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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CAPN5-HSD17B14 (FusionGDB2 ID:12888)

Fusion Gene Summary for CAPN5-HSD17B14

Fusion gene summary

Fusion gene information	Fusion gene name: CAPN5-HSD17B14
	Fusion gene ID: 12888
		Hgene	Tgene
	Gene symbol	CAPN5	HSD17B14
	Gene ID	726	51171
	Gene name	calpain 5	hydroxysteroid 17-beta dehydrogenase 14
	Synonyms	ADNIV\|HTRA3\|VRNI\|nCL-3	DHRS10\|SDR47C1\|retSDR3
	Cytomap	11q13.5	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	calpain-5calpain htra-3new calpain 3testis tissue sperm-binding protein Li 91mP	17-beta-hydroxysteroid dehydrogenase 1417-beta-HSD 1417-beta-hydroxysteroid dehydrogenase DHRS10dehydrogenase/reductase (SDR family) member 10retinal short-chain dehydrogenase/reductase 3retinal short-chain dehydrogenase/reductase retSDR3short chain
	Modification date	20200313	20200327
	UniProtAcc	O15484	Q9BPX1
	Ensembl transtripts involved in fusion gene	ENST00000278559, ENST00000456580, ENST00000529629, ENST00000531028,	ENST00000263278, ENST00000599157,
Fusion gene scores	* DoF score	8 X 5 X 5=200	10 X 3 X 7=210
	# samples	8	9
	** MAII score	log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/210*10)=-1.22239242133645 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CAPN5 [Title/Abstract] AND HSD17B14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CAPN5(76804859)-HSD17B14(49318398), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HSD17B14	GO:0006706	steroid catabolic process	17067289

Fusion gene breakpoints across CAPN5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HSD17B14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-AAE2-01A	CAPN5	chr11	76804859	-	HSD17B14	chr19	49318398	-
ChimerDB4	LIHC	TCGA-DD-AAE2-01A	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
ChimerDB4	LIHC	TCGA-DD-AAE2	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-

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Fusion Gene ORF analysis for CAPN5-HSD17B14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000278559	ENST00000263278	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
In-frame	ENST00000278559	ENST00000599157	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
In-frame	ENST00000456580	ENST00000263278	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
In-frame	ENST00000456580	ENST00000599157	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
In-frame	ENST00000529629	ENST00000263278	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
In-frame	ENST00000529629	ENST00000599157	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
intron-3CDS	ENST00000531028	ENST00000263278	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-
intron-3CDS	ENST00000531028	ENST00000599157	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000278559	CAPN5	chr11	76804859	+	ENST00000263278	HSD17B14	chr19	49318398	-	1088	486	63	929	288
ENST00000278559	CAPN5	chr11	76804859	+	ENST00000599157	HSD17B14	chr19	49318398	-	1081	486	63	929	288
ENST00000529629	CAPN5	chr11	76804859	+	ENST00000263278	HSD17B14	chr19	49318398	-	1125	523	43	966	307
ENST00000529629	CAPN5	chr11	76804859	+	ENST00000599157	HSD17B14	chr19	49318398	-	1118	523	43	966	307
ENST00000456580	CAPN5	chr11	76804859	+	ENST00000263278	HSD17B14	chr19	49318398	-	1156	554	11	997	328
ENST00000456580	CAPN5	chr11	76804859	+	ENST00000599157	HSD17B14	chr19	49318398	-	1149	554	11	997	328

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000278559	ENST00000263278	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-	0.029455045	0.97054493
ENST00000278559	ENST00000599157	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-	0.02976065	0.97023934
ENST00000529629	ENST00000263278	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-	0.072372355	0.9276276
ENST00000529629	ENST00000599157	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-	0.073138826	0.92686117
ENST00000456580	ENST00000263278	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-	0.09155785	0.9084422
ENST00000456580	ENST00000599157	CAPN5	chr11	76804859	+	HSD17B14	chr19	49318398	-	0.092211686	0.90778834

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Fusion Genomic Features for CAPN5-HSD17B14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPN5-HSD17B14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:76804859/chr19:49318398)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAPN5 O15484	HSD17B14 Q9BPX1
FUNCTION: Calcium-regulated non-lysosomal thiol-protease. {ECO:0000250}.	FUNCTION: Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro). {ECO:0000269\|PubMed:17067289}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CAPN5

chr11:76804859

chr19:49318398

ENST00000278559

26_343

641.0

Domain

Calpain catalytic

Hgene

CAPN5

chr11:76804859

chr19:49318398

ENST00000278559

499_614

641.0

Domain

Hgene

CAPN5

chr11:76804859

chr19:49318398

ENST00000529629

26_343

641.0

Domain

Calpain catalytic

Hgene

CAPN5

chr11:76804859

chr19:49318398

ENST00000529629

499_614

641.0

Domain

Hgene

CAPN5

chr11:76804859

chr19:49318398

ENST00000278559

344_496

641.0

Region

Note=Domain III

Hgene

CAPN5

chr11:76804859

chr19:49318398

ENST00000529629

344_496

641.0

Region

Note=Domain III

Tgene

HSD17B14

chr11:76804859

chr19:49318398

ENST00000263278

13_40

123

271.0

Nucleotide binding

NAD

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Fusion Gene Sequence for CAPN5-HSD17B14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>12888_12888_1_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=1088nt_BP=486nt
GAATGCGAGCGCCAGCCCCCGCCGCAGGCCAGTCCCAGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCC
GCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCGGCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCA
GCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGCCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTC
GAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCCGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATC
TGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGC
TCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGC
CTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGAT
GAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGAC
CCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTG
GCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACC
CCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCT
GTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCCGGGTCACCCTGCAGGTTCCCATAAAAACGATTTGCA

>12888_12888_1_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=288AA_BP=141
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVT
AMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELG

--------------------------------------------------------------
>12888_12888_2_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=1081nt_BP=486nt
GAATGCGAGCGCCAGCCCCCGCCGCAGGCCAGTCCCAGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCC
GCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCGGCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCA
GCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGCCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTC
GAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCCGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATC
TGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGC
TCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGC
CTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGAT
GAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGAC
CCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTG
GCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACC
CCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCT
GTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGCCGGGTCACCCTGCAGGTTCCCATAAAAACGATTTGCA

>12888_12888_2_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000278559_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=288AA_BP=141
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVT
AMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELG

--------------------------------------------------------------
>12888_12888_3_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=1156nt_BP=554nt
AGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCG
GCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAG
CCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGC
CGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGTACAGTGGCCATTCGCTGGCCCCTCACAGGCCTGGCTGGGGAGATGCACGGAGAATGG
AGAATGTCCCCAGGCCTGGGAGCTCAGGGTGTCCGTCCTCCTCGCTCAGGGCCCGGGACCTGGGCATCTGCGAGGACCCCCGCCTCTTTG
TGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGT
CGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGG
CCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAG
TCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGG
GCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCA
CGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCC
CTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGC

>12888_12888_3_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=328AA_BP=181
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKYSGHSLAPHRPGWGDARRMENVPRPGSSGCPSSSLRARDLGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQ
KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLA

--------------------------------------------------------------
>12888_12888_4_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=1149nt_BP=554nt
AGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAGCCCGGCTGGACCCGCG
GCGGCTCGGCCGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAG
CCCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGC
CGGGGCCCGCCGTCAGGTGGAAGCGACCCAAGTACAGTGGCCATTCGCTGGCCCCTCACAGGCCTGGCTGGGGAGATGCACGGAGAATGG
AGAATGTCCCCAGGCCTGGGAGCTCAGGGTGTCCGTCCTCCTCGCTCAGGGCCCGGGACCTGGGCATCTGCGAGGACCCCCGCCTCTTTG
TGGATGGCATCAGCTCCCACGACCTGCACCAGGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGT
CGCTGTGGCAAAAGCTCGCCCTCCCCTACCTGCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGG
CCCAGGCAGTTCCCTATGTGGCCACCAAGGGGGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAG
TCAACTGTATCTCCCCAGGAAACATCTGGACCCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGG
GCATGCTGGCCCAGCCACTGGGCCGCATGGGCCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCA
CGGGCATTGAACTGCTCGTGACGGGGGGTGCAGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCC
CTTCCTGATTTCTCTCATTTCTACTTGGGGCCCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGC

>12888_12888_4_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000456580_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=328AA_BP=181
MLRRAAAASAPAPAPCPASREPGWTRGGSAGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFEDPLFPATDDSLYYKGTPGPA
VRWKRPKYSGHSLAPHRPGWGDARRMENVPRPGSSGCPSSSLRARDLGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQ
KLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLA

--------------------------------------------------------------
>12888_12888_5_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000263278_length(transcript)=1125nt_BP=523nt
AGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAG
CCCGGCTGGACCCGCGGCGGCTCGGCCGATGAGAATTCTGAAGCACAAAGAGGTTAACTGCTTTGCACCTCGCTGGCCTCAGTCTCCCCA
TCTGAGGACGGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGC
CCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCC
GGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATCTGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCA
GGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCT
GCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGG
GGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGAC
CCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGG
CCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGC
AGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGC
CCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGC

>12888_12888_5_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000263278_length(amino acids)=307AA_BP=160
MQPPLQRPRRALHPGSPAGPAAARPMRILKHKEVNCFAPRWPQSPHLRTGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFED
PLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLV
GAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS

--------------------------------------------------------------
>12888_12888_6_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000599157_length(transcript)=1118nt_BP=523nt
AGCTGGATCTCCGGCCAGAGCCCGAGGCTGCTGCGCCGGGCGGCTGCAGCCTCCGCTCCAGCGCCCGCGCCGTGCCCTGCATCCCGGGAG
CCCGGCTGGACCCGCGGCGGCTCGGCCGATGAGAATTCTGAAGCACAAAGAGGTTAACTGCTTTGCACCTCGCTGGCCTCAGTCTCCCCA
TCTGAGGACGGGTGTTCCCCCTCCCCTCCCTGGGGCAGCAGCCACCATGTTCTCGTGTGTGAAGCCCTATGAGGACCAGAACTACTCAGC
CCTGAGGCGGGACTGCCGGCGCAGGAAGGTGCTCTTCGAGGACCCCCTCTTCCCCGCCACTGACGACTCACTCTACTATAAGGGCACGCC
GGGGCCCGCCGTCAGGTGGAAGCGACCCAAGGGCATCTGCGAGGACCCCCGCCTCTTTGTGGATGGCATCAGCTCCCACGACCTGCACCA
GGGCCAGGTGGGCAACTGCTGGTTTGTGGCAGCCTGCTCGTCACTTGCCTCCCGGGAGTCGCTGTGGCAAAAGCTCGCCCTCCCCTACCT
GCGGAAGAGTCAAGGGAATGTCATCAACATCTCCAGCCTGGTGGGGGCAATCGGCCAGGCCCAGGCAGTTCCCTATGTGGCCACCAAGGG
GGCAGTAACAGCCATGACCAAAGCTTTGGCCCTGGATGAAAGTCCATATGGTGTCCGAGTCAACTGTATCTCCCCAGGAAACATCTGGAC
CCCGCTGTGGGAGGAGCTGGCAGCCTTAATGCCAGACCCTAGGGCCACAATCCGAGAGGGCATGCTGGCCCAGCCACTGGGCCGCATGGG
CCAGCCCGCTGAGGTCGGGGCTGCGGCAGTGTTCCTGGCCTCCGAAGCCAACTTCTGCACGGGCATTGAACTGCTCGTGACGGGGGGTGC
AGAGCTGGGGTACGGGTGCAAGGCCAGTCGGAGCACCCCCGTGGACGCCCCCGATATCCCTTCCTGATTTCTCTCATTTCTACTTGGGGC
CCCCTTCCTAGGACTCTCCCACCCCAAACTCCAACCTGTATCAGATGCAGCCCCCAAGCCCTTAGACTCTAAGCCCAGTTAGCAAGGTGC

>12888_12888_6_CAPN5-HSD17B14_CAPN5_chr11_76804859_ENST00000529629_HSD17B14_chr19_49318398_ENST00000599157_length(amino acids)=307AA_BP=160
MQPPLQRPRRALHPGSPAGPAAARPMRILKHKEVNCFAPRWPQSPHLRTGVPPPLPGAAATMFSCVKPYEDQNYSALRRDCRRRKVLFED
PLFPATDDSLYYKGTPGPAVRWKRPKGICEDPRLFVDGISSHDLHQGQVGNCWFVAACSSLASRESLWQKLALPYLRKSQGNVINISSLV
GAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLAS

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Fusion Gene PPI Analysis for CAPN5-HSD17B14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CAPN5-HSD17B14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CAPN5-HSD17B14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source