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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ACER2-C8orf37 (FusionGDB2 ID:1283)

Fusion Gene Summary for ACER2-C8orf37

Fusion gene summary

Fusion gene information	Fusion gene name: ACER2-C8orf37
	Fusion gene ID: 1283
		Hgene	Tgene
	Gene symbol	ACER2	C8orf37
	Gene ID	340485	157657
	Gene name	alkaline ceramidase 2	chromosome 8 open reading frame 37
	Synonyms	ALKCDase2\|ASAH3L	BBS21\|CORD16\|FAP418\|MOT25\|RP64\|smalltalk
	Cytomap	9p22.1	8q22.1
	Type of gene	protein-coding	protein-coding
	Description	alkaline ceramidase 2alkCDase 2alkaline CDase 2ceramide hydrolasehaCER2	protein C8orf37Bardet-Biedl syndrome 21
	Modification date	20200313	20200313
	UniProtAcc	Q5QJU3	.
	Ensembl transtripts involved in fusion gene	ENST00000340967, ENST00000380376,	ENST00000286688,
Fusion gene scores	* DoF score	3 X 3 X 2=18	1 X 1 X 1=1
	# samples	3	1
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(1/1*10)=3.32192809488736
Context	PubMed: ACER2 [Title/Abstract] AND C8orf37 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACER2(19435082)-C8orf37(96276002), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ACER2	GO:0001953	negative regulation of cell-matrix adhesion	18945876
Hgene	ACER2	GO:0006974	cellular response to DNA damage stimulus	26943039
Hgene	ACER2	GO:0008284	positive regulation of cell proliferation	16940153
Hgene	ACER2	GO:0032526	response to retinoic acid	18945876
Hgene	ACER2	GO:0033629	negative regulation of cell adhesion mediated by integrin	18945876
Hgene	ACER2	GO:0046512	sphingosine biosynthetic process	16940153\|20089856\|20628055

Fusion gene breakpoints across ACER2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C8orf37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-EJ-A7NF-01A	ACER2	chr9	19435082	-	C8orf37	chr8	96276002	-
ChimerDB4	PRAD	TCGA-EJ-A7NF-01A	ACER2	chr9	19435082	+	C8orf37	chr8	96276002	-

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Fusion Gene ORF analysis for ACER2-C8orf37

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000340967	ENST00000286688	ACER2	chr9	19435082	+	C8orf37	chr8	96276002	-
In-frame	ENST00000380376	ENST00000286688	ACER2	chr9	19435082	+	C8orf37	chr8	96276002	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000380376

ACER2

chr9

19435082

ENST00000286688

C8orf37

chr8

96276002

3828

661

1129

350

ENST00000340967

ACER2

chr9

19435082

ENST00000286688

C8orf37

chr8

96276002

3696

529

997

331

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000380376	ENST00000286688	ACER2	chr9	19435082	+	C8orf37	chr8	96276002	-	0.000950006	0.99904996
ENST00000340967	ENST00000286688	ACER2	chr9	19435082	+	C8orf37	chr8	96276002	-	0.000850993	0.99914896

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Fusion Genomic Features for ACER2-C8orf37

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACER2-C8orf37

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:19435082/chr8:96276002)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ACER2 Q5QJU3	.
FUNCTION: Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20207939, PubMed:20089856). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876). {ECO:0000250\|UniProtKB:Q8VD53, ECO:0000269\|PubMed:16940153, ECO:0000269\|PubMed:18945876, ECO:0000269\|PubMed:20089856, ECO:0000269\|PubMed:20207939, ECO:0000269\|PubMed:20628055, ECO:0000269\|PubMed:26943039, ECO:0000269\|PubMed:28294157, ECO:0000269\|PubMed:29229990, ECO:0000303\|PubMed:20207939}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

1_13

167

276.0

Region

Required for proper localization to the Golgi apparatus

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

1_13

118

141.0

Region

Required for proper localization to the Golgi apparatus

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

108_124

167

276.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

143_143

167

276.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

1_32

167

276.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

54_62

167

276.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

84_86

167

276.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

1_32

118

141.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

54_62

118

141.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

84_86

118

141.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

125_142

167

276.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

144_164

167

276.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

33_53

167

276.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

63_83

167

276.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

87_107

167

276.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

33_53

118

141.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

63_83

118

141.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

87_107

118

141.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

165_173

167

276.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

195_211

167

276.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

233_275

167

276.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

108_124

118

141.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

143_143

118

141.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

165_173

118

141.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

195_211

118

141.0

Topological domain

Lumenal

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

233_275

118

141.0

Topological domain

Cytoplasmic

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

174_194

167

276.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000340967

212_232

167

276.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

125_142

118

141.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

144_164

118

141.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

174_194

118

141.0

Transmembrane

Helical

Hgene

ACER2

chr9:19435082

chr8:96276002

ENST00000380376

212_232

118

141.0

Transmembrane

Helical

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Fusion Gene Sequence for ACER2-C8orf37

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>1283_1283_1_ACER2-C8orf37_ACER2_chr9_19435082_ENST00000340967_C8orf37_chr8_96276002_ENST00000286688_length(transcript)=3696nt_BP=529nt
AGCTGCTCCAATGCCCCGGAGTGGCCATGGGCGCCCCGCACTGGTGGGACCAGCTGCAGGCTGGTAGCTCGGAGGTGGACTGGTGCGAGG
ACAACTACACCATCGTGCCTGCTATCGCCGAGTTCTACAACACGATCAGCAATGTCTTATTTTTCATTTTACCGCCCATCTGCATGTGCT
TGTTTCGTCAGTATGCAACATGCTTCAACAGTGGCATCTACTTAATCTGGACTCTTTTGGTTGTAGTGGGAATTGGATCCGTCTACTTCC
ATGCAACCCTTAGTTTCTTGGGTCAGATGCTTGATGAACTTGCAGTCCTTTGGGTTCTGATGTGTGCTTTGGCCATGTGGTTCCCCAGAA
GGTATCTACCAAAGATCTTTCGGAATGACCGGGGTAGGTTCAAGGTGGTGGTCAGTGTCCTGTCTGCGGTTACGACGTGCCTGGCATTTG
TCAAGCCTGCCATCAACAACATCTCTCTGATGACCCTGGGAGTTCCTTGCACTGCACTGCTCATCGCAGAGCTAAAGAGATCAACAGAAA
CATTTAAAAAAGAAGATGATCTTGACAGTCTTATTAATGAAATACTTGAAGAGCCCAACTTGGACAAAAAACCCTCTAAATTAAAATCTA
AATCTTCAGGTAACACATCTGTCAGAGCTTCCATTGAAGGCCTTGGTAAAAGTTGCAGTCCGGTGTACCTTGGTGGAAGCTCTATTCCAT
GTGGGATTGGAACAAATATTTCATGGAGAGCATGTGACCATCTGCGTTGTATAGCCTGTGATTTCTTGGTAGTCAGCTATGATGACTATA
TGTGGGACAAATCGTGTGATTATCTGTTTTTCAGGAACAACATGCCAGAATTTCACAAATTAAAAGCAAAGTTGATAAAGAAGAAAGGAA
CACGGGCATATGCCTGCCAGTGTAGCTGGAGAACTATTGAAGAAGTGACTGACCTTCAGACAGATCATCAGCTTCGCTGGGTTTGTGGTA
AACATTAAGAATGCAGACTGCACATTCGGACAGATGCATCCATGAGAGTGGTCTCCATGAATCATCATCATGTTTAGACAATAGTCCCTA
GCAATACCATTCCCTGTGGGAAAAGGCAGTGAATTTTATTGATACAACTACATACATTTTTGAAGACCAAATGGACTAAGGAAGATCATG
TATTATAACACTTTGGAATTATTCCTGATACATGGATGTTTCACTTAGTAACAGGCATCTACATTCTTTACTAATCTGTCTTCTGTTTAA
TAGAGGTTTGATTATGGAGTTCCATACAAATATCTAGTTTTTCATTAGCAACTGCAATATTGATTGCTAATACGTTTAGCAAATCATTCC
CCAACTTGTAGCAGTTAAAGTGGATAAAGCCGGCCAGGGCAAAGAGATCATTTAGGGGTGTCTACAACACTTCTTCCAGTCAGATCTTTT
GTTGCCAAAGATCATAATTTGGACATGGCAGAAACCAGGTGATCAGTGGCTGACTGAAGGGTGTTCAGAAGTAGTTACAGGTATTTTGCA
AAAACACTGCCTCATAGCTGATCTTACCTCATCAACTCAAAGCAATGTTATGCACAATATTAAATACATGTTACCAGTTTTAGCTTATTT
TTCCCTCTTTTGTTCATTTAACTATCAAAAGTTATTTTCTATTTTGATTACCCAATAATATATAAAAAGAGTTTGATGCACCCAAAATCA
CAAAAATCCTAATACATACAGGTTATTGTTGGATTTTCCAAGTACTTTCTATCCTTTAATGCCTAAAACTCCATCAAGGGAAGTAAACAG
CAAGTAATATAATTTTTCAGGCAGCCTGTGGACTTCTCTGGTAGGATCAGGTTGACATATCGTTTATTAGGTGAGTAAGTGAAAAGACAA
GTAAAGCATAACTGAACCAACAGGTAACCTGTTGGGCTCCTTCCTGACATCACTGAGATCTGAGGAGCCCTACAATAGCAGCACATTCAG
GAAATCAGGTCCCTCAAAATTTCTAGCTCCCAACCCCATTGAGAGATTTTGGGAGCTTTCCAATCTGCCACAAACTCCCTGCTACATATG
TACTATATAGTTCAAATGTGTGATACAGAGCACCCTGAAAGGGAATAATTGAAACAAAGTTATAATCTTCTTAGTCTTATGCTAAATTTA
TTCCAGCCACCCTACTGAAGGGAGGAAGATCTGATCATTAGAATCCTTTTCCTAGCCATGACACATTTACATACTTGTAAAATTTATTGT
AGTAAGTCTAGCATTGCAACAGAATAGATCTTATAATGGCCAATCCTCACACTTTTGTATTAAGGATATTATGACAGACTAAGCATGGTA
GCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATCAGCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGATA
AAACACCATCTCTACTAAAAATACAAAAATTAGCTGGGCGCGGTGGTGCATGCCTGTAATCCCAACTACTCGGGAGGCCGAGGCAGGAAA
ATTTATTGAACCTGGGAGGCAGAGGTTGTAGTGAGCCAAGGTCGCGCCACTGCGCTCCAGCCTGGACAACACAGTGAGACTCTGTCTCAA
AAAAAAAAAAAAGACATTATGACAGATTTTATCTTTTAATAAAAATGTATTATATCCCTAAAGTTATATCTATATGTAATTGAGTCAGAA
ACCTAGGGGGATGTCGATTGAAGTCGACTGCTGGAAAAAAATAGCAGAGCAACAAGATCCACACATTTAGAACCTCATAGAATTTGACAC
ATTATTCATAATGGTGCAATTCTTTCTTTTTTATTCCAGTAAGCAAATTTACTAAATCACTAATTTGAAAAAAAAAATTTTTTTTTTGAG
ATGGAGTGTCACTCTGTTGCCGGGCTGGAGTGCAGTGGCACGATCTCTGCTCACTGCAACCTCCGCCTCGCAGCTTCAAGTGATTGTCCT
GCCTCAGCCTCCCCAGTAGCTGGGATTACAGGCACACACCACCACGCCCAGCTAATTTTTGTATTTTTAATAGAGACAGGGTTTCACCAT
GTTGGCCAGAATGATGTCGATCTCCTGAACTCGTGATCCGCCCGCCTCAGCCTCCCAAAGTAGCCTACATTGCCTCTACTTTGAAGGGAC
AAAGTTGTCCTGGTTTTTTTTTCCCTTTTATTATTTCATTATAACTATCCTAAAACTTACATACATTGCCTATGTTTGGCATTCCATAAC
ATAATAATTATAATAATCCCCCAATGTCAGAAATGTATGTGTGAGTTCCCATGTTTATTGGCAATTTATAAGCTTTTTAATATTGTACTA
TTTTAAACTAAAATGTAGAAAGAATATTATGTTTATATACAGTCAGATAAATTATTAACTGTTGTAATTTAAGCTGAAAATGAAACTATT
TTAGTATCAGTATAGAAGAAAAGTATAGTTTCTAATCATCTATAATTTTAAAATGCAAAGCCTATAAAACTTTCAAGATGTTTTGCCTGT
TTGTTTTTAAGATTTATAATAATTTTCTATCTTTAGCAAGTAGCTATTTTTAAGCCAGGTAACTTCTTTATTTGAACTGTATTATACTCT
CAGACCCTCATCCTGCCTAGAAATGAATAAGTAATAAATAATTACTCTGTATTATTTACTTCTTTTATTTTATAGTAAAATATTCATTTG

>1283_1283_1_ACER2-C8orf37_ACER2_chr9_19435082_ENST00000340967_C8orf37_chr8_96276002_ENST00000286688_length(amino acids)=331AA_BP=173
LLQCPGVAMGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFH
ATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRSTET
FKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRACDHLRCIACDFLVVSYDDYM

--------------------------------------------------------------
>1283_1283_2_ACER2-C8orf37_ACER2_chr9_19435082_ENST00000380376_C8orf37_chr8_96276002_ENST00000286688_length(transcript)=3828nt_BP=661nt
GCGGAGCGCGGGAGGCCAGTTGGGAGGCGCACATCCGGCGGTTACCCGGTGCTTCATAAAGCCGCTTTCGCCGCTGGCTGTCGCCGCGTT
TTGCCTCCGCAGCAGCTCTGGGCTCTTCTCAGCTGCGCGAGCAGCTGCTCCAATGCCCCGGAGTGGCCATGGGCGCCCCGCACTGGTGGG
ACCAGCTGCAGGCTGGTAGCTCGGAGGTGGACTGGTGCGAGGACAACTACACCATCGTGCCTGCTATCGCCGAGTTCTACAACACGATCA
GCAATGTCTTATTTTTCATTTTACCGCCCATCTGCATGTGCTTGTTTCGTCAGTATGCAACATGCTTCAACAGTGGCATCTACTTAATCT
GGACTCTTTTGGTTGTAGTGGGAATTGGATCCGTCTACTTCCATGCAACCCTTAGTTTCTTGGGTCAGATGCTTGATGAACTTGCAGTCC
TTTGGGTTCTGATGTGTGCTTTGGCCATGTGGTTCCCCAGAAGGTATCTACCAAAGATCTTTCGGAATGACCGGGGTAGGTTCAAGGTGG
TGGTCAGTGTCCTGTCTGCGGTTACGACGTGCCTGGCATTTGTCAAGCCTGCCATCAACAACATCTCTCTGATGACCCTGGGAGTTCCTT
GCACTGCACTGCTCATCGCAGAGCTAAAGAGATCAACAGAAACATTTAAAAAAGAAGATGATCTTGACAGTCTTATTAATGAAATACTTG
AAGAGCCCAACTTGGACAAAAAACCCTCTAAATTAAAATCTAAATCTTCAGGTAACACATCTGTCAGAGCTTCCATTGAAGGCCTTGGTA
AAAGTTGCAGTCCGGTGTACCTTGGTGGAAGCTCTATTCCATGTGGGATTGGAACAAATATTTCATGGAGAGCATGTGACCATCTGCGTT
GTATAGCCTGTGATTTCTTGGTAGTCAGCTATGATGACTATATGTGGGACAAATCGTGTGATTATCTGTTTTTCAGGAACAACATGCCAG
AATTTCACAAATTAAAAGCAAAGTTGATAAAGAAGAAAGGAACACGGGCATATGCCTGCCAGTGTAGCTGGAGAACTATTGAAGAAGTGA
CTGACCTTCAGACAGATCATCAGCTTCGCTGGGTTTGTGGTAAACATTAAGAATGCAGACTGCACATTCGGACAGATGCATCCATGAGAG
TGGTCTCCATGAATCATCATCATGTTTAGACAATAGTCCCTAGCAATACCATTCCCTGTGGGAAAAGGCAGTGAATTTTATTGATACAAC
TACATACATTTTTGAAGACCAAATGGACTAAGGAAGATCATGTATTATAACACTTTGGAATTATTCCTGATACATGGATGTTTCACTTAG
TAACAGGCATCTACATTCTTTACTAATCTGTCTTCTGTTTAATAGAGGTTTGATTATGGAGTTCCATACAAATATCTAGTTTTTCATTAG
CAACTGCAATATTGATTGCTAATACGTTTAGCAAATCATTCCCCAACTTGTAGCAGTTAAAGTGGATAAAGCCGGCCAGGGCAAAGAGAT
CATTTAGGGGTGTCTACAACACTTCTTCCAGTCAGATCTTTTGTTGCCAAAGATCATAATTTGGACATGGCAGAAACCAGGTGATCAGTG
GCTGACTGAAGGGTGTTCAGAAGTAGTTACAGGTATTTTGCAAAAACACTGCCTCATAGCTGATCTTACCTCATCAACTCAAAGCAATGT
TATGCACAATATTAAATACATGTTACCAGTTTTAGCTTATTTTTCCCTCTTTTGTTCATTTAACTATCAAAAGTTATTTTCTATTTTGAT
TACCCAATAATATATAAAAAGAGTTTGATGCACCCAAAATCACAAAAATCCTAATACATACAGGTTATTGTTGGATTTTCCAAGTACTTT
CTATCCTTTAATGCCTAAAACTCCATCAAGGGAAGTAAACAGCAAGTAATATAATTTTTCAGGCAGCCTGTGGACTTCTCTGGTAGGATC
AGGTTGACATATCGTTTATTAGGTGAGTAAGTGAAAAGACAAGTAAAGCATAACTGAACCAACAGGTAACCTGTTGGGCTCCTTCCTGAC
ATCACTGAGATCTGAGGAGCCCTACAATAGCAGCACATTCAGGAAATCAGGTCCCTCAAAATTTCTAGCTCCCAACCCCATTGAGAGATT
TTGGGAGCTTTCCAATCTGCCACAAACTCCCTGCTACATATGTACTATATAGTTCAAATGTGTGATACAGAGCACCCTGAAAGGGAATAA
TTGAAACAAAGTTATAATCTTCTTAGTCTTATGCTAAATTTATTCCAGCCACCCTACTGAAGGGAGGAAGATCTGATCATTAGAATCCTT
TTCCTAGCCATGACACATTTACATACTTGTAAAATTTATTGTAGTAAGTCTAGCATTGCAACAGAATAGATCTTATAATGGCCAATCCTC
ACACTTTTGTATTAAGGATATTATGACAGACTAAGCATGGTAGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCAGGCAGATC
AGCTGAGGTCAGGAGTTCAAGACCAGCCTGGCCAACATGATAAAACACCATCTCTACTAAAAATACAAAAATTAGCTGGGCGCGGTGGTG
CATGCCTGTAATCCCAACTACTCGGGAGGCCGAGGCAGGAAAATTTATTGAACCTGGGAGGCAGAGGTTGTAGTGAGCCAAGGTCGCGCC
ACTGCGCTCCAGCCTGGACAACACAGTGAGACTCTGTCTCAAAAAAAAAAAAAAGACATTATGACAGATTTTATCTTTTAATAAAAATGT
ATTATATCCCTAAAGTTATATCTATATGTAATTGAGTCAGAAACCTAGGGGGATGTCGATTGAAGTCGACTGCTGGAAAAAAATAGCAGA
GCAACAAGATCCACACATTTAGAACCTCATAGAATTTGACACATTATTCATAATGGTGCAATTCTTTCTTTTTTATTCCAGTAAGCAAAT
TTACTAAATCACTAATTTGAAAAAAAAAATTTTTTTTTTGAGATGGAGTGTCACTCTGTTGCCGGGCTGGAGTGCAGTGGCACGATCTCT
GCTCACTGCAACCTCCGCCTCGCAGCTTCAAGTGATTGTCCTGCCTCAGCCTCCCCAGTAGCTGGGATTACAGGCACACACCACCACGCC
CAGCTAATTTTTGTATTTTTAATAGAGACAGGGTTTCACCATGTTGGCCAGAATGATGTCGATCTCCTGAACTCGTGATCCGCCCGCCTC
AGCCTCCCAAAGTAGCCTACATTGCCTCTACTTTGAAGGGACAAAGTTGTCCTGGTTTTTTTTTCCCTTTTATTATTTCATTATAACTAT
CCTAAAACTTACATACATTGCCTATGTTTGGCATTCCATAACATAATAATTATAATAATCCCCCAATGTCAGAAATGTATGTGTGAGTTC
CCATGTTTATTGGCAATTTATAAGCTTTTTAATATTGTACTATTTTAAACTAAAATGTAGAAAGAATATTATGTTTATATACAGTCAGAT
AAATTATTAACTGTTGTAATTTAAGCTGAAAATGAAACTATTTTAGTATCAGTATAGAAGAAAAGTATAGTTTCTAATCATCTATAATTT
TAAAATGCAAAGCCTATAAAACTTTCAAGATGTTTTGCCTGTTTGTTTTTAAGATTTATAATAATTTTCTATCTTTAGCAAGTAGCTATT
TTTAAGCCAGGTAACTTCTTTATTTGAACTGTATTATACTCTCAGACCCTCATCCTGCCTAGAAATGAATAAGTAATAAATAATTACTCT

>1283_1283_2_ACER2-C8orf37_ACER2_chr9_19435082_ENST00000380376_C8orf37_chr8_96276002_ENST00000286688_length(amino acids)=350AA_BP=192
MSPRFASAAALGSSQLREQLLQCPGVAMGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSG
IYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMT
LGVPCTALLIAELKRSTETFKKEDDLDSLINEILEEPNLDKKPSKLKSKSSGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNISWRAC

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Top

Fusion Gene PPI Analysis for ACER2-C8orf37

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ACER2-C8orf37

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ACER2-C8orf37

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source