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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPG-GGCX (FusionGDB2 ID:12832)

Fusion Gene Summary for CAPG-GGCX

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPG-GGCX
Fusion gene ID: 12832
HgeneTgene
Gene symbol

CAPG

GGCX

Gene ID

64151

2677

Gene namenon-SMC condensin I complex subunit Ggamma-glutamyl carboxylase
SynonymsCAPG|CHCG|NY-MEL-3|YCG1VKCFD1
Cytomap

4p15.31

2p11.2

Type of geneprotein-codingprotein-coding
Descriptioncondensin complex subunit 3XCAP-G homologchromosome condensation protein Gchromosome-associated protein Gcondensin subunit CAP-Gmelanoma antigen NY-MEL-3vitamin K-dependent gamma-carboxylasepeptidyl-glutamate 4-carboxylase
Modification date2020031320200313
UniProtAcc

P40121

P38435

Ensembl transtripts involved in fusion geneENST00000263867, ENST00000409670, 
ENST00000409724, ENST00000409921, 
ENST00000483659, 		ENST00000233838, 
ENST00000430215, ENST00000473665, 
Fusion gene scores* DoF score4 X 6 X 3=726 X 7 X 4=168
# samples 57
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPG [Title/Abstract] AND GGCX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPG(85626327)-GGCX(85781429), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAPG

GO:0007076

mitotic chromosome condensation

11136719


check buttonFusion gene breakpoints across CAPG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GGCX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-JY-A6FD-01ACAPGchr2

85626327

-GGCXchr2

85781429

-
ChimerDB4ESCATCGA-JY-A6FDCAPGchr2

85626290

-GGCXchr2

85781480

-
ChimerDB4ESCATCGA-JY-A6FDCAPGchr2

85626327

-GGCXchr2

85781429

-
ChimerDB4ESCATCGA-JY-A6FDCAPGchr2

85626358

-GGCXchr2

85781429

-


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Fusion Gene ORF analysis for CAPG-GGCX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000263867ENST00000233838CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000263867ENST00000233838CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000263867ENST00000430215CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000263867ENST00000430215CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000409670ENST00000233838CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000409670ENST00000233838CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000409670ENST00000430215CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000409670ENST00000430215CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000409724ENST00000233838CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000409724ENST00000233838CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000409724ENST00000430215CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000409724ENST00000430215CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000409921ENST00000233838CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000409921ENST00000233838CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000409921ENST00000430215CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000409921ENST00000430215CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000483659ENST00000233838CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000483659ENST00000233838CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-3CDSENST00000483659ENST00000430215CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-3CDSENST00000483659ENST00000430215CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-5UTRENST00000263867ENST00000473665CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-5UTRENST00000263867ENST00000473665CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-5UTRENST00000263867ENST00000473665CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-5UTRENST00000409670ENST00000473665CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-5UTRENST00000409670ENST00000473665CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-5UTRENST00000409670ENST00000473665CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-5UTRENST00000409724ENST00000473665CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-5UTRENST00000409724ENST00000473665CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-5UTRENST00000409724ENST00000473665CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-5UTRENST00000409921ENST00000473665CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-5UTRENST00000409921ENST00000473665CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-5UTRENST00000409921ENST00000473665CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-5UTRENST00000483659ENST00000473665CAPGchr2

85626327

-GGCXchr2

85781429

-
intron-5UTRENST00000483659ENST00000473665CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-5UTRENST00000483659ENST00000473665CAPGchr2

85626358

-GGCXchr2

85781429

-
intron-intronENST00000263867ENST00000233838CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000263867ENST00000430215CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000409670ENST00000233838CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000409670ENST00000430215CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000409724ENST00000233838CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000409724ENST00000430215CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000409921ENST00000233838CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000409921ENST00000430215CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000483659ENST00000233838CAPGchr2

85626290

-GGCXchr2

85781480

-
intron-intronENST00000483659ENST00000430215CAPGchr2

85626290

-GGCXchr2

85781480

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CAPG-GGCX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPG-GGCX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:85626327/:85781429)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPG

P40121

GGCX

P38435

FUNCTION: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.FUNCTION: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. {ECO:0000269|PubMed:17073445}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CAPG-GGCX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CAPG-GGCX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPG-GGCX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPG-GGCX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource