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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CAPN12-ACTN4 (FusionGDB2 ID:12837)

Fusion Gene Summary for CAPN12-ACTN4

Fusion gene summary

Fusion gene information	Fusion gene name: CAPN12-ACTN4
	Fusion gene ID: 12837
		Hgene	Tgene
	Gene symbol	CAPN12	ACTN4
	Gene ID	147968	81
	Gene name	calpain 12	actinin alpha 4
	Synonyms	-	ACTININ-4\|FSGS\|FSGS1
	Cytomap	19q13.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	calpain-12CANP 12calcium-activated neutral proteinase 12	alpha-actinin-4focal segmental glomerulosclerosis 1non-muscle alpha-actinin 4
	Modification date	20200313	20200327
	UniProtAcc	.	O43707
	Ensembl transtripts involved in fusion gene	ENST00000328867, ENST00000601953,	ENST00000252699, ENST00000390009, ENST00000424234, ENST00000497637,
Fusion gene scores	* DoF score	7 X 18 X 4=504	27 X 38 X 12=12312
	# samples	19	48
	** MAII score	log2(19/504*10)=-1.40742431516897 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/12312*10)=-4.68088692071969 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CAPN12 [Title/Abstract] AND ACTN4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ACTN4(39220118)-CAPN12(39220935), # samples:7 CAPN12(39220696)-ACTN4(39220694), # samples:7 CAPN12(39220722)-ACTN4(39220720), # samples:7
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACTN4	GO:0033209	tumor necrosis factor-mediated signaling pathway	25411248
Tgene	ACTN4	GO:0035357	peroxisome proliferator activated receptor signaling pathway	22351778
Tgene	ACTN4	GO:0048384	retinoic acid receptor signaling pathway	22351778
Tgene	ACTN4	GO:0051272	positive regulation of cellular component movement	9508771

Fusion gene breakpoints across CAPN12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-2H-A9GJ-01A7	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
ChimerDB4	STAD	TCGA-JY-A6FH-01A6	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
ChiTaRS5.0	N/A	AX184844	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
ChiTaRS5.0	N/A	AX186649	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
ChiTaRS5.0	N/A	AX187712	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
ChiTaRS5.0	N/A	EC444947	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
ChiTaRS5.0	N/A	EC446184	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
ChiTaRS5.0	N/A	EC451771	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
ChiTaRS5.0	N/A	EC451941	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
ChiTaRS5.0	N/A	EC457768	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
ChiTaRS5.0	N/A	EC487636	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
ChiTaRS5.0	N/A	EC499595	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
ChiTaRS5.0	N/A	EC504947	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
ChiTaRS5.0	N/A	EC510216	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
ChiTaRS5.0	N/A	EC521688	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
ChiTaRS5.0	N/A	EC524703	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
ChiTaRS5.0	N/A	EC526823	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
ChiTaRS5.0	N/A	EC538645	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
ChiTaRS5.0	N/A	EC539144	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
ChiTaRS5.0	N/A	EC557825	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
ChiTaRS5.0	N/A	EC558295	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
ChiTaRS5.0	N/A	EC562007	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
ChiTaRS5.0	N/A	EC564173	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
ChiTaRS5.0	N/A	EC566232	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
ChiTaRS5.0	N/A	EC567984	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
ChiTaRS5.0	N/A	EC568841	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
ChiTaRS5.0	N/A	EC572957	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
ChiTaRS5.0	N/A	EC577486	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
ChiTaRS5.0	N/A	EC577592	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
ChiTaRS5.0	N/A	EC578153	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
ChiTaRS5.0	N/A	EC584215	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-

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Fusion Gene ORF analysis for CAPN12-ACTN4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000328867	ENST00000252699	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-3CDS	ENST00000328867	ENST00000252699	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-3CDS	ENST00000328867	ENST00000390009	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-3CDS	ENST00000328867	ENST00000390009	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-3CDS	ENST00000328867	ENST00000424234	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-3CDS	ENST00000328867	ENST00000424234	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-3CDS	ENST00000601953	ENST00000252699	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-3CDS	ENST00000601953	ENST00000252699	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-3CDS	ENST00000601953	ENST00000390009	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-3CDS	ENST00000601953	ENST00000390009	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-3CDS	ENST00000601953	ENST00000424234	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-3CDS	ENST00000601953	ENST00000424234	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-3UTR	ENST00000328867	ENST00000252699	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-3UTR	ENST00000601953	ENST00000252699	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-intron	ENST00000328867	ENST00000390009	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-intron	ENST00000328867	ENST00000424234	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-intron	ENST00000328867	ENST00000497637	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-intron	ENST00000601953	ENST00000390009	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-intron	ENST00000601953	ENST00000424234	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39221033	-	ACTN4	chr19	39215165	+
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39221050	-	ACTN4	chr19	39214903	+
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220678	-	ACTN4	chr19	39221022	+
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220704	-	ACTN4	chr19	39220702	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220694	-	ACTN4	chr19	39220692	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220733	-	ACTN4	chr19	39220729	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220696	-	ACTN4	chr19	39220694	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220722	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220689	-	ACTN4	chr19	39220713	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220744	-	ACTN4	chr19	39220739	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220690	-	ACTN4	chr19	39220720	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220743	-	ACTN4	chr19	39220741	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220703	-	ACTN4	chr19	39220700	-
intron-intron	ENST00000601953	ENST00000497637	CAPN12	chr19	39220743	-	ACTN4	chr19	39220739	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CAPN12-ACTN4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPN12-ACTN4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:39220118/:39220935)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACTN4 O43707
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). {ECO:0000250\|UniProtKB:P57780, ECO:0000269\|PubMed:15772161, ECO:0000269\|PubMed:22351778, ECO:0000305\|PubMed:9508771}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CAPN12-ACTN4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CAPN12-ACTN4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CAPN12-ACTN4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CAPN12-ACTN4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source