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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPN13-GALNT14 (FusionGDB2 ID:12847)

Fusion Gene Summary for CAPN13-GALNT14

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPN13-GALNT14
Fusion gene ID: 12847
HgeneTgene
Gene symbol

CAPN13

GALNT14

Gene ID

92291

79623

Gene namecalpain 13polypeptide N-acetylgalactosaminyltransferase 14
Synonyms-GALNT15|GalNac-T10|GalNac-T14
Cytomap

2p23.1

2p23.1

Type of geneprotein-codingprotein-coding
Descriptioncalpain-13CANP 13calcium-activated neutral proteinase 13polypeptide N-acetylgalactosaminyltransferase 14UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (
Modification date2020031320200313
UniProtAcc.

Q96FL9

Ensembl transtripts involved in fusion geneENST00000295055, ENST00000534090, 
ENST00000465960, 		ENST00000486564, 
ENST00000324589, ENST00000349752, 
ENST00000356174, ENST00000406653, 
ENST00000420311, 
Fusion gene scores* DoF score4 X 5 X 4=807 X 9 X 5=315
# samples 59
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPN13 [Title/Abstract] AND GALNT14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPN13(31009994)-GALNT14(31155060), # samples:3
CAPN13(30980912)-GALNT14(31147689), # samples:3
Anticipated loss of major functional domain due to fusion event.CAPN13-GALNT14 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAPN13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GALNT14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-49-4514-01ACAPN13chr2

31009994

-GALNT14chr2

31155060

-
ChimerDB4LUSCTCGA-NC-A5HJ-01ACAPN13chr2

30980912

-GALNT14chr2

31147689

-
ChimerDB4LUSCTCGA-NC-A5HJCAPN13chr2

30980912

-GALNT14chr2

31147689

-


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Fusion Gene ORF analysis for CAPN13-GALNT14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000295055ENST00000486564CAPN13chr2

31009994

-GALNT14chr2

31155060

-
5CDS-5UTRENST00000534090ENST00000486564CAPN13chr2

31009994

-GALNT14chr2

31155060

-
5CDS-intronENST00000295055ENST00000486564CAPN13chr2

30980912

-GALNT14chr2

31147689

-
5CDS-intronENST00000465960ENST00000486564CAPN13chr2

30980912

-GALNT14chr2

31147689

-
5CDS-intronENST00000534090ENST00000486564CAPN13chr2

30980912

-GALNT14chr2

31147689

-
5UTR-3CDSENST00000465960ENST00000324589CAPN13chr2

31009994

-GALNT14chr2

31155060

-
5UTR-3CDSENST00000465960ENST00000349752CAPN13chr2

31009994

-GALNT14chr2

31155060

-
5UTR-3CDSENST00000465960ENST00000356174CAPN13chr2

31009994

-GALNT14chr2

31155060

-
5UTR-3CDSENST00000465960ENST00000406653CAPN13chr2

31009994

-GALNT14chr2

31155060

-
5UTR-3CDSENST00000465960ENST00000420311CAPN13chr2

31009994

-GALNT14chr2

31155060

-
5UTR-5UTRENST00000465960ENST00000486564CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000295055ENST00000324589CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000295055ENST00000324589CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000295055ENST00000349752CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000295055ENST00000349752CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000295055ENST00000356174CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000295055ENST00000356174CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000295055ENST00000406653CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000295055ENST00000406653CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000295055ENST00000420311CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000295055ENST00000420311CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000534090ENST00000324589CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000534090ENST00000324589CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000534090ENST00000349752CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000534090ENST00000349752CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000534090ENST00000356174CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000534090ENST00000356174CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000534090ENST00000406653CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000534090ENST00000406653CAPN13chr2

30980912

-GALNT14chr2

31147689

-
Frame-shiftENST00000534090ENST00000420311CAPN13chr2

31009994

-GALNT14chr2

31155060

-
Frame-shiftENST00000534090ENST00000420311CAPN13chr2

30980912

-GALNT14chr2

31147689

-
In-frameENST00000465960ENST00000324589CAPN13chr2

30980912

-GALNT14chr2

31147689

-
In-frameENST00000465960ENST00000349752CAPN13chr2

30980912

-GALNT14chr2

31147689

-
In-frameENST00000465960ENST00000356174CAPN13chr2

30980912

-GALNT14chr2

31147689

-
In-frameENST00000465960ENST00000406653CAPN13chr2

30980912

-GALNT14chr2

31147689

-
In-frameENST00000465960ENST00000420311CAPN13chr2

30980912

-GALNT14chr2

31147689

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000465960CAPN13chr230980912-ENST00000324589GALNT14chr231147689-215712153491722457
ENST00000465960CAPN13chr230980912-ENST00000349752GALNT14chr231147689-215712153491722457
ENST00000465960CAPN13chr230980912-ENST00000406653GALNT14chr231147689-215612153491722457
ENST00000465960CAPN13chr230980912-ENST00000356174GALNT14chr231147689-214912153491722457
ENST00000465960CAPN13chr230980912-ENST00000420311GALNT14chr231147689-182712153491722457

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000465960ENST00000324589CAPN13chr230980912-GALNT14chr231147689-0.0148802060.98511976
ENST00000465960ENST00000349752CAPN13chr230980912-GALNT14chr231147689-0.0148802060.98511976
ENST00000465960ENST00000406653CAPN13chr230980912-GALNT14chr231147689-0.0148147070.98518527
ENST00000465960ENST00000356174CAPN13chr230980912-GALNT14chr231147689-0.0154458420.9845541
ENST00000465960ENST00000420311CAPN13chr230980912-GALNT14chr231147689-0.0247920840.9752079

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Fusion Genomic Features for CAPN13-GALNT14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPN13-GALNT14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:31009994/chr2:31155060)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GALNT14

Q96FL9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGALNT14chr2:30980912chr2:31147689ENST000003245891116415_550388558.0DomainRicin B-type lectin
TgeneGALNT14chr2:30980912chr2:31147689ENST000003497521015415_550383553.0DomainRicin B-type lectin
TgeneGALNT14chr2:30980912chr2:31147689ENST00000356174914415_550350520.0DomainRicin B-type lectin
TgeneGALNT14chr2:30980912chr2:31147689ENST000004066531217415_550363533.0DomainRicin B-type lectin

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN13chr2:30980912chr2:31147689ENST00000295055-82334_333288719.3333333333334DomainCalpain catalytic
HgeneCAPN13chr2:30980912chr2:31147689ENST00000295055-823538_573288719.3333333333334DomainNote=EF-hand 1
HgeneCAPN13chr2:30980912chr2:31147689ENST00000295055-823636_669288719.3333333333334DomainNote=EF-hand 2
TgeneGALNT14chr2:30980912chr2:31147689ENST000003245891116110_215388558.0RegionNote=Catalytic subdomain A
TgeneGALNT14chr2:30980912chr2:31147689ENST000003245891116274_336388558.0RegionNote=Catalytic subdomain B
TgeneGALNT14chr2:30980912chr2:31147689ENST000003497521015110_215383553.0RegionNote=Catalytic subdomain A
TgeneGALNT14chr2:30980912chr2:31147689ENST000003497521015274_336383553.0RegionNote=Catalytic subdomain B
TgeneGALNT14chr2:30980912chr2:31147689ENST00000356174914110_215350520.0RegionNote=Catalytic subdomain A
TgeneGALNT14chr2:30980912chr2:31147689ENST00000356174914274_336350520.0RegionNote=Catalytic subdomain B
TgeneGALNT14chr2:30980912chr2:31147689ENST000004066531217110_215363533.0RegionNote=Catalytic subdomain A
TgeneGALNT14chr2:30980912chr2:31147689ENST000004066531217274_336363533.0RegionNote=Catalytic subdomain B
TgeneGALNT14chr2:30980912chr2:31147689ENST0000032458911161_6388558.0Topological domainCytoplasmic
TgeneGALNT14chr2:30980912chr2:31147689ENST00000324589111627_552388558.0Topological domainLumenal
TgeneGALNT14chr2:30980912chr2:31147689ENST0000034975210151_6383553.0Topological domainCytoplasmic
TgeneGALNT14chr2:30980912chr2:31147689ENST00000349752101527_552383553.0Topological domainLumenal
TgeneGALNT14chr2:30980912chr2:31147689ENST000003561749141_6350520.0Topological domainCytoplasmic
TgeneGALNT14chr2:30980912chr2:31147689ENST0000035617491427_552350520.0Topological domainLumenal
TgeneGALNT14chr2:30980912chr2:31147689ENST0000040665312171_6363533.0Topological domainCytoplasmic
TgeneGALNT14chr2:30980912chr2:31147689ENST00000406653121727_552363533.0Topological domainLumenal
TgeneGALNT14chr2:30980912chr2:31147689ENST0000032458911167_26388558.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGALNT14chr2:30980912chr2:31147689ENST0000034975210157_26383553.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGALNT14chr2:30980912chr2:31147689ENST000003561749147_26350520.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGALNT14chr2:30980912chr2:31147689ENST0000040665312177_26363533.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for CAPN13-GALNT14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12847_12847_1_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000324589_length(transcript)=2157nt_BP=1215nt
AGTGCTTGCACTGAGCCCACAGTCCTTATCCTCATGCGTGGCCCATTGTCTAATGATCGTCCCCTCAAAATAGGTGGCAGGCCACTGCCC
AATGCTGAAGTCACTGTTTAACGAAGGTGGAGCCTGCCTTTACCTGGTACACCCATATAAGGAAAAGCCTGAGGTCAGGAGTAAGCAGAC
ACCAGCACTGCTCTTTCTCCAAGACGGCCGGCCATGCTCTCCTCCTCTGCCAGTCTCCTCCACCACTCTCTAACCTGAGAGCCTGTGGAA
CCTGCCCGTCTCCCCTCCTCCATCAGACACACCTGCCTAGGAAACAGGAAAGGACCTCGGAAGTCTTCTAAGGAGAGTCATGGCGTATTA
CCAGGAGCCTTCAGTGGAGACCTCCATCATCAAGTTCAAAGACCAGGACTTTACCACCTTGCGGGATCACTGCCTGAGCATGGGCCGGAC
GTTTAAGGATGAGACATTCCCTGCAGCAGATTCTTCCATAGGCCAGAAGCTGCTCCAGGAAAAACGCCTCTCCAATGTGATATGGAAGCG
GCCACAGGATCTACCAGGGGGTCCTCCTCACTTCATCCTGGATGATATAAGCAGATTTGACATCCAACAAGGAGGCGCAGCTGACTGCTG
GTTCCTGGCAGCACTGGGATCCTTGACTCAGAACCCACAGTACAGGCAGAAGATCCTGATGGTCCAAAGCTTTTCACACCAGTATGCTGG
CATTTTCCGTTTCCGGTTCTGGCAATGTGGCCAGTGGGTGGAAGTGGTGATTGATGACCGCCTACCTGTCCAGGGAGATAAATGCCTCTT
TGTGCGTCCTCGCCACCAAAACCAAGAGTTCTGGCCCTGCCTGCTGGAGAAGGCCTATGCCAAGCTGCTCGGATCCTATTCCGATCTGCA
CTATGGCTTCCTCGAGGATGCCCTGGTGGACCTCACAGGAGGCGTGATCACCAACATCCATCTGCACTCTTCCCCTGTGGACCTGGTGAA
GGCAGTGAAGACAGCGACCAAGGCAGGCTCCCTGATAACCTGTGCCACTCCAAGTGGGCCAACAGATACAGCACAGGCGATGGAGAATGG
GCTGGTGAGTCTCCATGCCTACACTGTGACTGGGGCTGAGCAGATTCAATACCGAAGGGGCTGGGAAGAAATTATCTCCCTGTGGAACCC
CTGGGGCTGGGGCGAGGCCGAATGGAGAGGGCGCTGGAGTGATGGTGTTGAGAGCAGATTGGACCTGAGGAAGAATCTGCGCTGCCAGAG
CTTCAAGTGGTACCTGGAGAATATCTACCCTGAACTCAGCATCCCCAAGGAGTCCTCCATCCAGAAGGGCAATATCCGACAGAGACAGAA
GTGCCTGGAATCTCAAAGGCAGAACAACCAAGAAACCCCAAACCTAAAGTTGAGCCCCTGTGCCAAGGTCAAAGGCGAAGATGCAAAGTC
CCAGGTATGGGCCTTCACATACACCCAGCAGATCCTCCAGGAGGAGCTGTGCCTGTCAGTCATCACCTTGTTCCCTGGCGCCCCAGTGGT
TCTTGTCCTTTGCAAGAATGGAGATGACCGACAGCAATGGACCAAAACTGGTTCCCACATCGAGCACATAGCATCCCACCTCTGCCTCGA
TACAGATATGTTCGGTGATGGCACCGAGAACGGCAAGGAAATCGTCGTCAACCCATGTGAGTCCTCACTCATGAGCCAGCACTGGGACAT
GGTGAGCTCTTGAGGACCCCTGCCAGAAGCAGCAAGGGCCATGGGGTGGTGCTTCCCTGGACCAGAACAGACTGGAAACTGGGCAGCAAG
CAGCCTGCAACCACCTCAGACATCCTGGACTGGGAGGTGGAGGCAGAGCCCCCCAGGACAGGAGCAACTGTCTCAGGGAGGACAGAGGAA
AACATCACAAGCCAATGGGGCTCAAAGACAAATCCCACATGTTCTCAAGGCCGTTAAGTTCCAGTCCTGGCCAGTCATTCCCTGATTGGT
ATCTGGAGACAGAAACCTAATGGGAAGTGTTTATTGTTCCTTTTCCTACAAAGGAAGCAGTCTCTGGAGGCCAGAAAGAAAAGCCTTCTT

>12847_12847_1_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000324589_length(amino acids)=457AA_BP=91
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGA
ADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIIS
LWNPWGWGEAEWRGRWSDGVESRLDLRKNLRCQSFKWYLENIYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCAKVKGE
DAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSHIEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQ

--------------------------------------------------------------
>12847_12847_2_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000349752_length(transcript)=2157nt_BP=1215nt
AGTGCTTGCACTGAGCCCACAGTCCTTATCCTCATGCGTGGCCCATTGTCTAATGATCGTCCCCTCAAAATAGGTGGCAGGCCACTGCCC
AATGCTGAAGTCACTGTTTAACGAAGGTGGAGCCTGCCTTTACCTGGTACACCCATATAAGGAAAAGCCTGAGGTCAGGAGTAAGCAGAC
ACCAGCACTGCTCTTTCTCCAAGACGGCCGGCCATGCTCTCCTCCTCTGCCAGTCTCCTCCACCACTCTCTAACCTGAGAGCCTGTGGAA
CCTGCCCGTCTCCCCTCCTCCATCAGACACACCTGCCTAGGAAACAGGAAAGGACCTCGGAAGTCTTCTAAGGAGAGTCATGGCGTATTA
CCAGGAGCCTTCAGTGGAGACCTCCATCATCAAGTTCAAAGACCAGGACTTTACCACCTTGCGGGATCACTGCCTGAGCATGGGCCGGAC
GTTTAAGGATGAGACATTCCCTGCAGCAGATTCTTCCATAGGCCAGAAGCTGCTCCAGGAAAAACGCCTCTCCAATGTGATATGGAAGCG
GCCACAGGATCTACCAGGGGGTCCTCCTCACTTCATCCTGGATGATATAAGCAGATTTGACATCCAACAAGGAGGCGCAGCTGACTGCTG
GTTCCTGGCAGCACTGGGATCCTTGACTCAGAACCCACAGTACAGGCAGAAGATCCTGATGGTCCAAAGCTTTTCACACCAGTATGCTGG
CATTTTCCGTTTCCGGTTCTGGCAATGTGGCCAGTGGGTGGAAGTGGTGATTGATGACCGCCTACCTGTCCAGGGAGATAAATGCCTCTT
TGTGCGTCCTCGCCACCAAAACCAAGAGTTCTGGCCCTGCCTGCTGGAGAAGGCCTATGCCAAGCTGCTCGGATCCTATTCCGATCTGCA
CTATGGCTTCCTCGAGGATGCCCTGGTGGACCTCACAGGAGGCGTGATCACCAACATCCATCTGCACTCTTCCCCTGTGGACCTGGTGAA
GGCAGTGAAGACAGCGACCAAGGCAGGCTCCCTGATAACCTGTGCCACTCCAAGTGGGCCAACAGATACAGCACAGGCGATGGAGAATGG
GCTGGTGAGTCTCCATGCCTACACTGTGACTGGGGCTGAGCAGATTCAATACCGAAGGGGCTGGGAAGAAATTATCTCCCTGTGGAACCC
CTGGGGCTGGGGCGAGGCCGAATGGAGAGGGCGCTGGAGTGATGGTGTTGAGAGCAGATTGGACCTGAGGAAGAATCTGCGCTGCCAGAG
CTTCAAGTGGTACCTGGAGAATATCTACCCTGAACTCAGCATCCCCAAGGAGTCCTCCATCCAGAAGGGCAATATCCGACAGAGACAGAA
GTGCCTGGAATCTCAAAGGCAGAACAACCAAGAAACCCCAAACCTAAAGTTGAGCCCCTGTGCCAAGGTCAAAGGCGAAGATGCAAAGTC
CCAGGTATGGGCCTTCACATACACCCAGCAGATCCTCCAGGAGGAGCTGTGCCTGTCAGTCATCACCTTGTTCCCTGGCGCCCCAGTGGT
TCTTGTCCTTTGCAAGAATGGAGATGACCGACAGCAATGGACCAAAACTGGTTCCCACATCGAGCACATAGCATCCCACCTCTGCCTCGA
TACAGATATGTTCGGTGATGGCACCGAGAACGGCAAGGAAATCGTCGTCAACCCATGTGAGTCCTCACTCATGAGCCAGCACTGGGACAT
GGTGAGCTCTTGAGGACCCCTGCCAGAAGCAGCAAGGGCCATGGGGTGGTGCTTCCCTGGACCAGAACAGACTGGAAACTGGGCAGCAAG
CAGCCTGCAACCACCTCAGACATCCTGGACTGGGAGGTGGAGGCAGAGCCCCCCAGGACAGGAGCAACTGTCTCAGGGAGGACAGAGGAA
AACATCACAAGCCAATGGGGCTCAAAGACAAATCCCACATGTTCTCAAGGCCGTTAAGTTCCAGTCCTGGCCAGTCATTCCCTGATTGGT
ATCTGGAGACAGAAACCTAATGGGAAGTGTTTATTGTTCCTTTTCCTACAAAGGAAGCAGTCTCTGGAGGCCAGAAAGAAAAGCCTTCTT

>12847_12847_2_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000349752_length(amino acids)=457AA_BP=91
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGA
ADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIIS
LWNPWGWGEAEWRGRWSDGVESRLDLRKNLRCQSFKWYLENIYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCAKVKGE
DAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSHIEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQ

--------------------------------------------------------------
>12847_12847_3_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000356174_length(transcript)=2149nt_BP=1215nt
AGTGCTTGCACTGAGCCCACAGTCCTTATCCTCATGCGTGGCCCATTGTCTAATGATCGTCCCCTCAAAATAGGTGGCAGGCCACTGCCC
AATGCTGAAGTCACTGTTTAACGAAGGTGGAGCCTGCCTTTACCTGGTACACCCATATAAGGAAAAGCCTGAGGTCAGGAGTAAGCAGAC
ACCAGCACTGCTCTTTCTCCAAGACGGCCGGCCATGCTCTCCTCCTCTGCCAGTCTCCTCCACCACTCTCTAACCTGAGAGCCTGTGGAA
CCTGCCCGTCTCCCCTCCTCCATCAGACACACCTGCCTAGGAAACAGGAAAGGACCTCGGAAGTCTTCTAAGGAGAGTCATGGCGTATTA
CCAGGAGCCTTCAGTGGAGACCTCCATCATCAAGTTCAAAGACCAGGACTTTACCACCTTGCGGGATCACTGCCTGAGCATGGGCCGGAC
GTTTAAGGATGAGACATTCCCTGCAGCAGATTCTTCCATAGGCCAGAAGCTGCTCCAGGAAAAACGCCTCTCCAATGTGATATGGAAGCG
GCCACAGGATCTACCAGGGGGTCCTCCTCACTTCATCCTGGATGATATAAGCAGATTTGACATCCAACAAGGAGGCGCAGCTGACTGCTG
GTTCCTGGCAGCACTGGGATCCTTGACTCAGAACCCACAGTACAGGCAGAAGATCCTGATGGTCCAAAGCTTTTCACACCAGTATGCTGG
CATTTTCCGTTTCCGGTTCTGGCAATGTGGCCAGTGGGTGGAAGTGGTGATTGATGACCGCCTACCTGTCCAGGGAGATAAATGCCTCTT
TGTGCGTCCTCGCCACCAAAACCAAGAGTTCTGGCCCTGCCTGCTGGAGAAGGCCTATGCCAAGCTGCTCGGATCCTATTCCGATCTGCA
CTATGGCTTCCTCGAGGATGCCCTGGTGGACCTCACAGGAGGCGTGATCACCAACATCCATCTGCACTCTTCCCCTGTGGACCTGGTGAA
GGCAGTGAAGACAGCGACCAAGGCAGGCTCCCTGATAACCTGTGCCACTCCAAGTGGGCCAACAGATACAGCACAGGCGATGGAGAATGG
GCTGGTGAGTCTCCATGCCTACACTGTGACTGGGGCTGAGCAGATTCAATACCGAAGGGGCTGGGAAGAAATTATCTCCCTGTGGAACCC
CTGGGGCTGGGGCGAGGCCGAATGGAGAGGGCGCTGGAGTGATGGTGTTGAGAGCAGATTGGACCTGAGGAAGAATCTGCGCTGCCAGAG
CTTCAAGTGGTACCTGGAGAATATCTACCCTGAACTCAGCATCCCCAAGGAGTCCTCCATCCAGAAGGGCAATATCCGACAGAGACAGAA
GTGCCTGGAATCTCAAAGGCAGAACAACCAAGAAACCCCAAACCTAAAGTTGAGCCCCTGTGCCAAGGTCAAAGGCGAAGATGCAAAGTC
CCAGGTATGGGCCTTCACATACACCCAGCAGATCCTCCAGGAGGAGCTGTGCCTGTCAGTCATCACCTTGTTCCCTGGCGCCCCAGTGGT
TCTTGTCCTTTGCAAGAATGGAGATGACCGACAGCAATGGACCAAAACTGGTTCCCACATCGAGCACATAGCATCCCACCTCTGCCTCGA
TACAGATATGTTCGGTGATGGCACCGAGAACGGCAAGGAAATCGTCGTCAACCCATGTGAGTCCTCACTCATGAGCCAGCACTGGGACAT
GGTGAGCTCTTGAGGACCCCTGCCAGAAGCAGCAAGGGCCATGGGGTGGTGCTTCCCTGGACCAGAACAGACTGGAAACTGGGCAGCAAG
CAGCCTGCAACCACCTCAGACATCCTGGACTGGGAGGTGGAGGCAGAGCCCCCCAGGACAGGAGCAACTGTCTCAGGGAGGACAGAGGAA
AACATCACAAGCCAATGGGGCTCAAAGACAAATCCCACATGTTCTCAAGGCCGTTAAGTTCCAGTCCTGGCCAGTCATTCCCTGATTGGT
ATCTGGAGACAGAAACCTAATGGGAAGTGTTTATTGTTCCTTTTCCTACAAAGGAAGCAGTCTCTGGAGGCCAGAAAGAAAAGCCTTCTT

>12847_12847_3_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000356174_length(amino acids)=457AA_BP=91
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGA
ADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIIS
LWNPWGWGEAEWRGRWSDGVESRLDLRKNLRCQSFKWYLENIYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCAKVKGE
DAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSHIEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQ

--------------------------------------------------------------
>12847_12847_4_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000406653_length(transcript)=2156nt_BP=1215nt
AGTGCTTGCACTGAGCCCACAGTCCTTATCCTCATGCGTGGCCCATTGTCTAATGATCGTCCCCTCAAAATAGGTGGCAGGCCACTGCCC
AATGCTGAAGTCACTGTTTAACGAAGGTGGAGCCTGCCTTTACCTGGTACACCCATATAAGGAAAAGCCTGAGGTCAGGAGTAAGCAGAC
ACCAGCACTGCTCTTTCTCCAAGACGGCCGGCCATGCTCTCCTCCTCTGCCAGTCTCCTCCACCACTCTCTAACCTGAGAGCCTGTGGAA
CCTGCCCGTCTCCCCTCCTCCATCAGACACACCTGCCTAGGAAACAGGAAAGGACCTCGGAAGTCTTCTAAGGAGAGTCATGGCGTATTA
CCAGGAGCCTTCAGTGGAGACCTCCATCATCAAGTTCAAAGACCAGGACTTTACCACCTTGCGGGATCACTGCCTGAGCATGGGCCGGAC
GTTTAAGGATGAGACATTCCCTGCAGCAGATTCTTCCATAGGCCAGAAGCTGCTCCAGGAAAAACGCCTCTCCAATGTGATATGGAAGCG
GCCACAGGATCTACCAGGGGGTCCTCCTCACTTCATCCTGGATGATATAAGCAGATTTGACATCCAACAAGGAGGCGCAGCTGACTGCTG
GTTCCTGGCAGCACTGGGATCCTTGACTCAGAACCCACAGTACAGGCAGAAGATCCTGATGGTCCAAAGCTTTTCACACCAGTATGCTGG
CATTTTCCGTTTCCGGTTCTGGCAATGTGGCCAGTGGGTGGAAGTGGTGATTGATGACCGCCTACCTGTCCAGGGAGATAAATGCCTCTT
TGTGCGTCCTCGCCACCAAAACCAAGAGTTCTGGCCCTGCCTGCTGGAGAAGGCCTATGCCAAGCTGCTCGGATCCTATTCCGATCTGCA
CTATGGCTTCCTCGAGGATGCCCTGGTGGACCTCACAGGAGGCGTGATCACCAACATCCATCTGCACTCTTCCCCTGTGGACCTGGTGAA
GGCAGTGAAGACAGCGACCAAGGCAGGCTCCCTGATAACCTGTGCCACTCCAAGTGGGCCAACAGATACAGCACAGGCGATGGAGAATGG
GCTGGTGAGTCTCCATGCCTACACTGTGACTGGGGCTGAGCAGATTCAATACCGAAGGGGCTGGGAAGAAATTATCTCCCTGTGGAACCC
CTGGGGCTGGGGCGAGGCCGAATGGAGAGGGCGCTGGAGTGATGGTGTTGAGAGCAGATTGGACCTGAGGAAGAATCTGCGCTGCCAGAG
CTTCAAGTGGTACCTGGAGAATATCTACCCTGAACTCAGCATCCCCAAGGAGTCCTCCATCCAGAAGGGCAATATCCGACAGAGACAGAA
GTGCCTGGAATCTCAAAGGCAGAACAACCAAGAAACCCCAAACCTAAAGTTGAGCCCCTGTGCCAAGGTCAAAGGCGAAGATGCAAAGTC
CCAGGTATGGGCCTTCACATACACCCAGCAGATCCTCCAGGAGGAGCTGTGCCTGTCAGTCATCACCTTGTTCCCTGGCGCCCCAGTGGT
TCTTGTCCTTTGCAAGAATGGAGATGACCGACAGCAATGGACCAAAACTGGTTCCCACATCGAGCACATAGCATCCCACCTCTGCCTCGA
TACAGATATGTTCGGTGATGGCACCGAGAACGGCAAGGAAATCGTCGTCAACCCATGTGAGTCCTCACTCATGAGCCAGCACTGGGACAT
GGTGAGCTCTTGAGGACCCCTGCCAGAAGCAGCAAGGGCCATGGGGTGGTGCTTCCCTGGACCAGAACAGACTGGAAACTGGGCAGCAAG
CAGCCTGCAACCACCTCAGACATCCTGGACTGGGAGGTGGAGGCAGAGCCCCCCAGGACAGGAGCAACTGTCTCAGGGAGGACAGAGGAA
AACATCACAAGCCAATGGGGCTCAAAGACAAATCCCACATGTTCTCAAGGCCGTTAAGTTCCAGTCCTGGCCAGTCATTCCCTGATTGGT
ATCTGGAGACAGAAACCTAATGGGAAGTGTTTATTGTTCCTTTTCCTACAAAGGAAGCAGTCTCTGGAGGCCAGAAAGAAAAGCCTTCTT

>12847_12847_4_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000406653_length(amino acids)=457AA_BP=91
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGA
ADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIIS
LWNPWGWGEAEWRGRWSDGVESRLDLRKNLRCQSFKWYLENIYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCAKVKGE
DAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSHIEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQ

--------------------------------------------------------------
>12847_12847_5_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000420311_length(transcript)=1827nt_BP=1215nt
AGTGCTTGCACTGAGCCCACAGTCCTTATCCTCATGCGTGGCCCATTGTCTAATGATCGTCCCCTCAAAATAGGTGGCAGGCCACTGCCC
AATGCTGAAGTCACTGTTTAACGAAGGTGGAGCCTGCCTTTACCTGGTACACCCATATAAGGAAAAGCCTGAGGTCAGGAGTAAGCAGAC
ACCAGCACTGCTCTTTCTCCAAGACGGCCGGCCATGCTCTCCTCCTCTGCCAGTCTCCTCCACCACTCTCTAACCTGAGAGCCTGTGGAA
CCTGCCCGTCTCCCCTCCTCCATCAGACACACCTGCCTAGGAAACAGGAAAGGACCTCGGAAGTCTTCTAAGGAGAGTCATGGCGTATTA
CCAGGAGCCTTCAGTGGAGACCTCCATCATCAAGTTCAAAGACCAGGACTTTACCACCTTGCGGGATCACTGCCTGAGCATGGGCCGGAC
GTTTAAGGATGAGACATTCCCTGCAGCAGATTCTTCCATAGGCCAGAAGCTGCTCCAGGAAAAACGCCTCTCCAATGTGATATGGAAGCG
GCCACAGGATCTACCAGGGGGTCCTCCTCACTTCATCCTGGATGATATAAGCAGATTTGACATCCAACAAGGAGGCGCAGCTGACTGCTG
GTTCCTGGCAGCACTGGGATCCTTGACTCAGAACCCACAGTACAGGCAGAAGATCCTGATGGTCCAAAGCTTTTCACACCAGTATGCTGG
CATTTTCCGTTTCCGGTTCTGGCAATGTGGCCAGTGGGTGGAAGTGGTGATTGATGACCGCCTACCTGTCCAGGGAGATAAATGCCTCTT
TGTGCGTCCTCGCCACCAAAACCAAGAGTTCTGGCCCTGCCTGCTGGAGAAGGCCTATGCCAAGCTGCTCGGATCCTATTCCGATCTGCA
CTATGGCTTCCTCGAGGATGCCCTGGTGGACCTCACAGGAGGCGTGATCACCAACATCCATCTGCACTCTTCCCCTGTGGACCTGGTGAA
GGCAGTGAAGACAGCGACCAAGGCAGGCTCCCTGATAACCTGTGCCACTCCAAGTGGGCCAACAGATACAGCACAGGCGATGGAGAATGG
GCTGGTGAGTCTCCATGCCTACACTGTGACTGGGGCTGAGCAGATTCAATACCGAAGGGGCTGGGAAGAAATTATCTCCCTGTGGAACCC
CTGGGGCTGGGGCGAGGCCGAATGGAGAGGGCGCTGGAGTGATGGTGTTGAGAGCAGATTGGACCTGAGGAAGAATCTGCGCTGCCAGAG
CTTCAAGTGGTACCTGGAGAATATCTACCCTGAACTCAGCATCCCCAAGGAGTCCTCCATCCAGAAGGGCAATATCCGACAGAGACAGAA
GTGCCTGGAATCTCAAAGGCAGAACAACCAAGAAACCCCAAACCTAAAGTTGAGCCCCTGTGCCAAGGTCAAAGGCGAAGATGCAAAGTC
CCAGGTATGGGCCTTCACATACACCCAGCAGATCCTCCAGGAGGAGCTGTGCCTGTCAGTCATCACCTTGTTCCCTGGCGCCCCAGTGGT
TCTTGTCCTTTGCAAGAATGGAGATGACCGACAGCAATGGACCAAAACTGGTTCCCACATCGAGCACATAGCATCCCACCTCTGCCTCGA
TACAGATATGTTCGGTGATGGCACCGAGAACGGCAAGGAAATCGTCGTCAACCCATGTGAGTCCTCACTCATGAGCCAGCACTGGGACAT
GGTGAGCTCTTGAGGACCCCTGCCAGAAGCAGCAAGGGCCATGGGGTGGTGCTTCCCTGGACCAGAACAGACTGGAAACTGGGCAGCAAG

>12847_12847_5_CAPN13-GALNT14_CAPN13_chr2_30980912_ENST00000465960_GALNT14_chr2_31147689_ENST00000420311_length(amino acids)=457AA_BP=91
MAYYQEPSVETSIIKFKDQDFTTLRDHCLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGGPPHFILDDISRFDIQQGGA
ADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVIDDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSY
SDLHYGFLEDALVDLTGGVITNIHLHSSPVDLVKAVKTATKAGSLITCATPSGPTDTAQAMENGLVSLHAYTVTGAEQIQYRRGWEEIIS
LWNPWGWGEAEWRGRWSDGVESRLDLRKNLRCQSFKWYLENIYPELSIPKESSIQKGNIRQRQKCLESQRQNNQETPNLKLSPCAKVKGE
DAKSQVWAFTYTQQILQEELCLSVITLFPGAPVVLVLCKNGDDRQQWTKTGSHIEHIASHLCLDTDMFGDGTENGKEIVVNPCESSLMSQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAPN13-GALNT14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPN13-GALNT14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPN13-GALNT14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource