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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPN1-TNKS1BP1 (FusionGDB2 ID:12869)

Fusion Gene Summary for CAPN1-TNKS1BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPN1-TNKS1BP1
Fusion gene ID: 12869
HgeneTgene
Gene symbol

CAPN1

TNKS1BP1

Gene ID

823

85456

Gene namecalpain 1tankyrase 1 binding protein 1
SynonymsCANP|CANP1|CANPL1|SPG76|muCANP|muCLTAB182
Cytomap

11q13.1

11q12.1

Type of geneprotein-codingprotein-coding
Descriptioncalpain-1 catalytic subunitCANP 1calcium-activated neutral proteinase 1calpain 1, (mu/I) large subunitcalpain mu-typecalpain, large polypeptide L1calpain-1 large subunitcell proliferation-inducing gene 30 proteincell proliferation-inducing protein182 kDa tankyrase-1-binding proteintankyrase 1 binding protein 1, 182kDatankyrase 1-binding protein of 182 kDatestis secretory sperm-binding protein Li 206a
Modification date2020032220200313
UniProtAcc

P07384

.
Ensembl transtripts involved in fusion geneENST00000527469, ENST00000279247, 
ENST00000524773, ENST00000527323, 
ENST00000533129, ENST00000533820, 
ENST00000358252, ENST00000532437, 
ENST00000530920, 
Fusion gene scores* DoF score13 X 11 X 8=11448 X 8 X 3=192
# samples 138
** MAII scorelog2(13/1144*10)=-3.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPN1 [Title/Abstract] AND TNKS1BP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPN1(64951063)-TNKS1BP1(57068515), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAPN1

GO:0006508

proteolysis

2400579|2407243|16411745|21531719

HgeneCAPN1

GO:0050790

regulation of catalytic activity

8954105|9271093

HgeneCAPN1

GO:0097264

self proteolysis

8769305|8954105


check buttonFusion gene breakpoints across CAPN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNKS1BP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A6B5-01ACAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-


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Fusion Gene ORF analysis for CAPN1-TNKS1BP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000527469ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
3UTR-3CDSENST00000527469ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
3UTR-intronENST00000527469ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000279247ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000524773ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000527323ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000533129ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
5CDS-intronENST00000533820ENST00000530920CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000279247ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000279247ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000524773ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000524773ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000527323ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000527323ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000533129ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000533129ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000533820ENST00000358252CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-
In-frameENST00000533820ENST00000532437CAPN1chr11

64951063

+TNKS1BP1chr11

57068515

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000533820CAPN1chr1164951063+ENST00000358252TNKS1BP1chr1157068515-134567478869263
ENST00000533820CAPN1chr1164951063+ENST00000532437TNKS1BP1chr1157068515-134367478869263
ENST00000533129CAPN1chr1164951063+ENST00000358252TNKS1BP1chr1157068515-120253175749224
ENST00000533129CAPN1chr1164951063+ENST00000532437TNKS1BP1chr1157068515-120053175749224
ENST00000524773CAPN1chr1164951063+ENST00000358252TNKS1BP1chr1157068515-1227556100774224
ENST00000524773CAPN1chr1164951063+ENST00000532437TNKS1BP1chr1157068515-1225556100774224
ENST00000279247CAPN1chr1164951063+ENST00000358252TNKS1BP1chr1157068515-127059963794243
ENST00000279247CAPN1chr1164951063+ENST00000532437TNKS1BP1chr1157068515-126859963794243
ENST00000527323CAPN1chr1164951063+ENST00000358252TNKS1BP1chr1157068515-1367696207914235
ENST00000527323CAPN1chr1164951063+ENST00000532437TNKS1BP1chr1157068515-1365696207914235

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000533820ENST00000358252CAPN1chr1164951063+TNKS1BP1chr1157068515-0.0471934530.95280653
ENST00000533820ENST00000532437CAPN1chr1164951063+TNKS1BP1chr1157068515-0.0470304750.95296955
ENST00000533129ENST00000358252CAPN1chr1164951063+TNKS1BP1chr1157068515-0.056029410.9439706
ENST00000533129ENST00000532437CAPN1chr1164951063+TNKS1BP1chr1157068515-0.0563128780.9436872
ENST00000524773ENST00000358252CAPN1chr1164951063+TNKS1BP1chr1157068515-0.0556035680.94439644
ENST00000524773ENST00000532437CAPN1chr1164951063+TNKS1BP1chr1157068515-0.0558783450.94412166
ENST00000279247ENST00000358252CAPN1chr1164951063+TNKS1BP1chr1157068515-0.0405294260.95947057
ENST00000279247ENST00000532437CAPN1chr1164951063+TNKS1BP1chr1157068515-0.040587670.9594123
ENST00000527323ENST00000358252CAPN1chr1164951063+TNKS1BP1chr1157068515-0.042979830.95702016
ENST00000527323ENST00000532437CAPN1chr1164951063+TNKS1BP1chr1157068515-0.0432217230.9567783

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Fusion Genomic Features for CAPN1-TNKS1BP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPN1-TNKS1BP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64951063/chr11:57068515)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPN1

P07384

.
FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction (PubMed:21531719, PubMed:2400579). Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-387' and 'His-409' (PubMed:23707407). {ECO:0000269|PubMed:21531719, ECO:0000269|PubMed:23707407, ECO:0000269|PubMed:2400579}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+42299_106152715.0Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+42299_106152715.0Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+32199_106152715.0Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+42299_106152715.0Calcium bindingNote=1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+42299_106152715.0Calcium bindingNote=1
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000003582528121723_172916571818.6666666666667MotifNuclear localization signal
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000005324377111723_172916571553.6666666666667MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422302_333152715.0Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422598_609152715.0Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422628_639152715.0Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422302_333152715.0Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422598_609152715.0Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422628_639152715.0Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321302_333152715.0Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321598_609152715.0Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321628_639152715.0Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422302_333152715.0Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422598_609152715.0Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422628_639152715.0Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422302_333152715.0Calcium bindingNote=2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422598_609152715.0Calcium bindingNote=3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422628_639152715.0Calcium bindingNote=4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422541_576152715.0DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+42255_354152715.0DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422585_618152715.0DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422615_650152715.0DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422680_714152715.0DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422541_576152715.0DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+42255_354152715.0DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422585_618152715.0DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422615_650152715.0DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422680_714152715.0DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321541_576152715.0DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+32155_354152715.0DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321585_618152715.0DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321615_650152715.0DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321680_714152715.0DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422541_576152715.0DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+42255_354152715.0DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422585_618152715.0DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422615_650152715.0DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422680_714152715.0DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422541_576152715.0DomainEF-hand 1
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+42255_354152715.0DomainCalpain catalytic
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422585_618152715.0DomainEF-hand 2
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422615_650152715.0DomainEF-hand 3
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422680_714152715.0DomainEF-hand 4
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422355_526152715.0RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422527_542152715.0RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000279247+422543_713152715.0RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422355_526152715.0RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422527_542152715.0RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000524773+422543_713152715.0RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321355_526152715.0RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321527_542152715.0RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000527323+321543_713152715.0RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422355_526152715.0RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422527_542152715.0RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533129+422543_713152715.0RegionNote=Domain IV
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422355_526152715.0RegionNote=Domain III
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422527_542152715.0RegionNote=Linker
HgeneCAPN1chr11:64951063chr11:57068515ENST00000533820+422543_713152715.0RegionNote=Domain IV
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000003582528121010_134016571818.6666666666667Compositional biasNote=Gly-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252812127_76716571818.6666666666667Compositional biasNote=Pro-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000003582528121572_172916571818.6666666666667Compositional biasNote=Arg/Glu/Lys-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000003582528122_10316571818.6666666666667Compositional biasNote=Arg/Glu/Lys/Pro-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000005324377111010_134016571553.6666666666667Compositional biasNote=Gly-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437711127_76716571553.6666666666667Compositional biasNote=Pro-rich
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000005324377111572_172916571553.6666666666667Compositional biasNote=Arg/Glu/Lys-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000005324377112_10316571553.6666666666667Compositional biasNote=Arg/Glu/Lys/Pro-rich (charged)
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000003582528121629_163516571818.6666666666667MotifNuclear localization signal
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000005324377111629_163516571553.6666666666667MotifNuclear localization signal
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000003582528121450_154216571818.6666666666667RegionNote=Tankyrase-binding
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000358252812210_157216571818.6666666666667RegionNote=Acidic
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST000005324377111450_154216571553.6666666666667RegionNote=Tankyrase-binding
TgeneTNKS1BP1chr11:64951063chr11:57068515ENST00000532437711210_157216571553.6666666666667RegionNote=Acidic


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Fusion Gene Sequence for CAPN1-TNKS1BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12869_12869_1_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000279247_TNKS1BP1_chr11_57068515_ENST00000358252_length(transcript)=1270nt_BP=599nt
AAGGAGAGAGGGAGGGCGGAGGGCGGAGGGGCGGCGGGAGGAGGGCGGGGAGGAGCGCTCTTCCTGGTTGGGCCCTGCCCTGAGCTGCCA
CCGGGAAGCCAGCCTCAGGGACTGCAGCGACCCCCAAACACCCCTCCCCCAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTG
GGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATG
AGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACC
TGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTA
CCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACC
GAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTG
AGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGC
CCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGA
AGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAG
CCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCG
AACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGC
TTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTG
TATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAAATAAAGT

>12869_12869_1_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000279247_TNKS1BP1_chr11_57068515_ENST00000358252_length(amino acids)=243AA_BP=172
MVGPCPELPPGSQPQGLQRPPNTPPPGCRRRSSRRCTALGCQPKCRSSGPGSWAWAAMRMPSSTWARIMSSCGCDACRVGPSSVMRPSPR
YPRAWVTRTWVPIPPRPMASSGSVPRNCCQTPSSLWMELPAQTSAREHWGTAGSWRPSPPSLSTTPSCTEWFRTARASRMAMPASSISRP

--------------------------------------------------------------
>12869_12869_2_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000279247_TNKS1BP1_chr11_57068515_ENST00000532437_length(transcript)=1268nt_BP=599nt
AAGGAGAGAGGGAGGGCGGAGGGCGGAGGGGCGGCGGGAGGAGGGCGGGGAGGAGCGCTCTTCCTGGTTGGGCCCTGCCCTGAGCTGCCA
CCGGGAAGCCAGCCTCAGGGACTGCAGCGACCCCCAAACACCCCTCCCCCAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTG
GGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATG
AGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACC
TGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTA
CCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACC
GAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTG
AGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGC
CCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGA
AGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAG
CCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCG
AACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGC
TTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTG
TATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAAATAAAGT

>12869_12869_2_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000279247_TNKS1BP1_chr11_57068515_ENST00000532437_length(amino acids)=243AA_BP=172
MVGPCPELPPGSQPQGLQRPPNTPPPGCRRRSSRRCTALGCQPKCRSSGPGSWAWAAMRMPSSTWARIMSSCGCDACRVGPSSVMRPSPR
YPRAWVTRTWVPIPPRPMASSGSVPRNCCQTPSSLWMELPAQTSAREHWGTAGSWRPSPPSLSTTPSCTEWFRTARASRMAMPASSISRP

--------------------------------------------------------------
>12869_12869_3_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000524773_TNKS1BP1_chr11_57068515_ENST00000358252_length(transcript)=1227nt_BP=556nt
TGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGTGCCGGAGAGATAAGGGAGAGCCGAGA
GGAAGCGGGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGG
CCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCG
TGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCG
TCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCT
CTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGG
CATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTC
CGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGA
AGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCA
GGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCT
GAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTG
GTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTT
ATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTAC

>12869_12869_3_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000524773_TNKS1BP1_chr11_57068515_ENST00000358252_length(amino acids)=224AA_BP=151
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

--------------------------------------------------------------
>12869_12869_4_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000524773_TNKS1BP1_chr11_57068515_ENST00000532437_length(transcript)=1225nt_BP=556nt
TGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGTGCCGGAGAGATAAGGGAGAGCCGAGA
GGAAGCGGGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGG
CCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCG
TGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCG
TCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCT
CTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGG
CATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTC
CGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGA
AGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCA
GGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCT
GAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTG
GTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTT
ATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTAC

>12869_12869_4_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000524773_TNKS1BP1_chr11_57068515_ENST00000532437_length(amino acids)=224AA_BP=151
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

--------------------------------------------------------------
>12869_12869_5_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000527323_TNKS1BP1_chr11_57068515_ENST00000358252_length(transcript)=1367nt_BP=696nt
GGGATCCGGGAAAGGAGAGGTGGCCGGCACGCCTGGGAACTGGGAAATCCCTTTCCTGGATTCACTGGGAGCACCGGGAGGTGGCTGAGA
ACCCTACTTCTGTGAGGGGAGCAGTGAGGCAGGGAAACCCTAGGTTTGGGGATGGATAAGCAGGGGCAGGAGAGCAGAGCTTGCAGGCAG
GAGCCCAGGTTCTAGTCTTGGGAAGGCCTGGGTTCTGAGCAGGCCCATCTGTCCGGCAGGATGTCGGAGGAGATCATCACGCCGGTGTAC
TGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAG
GATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTAC
AAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGAT
GGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTC
CTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGC
TCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTG
GGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAG
AAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACG
GCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCA
CCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCC
TCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGT
GGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAA

>12869_12869_5_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000527323_TNKS1BP1_chr11_57068515_ENST00000358252_length(amino acids)=235AA_BP=162
MGSEQAHLSGRMSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSK
TYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAE

--------------------------------------------------------------
>12869_12869_6_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000527323_TNKS1BP1_chr11_57068515_ENST00000532437_length(transcript)=1365nt_BP=696nt
GGGATCCGGGAAAGGAGAGGTGGCCGGCACGCCTGGGAACTGGGAAATCCCTTTCCTGGATTCACTGGGAGCACCGGGAGGTGGCTGAGA
ACCCTACTTCTGTGAGGGGAGCAGTGAGGCAGGGAAACCCTAGGTTTGGGGATGGATAAGCAGGGGCAGGAGAGCAGAGCTTGCAGGCAG
GAGCCCAGGTTCTAGTCTTGGGAAGGCCTGGGTTCTGAGCAGGCCCATCTGTCCGGCAGGATGTCGGAGGAGATCATCACGCCGGTGTAC
TGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAG
GATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTAC
AAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGAT
GGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTC
CTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGC
TCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTG
GGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAG
AAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACG
GCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCA
CCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCC
TCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGT
GGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGCCACTTGAAACAATAA

>12869_12869_6_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000527323_TNKS1BP1_chr11_57068515_ENST00000532437_length(amino acids)=235AA_BP=162
MGSEQAHLSGRMSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSK
TYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAE

--------------------------------------------------------------
>12869_12869_7_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533129_TNKS1BP1_chr11_57068515_ENST00000358252_length(transcript)=1202nt_BP=531nt
CTCTCGCGGAATTGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGATGTCGGAGGAGATC
ATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATC
AAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCC
CAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCC
CAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACT
CTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTG
CGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGC
AAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAA
GCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCC
CTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTT
ATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTC
CTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTG
ATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGC

>12869_12869_7_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533129_TNKS1BP1_chr11_57068515_ENST00000358252_length(amino acids)=224AA_BP=151
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

--------------------------------------------------------------
>12869_12869_8_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533129_TNKS1BP1_chr11_57068515_ENST00000532437_length(transcript)=1200nt_BP=531nt
CTCTCGCGGAATTGGCCCCCGGCCTGCGGAGGGAGGGGCGGGGAGACACCGTGAGTAAGAGATAGTCAGAGACCGATGTCGGAGGAGATC
ATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAGTGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATC
AAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGCGATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCC
CAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCTCCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCC
CAGTTCATTGTGGATGGAGCTACCCGCACAGACATCTGCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACT
CTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACGGCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTG
CGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGGCTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGC
AAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTCCCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAA
GCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCACTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCC
CTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCAGGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTT
ATGCACTTTGTATCACCCTCCGAACTCCCCCCACACCTTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTC
CTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCTCCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTG
ATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACCCCAGGTCTCCGTCTGCCCCGCCAGGTACCCCACAGAGACCAATGACATTTTGC

>12869_12869_8_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533129_TNKS1BP1_chr11_57068515_ENST00000532437_length(amino acids)=224AA_BP=151
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTE
LLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQAKLRPRNRSAEEGELAESKSSQKESAVQ

--------------------------------------------------------------
>12869_12869_9_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533820_TNKS1BP1_chr11_57068515_ENST00000358252_length(transcript)=1345nt_BP=674nt
GAAAGTCGGGCCGAACGGGGCAGGGACTTACCCAAGGTCACGCAGCGAGCCCGGTCCCCCTGCGTTCCCCGGGGAGCGCTGAGCCGGGAC
GCGGCGGTGGGGTGGGGAAGGGGAGTGGCGCGGCCCTGCGGGGTGAGGCTGCCGTTTGCTGAGTGTCCGGCAGGGGTCTGCTCGCTGCCA
GCCCGGCCCCTCCTCAGAGCAGCTGCCGCAGCCCGAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAG
TGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGC
GATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCT
CCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCT
GCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACG
GCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGG
CTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTC
CCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCA
CTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCA
GGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACC
TTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCT
CCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACC

>12869_12869_9_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533820_TNKS1BP1_chr11_57068515_ENST00000358252_length(amino acids)=263AA_BP=192
MSRDAAVGWGRGVARPCGVRLPFAECPAGVCSLPARPLLRAAAAARGCRRRSSRRCTALGCQPKCRSSGPGSWAWAAMRMPSSTWARIMS
SCGCDACRVGPSSVMRPSPRYPRAWVTRTWVPIPPRPMASSGSVPRNCCQTPSSLWMELPAQTSAREHWGTAGSWRPSPPSLSTTPSCTE

--------------------------------------------------------------
>12869_12869_10_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533820_TNKS1BP1_chr11_57068515_ENST00000532437_length(transcript)=1343nt_BP=674nt
GAAAGTCGGGCCGAACGGGGCAGGGACTTACCCAAGGTCACGCAGCGAGCCCGGTCCCCCTGCGTTCCCCGGGGAGCGCTGAGCCGGGAC
GCGGCGGTGGGGTGGGGAAGGGGAGTGGCGCGGCCCTGCGGGGTGAGGCTGCCGTTTGCTGAGTGTCCGGCAGGGGTCTGCTCGCTGCCA
GCCCGGCCCCTCCTCAGAGCAGCTGCCGCAGCCCGAGGATGTCGGAGGAGATCATCACGCCGGTGTACTGCACTGGGGTGTCAGCCCAAG
TGCAGAAGCAGCGGGCCAGGGAGCTGGGCCTGGGCCGCCATGAGAATGCCATCAAGTACCTGGGCCAGGATTATGAGCAGCTGCGGGTGC
GATGCCTGCAGAGTGGGACCCTCTTCCGTGATGAGGCCTTCCCCCCGGTACCCCAGAGCCTGGGTTACAAGGACCTGGGTCCCAATTCCT
CCAAGACCTATGGCATCAAGTGGAAGCGTCCCACGGAACTGCTGTCAAACCCCCAGTTCATTGTGGATGGAGCTACCCGCACAGACATCT
GCCAGGGAGCACTGGGGGACTGCTGGCTCTTGGCGGCCATCGCCTCCCTCACTCTCAACGACACCCTCCTGCACCGAGTGGTTCCGCACG
GCCAGAGCTTCCAGAATGGCTATGCCGGCATCTTCCATTTCCAGGCCAAGCTGCGCCCCCGGAATCGCTCAGCTGAGGAGGGAGAGCTGG
CTGAGAGCAAGTCGAGCCAGAAGGAGTCCGCGGTCCAGCGTTCGAAATCCTGCAAGGTCCCAGGACTGGGAAAGCCCCTCACGTTACCTC
CCAAGCCAGAGAAATCCTCAGGGTCAGAAGGATCGTCGCCCAACTGGCTTCAAGCCCTGAAACTGAAGAAGAAGAAGGTCTGAGAAGTCA
CTGAGGTTCTTCCCACCTGGCAGTCTCAGGCAGTGCCCATTCCTGTGGGGTCCCTGGGTGAGGAGACGGCTGGAGCCCCACCATGCCCCA
GGCTGCAGCCTCTGTCCCCTCCACCTCTGAGGAGCGTCTGGGGAGGCACATTTATGCACTTTGTATCACCCTCCGAACTCCCCCCACACC
TTCCCTTCCCTGGATTTCATCACTAGTGGTTGAAGGTTTTGTCCCTTCCTCTCCTCCTTCCCTCTCCCTCTCTGCTTCCTCCTCCAGCCT
CCCTTGGGTTTTCTTTTGATACCAATTTATAGCATTTTTTATAAAAGCCTTTGATTTTTATAATGGGTGGGACTGTATCCCTGCCTCACC

>12869_12869_10_CAPN1-TNKS1BP1_CAPN1_chr11_64951063_ENST00000533820_TNKS1BP1_chr11_57068515_ENST00000532437_length(amino acids)=263AA_BP=192
MSRDAAVGWGRGVARPCGVRLPFAECPAGVCSLPARPLLRAAAAARGCRRRSSRRCTALGCQPKCRSSGPGSWAWAAMRMPSSTWARIMS
SCGCDACRVGPSSVMRPSPRYPRAWVTRTWVPIPPRPMASSGSVPRNCCQTPSSLWMELPAQTSAREHWGTAGSWRPSPPSLSTTPSCTE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAPN1-TNKS1BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPN1-TNKS1BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPN1-TNKS1BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource