FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CAPZA2-TES (FusionGDB2 ID:12992)

Fusion Gene Summary for CAPZA2-TES

check button Fusion gene summary
Fusion gene informationFusion gene name: CAPZA2-TES
Fusion gene ID: 12992
HgeneTgene
Gene symbol

CAPZA2

TES

Gene ID

830

26136

Gene namecapping actin protein of muscle Z-line subunit alpha 2testin LIM domain protein
SynonymsCAPPA2|CAPZTESS|TESS-2
Cytomap

7q31.2

7q31.2

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2epididymis secretory sperm binding proteintestintestis derived transcript (3 LIM domains)
Modification date2020031320200313
UniProtAcc.

PRSS21

Ensembl transtripts involved in fusion geneENST00000466023, ENST00000361183, 
ENST00000458284, ENST00000490693, 
ENST00000358204, ENST00000485009, 
ENST00000393481, ENST00000537767, 
Fusion gene scores* DoF score17 X 6 X 9=9189 X 6 X 7=378
# samples 2010
** MAII scorelog2(20/918*10)=-2.19849415363908
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CAPZA2 [Title/Abstract] AND TES [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAPZA2(116502704)-TES(115874587), # samples:1
CAPZA2(116502704)-TES(115889074), # samples:1
Anticipated loss of major functional domain due to fusion event.CAPZA2-TES seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CAPZA2-TES seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CAPZA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TES (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HI-7168CAPZA2chr7

116502704

+TESchr7

115874587

+
ChimerDB4STADTCGA-D7-8576-01ACAPZA2chr7

116502704

+TESchr7

115889074

+


Top

Fusion Gene ORF analysis for CAPZA2-TES

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000466023ENST00000358204CAPZA2chr7

116502704

+TESchr7

115874587

+
3UTR-3CDSENST00000466023ENST00000358204CAPZA2chr7

116502704

+TESchr7

115889074

+
3UTR-3UTRENST00000466023ENST00000485009CAPZA2chr7

116502704

+TESchr7

115874587

+
3UTR-3UTRENST00000466023ENST00000485009CAPZA2chr7

116502704

+TESchr7

115889074

+
3UTR-5UTRENST00000466023ENST00000393481CAPZA2chr7

116502704

+TESchr7

115874587

+
3UTR-5UTRENST00000466023ENST00000537767CAPZA2chr7

116502704

+TESchr7

115874587

+
3UTR-intronENST00000466023ENST00000393481CAPZA2chr7

116502704

+TESchr7

115889074

+
3UTR-intronENST00000466023ENST00000537767CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-3UTRENST00000361183ENST00000485009CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-3UTRENST00000361183ENST00000485009CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-3UTRENST00000458284ENST00000485009CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-3UTRENST00000458284ENST00000485009CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-3UTRENST00000490693ENST00000485009CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-3UTRENST00000490693ENST00000485009CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-5UTRENST00000361183ENST00000393481CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-5UTRENST00000361183ENST00000537767CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-5UTRENST00000458284ENST00000393481CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-5UTRENST00000458284ENST00000537767CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-5UTRENST00000490693ENST00000393481CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-5UTRENST00000490693ENST00000537767CAPZA2chr7

116502704

+TESchr7

115874587

+
5CDS-intronENST00000361183ENST00000393481CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-intronENST00000361183ENST00000537767CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-intronENST00000458284ENST00000393481CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-intronENST00000458284ENST00000537767CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-intronENST00000490693ENST00000393481CAPZA2chr7

116502704

+TESchr7

115889074

+
5CDS-intronENST00000490693ENST00000537767CAPZA2chr7

116502704

+TESchr7

115889074

+
Frame-shiftENST00000361183ENST00000358204CAPZA2chr7

116502704

+TESchr7

115889074

+
Frame-shiftENST00000458284ENST00000358204CAPZA2chr7

116502704

+TESchr7

115889074

+
Frame-shiftENST00000490693ENST00000358204CAPZA2chr7

116502704

+TESchr7

115889074

+
In-frameENST00000361183ENST00000358204CAPZA2chr7

116502704

+TESchr7

115874587

+
In-frameENST00000458284ENST00000358204CAPZA2chr7

116502704

+TESchr7

115874587

+
In-frameENST00000490693ENST00000358204CAPZA2chr7

116502704

+TESchr7

115874587

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361183CAPZA2chr7116502704+ENST00000358204TESchr7115874587+27181781001416438
ENST00000458284CAPZA2chr7116502704+ENST00000358204TESchr7115874587+263292141330438
ENST00000490693CAPZA2chr7116502704+ENST00000358204TESchr7115874587+259151121289425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361183ENST00000358204CAPZA2chr7116502704+TESchr7115874587+0.0004394020.99956053
ENST00000458284ENST00000358204CAPZA2chr7116502704+TESchr7115874587+0.0004303120.9995697
ENST00000490693ENST00000358204CAPZA2chr7116502704+TESchr7115874587+0.0004115060.99958855

Top

Fusion Genomic Features for CAPZA2-TES


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CAPZA2chr7116502704+TESchr7115874587+1.88E-060.9999981
CAPZA2chr7116502704+TESchr7115889073+5.66E-081
CAPZA2chr7116502704+TESchr7115874587+1.88E-060.9999981
CAPZA2chr7116502704+TESchr7115889073+5.66E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CAPZA2-TES


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116502704/chr7:115874587)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TES

PRSS21

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.314

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTESchr7:116502704chr7:115874587ENST000003582040722_469422.0Compositional biasNote=Cys-rich
TgeneTESchr7:116502704chr7:115874587ENST000003934810722_460413.0Compositional biasNote=Cys-rich
TgeneTESchr7:116502704chr7:115874587ENST0000035820407234_2979422.0DomainLIM zinc-binding 1
TgeneTESchr7:116502704chr7:115874587ENST0000035820407299_3599422.0DomainLIM zinc-binding 2
TgeneTESchr7:116502704chr7:115874587ENST0000035820407362_4219422.0DomainLIM zinc-binding 3
TgeneTESchr7:116502704chr7:115874587ENST000003582040792_1999422.0DomainPET
TgeneTESchr7:116502704chr7:115874587ENST0000039348107234_2970413.0DomainLIM zinc-binding 1
TgeneTESchr7:116502704chr7:115874587ENST0000039348107299_3590413.0DomainLIM zinc-binding 2
TgeneTESchr7:116502704chr7:115874587ENST0000039348107362_4210413.0DomainLIM zinc-binding 3
TgeneTESchr7:116502704chr7:115874587ENST000003934810792_1990413.0DomainPET

