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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CALR-BRD2 (FusionGDB2 ID:12599)

Fusion Gene Summary for CALR-BRD2

check button Fusion gene summary
Fusion gene informationFusion gene name: CALR-BRD2
Fusion gene ID: 12599
HgeneTgene
Gene symbol

CALR

BRD2

Gene ID

811

6046

Gene namecalreticulinbromodomain containing 2
SynonymsCRT|HEL-S-99n|RO|SSA|cC1qRBRD2-IT1|D6S113E|FSH|FSRG1|NAT|O27.1.1|RING3|RNF3
Cytomap

19p13.13

6p21.32

Type of geneprotein-codingprotein-coding
DescriptioncalreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60bromodomain-containing protein 2BRD2 intronic transcript 1female sterile homeotic-related gene 1really interesting new gene 3 protein
Modification date2020032920200313
UniProtAcc

P27797

P25440

Ensembl transtripts involved in fusion geneENST00000316448, ENST00000374831, 
ENST00000383108, ENST00000395287, 
ENST00000395289, ENST00000399527, 
ENST00000399528, ENST00000399529, 
ENST00000414731, ENST00000425201, 
ENST00000436979, ENST00000438194, 
ENST00000442219, ENST00000442863, 
ENST00000443797, ENST00000448067, 
ENST00000449085, ENST00000449118, 
ENST00000450320, ENST00000466208, 
ENST00000466744, ENST00000479973, 
ENST00000482105, ENST00000488549, 
ENST00000496118, ENST00000498329, 
ENST00000546777, ENST00000547286, 
ENST00000547895, ENST00000548837, 
ENST00000549126, ENST00000549236, 
ENST00000549843, ENST00000550142, 
ENST00000550598, ENST00000552513, 
ENST00000552587, ENST00000553146, 
ENST00000580234, ENST00000374825, 
Fusion gene scores* DoF score18 X 17 X 9=275410 X 15 X 3=450
# samples 2416
** MAII scorelog2(24/2754*10)=-3.52042224852645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/450*10)=-1.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CALR [Title/Abstract] AND BRD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCALR(13055304)-BRD2(32944339), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCALR

GO:0000122

negative regulation of transcription by RNA polymerase II

8107809

HgeneCALR

GO:0006611

protein export from nucleus

11149926

HgeneCALR

GO:0017148

negative regulation of translation

14726956

HgeneCALR

GO:0033144

negative regulation of intracellular steroid hormone receptor signaling pathway

8107809

HgeneCALR

GO:0034504

protein localization to nucleus

15998798

HgeneCALR

GO:0045665

negative regulation of neuron differentiation

8107809

HgeneCALR

GO:0045892

negative regulation of transcription, DNA-templated

8107809

HgeneCALR

GO:0048387

negative regulation of retinoic acid receptor signaling pathway

8107809

TgeneBRD2

GO:0006357

regulation of transcription by RNA polymerase II

18406326


check buttonFusion gene breakpoints across CALR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A6E5-01ACALRchr19

13055304

-BRD2chr6

32944339

+


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Fusion Gene ORF analysis for CALR-BRD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000316448ENST00000374831CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000383108CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000395287CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000395289CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000399527CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000399528CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000399529CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000414731CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000425201CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000436979CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000438194CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000442219CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000442863CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000443797CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000448067CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000449085CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000449118CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000450320CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000466208CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000466744CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000479973CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000482105CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000488549CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000496118CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000498329CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000546777CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000547286CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000547895CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000548837CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000549126CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000549236CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000549843CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000550142CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000550598CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000552513CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000552587CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000553146CALRchr19

13055304

-BRD2chr6

32944339

+
5CDS-intronENST00000316448ENST00000580234CALRchr19

13055304

-BRD2chr6

32944339

+
In-frameENST00000316448ENST00000374825CALRchr19

13055304

-BRD2chr6

32944339

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000316448CALRchr1913055304-ENST00000374825BRD2chr632944339+4271190318943483529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000316448ENST00000374825CALRchr1913055304-BRD2chr632944339+0.0054367320.9945633

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Fusion Genomic Features for CALR-BRD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CALR-BRD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:13055304/chr6:32944339)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CALR

P27797

BRD2

P25440

FUNCTION: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7, ECO:0000269|PubMed:11149926, ECO:0000269|PubMed:7876246}.FUNCTION: May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly. {ECO:0000250, ECO:0000269|PubMed:18406326}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99351_408610418.0Compositional biasNote=Asp/Glu/Lys-rich
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99414_417610418.0MotifNote=Prevents secretion from ER
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-9918_197610418.0RegionNote=N-domain
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99191_255610418.0RegionNote=4 X approximate repeats
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99198_308610418.0RegionNote=P-domain
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99259_297610418.0RegionNote=3 X approximate repeats
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99309_417610418.0RegionNote=C-domain
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99191_202610418.0RepeatNote=1-1
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99210_221610418.0RepeatNote=1-2
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99227_238610418.0RepeatNote=1-3
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99244_255610418.0RepeatNote=1-4
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99259_269610418.0RepeatNote=2-1
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99273_283610418.0RepeatNote=2-2
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99287_297610418.0RepeatNote=2-3
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513476_515275802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513492_506275802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513544_566275802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513551_559275802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513775_793275802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513775_801275802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513476_515275802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513492_506275802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513544_566275802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513551_559275802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513775_793275802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513775_801275802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000038310801361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413476_515275837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413492_506275837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413544_566275837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413551_559275837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413775_793275837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413775_801275837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514476_515275837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514492_506275837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514544_566275837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514551_559275837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514775_793275837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514775_801275837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952701361_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952801361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952901361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000041473101361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000043697901261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000043819401361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000044286301361_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000044806701361_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412476_515228755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412492_506228755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412544_566228755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412551_559228755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412775_793228755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412775_801228755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000044911801361_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054728601261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054789501461_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054912601561_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000054923601261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014476_5150837.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014492_5060837.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014544_5660837.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014551_5590837.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000055014201461_640837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014775_7930837.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014775_8010837.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012476_5150755.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012492_5060755.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012544_5660755.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012551_5590755.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000055251301261_640755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012775_7930755.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012775_8010755.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014476_5150802.0Compositional biasNote=Glu/Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014492_5060802.0Compositional biasNote=Poly-Glu
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014544_5660802.0Compositional biasNote=Arg/Lys-rich (highly basic)
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014551_5590802.0Compositional biasNote=Poly-Lys
TgeneBRD2chr19:13055304chr6:32944339ENST0000055258701461_640802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014775_7930802.0Compositional biasNote=Poly-Ser
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014775_8010802.0Compositional biasNote=Ser-rich
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513364_436275802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513632_714275802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513364_436275802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513632_714275802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000038310801391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413364_436275837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413632_714275837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514364_436275837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514632_714275837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952701391_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952801391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000039952901391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000041473101391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000043697901291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000043819401391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000044286301391_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000044806701391_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412364_436228755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412632_714228755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000044911801391_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054728601291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054789501491_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054912601591_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000054923601291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014364_4360837.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014632_7140837.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000055014201491_1630837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012364_4360755.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012632_7140755.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000055251301291_1630755.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014364_4360802.0DomainBromo 2
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014632_7140802.0DomainNET
TgeneBRD2chr19:13055304chr6:32944339ENST0000055258701491_1630802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST00000374825513555_559275802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000374831513555_559275802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000383108013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000395287413555_559275837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000395289514555_559275837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000399527013555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000399528013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000399529013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000414731013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000436979012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000438194013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000442863013555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000448067013555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000449085412555_559228755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000449118013555_5590802.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000547286012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000547895014555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000549126015555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000549236012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000550142014555_5590837.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000552513012555_5590755.0MotifNuclear localization signal
TgeneBRD2chr19:13055304chr6:32944339ENST00000552587014555_5590802.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRD2chr19:13055304chr6:32944339ENST0000037482551361_64275802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000037483151361_64275802.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528741361_64275837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528951461_64275837.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000044908541261_64228755.0Compositional biasNote=Poly-Pro
TgeneBRD2chr19:13055304chr6:32944339ENST0000037482551391_163275802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000037483151391_163275802.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528741391_163275837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000039528951491_163275837.0DomainBromo 1
TgeneBRD2chr19:13055304chr6:32944339ENST0000044908541291_163228755.0DomainBromo 1


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Fusion Gene Sequence for CALR-BRD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12599_12599_1_CALR-BRD2_CALR_chr19_13055304_ENST00000316448_BRD2_chr6_32944339_ENST00000374825_length(transcript)=4271nt_BP=1903nt
CCGTCCGTACTGCAGAGCCGCTGCCGGAGGGTCGTTTTAAAGGGCCCGCGCGTTGCCGCCCCCTCGGCCCGCCATGCTGCTATCCGTGCC
GCTGCTGCTCGGCCTCCTCGGCCTGGCCGTCGCCGAGCCTGCCGTCTACTTCAAGGAGCAGTTTCTGGACGGAGACGGGTGGACTTCCCG
CTGGATCGAATCCAAACACAAGTCAGATTTTGGCAAATTCGTTCTCAGTTCCGGCAAGTTCTACGGTGACGAGGAGAAAGATAAAGGTTT
GCAGACAAGCCAGGATGCACGCTTTTATGCTCTGTCGGCCAGTTTCGAGCCTTTCAGCAACAAAGGCCAGACGCTGGTGGTGCAGTTCAC
GGTGAAACATGAGCAGAACATCGACTGTGGGGGCGGCTATGTGAAGCTGTTTCCTAATAGTTTGGACCAGACAGACATGCACGGAGACTC
AGAATACAACATCATGTTTGGTCCCGACATCTGTGGCCCTGGCACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAACGTGCT
GATCAACAAGGACATCCGTTGCAAGGATGATGAGTTTACACACCTGTACACACTGATTGTGCGGCCAGACAACACCTATGAGGTGAAGAT
TGACAACAGCCAGGTGGAGTCCGGCTCCTTGGAAGACGATTGGGACTTCCTGCCACCCAAGAAGATAAAGGATCCTGATGCTTCAAAACC
GGAAGACTGGGATGAGCGGGCCAAGATCGATGATCCCACAGACTCCAAGCCTGAGGACTGGGACAAGCCCGAGCATATCCCTGACCCTGA
TGCTAAGAAGCCCGAGGACTGGGATGAAGAGATGGACGGAGAGTGGGAACCCCCAGTGATTCAGAACCCTGAGTACAAGGGTGAGTGGAA
GCCCCGGCAGATCGACAACCCAGATTACAAGGGCACTTGGATCCACCCAGAAATTGACAACCCCGAGTATTCTCCCGATCCCAGTATCTA
TGCCTATGATAACTTTGGCGTGCTGGGCCTGGACCTCTGGCAGGTCAAGTCTGGCACCATCTTTGACAACTTCCTCATCACCAACGATGA
GGCATACGCTGAGGAGTTTGGCAACGAGACGTGGGGCGTAACAAAGGCAGCAGAGAAACAAATGAAGGACAAACAGGACGAGGAGCAGAG
GCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAGGAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGA
GGATGAGGAGGACAAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAGAGAGGCCTGCCTCCAGGGCTGGA
CTGAGGCCTGAGCGCTCCTGCCGCAGAGCTGGCCGCGCCAAATAATGTCTCTGTGAGACTCGAGAACTTTCATTTTTTTCCAGGCTGGTT
CGGATTTGGGGTGGATTTTGGTTTTGTTCCCCTCCTCCACTCTCCCCCACCCCCTCCCCGCCCTTTTTTTTTTTTTTTTTTAAACTGGTA
TTTTATCTTTGATTCTCCTTCAGCCCTCACCCCTGGTTCTCATCTTTCTTGATCAACATCTTTTCTTGCCTCTGTCCCCTTCTCTCATCT
CTTAGCTCCCCTCCAACCTGGGGGGCAGTGGTGTGGAGAAGCCACAGGCCTGAGATTTCATCTGCTCTCCTTCCTGGAGCCCAGAGGAGG
GCAGCAGAAGGGGGTGGTGTCTCCAACCCCCCAGCACTGAGGAAGAACGGGGCTCTTCTCATTTCACCCCTCCCTTTCTCCCCTGCCCCC
AGGACTGGGCCACTTCTGGGTGGGGCAGTGGGTCCCAGATTGGCTCACACTGAGAATGTAAGAACTACAAACAAAATTTCTATTAAATTA
AATTTTGTGTCTCAAAAAAGGCGTAAAGCGGAAAGCAGATACTACCACCCCTACACCTACAGCCATCTTGGCTCCTGGTTCTCCAGCTAG
CCCTCCTGGGAGTCTTGAGCCTAAGGCAGCACGGCTTCCCCCTATGCGTAGAGAGAGTGGTCGCCCCATCAAGCCCCCACGCAAAGACTT
GCCTGACTCTCAGCAACAACACCAGAGCTCTAAGAAAGGAAAGCTTTCAGAACAGTTAAAACATTGCAATGGCATTTTGAAGGAGTTACT
CTCTAAGAAGCATGCTGCCTATGCTTGGCCTTTCTATAAACCAGTGGATGCTTCTGCACTTGGCCTGCATGACTACCATGACATCATTAA
GCACCCCATGGACCTCAGCACTGTCAAGCGGAAGATGGAGAACCGTGATTACCGGGATGCACAGGAGTTTGCTGCTGATGTACGGCTTAT
GTTCTCCAACTGCTATAAGTACAATCCCCCAGATCACGATGTTGTGGCAATGGCACGAAAGCTACAGGATGTATTTGAGTTCCGTTATGC
CAAGATGCCAGATGAACCACTAGAACCAGGGCCTTTACCAGTCTCTACTGCCATGCCCCCTGGCTTGGCCAAATCGTCTTCAGAGTCCTC
CAGTGAGGAAAGTAGCAGTGAGAGCTCCTCTGAGGAAGAGGAGGAGGAAGATGAGGAGGACGAGGAGGAAGAAGAGAGTGAAAGCTCAGA
CTCAGAGGAAGAAAGGGCTCATCGCTTAGCAGAACTACAGGAACAGCTTCGGGCAGTACATGAACAACTGGCTGCTCTGTCCCAGGGTCC
AATATCCAAGCCCAAGAGGAAAAGAGAGAAAAAAGAGAAAAAGAAGAAACGGAAGGCAGAGAAGCATCGAGGCCGAGCTGGGGCCGATGA
AGATGACAAGGGGCCTAGGGCACCCCGCCCACCTCAACCTAAGAAGTCCAAGAAAGCAAGTGGCAGTGGGGGTGGCAGTGCTGCTTTAGG
CCCTTCTGGCTTTGGACCTTCTGGAGGAAGTGGCACCAAGCTCCCCAAAAAGGCCACAAAGACAGCCCCACCTGCCCTGCCTACAGGTTA
TGATTCAGAGGAGGAGGAAGAGAGCAGGCCCATGAGTTACGATGAGAAGCGGCAGCTGAGCCTGGACATCAACAAATTACCTGGGGAGAA
GCTGGGCCGAGTTGTGCATATAATCCAAGCCAGGGAGCCCTCTTTACGTGATTCAAACCCAGAAGAGATTGAGATTGATTTTGAAACACT
CAAGCCATCCACACTTAGAGAGCTTGAGCGCTATGTCCTTTCCTGCCTACGTAAGAAACCCCGGAAGCCCTACACCATTAAGAAGCCTGT
GGGAAAGACAAAGGAGGAACTGGCTTTGGAGAAAAAGCGGGAATTAGAAAAGCGGTTACAAGATGTCAGCGGACAGCTCAATTCTACTAA
AAAGCCCCCCAAGAAAGCGAATGAGAAAACAGAGTCATCCTCTGCACAGCAAGTAGCAGTGTCACGCCTTAGCGCTTCCAGCTCCAGCTC
AGATTCCAGCTCCTCCTCTTCCTCGTCGTCGTCTTCAGACACCAGTGATTCAGACTCAGGCTAAGGGGTCAGGCCAGATGGGGCAGGAAG
GCTCCGCAGGACCGGACCCCTAGACCACCCTGCCCCACCTGCCCCTTCCCCCTTTGCTGTGACACTTCTTCATCTCACCCCCCCCCGCCC
CCCTCTAGGAGAGCTGGCTCTGCAGTGGGGGAGGGATGCAGGGACATTTACTGAAGGAGGGACATGGACAAAACAACATTGAATTCCCAG
CCCCATTGGGGAGTGATCTCTTGGACACAGAGCCCCCATTCAAAATGGGGCAGGGCAAGGGTGGGAGTGTGCAAAGCCCTGATCTGGAGT
TACCTGAGGCCACAGCTGCCCTATTCACTTCTAAGGGCCCTGTTTTGAGATTGTTTGTTCTAATTTATTTTAAGCTAGGTAAGGCTGGGG
GGAGGGTGGGGCCGTGGTCCCCTCAGCCTCCATGGGGAGGGAAGAAGGGGGAGCTCTTTTTTTACGTTGATTTTTTTTTTTCTACTCTGT
TTTCCCTTTTTCCTTCCGCTCCATTTGGGGCCCTGGGGGTTTCAGTCATCTCCCCATTTGGTCCCCTGGACTGTCTTTGTTGATTCTAAC
TTGTAAATAAAGAAAATATTATTCAAGTTTTGAGTTACCTTAATATTTGCTTTTGTAGTGTTTCAAAAGGAACATCATAAGAATTGTCTT
GATAATTTTGAGGGAAATATTACTGCAGTGAGAAAAGGCAATAGCTAACCTATAATTGGATTGTCTTAATTTTTAAACCAGTAGGCTTTT

>12599_12599_1_CALR-BRD2_CALR_chr19_13055304_ENST00000316448_BRD2_chr6_32944339_ENST00000374825_length(amino acids)=529AA_BP=3
MCLKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLS
KKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAK
MPDEPLEPGPLPVSTAMPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPI
SKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAALGPSGFGPSGGSGTKLPKKATKTAPPALPTGYD
SEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKPVG

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Fusion Gene PPI Analysis for CALR-BRD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneCALRchr19:13055304chr6:32944339ENST00000316448-99237_270610.0418.0PPIB


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CALR-BRD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CALR-BRD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource