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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CAPZA2-STYXL1 (FusionGDB2 ID:12991)

Fusion Gene Summary for CAPZA2-STYXL1

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZA2-STYXL1
Fusion gene ID: 12991
HgeneTgene
Gene symbol

CAPZA2

STYXL1

Gene ID

830

51657

Gene namecapping actin protein of muscle Z-line subunit alpha 2serine/threonine/tyrosine interacting like 1
SynonymsCAPPA2|CAPZDUSP24|MK-STYX|MKSTYX
Cytomap

7q31.2

7q11.23

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2epididymis secretory sperm binding proteinserine/threonine/tyrosine-interacting-like protein 1dual specificity phosphatase 24 (putative)dual specificity phosphatase inhibitor MK-STYXdual specificity protein phosphatase 24inactive dual specificity protein phosphatase MK-STYXmap kinase phospha
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000361183, ENST00000458284, 
ENST00000490693, ENST00000466023, 
ENST00000460184, ENST00000360591, 
ENST00000248600, ENST00000340062, 
ENST00000359697, ENST00000431581, 
ENST00000451157, 
Fusion gene scores* DoF score17 X 6 X 9=9188 X 7 X 6=336
# samples 209
** MAII scorelog2(20/918*10)=-2.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPZA2 [Title/Abstract] AND STYXL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPZA2(116528244)-STYXL1(75658021), # samples:3
Anticipated loss of major functional domain due to fusion event.CAPZA2-STYXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTYXL1

GO:0032515

negative regulation of phosphoprotein phosphatase activity

24709986


check buttonFusion gene breakpoints across CAPZA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STYXL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A4OU-01ACAPZA2chr7

116528244

-STYXL1chr7

75658021

-
ChimerDB4ESCATCGA-L5-A4OU-01ACAPZA2chr7

116528244

+STYXL1chr7

75658021

-
ChimerDB4ESCATCGA-L5-A4OUCAPZA2chr7

116528244

+STYXL1chr7

75658021

-


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Fusion Gene ORF analysis for CAPZA2-STYXL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361183ENST00000460184CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
5CDS-5UTRENST00000458284ENST00000460184CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
5CDS-5UTRENST00000490693ENST00000460184CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
Frame-shiftENST00000361183ENST00000360591CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
Frame-shiftENST00000458284ENST00000360591CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
Frame-shiftENST00000490693ENST00000360591CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000361183ENST00000248600CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000361183ENST00000340062CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000361183ENST00000359697CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000361183ENST00000431581CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000361183ENST00000451157CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000458284ENST00000248600CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000458284ENST00000340062CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000458284ENST00000359697CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000458284ENST00000431581CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000458284ENST00000451157CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000490693ENST00000248600CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000490693ENST00000340062CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000490693ENST00000359697CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000490693ENST00000431581CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
In-frameENST00000490693ENST00000451157CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
intron-3CDSENST00000466023ENST00000248600CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
intron-3CDSENST00000466023ENST00000340062CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
intron-3CDSENST00000466023ENST00000359697CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
intron-3CDSENST00000466023ENST00000360591CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
intron-3CDSENST00000466023ENST00000431581CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
intron-3CDSENST00000466023ENST00000451157CAPZA2chr7

116528244

+STYXL1chr7

75658021

-
intron-5UTRENST00000466023ENST00000460184CAPZA2chr7

116528244

+STYXL1chr7

75658021

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361183CAPZA2chr7116528244+ENST00000248600STYXL1chr775658021-12112421001080326
ENST00000361183CAPZA2chr7116528244+ENST00000359697STYXL1chr775658021-12072421001080326
ENST00000361183CAPZA2chr7116528244+ENST00000340062STYXL1chr775658021-919242100792230
ENST00000361183CAPZA2chr7116528244+ENST00000431581STYXL1chr775658021-11402421001080326
ENST00000361183CAPZA2chr7116528244+ENST00000451157STYXL1chr775658021-1539242100987295
ENST00000458284CAPZA2chr7116528244+ENST00000248600STYXL1chr775658021-112515614994326
ENST00000458284CAPZA2chr7116528244+ENST00000359697STYXL1chr775658021-112115614994326
ENST00000458284CAPZA2chr7116528244+ENST00000340062STYXL1chr775658021-83315614706230
ENST00000458284CAPZA2chr7116528244+ENST00000431581STYXL1chr775658021-105415614994326
ENST00000458284CAPZA2chr7116528244+ENST00000451157STYXL1chr775658021-145315614901295
ENST00000490693CAPZA2chr7116528244+ENST00000248600STYXL1chr775658021-108411512953313
ENST00000490693CAPZA2chr7116528244+ENST00000359697STYXL1chr775658021-108011512953313
ENST00000490693CAPZA2chr7116528244+ENST00000340062STYXL1chr775658021-79211512665217
ENST00000490693CAPZA2chr7116528244+ENST00000431581STYXL1chr775658021-101311512953313
ENST00000490693CAPZA2chr7116528244+ENST00000451157STYXL1chr775658021-141211512860282

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361183ENST00000248600CAPZA2chr7116528244+STYXL1chr775658021-0.0008335030.9991665
ENST00000361183ENST00000359697CAPZA2chr7116528244+STYXL1chr775658021-0.0008834470.9991166
ENST00000361183ENST00000340062CAPZA2chr7116528244+STYXL1chr775658021-0.0022763010.99772364
ENST00000361183ENST00000431581CAPZA2chr7116528244+STYXL1chr775658021-0.0008529920.99914694
ENST00000361183ENST00000451157CAPZA2chr7116528244+STYXL1chr775658021-0.0004642190.9995358
ENST00000458284ENST00000248600CAPZA2chr7116528244+STYXL1chr775658021-0.0005849980.99941504
ENST00000458284ENST00000359697CAPZA2chr7116528244+STYXL1chr775658021-0.0006217040.9993783
ENST00000458284ENST00000340062CAPZA2chr7116528244+STYXL1chr775658021-0.0010672210.9989328
ENST00000458284ENST00000431581CAPZA2chr7116528244+STYXL1chr775658021-0.0005283260.9994717
ENST00000458284ENST00000451157CAPZA2chr7116528244+STYXL1chr775658021-0.0003503730.99964964
ENST00000490693ENST00000248600CAPZA2chr7116528244+STYXL1chr775658021-0.000682420.99931765
ENST00000490693ENST00000359697CAPZA2chr7116528244+STYXL1chr775658021-0.0007362760.9992637
ENST00000490693ENST00000340062CAPZA2chr7116528244+STYXL1chr775658021-0.0012607350.9987393
ENST00000490693ENST00000431581CAPZA2chr7116528244+STYXL1chr775658021-0.0006567290.9993432
ENST00000490693ENST00000451157CAPZA2chr7116528244+STYXL1chr775658021-0.000415670.9995844

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Fusion Genomic Features for CAPZA2-STYXL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CAPZA2-STYXL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116528244/chr7:75658021)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTYXL1chr7:116528244chr7:75658021ENST0000024860019159_30234314.0DomainTyrosine-protein phosphatase
TgeneSTYXL1chr7:116528244chr7:75658021ENST0000034006217159_30234218.0DomainTyrosine-protein phosphatase
TgeneSTYXL1chr7:116528244chr7:75658021ENST0000035969719159_30234314.0DomainTyrosine-protein phosphatase
TgeneSTYXL1chr7:116528244chr7:75658021ENST0000043158119159_30234314.0DomainTyrosine-protein phosphatase

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTYXL1chr7:116528244chr7:75658021ENST000002486001927_13834314.0DomainRhodanese
TgeneSTYXL1chr7:116528244chr7:75658021ENST000003400621727_13834218.0DomainRhodanese
TgeneSTYXL1chr7:116528244chr7:75658021ENST000003596971927_13834314.0DomainRhodanese
TgeneSTYXL1chr7:116528244chr7:75658021ENST000004315811927_13834314.0DomainRhodanese


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Fusion Gene Sequence for CAPZA2-STYXL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12991_12991_1_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000248600_length(transcript)=1211nt_BP=242nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGA
AAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTG
CGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCT
TGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTT
CTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGT
GCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTC
CATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTT
CTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTG
TGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTG
TCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTG
ATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGGCTTG

>12991_12991_1_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000248600_length(amino acids)=326AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_2_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000340062_length(transcript)=919nt_BP=242nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGA
AAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGT
TGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTT
TTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCA
CTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTA
CCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGT
GAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCAC
CGAAGGGTACTGAAGAGCCTCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGGCTTGTCTGGAAGGAGAAGGCCT

>12991_12991_2_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000340062_length(amino acids)=230AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKELDAFQPYPIEIVPGKVFVGNF
SQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMH

--------------------------------------------------------------
>12991_12991_3_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000359697_length(transcript)=1207nt_BP=242nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGA
AAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTG
CGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCT
TGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTT
CTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGT
GCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTC
CATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTT
CTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTG
TGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTG
TCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTG
ATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGGCTTG

>12991_12991_3_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000359697_length(amino acids)=326AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_4_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000431581_length(transcript)=1140nt_BP=242nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGA
AAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTG
CGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCT
TGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTT
CTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGT
GCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTC
CATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTT
CTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTG
TGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTG
TCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTG

>12991_12991_4_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000431581_length(amino acids)=326AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_5_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000451157_length(transcript)=1539nt_BP=242nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGT
GCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGA
AAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTG
CGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCT
TGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTT
CTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGT
GCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTC
CATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTT
CTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTG
TGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTAGCA
CAATCTCGACTCACTGCAAGCTCTGCCTCCCGGGCTCATGCCATTCTTCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGCATCTGCC
ACCACTCAATTTCTTTAATATATGTAGGCCTATTCAGATTGTCTGTTTCTTCTTGTGTGAGTTTTGGCAGTCTGTGTCTTTCAAGGAATT
GATCAATCACATTTGTGGATATGAATATTCTTCTATTATCCTTTTAATGTCTGTGGGATCTGTAGCAATGTCTTCTCTTTCACTTCTGTA
TTAGTAATTTGTGTCTTCTGTTTAAGTTAGCCTGGCTAGCGGTGTATCGATTTTATTGATCTTTTCAAAGAACCGGCTTTTGGTTTTTTT
GATTTTCTCTATTGATTTCCTGTTTTCAATTTCATTCTTTGCATGGCGTATCTAGTTTTCCTAGCACCATTTGTTGAAATGACTGTCCTT
TTCCCCCATCGAATGGTCTTGGCATACTATCAAAAATTCCTTGACAGGCCCGGTGCAGTGGCTCACACCTGTAATCCCAGCAGGTTGGGA

>12991_12991_5_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000361183_STYXL1_chr7_75658021_ENST00000451157_length(amino acids)=295AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_6_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000248600_length(transcript)=1125nt_BP=156nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATG
ACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGT
ACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAG
ATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGC
GCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAA
TCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATG
TCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTC
CCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCA
GTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACA
TGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCT
ACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGG

>12991_12991_6_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000248600_length(amino acids)=326AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_7_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000340062_length(transcript)=833nt_BP=156nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATG
ACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCT
TCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGC
CCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGT
GTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAG
CCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGAT
TGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGC
CCACCGAAGGGTACTGAAGAGCCTCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGGCTTGTCTGGAAGGAGAAG

>12991_12991_7_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000340062_length(amino acids)=230AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKELDAFQPYPIEIVPGKVFVGNF
SQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMH

--------------------------------------------------------------
>12991_12991_8_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000359697_length(transcript)=1121nt_BP=156nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATG
ACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGT
ACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAG
ATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGC
GCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAA
TCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATG
TCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTC
CCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCA
GTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACA
TGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCT
ACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGG

>12991_12991_8_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000359697_length(amino acids)=326AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_9_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000431581_length(transcript)=1054nt_BP=156nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATG
ACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGT
ACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAG
ATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGC
GCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAA
TCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATG
TCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTC
CCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCA
GTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACA
TGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCT

>12991_12991_9_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000431581_length(amino acids)=326AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_10_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000451157_length(transcript)=1453nt_BP=156nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCTGGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATG
ACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAAAATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGT
ACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATACTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAG
ATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTGACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGC
GCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATCATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAA
TCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATG
TCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTC
CCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCA
GTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTACAGT
AGCACAATCTCGACTCACTGCAAGCTCTGCCTCCCGGGCTCATGCCATTCTTCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGCATC
TGCCACCACTCAATTTCTTTAATATATGTAGGCCTATTCAGATTGTCTGTTTCTTCTTGTGTGAGTTTTGGCAGTCTGTGTCTTTCAAGG
AATTGATCAATCACATTTGTGGATATGAATATTCTTCTATTATCCTTTTAATGTCTGTGGGATCTGTAGCAATGTCTTCTCTTTCACTTC
TGTATTAGTAATTTGTGTCTTCTGTTTAAGTTAGCCTGGCTAGCGGTGTATCGATTTTATTGATCTTTTCAAAGAACCGGCTTTTGGTTT
TTTTGATTTTCTCTATTGATTTCCTGTTTTCAATTTCATTCTTTGCATGGCGTATCTAGTTTTCCTAGCACCATTTGTTGAAATGACTGT
CCTTTTCCCCCATCGAATGGTCTTGGCATACTATCAAAAATTCCTTGACAGGCCCGGTGCAGTGGCTCACACCTGTAATCCCAGCAGGTT

>12991_12991_10_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000458284_STYXL1_chr7_75658021_ENST00000451157_length(amino acids)=295AA_BP=45
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVY
DNNSSTLEILLKDDDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGK
VFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI

--------------------------------------------------------------
>12991_12991_11_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000248600_length(transcript)=1084nt_BP=115nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAA
AATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATA
CTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTG
ACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATC
ATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCC
TGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGAC
AAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCAT
CACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAG
CAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGG
GAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCC
TCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGGCTTGTCTGGAAGGAGAAGGCCTTTGCTGCCTGAAAGTCTCA

>12991_12991_11_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000248600_length(amino acids)=313AA_BP=32
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVYDNNSSTLEILLKD
DDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGKVFVGNFSQACDPK
IQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQ

--------------------------------------------------------------
>12991_12991_12_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000340062_length(transcript)=792nt_BP=115nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGGAA
CTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCCTGTGACCCCAAGATTCAG
AAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGACAAGCTTCTGCACATCCGG
ATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCATCACCTTGGCTCTGTCATT
CTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAGCAGACCTTGCAGAGGTCC
TGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGGGAGAAGACTATCCTTGGA
GATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCCTCACCTGGGGGCATTTTG

>12991_12991_12_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000340062_length(amino acids)=217AA_BP=32
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLK
IKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYV

--------------------------------------------------------------
>12991_12991_13_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000359697_length(transcript)=1080nt_BP=115nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAA
AATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATA
CTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTG
ACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATC
ATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCC
TGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGAC
AAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCAT
CACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAG
CAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGG
GAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCC
TCACCTGGGGGCATTTTGTGGGTGGAGGGCCAGAGTGTGTATACCCAGGCTTGTCTGGAAGGAGAAGGCCTTTGCTGCCTGAAAGTCTCA

>12991_12991_13_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000359697_length(amino acids)=313AA_BP=32
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVYDNNSSTLEILLKD
DDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGKVFVGNFSQACDPK
IQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQ

--------------------------------------------------------------
>12991_12991_14_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000431581_length(transcript)=1013nt_BP=115nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAA
AATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATA
CTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTG
ACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATC
ATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCC
TGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGAC
AAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCAT
CACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAG
CAGACCTTGCAGAGGTCCTGGGCCTATGTCAAGAAGTGCAAAAACAACATGTGTCCAAATCGGGGATTGGTGAGCCAGCTGCTGGAATGG
GAGAAGACTATCCTTGGAGATTCCATCACAAACATCATGGATCCGCTCTACTGATCTTCTCCGAGGCCCACCGAAGGGTACTGAAGAGCC

>12991_12991_14_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000431581_length(amino acids)=313AA_BP=32
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVYDNNSSTLEILLKD
DDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGKVFVGNFSQACDPK
IQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQ

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>12991_12991_15_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000451157_length(transcript)=1412nt_BP=115nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGGTGCGTATAGCAGCAAAATTCATCATTCATGCCCCTCCT
GGAGAATTTAATGAGGTTTTCAATGATGTCCGTTCCAAATGGGAGTATGACGAAAGCCATGTGATCACTGCCCTTCGAGTGAAGAAGAAA
AATAATGAATATCTTCTCCCGGAGTCTGTGGACCTGGAGTGTGTGAAGTACTGCGTGGTGTATGATAACAACAGCAGCACCCTGGAGATA
CTCTTAAAAGATGATGATGATGATTCAGACTCTGATGGTGATGGCAAAGATCTTGTGCCTCAAGCAGCCATTGAGTATGGCAGGATCCTG
ACCCGCCTCACCCACCACCCCGTCTACATCCTGAAAGGGGGCTATGAGCGCTTCTCAGGCACGTACCACTTTCTCCGGACCCAGAAGATC
ATCTGGATGCCTCAGGAACTGGATGCATTTCAGCCATACCCCATTGAAATCGTGCCAGGGAAGGTCTTCGTTGGCAATTTCAGTCAAGCC
TGTGACCCCAAGATTCAGAAGGACTTGAAAATCAAAGCCCATGTCAATGTCTCCATGGATACAGGGCCCTTTTTTGCAGGCGATGCTGAC
AAGCTTCTGCACATCCGGATAGAAGATTCCCCGGAAGCCCAGATTCTTCCCTTCTTACGCCACATGTGTCACTTCATTGAAATTCACCAT
CACCTTGGCTCTGTCATTCTGATCTTTTCCACCCAAGGTATCAGCCGCAGTTGTGCCGCCATCATAGCCTACCTCATGCATAGTAACGAG
CAGACCTTGCAGACGGAGTCTCGCTCTGTCACCCAGGCTGGAGTACAGTAGCACAATCTCGACTCACTGCAAGCTCTGCCTCCCGGGCTC
ATGCCATTCTTCTGCCTCAGCCTCCCGAGTAACTGGGACTACAGGCATCTGCCACCACTCAATTTCTTTAATATATGTAGGCCTATTCAG
ATTGTCTGTTTCTTCTTGTGTGAGTTTTGGCAGTCTGTGTCTTTCAAGGAATTGATCAATCACATTTGTGGATATGAATATTCTTCTATT
ATCCTTTTAATGTCTGTGGGATCTGTAGCAATGTCTTCTCTTTCACTTCTGTATTAGTAATTTGTGTCTTCTGTTTAAGTTAGCCTGGCT
AGCGGTGTATCGATTTTATTGATCTTTTCAAAGAACCGGCTTTTGGTTTTTTTGATTTTCTCTATTGATTTCCTGTTTTCAATTTCATTC
TTTGCATGGCGTATCTAGTTTTCCTAGCACCATTTGTTGAAATGACTGTCCTTTTCCCCCATCGAATGGTCTTGGCATACTATCAAAAAT

>12991_12991_15_CAPZA2-STYXL1_CAPZA2_chr7_116528244_ENST00000490693_STYXL1_chr7_75658021_ENST00000451157_length(amino acids)=282AA_BP=32
MADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRSKWEYDESHVITALRVKKKNNEYLLPESVDLECVKYCVVYDNNSSTLEILLKD
DDDDSDSDGDGKDLVPQAAIEYGRILTRLTHHPVYILKGGYERFSGTYHFLRTQKIIWMPQELDAFQPYPIEIVPGKVFVGNFSQACDPK
IQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CAPZA2-STYXL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CAPZA2-STYXL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CAPZA2-STYXL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource