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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPNS1-KLC1 (FusionGDB2 ID:12921)

Fusion Gene Summary for CAPNS1-KLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPNS1-KLC1
Fusion gene ID: 12921
HgeneTgene
Gene symbol

CAPNS1

KLC1

Gene ID

826

3831

Gene namecalpain small subunit 1kinesin light chain 1
SynonymsCALPAIN4|CANP|CANPS|CAPN4|CDPS|CSS1KLC|KNS2|KNS2A
Cytomap

19q13.12

14q32.33

Type of geneprotein-codingprotein-coding
Descriptioncalpain small subunit 1CANP small subunitcalcium-activated neutral proteinase small subunitcalcium-dependent protease small subunit 1calcium-dependent protease, small subunitcalpain 4, small subunit (30K)calpain regulatory subunitcalpain, small polkinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50
Modification date2020031320200313
UniProtAcc

P04632

Q07866

Ensembl transtripts involved in fusion geneENST00000246533, ENST00000587718, 
ENST00000588780, ENST00000588815, 
ENST00000589146, ENST00000590874, 
ENST00000246489, ENST00000334553, 
ENST00000347839, ENST00000380038, 
ENST00000389744, ENST00000445352, 
ENST00000452929, ENST00000553286, 
ENST00000554280, ENST00000555836, 
ENST00000557450, ENST00000557575, 
ENST00000348520, 
Fusion gene scores* DoF score29 X 25 X 9=652520 X 16 X 10=3200
# samples 3122
** MAII scorelog2(31/6525*10)=-4.39563778107037
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/3200*10)=-3.86249647625007
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPNS1 [Title/Abstract] AND KLC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPNS1(36640524)-KLC1(104145849), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAPNS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABF082024CAPNS1chr19

36640524

+KLC1chr14

104145849

+


Top

Fusion Gene ORF analysis for CAPNS1-KLC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000246533ENST00000246489CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000334553CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000347839CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000380038CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000389744CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000445352CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000452929CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000553286CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000554280CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000555836CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000557450CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000246533ENST00000557575CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000246489CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000334553CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000347839CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000380038CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000389744CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000445352CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000452929CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000553286CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000554280CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000555836CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000557450CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000587718ENST00000557575CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000246489CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000334553CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000347839CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000380038CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000389744CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000445352CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000452929CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000553286CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000554280CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000555836CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000557450CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588780ENST00000557575CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000246489CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000334553CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000347839CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000380038CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000389744CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000445352CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000452929CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000553286CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000554280CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000555836CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000557450CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000588815ENST00000557575CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000246489CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000334553CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000347839CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000380038CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000389744CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000445352CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000452929CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000553286CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000554280CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000555836CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000557450CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000589146ENST00000557575CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000246489CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000334553CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000347839CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000380038CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000389744CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000445352CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000452929CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000553286CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000554280CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000555836CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000557450CAPNS1chr19

36640524

+KLC1chr14

104145849

+
5CDS-intronENST00000590874ENST00000557575CAPNS1chr19

36640524

+KLC1chr14

104145849

+
Frame-shiftENST00000587718ENST00000348520CAPNS1chr19

36640524

+KLC1chr14

104145849

+
In-frameENST00000246533ENST00000348520CAPNS1chr19

36640524

+KLC1chr14

104145849

+
In-frameENST00000588780ENST00000348520CAPNS1chr19

36640524

+KLC1chr14

104145849

+
In-frameENST00000588815ENST00000348520CAPNS1chr19

36640524

+KLC1chr14

104145849

+
In-frameENST00000589146ENST00000348520CAPNS1chr19

36640524

+KLC1chr14

104145849

+
In-frameENST00000590874ENST00000348520CAPNS1chr19

36640524

+KLC1chr14

104145849

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000246533CAPNS1chr1936640524+ENST00000348520KLC1chr14104145849+179013335981437279
ENST00000589146CAPNS1chr1936640524+ENST00000348520KLC1chr14104145849+890433220537105
ENST00000590874CAPNS1chr1936640524+ENST00000348520KLC1chr14104145849+114969247796249
ENST00000588815CAPNS1chr1936640524+ENST00000348520KLC1chr14104145849+1343886151990279
ENST00000588780CAPNS1chr1936640524+ENST00000348520KLC1chr14104145849+126680944913289

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000246533ENST00000348520CAPNS1chr1936640524+KLC1chr14104145849+0.003173210.9968267
ENST00000589146ENST00000348520CAPNS1chr1936640524+KLC1chr14104145849+0.0453431160.95465684
ENST00000590874ENST00000348520CAPNS1chr1936640524+KLC1chr14104145849+0.0027339780.99726605
ENST00000588815ENST00000348520CAPNS1chr1936640524+KLC1chr14104145849+0.0024637660.9975362
ENST00000588780ENST00000348520CAPNS1chr1936640524+KLC1chr14104145849+0.0035241970.99647576

Top

Fusion Genomic Features for CAPNS1-KLC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPNS1-KLC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:36640524/chr14:104145849)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPNS1

P04632

KLC1

Q07866

FUNCTION: Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLC1chr19:36640524chr14:104145849ENST0000024648901627_1560638.0Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST0000033455301727_1560668.6666666666666Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST0000034783901627_1560629.0Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST0000034852001527_1560585.0Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST0000038974401527_1560898.3333333333334Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST0000045292901627_1560619.0Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST0000055328601427_1560561.0Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST0000055745001527_1560585.0Coiled coil.
TgeneKLC1chr19:36640524chr14:104145849ENST00000246489016213_2460638.0RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000246489016255_2880638.0RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000246489016297_3300638.0RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000246489016339_3720638.0RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000246489016381_4140638.0RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000246489016464_4970638.0RepeatNote=TPR 6
TgeneKLC1chr19:36640524chr14:104145849ENST00000334553017213_2460668.6666666666666RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000334553017255_2880668.6666666666666RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000334553017297_3300668.6666666666666RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000334553017339_3720668.6666666666666RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000334553017381_4140668.6666666666666RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000334553017464_4970668.6666666666666RepeatNote=TPR 6
TgeneKLC1chr19:36640524chr14:104145849ENST00000347839016213_2460629.0RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000347839016255_2880629.0RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000347839016297_3300629.0RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000347839016339_3720629.0RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000347839016381_4140629.0RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000347839016464_4970629.0RepeatNote=TPR 6
TgeneKLC1chr19:36640524chr14:104145849ENST00000348520015213_2460585.0RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000348520015255_2880585.0RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000348520015297_3300585.0RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000348520015339_3720585.0RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000348520015381_4140585.0RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000348520015464_4970585.0RepeatNote=TPR 6
TgeneKLC1chr19:36640524chr14:104145849ENST00000389744015213_2460898.3333333333334RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000389744015255_2880898.3333333333334RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000389744015297_3300898.3333333333334RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000389744015339_3720898.3333333333334RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000389744015381_4140898.3333333333334RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000389744015464_4970898.3333333333334RepeatNote=TPR 6
TgeneKLC1chr19:36640524chr14:104145849ENST00000452929016213_2460619.0RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000452929016255_2880619.0RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000452929016297_3300619.0RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000452929016339_3720619.0RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000452929016381_4140619.0RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000452929016464_4970619.0RepeatNote=TPR 6
TgeneKLC1chr19:36640524chr14:104145849ENST00000553286014213_2460561.0RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000553286014255_2880561.0RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000553286014297_3300561.0RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000553286014339_3720561.0RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000553286014381_4140561.0RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000553286014464_4970561.0RepeatNote=TPR 6
TgeneKLC1chr19:36640524chr14:104145849ENST00000557450015213_2460585.0RepeatNote=TPR 1
TgeneKLC1chr19:36640524chr14:104145849ENST00000557450015255_2880585.0RepeatNote=TPR 2
TgeneKLC1chr19:36640524chr14:104145849ENST00000557450015297_3300585.0RepeatNote=TPR 3
TgeneKLC1chr19:36640524chr14:104145849ENST00000557450015339_3720585.0RepeatNote=TPR 4
TgeneKLC1chr19:36640524chr14:104145849ENST00000557450015381_4140585.0RepeatNote=TPR 5
TgeneKLC1chr19:36640524chr14:104145849ENST00000557450015464_4970585.0RepeatNote=TPR 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+111108_1190269.0Calcium binding1
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+111152_1630269.0Calcium binding2
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+111182_1930269.0Calcium binding3
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+110108_1190323.0Calcium binding1
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+110152_1630323.0Calcium binding2
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+110182_1930323.0Calcium binding3
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+111108_1190269.0Calcium binding1
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+111152_1630269.0Calcium binding2
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+111182_1930269.0Calcium binding3
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+11110_260269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+1111_660269.0Compositional biasNote=Gly-rich (hydrophobic)
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+11135_560269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+11178_830269.0Compositional biasNote=Poly-Pro
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+11010_260323.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+1101_660323.0Compositional biasNote=Gly-rich (hydrophobic)
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+11035_560323.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+11078_830323.0Compositional biasNote=Poly-Pro
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+11110_260269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+1111_660269.0Compositional biasNote=Gly-rich (hydrophobic)
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+11135_560269.0Compositional biasNote=Poly-Gly
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+11178_830269.0Compositional biasNote=Poly-Pro
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+111139_1720269.0DomainEF-hand 2
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+111169_2040269.0DomainEF-hand 3
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+111205_2330269.0DomainEF-hand 4
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+111234_2680269.0DomainEF-hand 5
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000246533+11191_1250269.0DomainEF-hand 1%3B atypical
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+110139_1720323.0DomainEF-hand 2
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+110169_2040323.0DomainEF-hand 3
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+110205_2330323.0DomainEF-hand 4
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+110234_2680323.0DomainEF-hand 5
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000587718+11091_1250323.0DomainEF-hand 1%3B atypical
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+111139_1720269.0DomainEF-hand 2
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+111169_2040269.0DomainEF-hand 3
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+111205_2330269.0DomainEF-hand 4
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+111234_2680269.0DomainEF-hand 5
HgeneCAPNS1chr19:36640524chr14:104145849ENST00000588815+11191_1250269.0DomainEF-hand 1%3B atypical


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Fusion Gene Sequence for CAPNS1-KLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12921_12921_1_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000246533_KLC1_chr14_104145849_ENST00000348520_length(transcript)=1790nt_BP=1333nt
TGCCATCCGGGCTGCTGCAGGCACTGGGAAAGGCAATCCAGCCTCAATCCTCGCCACAGACACGGGCGACTGTCCCCCAGCGTGTGAGTC
AAACCATACTCCAGGCCTCCAGGAGGTGTTTGTCGCGACAACACCTGCAGAGGGCCCGTGCGGAGTCCCTTAGTGAGCGGACCGAAAACC
GCCACCCTGGAAGGATATTGGCATGCCCTAGGGTGAAAATTCACACTACGACACTCGGGGGGTGGGTCCCCTCCGAGTTCTCGTCCGCGG
GTGCCTCCACCCAGACCTGAGGGGTGTCGGGAAGACCCCCGCCTACCGAGTCAGGGCGGGATTAAGACCTCCGGCGCTGGAAACGCGTAG
GGCGGGGCCCAGACCTGGATCCAGCTAGCCGGGCGGTGTGGGGTGCGCATGCGCAATGTCCGCTTCGGCTCTAGGACCGCGCGGGCGACA
GCAGGGCCGCGGTGCAGTGTCCGACCCGAGAGTTGCGGCCTGAGTCACCGGCCCCGCCCTCCGGAGCCGGACGCTGCGGGAGGCCCGGGA
GCGGCAGTGGAACCGACTCCCAGAACTCCGGACGTGTGCGGCGCAGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGGCGG
CGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAGCGA
GGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTT
CCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACA
CCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGGCTT
TGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTGCAG
TAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGAAAG
TGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCTGAACATCCAGGAGGAGGAAGTGAGTATGAG
CGTAGAGTGGAACGGGGGCGTCTCTGGCCGAGCCTCTTTTTGTGGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTAACT
GACCCCGACCTGGCCCCGCTCCAGGATGGGACTGCCGAGTGTGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCCTGG
CCGGGAGCCGCAGCGCTCACTCATTTCTCCTGCGTCTGTGTGCATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGGGCT
GGGGCTGGGCCTAAGCTGGTGCCCTGGTGCGGCGTGGTCTCTCCCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCATGT

>12921_12921_1_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000246533_KLC1_chr14_104145849_ENST00000348520_length(amino acids)=279AA_BP=17
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNI
EANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFLNIQEEEVSMSVEWNGGVSGRASFCGKRQQ

--------------------------------------------------------------
>12921_12921_2_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000588780_KLC1_chr14_104145849_ENST00000348520_length(transcript)=1266nt_BP=809nt
CACCCACTGGTCCCCTTTTTTCCCCCCAGCAGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCG
GGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGGCGGCGGCGGCGGCGGCG
GCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAGCGAGGCGGCTGCGCAGT
ACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCAGTTCCGGAGACTCTTTG
CCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACACCCTGATCTGAAGA
CTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATCTGTCACTCTTCTTAACACCCTCCCACCAGAGCGACACCA
CAGGCAAGCTGGGCTTTGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGAT
CAGGGACCATTTGCAGTAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGAC
GCTACTCAGATGAAAGTGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCTGAACATCCAGGAGG
AGGAAGTGAGTATGAGCGTAGAGTGGAACGGGGGCGTCTCTGGCCGAGCCTCTTTTTGTGGAAAACGACAGCAGCAGCAGTGGCCTGGAA
GACGCCACCGCTAACTGACCCCGACCTGGCCCCGCTCCAGGATGGGACTGCCGAGTGTGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGG
CAGGGAGGGCCCCTGGCCGGGAGCCGCAGCGCTCACTCATTTCTCCTGCGTCTGTGTGCATAGGACATGATACTAATAACCACACGGCTG
GCGTGACCTTGGGGCTGGGGCTGGGCCTAAGCTGGTGCCCTGGTGCGGCGTGGTCTCTCCCAGGAGACCTGGGGCATGAGCTGGGCCCAC
GGCTCCCTTCCCATGTGTAACTTCCTCACGTTGTGTGCGATAACGTATTTTATTGTACATTTTTTTAAATTAAAAGTTTATATGCCTTAT

>12921_12921_2_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000588780_KLC1_chr14_104145849_ENST00000348520_length(amino acids)=289AA_BP=17
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNI
EANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDLSLFLTPSHQSDTTGKLGFEEFKYLWNN
IKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFLNIQEEEVSMSVEWNGGVSG

--------------------------------------------------------------
>12921_12921_3_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000588815_KLC1_chr14_104145849_ENST00000348520_length(transcript)=1343nt_BP=886nt
CCGACTCCCAGAACTCCGGACGTGTGCGGCGGTAAGCGCCCGGCCCGTACCCCCTCCGCACCCCGCAACTCCGACTTTGGCGGCCCCCAG
ACCCGGCGAAACCGTGAAGTCTCGGCCTCAGGAGCCCCCCAGATCCATGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGG
CGGCGGCGGCGGCGGCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAG
CGAGGCGGCTGCGCAGTACAACCCGGAGCCCCCGCCCCCACGCACACATTACTCCAACATTGAGGCCAACGAGAGTGAGGAGGTCCGGCA
GTTCCGGAGACTCTTTGCCCAGCTGGCTGGAGATGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACG
ACACCCTGATCTGAAGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGG
CTTTGAGGAATTCAAGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTG
CAGTAGTGAACTCCCAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGA
AAGTGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCTGAACATCCAGGAGGAGGAAGTGAGTAT
GAGCGTAGAGTGGAACGGGGGCGTCTCTGGCCGAGCCTCTTTTTGTGGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTA
ACTGACCCCGACCTGGCCCCGCTCCAGGATGGGACTGCCGAGTGTGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCC
TGGCCGGGAGCCGCAGCGCTCACTCATTTCTCCTGCGTCTGTGTGCATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGG
GCTGGGGCTGGGCCTAAGCTGGTGCCCTGGTGCGGCGTGGTCTCTCCCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCA

>12921_12921_3_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000588815_KLC1_chr14_104145849_ENST00000348520_length(amino acids)=279AA_BP=17
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPPPRTHYSNI
EANESEEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQ
FDTDRSGTICSSELPGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFLNIQEEEVSMSVEWNGGVSGRASFCGKRQQ

--------------------------------------------------------------
>12921_12921_4_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000589146_KLC1_chr14_104145849_ENST00000348520_length(transcript)=890nt_BP=433nt
ATCCAGCTAGCCGGGCGGTGTGGGGTGCGCATGCGCAATGTCCGCTTCGGCTCTAGGACCGCGCGGGCGACAGCAGGGCCGCGGTGCAGT
GTCCGACCCGAGAGTTGCGGCCTGAGTCACCGGCCCCGCCCTCCGGAGCCGGACGCTGCGGGAGGCCCGGGAGCGGCAGTGGAACCGACT
CCCAGAACTCCGGACGTGTGCGGCGCAGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCGGCGGGGG
AGGCGGGGGCCTGGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGAAAG
TGGGAACATGGATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCTGAACATCCAGGAGGAGGAAGTGAGTATGAG
CGTAGAGTGGAACGGGGGCGTCTCTGGCCGAGCCTCTTTTTGTGGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTAACT
GACCCCGACCTGGCCCCGCTCCAGGATGGGACTGCCGAGTGTGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCCTGG
CCGGGAGCCGCAGCGCTCACTCATTTCTCCTGCGTCTGTGTGCATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGGGCT
GGGGCTGGGCCTAAGCTGGTGCCCTGGTGCGGCGTGGTCTCTCCCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCATGT

>12921_12921_4_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000589146_KLC1_chr14_104145849_ENST00000348520_length(amino acids)=105AA_BP=71
MFLVNSFLKGGGGGGGGGGGLGAFEAAGFHLNEHLYNMIIRRYSDESGNMDFDNFISCLVRLDAMFLNIQEEEVSMSVEWNGGVSGRASF

--------------------------------------------------------------
>12921_12921_5_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000590874_KLC1_chr14_104145849_ENST00000348520_length(transcript)=1149nt_BP=692nt
GGAACCGACTCCCAGAACTCCGGACGTGTGCGGCGTGAGTCGCAGCCATGTTCCTGGTTAACTCGTTCTTGAAGGGCGGCGGCGGCGGCG
GCGGGGGAGGCGGGGGCCTGGGTGGGGGCCTGGGAAATGTGCTTGGAGGCCTGATCAGCGGGGCCGGGGGCGGCGGCGGCGGCGGCGGCG
GCGGCGGCGGTGGTGGAGGCGGCGGTGGCGGTGGAACGGCCATGCGCATCCTAGGCGGAGTCATCAGCGCCATCAGCGAGGCGGCTGCGC
AGTACAACCCGGAGCCCCCGGACATGGAGGTCAGCGCCACAGAACTCATGAACATTCTCAATAAGGTTGTGACACGACACCCTGATCTGA
AGACTGATGGTTTTGGCATTGACACATGTCGCAGCATGGTGGCCGTGATGGATAGCGACACCACAGGCAAGCTGGGCTTTGAGGAATTCA
AGTACTTGTGGAACAACATCAAAAGGTGGCAGGCCATATACAAACAGTTCGACACTGACCGATCAGGGACCATTTGCAGTAGTGAACTCC
CAGGTGCCTTTGAGGCAGCAGGGTTCCACCTGAATGAGCATCTCTATAACATGATCATCCGACGCTACTCAGATGAAAGTGGGAACATGG
ATTTTGACAACTTCATCAGCTGCTTGGTCAGGCTGGACGCCATGTTCCTGAACATCCAGGAGGAGGAAGTGAGTATGAGCGTAGAGTGGA
ACGGGGGCGTCTCTGGCCGAGCCTCTTTTTGTGGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTAACTGACCCCGACCT
GGCCCCGCTCCAGGATGGGACTGCCGAGTGTGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCCTGGCCGGGAGCCGC
AGCGCTCACTCATTTCTCCTGCGTCTGTGTGCATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGGGCTGGGGCTGGGCC
TAAGCTGGTGCCCTGGTGCGGCGTGGTCTCTCCCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCATGTGTAACTTCCTC

>12921_12921_5_CAPNS1-KLC1_CAPNS1_chr19_36640524_ENST00000590874_KLC1_chr14_104145849_ENST00000348520_length(amino acids)=249AA_BP=17
MFLVNSFLKGGGGGGGGGGGLGGGLGNVLGGLISGAGGGGGGGGGGGGGGGGGGGGTAMRILGGVISAISEAAAQYNPEPPDMEVSATEL
MNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKRWQAIYKQFDTDRSGTICSSELPGAFEAAGFHLNEHLY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAPNS1-KLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPNS1-KLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPNS1-KLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource