepeatFG-GAP 5
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730528_5867741190.0RepeatFG-GAP 6
TgeneITGA11chr15:68489778chr15:68613841ENST000004232181730590_6507741190.0RepeatFG-GAP 7
TgeneITGA11chr15:68489778chr15:68613841ENST00000423218173091_1517741190.0RepeatFG-GAP 2
TgeneITGA11chr15:68489778chr15:68613841ENST00000315757173023_11417741189.0Topological domainExtracellular
TgeneITGA11chr15:68489778chr15:68613841ENST00000423218173023_11417741190.0Topological domainExtracellular


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Fusion Gene Sequence for CALML4-ITGA11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12579_12579_1_CALML4-ITGA11_CALML4_chr15_68489778_ENST00000540479_ITGA11_chr15_68613841_ENST00000315757_length(transcript)=3727nt_BP=1135nt
CCGGCACTAAGAGGCCTCACTCCAAGCCCCCGAGGAGCCTGTGGTGGGGCTGGAGACCCGGCTCAGGCCCCTCCACCACCCTTAAAGTCC
TCAGAAGGTGGGAACTGAACTGGCACAGGATGGGAACCGGCTGTGCGCTGGCCACTTGATTTTGCCAGCTGCCCTGTAATTCAGCTGGTG
AGGAAACTGAGGCACAGACTGAGGTAGAATGATTCGCCAGTCACTCAGCAAGTCAGCAGACGGGGAGGACTGAATCCCAGCCTGAGAGCA
CCGAAGCTTGTATCCCTGCAATACCGAGCCCCAAGCCTGCGAGCCCCGGTGCCCATCTCTGAGTTAGGCCGTCTTGGAAGGGTTCCCTTC
CTCCTACAAGATGGTGTGTGAGGAGCCTTCAATACGACCCGGGGTGTAAAGTGTCCAACTCTAGTAGGGGCCTGATGGCATCCCCGCCGA
GTCCCAGGAGAGAGAGAGAAGACCCCTTCCTGGAGTCCAGGGCTCCCGGGAAGAAACACTGGCATTTGTCCCTTTGCTTCGGCTTCTGGA
GGCAGAGACTCTGAGCCCAGGGAGAGCCTTCTGCAGCCCCATTTCCTCAAAAATCCAACCTGCCCAGGTGGCGGGTCATGAGCTGTGCTC
AGGAAGCTGGAATCTGACCCTGGTGGCGTCGGGCCCAGTCTCCATGGCAGCCGAGCATTTATTACCCGGGCCTCCACCCAGCTTGGCAGA
CTTTAGACTTGAGGCTGGAGGAAAGGGAACTGAACGCGGTTCTGGGAGCAGCAAGCCCACGGGTAGCAGCCGAGGCCCCAGAATGAGTAC
AAGGAATGCTTCTCCCTGTATGACAAGCAGCAGAGGGGGAAGATAAAAGCCACCGACCTCATGGTGGCCATGAGGTGCCTGGGGGCCAGC
CCGACGCCAGGGGAGGTGCAGCGGCACCTGCAGACCCACGGGATAGACGGAAATGGAGAGCTGGATTTCTCCACTTTTCTGACCATTATG
CACATGCAAATAAAACAAGAAGACCCAAAGAAAGAAATTCTTCTAGCCATGTTGATGGTGGACAAGGAGAAGAAAGGTTACGTCATGGCG
TCCGACCTGCGGTCAAAACTCACGAGTCTGGGGGAGAAGCTCACCCACAAGGAAGGTGCCCTTCTGGAACGGCTGCAATGAGGATGAGCA
CTGTGTCCCTGACCTTGTGTTGGATGCCCGGAGTGACCTGCCCACGGCCATGGAGTACTGCCAGAGGGTGCTGAGGAAGCCTGCGCAGGA
CTGCTCCGCATACACGCTGTCCTTCGACACCACAGTCTTCATCATAGAGAGCACACGCCAGCGAGTGGCGGTGGAGGCCACACTGGAGAA
CAGGGGCGAGAACGCCTACAGCACGGTCCTAAATATCTCGCAGTCAGCAAACCTGCAGTTTGCCAGCTTGATCCAGAAGGAGGACTCAGA
CGGTAGCATTGAGTGTGTGAACGAGGAGAGGAGGCTCCAGAAGCAAGTCTGCAACGTCAGCTATCCCTTCTTCCGGGCCAAGGCCAAGGT
GGCTTTCCGTCTTGATTTTGAGTTCAGCAAATCCATCTTCCTACACCACCTGGAGATCGAGCTCGCTGCAGGCAGTGACAGTAATGAGCG
GGACAGCACCAAGGAAGACAACGTGGCCCCCTTACGCTTCCACCTCAAATACGAGGCTGACGTCCTCTTCACCAGGAGCAGCAGCCTGAG
CCACTACGAGGTCAAGCCCAACAGCTCGCTGGAGAGATACGATGGTATCGGGCCTCCCTTCAGCTGCATCTTCAGGATCCAGAACTTGGG
CTTGTTCCCCATCCACGGGATGATGATGAAGATCACCATTCCCATCGCCACCAGGAGCGGCAACCGCCTACTGAAGCTGAGGGACTTCCT
CACGGACGAGGCGAACACGTCCTGTAACATCTGGGGCAATAGCACTGAGTACCGGCCCACCCCAGTGGAGGAAGACTTGCGTCGTGCTCC
ACAGCTGAATCACAGCAACTCTGATGTCGTCTCCATCAACTGCAATATACGGCTGGTCCCCAACCAGGAAATCAATTTCCATCTACTGGG
GAACCTGTGGTTGAGGTCCCTAAAAGCACTCAAGTACAAATCCATGAAAATCATGGTCAACGCAGCCTTGCAGAGGCAGTTCCACAGCCC
CTTCATCTTCCGTGAGGAGGATCCCAGCCGCCAGATCGTGTTTGAGATCTCCAAGCAAGAGGACTGGCAGGTCCCCATCTGGATCATTGT
AGGCAGCACCCTGGGGGGCCTCCTACTGCTGGCCCTGCTGGTCCTGGCACTGTGGAAGCTCGGCTTCTTTAGAAGTGCCAGGCGCAGGAG
GGAGCCTGGTCTGGACCCCACCCCCAAAGTGCTGGAGTGAGGCTCCAGAGGAGACTTTGAGTTGATGGGGGCCAGGACACCAGTCCAGGT
AGTGTTGAGACCCAGGCCTGTGGCCCCACCGAGCTGGAGCGGAGAGGAAGCCAGCTGGCTTTGCACTTGACCTCATCTCCCGAGCAATGG
CGCCTGCTCCCTCCAGAATGGAACTCAAGCTGGTTTTAAGTGGAACTGCCCTACTGGGAGACTGGGACACCTTTAACACAGACCCCTAGG
GATTTAAAGGGACACCCCTACACACACCCAGGCCCATGCCAAGGCCTCCCTCAGGCTCTGTGGAGGGCATTTGCTGCCCCAGCTACTAAG
GTGCTAGGAATTCGTAATCATCCCCATCCTCCAGAGAAACCCAGGGAGGAAGACTGTAAATACGAACCCAATCTGCACACTCCAGGCCTC
TAGTTCCAGAAGGATCCAAGACAAAACAGATCTGAATTCTGCCCTTTTCTCTCACCCATCCCACCCCTCCATTGGCTCCCAAGTCACACC
CACTCCCTTCCCCATAGATAGGCCCCTGGGGCTCCCGAAGAATGAACCCAAGAGCAAGGGCTTGATGGTGACAGCTGCAAGCCAGGGATG
AAGAAAGACTCTGAGATGTGGAGACTGATGGCCAGGCAAGTGGGACCAGGATACTGGACGCTGTCCTGAGATGAGAGGTAGCCGGGCTCT
GCACCCACGTGCATTCACATTGACCGCAACTCACACATTCCCCCACCAGCTGCAGCCCCTTGCTCTCAGCTGCCAACCCTCCCGGGTCAC
TTTTGTTCCCAGGTACCTCATGGGAAGCATGTGGATGACACAATCCCTGGGGCTGTGCATTCCCACGTCTTCTTGCTGCAGCCTGCCCCT
AGACATGGACGCACCGGCCTGGCTGCAGCTGGGCAGCAGGGGTAGGGGTAGGGAGCCTCCCCTCCCTGTATCACCCCCTCCCTACACACA
CACACACACACACACACACACACACACACACACACACACACACACACACACACTGCCTCCCATCCTTCCCTCATGCCCGCCAGTGCACAG
GGAAGGGCTTGGCCAGCGCTGTTGAGGGGTCCCCTCTGGAATGCACTGAATAAAGCACGTGCAAGGACTCCCGGAGCCTGTGCAGCCTTG
GTGGCAAATATCTCATCTGCCGGCCCCCAGGACAAGTGGTATGACCAGTGATAATGCCCCAAGGACAAGGGGCGTGCCTGGCGCCCAGTG
GAGTAATTTATGCCTTAGTCTTGTTTTGAGGTAGAAATGCAAGGGGGACACATGAAAGGCATCAGTCCCCCTGTGCATAGTACGACCTTT

>12579_12579_1_CALML4-ITGA11_CALML4_chr15_68489778_ENST00000540479_ITGA11_chr15_68613841_ENST00000315757_length(amino acids)=396AA_BP=
MDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECV
NEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKP
NSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSN
SDVVSINCNIRLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQVPIWIIVGSTLGG

--------------------------------------------------------------
>12579_12579_2_CALML4-ITGA11_CALML4_chr15_68489778_ENST00000540479_ITGA11_chr15_68613841_ENST00000423218_length(transcript)=3730nt_BP=1135nt
CCGGCACTAAGAGGCCTCACTCCAAGCCCCCGAGGAGCCTGTGGTGGGGCTGGAGACCCGGCTCAGGCCCCTCCACCACCCTTAAAGTCC
TCAGAAGGTGGGAACTGAACTGGCACAGGATGGGAACCGGCTGTGCGCTGGCCACTTGATTTTGCCAGCTGCCCTGTAATTCAGCTGGTG
AGGAAACTGAGGCACAGACTGAGGTAGAATGATTCGCCAGTCACTCAGCAAGTCAGCAGACGGGGAGGACTGAATCCCAGCCTGAGAGCA
CCGAAGCTTGTATCCCTGCAATACCGAGCCCCAAGCCTGCGAGCCCCGGTGCCCATCTCTGAGTTAGGCCGTCTTGGAAGGGTTCCCTTC
CTCCTACAAGATGGTGTGTGAGGAGCCTTCAATACGACCCGGGGTGTAAAGTGTCCAACTCTAGTAGGGGCCTGATGGCATCCCCGCCGA
GTCCCAGGAGAGAGAGAGAAGACCCCTTCCTGGAGTCCAGGGCTCCCGGGAAGAAACACTGGCATTTGTCCCTTTGCTTCGGCTTCTGGA
GGCAGAGACTCTGAGCCCAGGGAGAGCCTTCTGCAGCCCCATTTCCTCAAAAATCCAACCTGCCCAGGTGGCGGGTCATGAGCTGTGCTC
AGGAAGCTGGAATCTGACCCTGGTGGCGTCGGGCCCAGTCTCCATGGCAGCCGAGCATTTATTACCCGGGCCTCCACCCAGCTTGGCAGA
CTTTAGACTTGAGGCTGGAGGAAAGGGAACTGAACGCGGTTCTGGGAGCAGCAAGCCCACGGGTAGCAGCCGAGGCCCCAGAATGAGTAC
AAGGAATGCTTCTCCCTGTATGACAAGCAGCAGAGGGGGAAGATAAAAGCCACCGACCTCATGGTGGCCATGAGGTGCCTGGGGGCCAGC
CCGACGCCAGGGGAGGTGCAGCGGCACCTGCAGACCCACGGGATAGACGGAAATGGAGAGCTGGATTTCTCCACTTTTCTGACCATTATG
CACATGCAAATAAAACAAGAAGACCCAAAGAAAGAAATTCTTCTAGCCATGTTGATGGTGGACAAGGAGAAGAAAGGTTACGTCATGGCG
TCCGACCTGCGGTCAAAACTCACGAGTCTGGGGGAGAAGCTCACCCACAAGGAAGGTGCCCTTCTGGAACGGCTGCAATGAGGATGAGCA
CTGTGTCCCTGACCTTGTGTTGGATGCCCGGAGTGACCTGCCCACGGCCATGGAGTACTGCCAGAGGGTGCTGAGGAAGCCTGCGCAGGA
CTGCTCCGCATACACGCTGTCCTTCGACACCACAGTCTTCATCATAGAGAGCACACGCCAGCGAGTGGCGGTGGAGGCCACACTGGAGAA
CAGGGGCGAGAACGCCTACAGCACGGTCCTAAATATCTCGCAGTCAGCAAACCTGCAGTTTGCCAGCTTGATCCAGAAGGAGGACTCAGA
CGGTAGCATTGAGTGTGTGAACGAGGAGAGGAGGCTCCAGAAGCAAGTCTGCAACGTCAGCTATCCCTTCTTCCGGGCCAAGGCCAAGGT
GGCTTTCCGTCTTGATTTTGAGTTCAGCAAATCCATCTTCCTACACCACCTGGAGATCGAGCTCGCTGCAGGCAGTGACAGTAATGAGCG
GGACAGCACCAAGGAAGACAACGTGGCCCCCTTACGCTTCCACCTCAAATACGAGGCTGACGTCCTCTTCACCAGGAGCAGCAGCCTGAG
CCACTACGAGGTCAAGCCCAACAGCTCGCTGGAGAGATACGATGGTATCGGGCCTCCCTTCAGCTGCATCTTCAGGATCCAGAACTTGGG
CTTGTTCCCCATCCACGGGATGATGATGAAGATCACCATTCCCATCGCCACCAGGAGCGGCAACCGCCTACTGAAGCTGAGGGACTTCCT
CACGGACGAGGTGGCGAACACGTCCTGTAACATCTGGGGCAATAGCACTGAGTACCGGCCCACCCCAGTGGAGGAAGACTTGCGTCGTGC
TCCACAGCTGAATCACAGCAACTCTGATGTCGTCTCCATCAACTGCAATATACGGCTGGTCCCCAACCAGGAAATCAATTTCCATCTACT
GGGGAACCTGTGGTTGAGGTCCCTAAAAGCACTCAAGTACAAATCCATGAAAATCATGGTCAACGCAGCCTTGCAGAGGCAGTTCCACAG
CCCCTTCATCTTCCGTGAGGAGGATCCCAGCCGCCAGATCGTGTTTGAGATCTCCAAGCAAGAGGACTGGCAGGTCCCCATCTGGATCAT
TGTAGGCAGCACCCTGGGGGGCCTCCTACTGCTGGCCCTGCTGGTCCTGGCACTGTGGAAGCTCGGCTTCTTTAGAAGTGCCAGGCGCAG
GAGGGAGCCTGGTCTGGACCCCACCCCCAAAGTGCTGGAGTGAGGCTCCAGAGGAGACTTTGAGTTGATGGGGGCCAGGACACCAGTCCA
GGTAGTGTTGAGACCCAGGCCTGTGGCCCCACCGAGCTGGAGCGGAGAGGAAGCCAGCTGGCTTTGCACTTGACCTCATCTCCCGAGCAA
TGGCGCCTGCTCCCTCCAGAATGGAACTCAAGCTGGTTTTAAGTGGAACTGCCCTACTGGGAGACTGGGACACCTTTAACACAGACCCCT
AGGGATTTAAAGGGACACCCCTACACACACCCAGGCCCATGCCAAGGCCTCCCTCAGGCTCTGTGGAGGGCATTTGCTGCCCCAGCTACT
AAGGTGCTAGGAATTCGTAATCATCCCCATCCTCCAGAGAAACCCAGGGAGGAAGACTGTAAATACGAACCCAATCTGCACACTCCAGGC
CTCTAGTTCCAGAAGGATCCAAGACAAAACAGATCTGAATTCTGCCCTTTTCTCTCACCCATCCCACCCCTCCATTGGCTCCCAAGTCAC
ACCCACTCCCTTCCCCATAGATAGGCCCCTGGGGCTCCCGAAGAATGAACCCAAGAGCAAGGGCTTGATGGTGACAGCTGCAAGCCAGGG
ATGAAGAAAGACTCTGAGATGTGGAGACTGATGGCCAGGCAAGTGGGACCAGGATACTGGACGCTGTCCTGAGATGAGAGGTAGCCGGGC
TCTGCACCCACGTGCATTCACATTGACCGCAACTCACACATTCCCCCACCAGCTGCAGCCCCTTGCTCTCAGCTGCCAACCCTCCCGGGT
CACTTTTGTTCCCAGGTACCTCATGGGAAGCATGTGGATGACACAATCCCTGGGGCTGTGCATTCCCACGTCTTCTTGCTGCAGCCTGCC
CCTAGACATGGACGCACCGGCCTGGCTGCAGCTGGGCAGCAGGGGTAGGGGTAGGGAGCCTCCCCTCCCTGTATCACCCCCTCCCTACAC
ACACACACACACACACACACACACACACACACACACACACACACACACACACACACTGCCTCCCATCCTTCCCTCATGCCCGCCAGTGCA
CAGGGAAGGGCTTGGCCAGCGCTGTTGAGGGGTCCCCTCTGGAATGCACTGAATAAAGCACGTGCAAGGACTCCCGGAGCCTGTGCAGCC
TTGGTGGCAAATATCTCATCTGCCGGCCCCCAGGACAAGTGGTATGACCAGTGATAATGCCCCAAGGACAAGGGGCGTGCCTGGCGCCCA
GTGGAGTAATTTATGCCTTAGTCTTGTTTTGAGGTAGAAATGCAAGGGGGACACATGAAAGGCATCAGTCCCCCTGTGCATAGTACGACC

>12579_12579_2_CALML4-ITGA11_CALML4_chr15_68489778_ENST00000540479_ITGA11_chr15_68613841_ENST00000423218_length(amino acids)=397AA_BP=
MDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAVEATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECV
NEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKP
NSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLLKLRDFLTDEVANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHS
NSDVVSINCNIRLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQVPIWIIVGSTLG

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Fusion Gene PPI Analysis for CALML4-ITGA11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CALML4-ITGA11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CALML4-ITGA11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource