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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CALR-QSOX1 (FusionGDB2 ID:12613)

Fusion Gene Summary for CALR-QSOX1

Fusion gene summary

Fusion gene information	Fusion gene name: CALR-QSOX1
	Fusion gene ID: 12613
		Hgene	Tgene
	Gene symbol	CALR	QSOX1
	Gene ID	811	5768
	Gene name	calreticulin	quiescin sulfhydryl oxidase 1
	Synonyms	CRT\|HEL-S-99n\|RO\|SSA\|cC1qR	Q6\|QSCN6
	Cytomap	19p13.13	1q25.2
	Type of gene	protein-coding	protein-coding
	Description	calreticulinCRP55ERp60HACBPSicca syndrome antigen A (autoantigen Ro; calreticulin)calregulinendoplasmic reticulum resident protein 60epididymis secretory sperm binding protein Li 99ngrp60	sulfhydryl oxidase 1quiescin Q6 sulfhydryl oxidase 1testis tissue sperm-binding protein Li 62nthiol oxidase 1
	Modification date	20200329	20200313
	UniProtAcc	P27797	.
	Ensembl transtripts involved in fusion gene	ENST00000316448,	ENST00000367600, ENST00000367602,
Fusion gene scores	* DoF score	18 X 17 X 9=2754	8 X 9 X 3=216
	# samples	24	9
	** MAII score	log2(24/2754*10)=-3.52042224852645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CALR [Title/Abstract] AND QSOX1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CALR(13051468)-QSOX1(180165396), # samples:1
Anticipated loss of major functional domain due to fusion event.	CALR-QSOX1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. CALR-QSOX1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CALR	GO:0000122	negative regulation of transcription by RNA polymerase II	8107809
Hgene	CALR	GO:0006611	protein export from nucleus	11149926
Hgene	CALR	GO:0017148	negative regulation of translation	14726956
Hgene	CALR	GO:0033144	negative regulation of intracellular steroid hormone receptor signaling pathway	8107809
Hgene	CALR	GO:0034504	protein localization to nucleus	15998798
Hgene	CALR	GO:0045665	negative regulation of neuron differentiation	8107809
Hgene	CALR	GO:0045892	negative regulation of transcription, DNA-templated	8107809
Hgene	CALR	GO:0048387	negative regulation of retinoic acid receptor signaling pathway	8107809

Fusion gene breakpoints across CALR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across QSOX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0919	CALR	chr19	13051468	+	QSOX1	chr1	180165396	+

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Fusion Gene ORF analysis for CALR-QSOX1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000316448	ENST00000367600	CALR	chr19	13051468	+	QSOX1	chr1	180165396	+
In-frame	ENST00000316448	ENST00000367602	CALR	chr19	13051468	+	QSOX1	chr1	180165396	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000316448

CALR

chr19

13051468

ENST00000367602

QSOX1

chr1

180165396

8658

889

1176

374

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000316448	ENST00000367602	CALR	chr19	13051468	+	QSOX1	chr1	180165396	+	0.002033868	0.9979662

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Fusion Genomic Features for CALR-QSOX1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CALR	chr19	13051468	+	QSOX1	chr1	180165396	+	3.54E-05	0.9999646
CALR	chr19	13051468	+	QSOX1	chr1	180165396	+	3.54E-05	0.9999646

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CALR-QSOX1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:13051468/chr1:180165396)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CALR P27797	.
FUNCTION: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250\|UniProtKB:P28491, ECO:0000250\|UniProtKB:Q8K3H7, ECO:0000269\|PubMed:11149926, ECO:0000269\|PubMed:7876246}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

18_197

272

418.0

Region

Note=N-domain

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

191_255

272

418.0

Region

Note=4 X approximate repeats

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

191_202

272

418.0

Repeat

Note=1-1

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

210_221

272

418.0

Repeat

Note=1-2

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

227_238

272

418.0

Repeat

Note=1-3

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

244_255

272

418.0

Repeat

Note=1-4

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

259_269

272

418.0

Repeat

Note=2-1

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367600

710_730

489

605.0

Transmembrane

Helical

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367602

710_730

489

748.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

351_408

272

418.0

Compositional bias

Note=Asp/Glu/Lys-rich

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

414_417

272

418.0

Motif

Note=Prevents secretion from ER

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

198_308

272

418.0

Region

Note=P-domain

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

259_297

272

418.0

Region

Note=3 X approximate repeats

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

309_417

272

418.0

Region

Note=C-domain

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

273_283

272

418.0

Repeat

Note=2-2

Hgene

CALR

chr19:13051468

chr1:180165396

ENST00000316448

287_297

272

418.0

Repeat

Note=2-3

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367600

36_156

489

605.0

Domain

Thioredoxin

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367600

396_503

489

605.0

Domain

ERV/ALR sulfhydryl oxidase

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367602

36_156

489

748.0

Domain

Thioredoxin

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367602

396_503

489

748.0

Domain

ERV/ALR sulfhydryl oxidase

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367600

478_485

489

605.0

Nucleotide binding

FAD

Tgene

QSOX1

chr19:13051468

chr1:180165396

ENST00000367602

478_485

489

748.0

Nucleotide binding

FAD

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Fusion Gene Sequence for CALR-QSOX1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>12613_12613_1_CALR-QSOX1_CALR_chr19_13051468_ENST00000316448_QSOX1_chr1_180165396_ENST00000367602_length(transcript)=8658nt_BP=889nt
CCGTCCGTACTGCAGAGCCGCTGCCGGAGGGTCGTTTTAAAGGGCCCGCGCGTTGCCGCCCCCTCGGCCCGCCATGCTGCTATCCGTGCC
GCTGCTGCTCGGCCTCCTCGGCCTGGCCGTCGCCGAGCCTGCCGTCTACTTCAAGGAGCAGTTTCTGGACGGAGACGGGTGGACTTCCCG
CTGGATCGAATCCAAACACAAGTCAGATTTTGGCAAATTCGTTCTCAGTTCCGGCAAGTTCTACGGTGACGAGGAGAAAGATAAAGGTTT
GCAGACAAGCCAGGATGCACGCTTTTATGCTCTGTCGGCCAGTTTCGAGCCTTTCAGCAACAAAGGCCAGACGCTGGTGGTGCAGTTCAC
GGTGAAACATGAGCAGAACATCGACTGTGGGGGCGGCTATGTGAAGCTGTTTCCTAATAGTTTGGACCAGACAGACATGCACGGAGACTC
AGAATACAACATCATGTTTGGTCCCGACATCTGTGGCCCTGGCACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAACGTGCT
GATCAACAAGGACATCCGTTGCAAGGATGATGAGTTTACACACCTGTACACACTGATTGTGCGGCCAGACAACACCTATGAGGTGAAGAT
TGACAACAGCCAGGTGGAGTCCGGCTCCTTGGAAGACGATTGGGACTTCCTGCCACCCAAGAAGATAAAGGATCCTGATGCTTCAAAACC
GGAAGACTGGGATGAGCGGGCCAAGATCGATGATCCCACAGACTCCAAGCCTGAGGACTGGGACAAGCCCGAGCATATCCCTGACCCTGA
TGCTAAGAAGCCCGAGGACTGGGATGAAGAGATGGACGGAGAGTGGGAACCCCCAGTGATTCAGAACCCTGAGTACAAGGTGCCCCCAGC
GAGGACCCCCAGTTCCCCAAGGTGCAGTGGCCACCCCGTGAACTTTGTTCTGCCTGCCACAATGAACGCCTGGATGTGCCCGTGTGGGAC
GTGGAAGCCACCCTCAACTTCCTCAAGGCCCACTTCTCCCCAAGCAACATCATCCTGGACTTCCCTGCAGCTGGGTCAGCTGCCCGGAGG
GATGTGCAGAATGTGGCAGCCGCCCCAGAGCTGGCGATGGGAGCCCTGGAGCTGGAAAGCCGGAATTCAACTCTGGACCCTGGGAAGCCT
GAGATGATGAAGTCCCCCACAAACACCACCCCACATGTGCCGGCTGAGGGACCTGAGGCAAGTCGACCCCCGAAGCTGCACCCTGGCCTC
AGAGCTGCACCAGGCCAGGAGCCTCCTGAGCACATGGCAGAGCTTCAGAGGAATGAGCAGGAGCAGCCGCTTGGGCAGTGGCACTTGAGC
AAGCGAGACACAGGGGCTGCATTGCTGGCTGAGTCCAGGGCTGAGAAGAACCGCCTCTGGGGCCCTTTGGAGGTCAGGCGCGTGGGCCGC
AGCTCCAAGCAGCTGGTCGACATCCCTGAGGGCCAGCTGGAGGCCCGAGCTGGACGGGGCCGAGGCCAGTGGCTGCAGGTGCTGGGAGGG
GGCTTCTCTTACCTGGACATCAGCCTCTGTGTGGGGCTCTATTCCCTGTCCTTCATGGGCCTGCTGGCCATGTACACCTACTTCCAGGCC
AAGATAAGGGCCCTGAAGGGCCATGCTGGCCACCCTGCAGCCTGAACCACCTGGGGAGGAGGCGGGAGAGGGAGCTGCCATCTCTAGGCA
CCTCAAGCCCCCTGACCCCATTCCCTCCCCTCCCACCCCTTGCTCCTTGTCTGGCCTAGAAGTGTGGGAAATTCAGGAAAACGAGTTGCT
CCAGTGAAGCTTCTTGGGGTTGCTAGGACAGAGAGCTCCTTTGACACAAAAGACAGGAGCAGGGTCCAGGTTCCCCTGCTGTGCAGGGAG
GGCAGCCCCGGGCAGTGGGCATAGGGCAGCTCAGTCCCTGGCCTCTTAGCACCACATTCCTGTTTTTCAGCTTATTTGAAGTCCTGCCTC
ATTCTCACTGGAGCCTCAGTCTCTCCTGCTTGGTCTTGGCCCTCAACTGGGGCAAGTGAAGCCAGAGGAGGGTCCCCCAGCTGGGTGGGC
TGGAATGGAACTCCTCACTAGCTGCTGGGGCTCCGCCCACCCTGCTCCCTTCCGGACAATGAAGAAGCCTTTGCACCCTGGGAGGAAGGA
CCACCCCGGGCCCTCTATGCCTGGCCAGCCTCCAGCTCCTCAGACCTCCTGGGTGGGGTTTGGCTTCAGGGTGGGGTTTGGAAGCTTCTG
GAAGTCGTGCTGGTCTCCCAGGTGAGGCAAGCCATGGTTGCTGGGCTGTAGGGTGAGTGGCTTGCTTGGTGGGACCTGACGAGTTGGTGG
CATGGGAAGGATGTGGGTCTCTAGTGCCTTGCCCTGGCTTAGCTGCAGGAGAAGATGGCTGCTTTCACTTCCCCCCATTGAGCTCTGCTC
CCTCTGAGCCTGGTCTTTTGTCCTTTTTTATTTTGGTCTCCAAGATGAATGCTCATCTTTGGAGGGTGCCAGGTAGAAGCTAGGGAGGGG
AGTGTCTTCTCTCTCCAGGTTTCACCTTCCAGTGTGCAGAAGTTAGAAGGGTCTGGCGGGGGCAGTGCCTTACACATGCTTGATTCCCAC
GCTACCCCCTGCCTTGGGAGGTGTGTGGAATAAATTATTTTTGTTAAGGCAAGCATTGGTGTGTTCTTTAACTTGCTACTTGGAGACCTA
GTGTCCAGTCTGGACAGAATGCACAGAGACCAGCCTCACCTGGAATGCAGCCAGACTCGATGTCCCTCAGCACACACAGCTCCTGGCCAC
AGACTGCCCATAGAACTGTCTGCACCCAAACCCCATGGCCTTTTCATGCACGGAGACAGGCCTCTGGATGTGCAGCCTTGCCACCCCCTG
CCCCAATCCTCCCTGAGAGCTCCTGCCTCAGTGCCCTGGGCTGGTGAGGGAGAAGCCTGTCTGCACCTGCCTAATTCCAGCTCCTCCAGG
AAGCAAGGGCTTGTTTGTCAGAGCTGCAGGGTTGGCCACTCGGTGGGGAGGAGTCAGCCAGGATTAGAGAGCCTGCCCCTAATCCGGCCT
GCTGGGTTTTACAAGGATCAGAGCTGCTGATAATGAACCTCATTAAGGGGGAGCAGGAGCCTCAATCCGATTTGGTTTTCTCTTTGACAT
CTTCACTCTGCTCAGATGGCCTGGGTGCTATGTGGAGCAGGTGGGATGCCAAGGCCACTCCTGCTATGGGGCAGCTGGGGCTGGGGAGGG
ATGGCAGTCTCCCTGCATGTTTCCCTCGACCTCTTTAGCTGCAGCGCCTTGCTGGGCTCCTGGGTTGGACTCCCTCTCTGTGCCCCTGCT
CCAGGCACCCATTGGCTCCATCCTCCTGGTTGTGCTCTGCACCCCCTGCTCCCTTGGGCTGGCCCTGGCTGGGGGCCTGAGAGACAGACA
GGAACCCACAATCAGGAGGCAACCCTGGCCTGCAAGAGGAAGACAGAGGCTCCCAGGGCCGGTGCCCTGTGTGCCCACTGCACCAAGGCC
GCTGAATAAGCCTGCCCTTCACCCCCTAAGGGCTCCTTGCCCAATGCCAAGTGCTGGGGATTTCTGTCAGCAAGCCCTGTGGCTCCAGTG
ACGGTATTTCTAAAGCCAAACTTAGTTACCTAGAATTAGCGCCATGTTGGAAACACTGTCGCAGCAGCCCGGGCTGCACAGTGTGTAGCC
CAGCCTCCAGGTCCACGGAGTGGTGTGGACCTCCCACCTCACAGCTGCCTCTGGCAGCCAAGCCTCTTTTCGCCCGGCCCCAGCCCCTCT
GGTTGATAAACGGGTGGGCCTCCTCAGCAGCGTGGCTGCCTTTCACCTTGATTTCCCCAGGGCTCTCGGCAACATCGATAAACCAGCCTC
GCCCACCAGCTGGGCCCTCCCCCACCCAGTCTGCCAGGCTGGGAGCTGGAGCTTGCTGAGTCTTGAATGCCCTTCTAGATGGCTTCTCTA
GAGGCTCTCCTGGCAAGAGAGGGTCCCAAGGGGAGCCCTGCAAAGCAAAGGCTCCTTGTCTGGGGCGGGATAGAGAATCTCGCCTCTGTC
TGGTGTGTTACCTACTGGGGGCACAGGAACAATTTCCTCAAGGAGACAGTGGCATGGAGCTTTGAAAGACGAGTAGGTGTTAGCAAGGAA
ATAAGGAGGAACGGGGGTTACGGGCAGAGGAGAAAGCACATGCCAAGTCAGCAAAGAAAAGTAGAATTCGAAAACTTTTTAAAAATATTA
CTAAGGATTTTCACAATGCTGCACTGGGCTAGAAACTGAAGCTAAAACAGATACGTGGTCCCTGCTGCTATGGGGCTTCCGTTCTAGAGG
CAAGGACAGGTTGTGATGAGGGTTCTGAAGGATAGAGACCAAGCAGGGAGGGTGTTGAGGAGGCTTCTGCGAGACCTGAAGGATGGGAAG
CCAGGAAGTGGGAGGGGTGGGGGTCCAGGCTGGAGGGGCCCAATGTAGGTGTAGAGGGACTACAGCCCTGAGGGGCTGCTCCATGCGGCA
TTCTTGGAGGTCCAAGAGGGGCAGCGCCACCTTGGGCCAGGCTCCTCTCCAGCAGCCTTGGTATGGGGTGGGGGTGGGAAGACCCCTGAT
GCAGCCTGTCCTCTGGGTGTGGGGGTGGAGGAGAGGGCTCCAGGGGACCCAGCCAGCCTTGACCCTGGAGGAAAGTCAGGTGGGCTCAGA
GAGAGCCCTCAAATCTGGGCCCTGGGTCAGGGTGGGGTCAAGTCCAGCCTTGAAGAGAATGGACTCTGGAATCTGACGTCTGGGTTTGAA
TCCAGCTTCCAACACTCACTGGCTGTGTGACTTTGGGCAAGATAACTTATCCCCTTGTCCCCATGTGTCATTGGAGATAAACTACCCACC
TACCAGATTGTTGTACCATGCTGGGCAAACACTAAGTGCTTAATAATGGTAGCCCACTGCTCATGTCGTGTCGTCTCCTGTCTTGATACC
TGAAAACTCAAGGGGCCCTGTTGTGCTTGGAGGGGGGTGCCGTTCCCACAGGATATTCTGTGAAGGGTGTCCCTGGAGCTGGGCCTCCAG
GTGGCAAGCCCCAAGCCACCCCGGCAGGTGCCACTGGCCAGAGTTGAACTGAGGTGTTGAGTGGAAAGTGCCTCCCCACCCCCATCTGCC
ACAGTAGTATGGATTTCCTTCATGAGATGGGGCTCCTAAAATGCCTGAAATGTGTATGCTGTTGGAGAATTGATGTGTATGATTTATTGA
ACTTTGCACTCATTTAAATCTCATTTAATCCTCCAACAACGCAAGATGAAGAAGCTGAGGCTTAAAGAGATTAAGAAACATCCTATCCCC
TTTACTCCCACCAAAATAAATACATTTGCCCTATTCTCCCAAATGGTGAGAGGTAGATCCAGGACTTGACCCCAGATCCCACCCACTCAA
CCCTGGAGCTGCAGTCTCTACCCCTTCTAACACATGTGATTCTGTTTCATGTCCTGTTCCATCGGTAGAGTTACACACTTTCCTGAGACT
TTATATGGTGGTGCTGCTGGGTGCCAGCCCTTCTTCCCTCCAACAGTGGCAGTAACCACTGTTGTGTGTTGGTGTCAAGGAGTGGGGACA
CCCTGAAGGAATCCGCCTTTTCTAGAGCTCTCGCTCCATTCCCTACATCGAGGCTGAAGTGCCCTGTCTCGGGTCCTTGTTTTTAGGCCT
CGTTTGAAGGAGGGGAAGAAACCAGGTTCGTTGGGCGTGACCTTGGCTCAGCTCGTCTGTGAAATTGGGGCCGCAGACTTAGTTTGCGGG
TCCCTGCTAAATTCCTCTCCCTCTTCCTGGGATTCCCATCCATGTATTGCCAGCTACATGTAGAGTGGAGAGGAGAGGTTTTTCCTGCAG
GGCCTTCCAGAGAAAGGATTCTTGGCCAGAGGAAATCACAGCCTATAAGATCAATATCCTGATAGAATCCCGGGCCAGGTGTGAGAGGGG
AGAGCTCACTCACACCAGCCTGACAGTCTTGGGGCAGAGCGCCCCATAGGCCTCTGCAGCCCCATCACTGCCTCATTCTCCCTCAGGTGC
CAAGGAAGCTCCAGGGTGGGCCCAGTATCCTTCCACAGCATCCCTCCTCTTCCCCTTCAACACCCCTTTCACCCCTCCCTCCACCACCTC
TGAAAGGTGCTCCTTGGGCAGGGCGATAGGATTCCCACCCCTAGCTTTAAGAACTAAACCAAACTTCAAGAGGAGCAATTTAATCTTCAT
ACCTGACTCCTTGTCCCTCCTCAGGCATGCTGTTGTGCAGGACAGAGCCCTGGCTTCTCCTGGATGTCACACCTGGCCTGTCTCTGACCC
TTGCTTTCCCTTTCTCTGCTGCCCTCAAGGGTCATTCACACCCAAGAGGGTAAGAAGCTGCCCTCTCATCCCTTCCTCTCCCACCCTGGG
CCTCTGCCCTCTGCCTGGCCCCAGCAGCACAGTCTTCTCCATAGAGAGGGGCTGGGCCATGGGACCCCAGTTCCTGGGGTCTCGGTGACA
CAGTTCACTGTTTGCTGCAGAGGAGGCCCCACTCGCAGCCTTGGCCTCTGCCCTGCAGAAGAATTCCCTGTAACTCACTCACCAATGGCC
GTGGGAGCCAGTGGCCTCGGCGAGGGTCAGTTGGACTGCATAGCTGCCGGCTGAGTCTCTCTGGCCACCCTCACTGGCCCCATCACTCCA
GGTTGCACTGCTGCCCAGGGGGTTTGTGCCAGGCCTGGGTCACAGTGGAAGAGAGTCTGGAAATCACAAGGCAGAGGAGGAGACCTTTGC
CAATGTGAGAGAACAAAGTTAAGGGGCAGTCCATGGGGGCATTGACCTTACTTAGGTGAGGAGGACTCAGGGAACATCTACAGACTCTAG
GGCTAGGGTGAGATCCTCCTGATAGTGCTGGTAGCTCCAGCTGCTGCTTTGGCAAGACTTGGTCGTCTCTATACTGAGAGAGCAAAAGCT
CTTTTCCTGGGGCTGCATGTTCTTCCATAGGAAAGTGGGCTTCAGGTGCTGCCTATTAAACCTCCTGCCTCCCCTGCTGCAGTGCTTTGA
TGCCTTTCACCTGTGTCTACCTGCGAACCTCTGCCCACCACGGAAGAGCAGCTCACATTTGGAAGGGGCTAAAATTTTTACCTAGTTTGA
ATCTGCTCTGCAATGTCCCCATCAAGTTCTTAACCATCCCGGGTTCCAATGGTTACAGAGTTCTGCCCTGGGGAGGGAGGAATTGCTTAG
CAAATGATGTTGAGAATAGTGATTATTTGGGGGAAAATTCAGGTAAGATCTCACCTTCATACCATATACCAAAATACATCTCAGTAGATT
AGTAAGCTAATGCAAAAAAAAAAAAAAAAGGGGAAATATAATTGAATACTTCACTGTTTTTGAAAGCATGAAAACAATGGAAAATGCAAC
TGATGTGAGTAATCCATCTACTTGACGTCACTTTTAAGAAATAAGGCCAGGCACGGTGGCTCACGCTTGTAATCCTAGCACTTTGGGAGG
CCGAGGTGGGTGGATCACGAGGTCAGGAGTTTGAGACCAGCTTGGCCAACATGGTGAAACCCCCATCTCTACTAAAATATTACACAGGCA
TTGTGGCACACATCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAACCTGGGAGGTGGAGGTTGCAGTGAGCTGAG
ATCGCGCCATTGCACTCCAGCCTGGGGGACAGAGCGAGACTCTGTCTCAAAAAAATAAAAAAATAAAAATAAAAAAATAAAGTAAAGCTA
CATATTTAAAAGCTGGGGAAATATATGCTGTAAATATGACAAAGGGCTGTGACTCTTCTGCAACACACCATTTTAAGAATGAGCTAGGTC
TGCATTTATTGACCTGATAAAATGTCCCAAGAAGGACACATTTTTATAAACATAAGTTACTATTGTTATATATATGCTAACGTTTGTCTA
GAAAAAGTCTAGAAAAATACACACTGAACTGTGAATAGCAGTTATATTTAGAAAGCAACATTAGGATGAACTTAAGTCAGGGCTTGGACT
AGAGCAAGGCAAGTGAGGTGCCAGGATGCAAAAGTTAAGGAGACACCTGACCTCAGGGGCCCACAACTGCAGAGCCCCTGACAGTGAGTG
TCTCAGTAGCCTCGCCCTAGTCCTGGCTTTCACTTAAATATGTTTTCGAATGTTTGTAATAAAATATTTCTTTTGGAAGGCAAAAATAGC
AAGGAAAATAAATAGGATTAAAGGATACTAAAGCCCATTCAATAAAATTTGTAGGAGGCCACTGATTTGGCCTAGGCTCCTATGATGTAA
CCAACAGACCAAACCAATATGGAGTCATTCATGCTAAATGAAACTAGTTAGGAGTATATTCATATAACAAGTGGCTAAGTGTCAGTTACA
GCCTCTGAGCTTTAGTCAATTGTAGGTGGTCAATAGATTCAGATAAGGCAATCCAGTTAAACTGTATATCCCACTTGCTGTTTTCTGTCC
CTAAATTCTCTCTGAGTACACTGCAGCCCTGAAGTTCTTTGAACCTGTTCTGGGTTCTGAGGGCTGTCCAATTACTGAATCATACATAAA
AGCCAAGTAAGATTTTAAAATTTGTTATAATTTTGGTTTTTAACAACTTCTGTTGTAAATAATAAAAGCACTAAATCCCTACTGAAAATA

>12613_12613_1_CALR-QSOX1_CALR_chr19_13051468_ENST00000316448_QSOX1_chr1_180165396_ENST00000367602_length(amino acids)=374AA_BP=279
MPPPRPAMLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDEEKDKGLQTSQDARFYALSASFEP
FSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQTDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYT
LIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEP
PVIQNPEYKVPPARTPSSPRCSGHPVNFVLPATMNAWMCPCGTWKPPSTSSRPTSPQATSSWTSLQLGQLPGGMCRMWQPPQSWRWEPWS

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Fusion Gene PPI Analysis for CALR-QSOX1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	CALR	chr19:13051468	chr1:180165396	ENST00000316448	+	6	9	237_270	272.0	418.0	PPIB

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CALR-QSOX1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CALR-QSOX1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source