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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:CAMTA2-LCK (FusionGDB2 ID:12760) |
Fusion Gene Summary for CAMTA2-LCK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CAMTA2-LCK | Fusion gene ID: 12760 | Hgene | Tgene | Gene symbol | CAMTA2 | LCK | Gene ID | 23125 | 3932 |
| Gene name | calmodulin binding transcription activator 2 | LCK proto-oncogene, Src family tyrosine kinase | |
| Synonyms | - | IMD22|LSK|YT16|p56lck|pp58lck | |
| Cytomap | 17p13.2 | 1p35.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | calmodulin-binding transcription activator 2 | tyrosine-protein kinase LckT-lymphocyte specific protein tyrosine kinase p56lckleukocyte C-terminal Src kinaselymphocyte cell-specific protein-tyrosine kinasep56(LSTRA) protein-tyrosine kinaseproto-oncogene tyrosine-protein kinase LCKt cell-specific | |
| Modification date | 20200313 | 20200327 | |
| UniProtAcc | O94983 | P06239 | |
| Ensembl transtripts involved in fusion gene | ENST00000348066, ENST00000358183, ENST00000572543, ENST00000381311, ENST00000361571, ENST00000414043, ENST00000571831, | ENST00000333070, ENST00000336890, ENST00000373564, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 7 X 6 X 5=210 |
| # samples | 3 | 8 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CAMTA2 [Title/Abstract] AND LCK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | CAMTA2(4890888)-LCK(32745272), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | CAMTA2-LCK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CAMTA2-LCK seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. CAMTA2-LCK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CAMTA2-LCK seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. CAMTA2-LCK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. CAMTA2-LCK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CAMTA2 | GO:0006357 | regulation of transcription by RNA polymerase II | 16678093 |
| Hgene | CAMTA2 | GO:0014898 | cardiac muscle hypertrophy in response to stress | 16678093 |
| Tgene | LCK | GO:0006468 | protein phosphorylation | 214242 |
| Tgene | LCK | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 16116473 |
| Tgene | LCK | GO:0042493 | response to drug | 16116473 |
| Tgene | LCK | GO:0050870 | positive regulation of T cell activation | 8943371 |
| Fusion gene breakpoints across CAMTA2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across LCK (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | READ | TCGA-AG-3731-01A | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
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Fusion Gene ORF analysis for CAMTA2-LCK |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000348066 | ENST00000333070 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000348066 | ENST00000336890 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000348066 | ENST00000373564 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000358183 | ENST00000333070 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000358183 | ENST00000336890 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000358183 | ENST00000373564 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000572543 | ENST00000333070 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000572543 | ENST00000336890 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| 5UTR-3CDS | ENST00000572543 | ENST00000373564 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| Frame-shift | ENST00000381311 | ENST00000333070 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| Frame-shift | ENST00000381311 | ENST00000336890 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| Frame-shift | ENST00000381311 | ENST00000373564 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000361571 | ENST00000333070 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000361571 | ENST00000336890 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000361571 | ENST00000373564 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000414043 | ENST00000333070 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000414043 | ENST00000336890 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000414043 | ENST00000373564 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000571831 | ENST00000333070 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000571831 | ENST00000336890 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| intron-3CDS | ENST00000571831 | ENST00000373564 | CAMTA2 | chr17 | 4890888 | - | LCK | chr1 | 32745272 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for CAMTA2-LCK |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| CAMTA2 | chr17 | 4890887 | - | LCK | chr1 | 32745271 | + | 6.29E-06 | 0.9999937 |
| CAMTA2 | chr17 | 4890887 | - | LCK | chr1 | 32745271 | + | 6.29E-06 | 0.9999937 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CAMTA2-LCK |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:4890888/:32745272) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CAMTA2 | LCK |
| FUNCTION: Transcription activator. May act as tumor suppressor. {ECO:0000269|PubMed:11925432}. | FUNCTION: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP. Interacts with FYB2 (PubMed:27335501). {ECO:0000269|PubMed:16339550, ECO:0000269|PubMed:16709819, ECO:0000269|PubMed:20028775, ECO:0000269|PubMed:20100835, ECO:0000269|PubMed:20851766, ECO:0000269|PubMed:21269457, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:27335501}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for CAMTA2-LCK |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for CAMTA2-LCK |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CAMTA2-LCK |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CAMTA2-LCK |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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