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for CAPZA2-TES


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>12992_12992_1_CAPZA2-TES_CAPZA2_chr7_116502704_ENST00000361183_TES_chr7_115874587_ENST00000358204_length(transcript)=2718nt_BP=178nt
CCCGGGGTGCGCGTGCGCGGCGGCCTGAGCGGCGGGCCCCTCCCTTAGCGGGGGCGCGCGGCGCTGAGGACCGCACGGAAACGGGGAAGT
CAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGAT
GGGCTTAGGTCACGAGCAAGGATTTGGAGCCCCTTGTTTAAAATGCAAAGAAAAATGTGAAGGATTCGAACTGCACTTCTGGAGAAAAAT
ATGTCGTAACTGCAAGTGTGGCCAAGAAGAGCATGATGTCCTCTTGAGCAATGAAGAGGATCGAAAAGTGGGAAAACTTTTTGAAGACAC
CAAGTATACCACTCTGATTGCAAAACTAAAGTCAGATGGAATTCCCATGTATAAACGCAATGTTATGATATTGACGAATCCAGTTGCTGC
CAAGAAGAATGTCTCCATCAATACAGTTACCTATGAGTGGGCTCCTCCTGTCCAGAATCAAGCATTGGCCAGGCAGTACATGCAGATGCT
ACCCAAGGAAAAGCAGCCAGTAGCAGGCTCAGAGGGGGCACAGTACCGGAAGAAGCAGCTGGCAAAGCAGCTCCCTGCACATGACCAGGA
CCCTTCAAAGTGCCATGAGTTGTCTCCCAGAGAGGTGAAGGAGATGGAGCAGTTTGTGAAGAAATATAAGAGCGAAGCTCTGGGAGTAGG
AGATGTCAAACTTCCCTGTGAGATGGATGCCCAAGGCCCCAAACAAATGAACATTCCTGGAGGGGATAGAAGCACCCCAGCAGCAGTGGG
GGCCATGGAGGACAAATCTGCTGAGCACAAAAGAACTCAATATTCCTGCTATTGCTGCAAACTGAGTATGAAAGAAGGTGACCCAGCCAT
CTATGCCGAAAGGGCTGGCTATGATAAACTGTGGCACCCAGCTTGTTTTGTCTGCAGCACCTGCCATGAACTCCTGGTTGACATGATTTA
TTTTTGGAAGAATGAGAAGCTATACTGTGGCAGACATTACTGTGACAGCGAGAAACCCCGATGTGCTGGCTGTGACGAGCTGATATTCAG
CAATGAGTATACCCAGGCAGAAAACCAGAATTGGCACCTGAAACACTTCTGCTGCTTTGACTGTGATAGCATTCTAGCTGGGGAGATATA
CGTGATGGTCAATGACAAGCCCGTGTGCAAGCCCTGCTATGTGAAGAATCACGCTGTGGTGTGTCAAGGATGCCACAATGCCATCGACCC
AGAAGTGCAGCGGGTGACCTATAACAATTTCAGCTGGCATGCATCCACAGAGTGCTTTCTGTGCTCTTGCTGCAGCAAATGCCTCATTGG
GCAGAAGTTCATGCCAGTAGAAGGGATGGTTTTCTGTTCAGTGGAATGTAAGAAGAGGATGTCTTAGGAGGAGGGCACCCAGAAGTATCG
AGCCATAGCTATCCAAAGTGGTCTGCATTTCTACTGTAAAATGCAATTTGAAAAAAATAAAACGCAAAAAAAGAAACTGTAAAGGAAACC
AAGAGATTTTGTTTAATTTTTTTGGCCATTTTTTCTTCATCAATTTTTTTTCGGTCTCAACTTTTAAACTTGGTTTAAGCATTTGATTTG
TAAAACAGTAAATAATTGTATCTTTCCATAGCTTTTCAAATGTGAAATCATTTTTGGAAGCTTGGATCTCATTAAACTTCATGTCTCTAT
TCCATTTGTGCCACACACTTAAAAGTTAGTGTACTGAATGGAAAGATGAGCATTCCTAGTTCTACACTTCTTTTTTCCCCCTCATGTGTA
AAATGAAAAGAAAACTAAATTTGCCCTAATACCAAGGCGCTACGTTTATTGCCTCGTCTTATTCACTGACCTTTGTAATGATACACAGTG
AATTCTTTTTGACAAAGAGAAATGCAGTGTAGTATGCAGAGCTGCTGTTTTAATGCCTATGCATTTACTCTTTCCTGATTTAGGCAGAGG
TGGCATTTTCTTTATTGCATTTCTCTATTTTTTTAATGTACCCTACCTTCAGTATTCTCTTTGTAAGTTGGTGACTTGCATCTGTGGCCT
TGAATATTTTATTATCACATGTGGCATAACAGTATCCACACTTTTTAGTTCTTTATTTTTTTTTTTTTATTTTGAGCAATTCTCCTGCCT
CAGCCTCCCAAATAGCTGGGATTACAGGTGCATGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGTTTTCACCATGTTA
GCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGGAGCCACCATGC
CTGACCCACACACTTTTTACTTGTATAGATGATTTTTGGCTTGGACATAAAAGCCAAGCCACCCATTTGCTTTTAATCCAAAGAACATGT
ATAGTTTTTGTACCCAGAGACTATGATTTATATTGATTGCACTTGCCTGCCATGATTTAGATAAGATTTTTTTTGCATGGTTTTTATTCT
TTCCTAATGGATCCTGTTTTATAATACTTCCAAGCCTGTCCATGGATATATCAAATGTCTTCACTTGTATATTTTCATGGCTAGGTATTT
CTAATGTTTATTCTTCCCTGTGTACTTCTACACATAGCTATGCACTATGAAAATTAAATGGAATGAATGATATGTATATTACTCAAAATA

>12992_12992_1_CAPZA2-TES_CAPZA2_chr7_116502704_ENST00000361183_TES_chr7_115874587_ENST00000358204_length(amino acids)=438AA_BP=26
MPPPPPRFVARRKMADLEEQLSDEEKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYT
TLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSK
CHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAE
RAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMV

--------------------------------------------------------------
>12992_12992_2_CAPZA2-TES_CAPZA2_chr7_116502704_ENST00000458284_TES_chr7_115874587_ENST00000358204_length(transcript)=2632nt_BP=92nt
AAGTCAGGTGGCCGCTGCCGCCGCCGCCGCCGCGGTTTGTCGCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGA
AGATGGGCTTAGGTCACGAGCAAGGATTTGGAGCCCCTTGTTTAAAATGCAAAGAAAAATGTGAAGGATTCGAACTGCACTTCTGGAGAA
AAATATGTCGTAACTGCAAGTGTGGCCAAGAAGAGCATGATGTCCTCTTGAGCAATGAAGAGGATCGAAAAGTGGGAAAACTTTTTGAAG
ACACCAAGTATACCACTCTGATTGCAAAACTAAAGTCAGATGGAATTCCCATGTATAAACGCAATGTTATGATATTGACGAATCCAGTTG
CTGCCAAGAAGAATGTCTCCATCAATACAGTTACCTATGAGTGGGCTCCTCCTGTCCAGAATCAAGCATTGGCCAGGCAGTACATGCAGA
TGCTACCCAAGGAAAAGCAGCCAGTAGCAGGCTCAGAGGGGGCACAGTACCGGAAGAAGCAGCTGGCAAAGCAGCTCCCTGCACATGACC
AGGACCCTTCAAAGTGCCATGAGTTGTCTCCCAGAGAGGTGAAGGAGATGGAGCAGTTTGTGAAGAAATATAAGAGCGAAGCTCTGGGAG
TAGGAGATGTCAAACTTCCCTGTGAGATGGATGCCCAAGGCCCCAAACAAATGAACATTCCTGGAGGGGATAGAAGCACCCCAGCAGCAG
TGGGGGCCATGGAGGACAAATCTGCTGAGCACAAAAGAACTCAATATTCCTGCTATTGCTGCAAACTGAGTATGAAAGAAGGTGACCCAG
CCATCTATGCCGAAAGGGCTGGCTATGATAAACTGTGGCACCCAGCTTGTTTTGTCTGCAGCACCTGCCATGAACTCCTGGTTGACATGA
TTTATTTTTGGAAGAATGAGAAGCTATACTGTGGCAGACATTACTGTGACAGCGAGAAACCCCGATGTGCTGGCTGTGACGAGCTGATAT
TCAGCAATGAGTATACCCAGGCAGAAAACCAGAATTGGCACCTGAAACACTTCTGCTGCTTTGACTGTGATAGCATTCTAGCTGGGGAGA
TATACGTGATGGTCAATGACAAGCCCGTGTGCAAGCCCTGCTATGTGAAGAATCACGCTGTGGTGTGTCAAGGATGCCACAATGCCATCG
ACCCAGAAGTGCAGCGGGTGACCTATAACAATTTCAGCTGGCATGCATCCACAGAGTGCTTTCTGTGCTCTTGCTGCAGCAAATGCCTCA
TTGGGCAGAAGTTCATGCCAGTAGAAGGGATGGTTTTCTGTTCAGTGGAATGTAAGAAGAGGATGTCTTAGGAGGAGGGCACCCAGAAGT
ATCGAGCCATAGCTATCCAAAGTGGTCTGCATTTCTACTGTAAAATGCAATTTGAAAAAAATAAAACGCAAAAAAAGAAACTGTAAAGGA
AACCAAGAGATTTTGTTTAATTTTTTTGGCCATTTTTTCTTCATCAATTTTTTTTCGGTCTCAACTTTTAAACTTGGTTTAAGCATTTGA
TTTGTAAAACAGTAAATAATTGTATCTTTCCATAGCTTTTCAAATGTGAAATCATTTTTGGAAGCTTGGATCTCATTAAACTTCATGTCT
CTATTCCATTTGTGCCACACACTTAAAAGTTAGTGTACTGAATGGAAAGATGAGCATTCCTAGTTCTACACTTCTTTTTTCCCCCTCATG
TGTAAAATGAAAAGAAAACTAAATTTGCCCTAATACCAAGGCGCTACGTTTATTGCCTCGTCTTATTCACTGACCTTTGTAATGATACAC
AGTGAATTCTTTTTGACAAAGAGAAATGCAGTGTAGTATGCAGAGCTGCTGTTTTAATGCCTATGCATTTACTCTTTCCTGATTTAGGCA
GAGGTGGCATTTTCTTTATTGCATTTCTCTATTTTTTTAATGTACCCTACCTTCAGTATTCTCTTTGTAAGTTGGTGACTTGCATCTGTG
GCCTTGAATATTTTATTATCACATGTGGCATAACAGTATCCACACTTTTTAGTTCTTTATTTTTTTTTTTTTATTTTGAGCAATTCTCCT
GCCTCAGCCTCCCAAATAGCTGGGATTACAGGTGCATGCCACCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGTTTTCACCAT
GTTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCCGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGGAGCCACC
ATGCCTGACCCACACACTTTTTACTTGTATAGATGATTTTTGGCTTGGACATAAAAGCCAAGCCACCCATTTGCTTTTAATCCAAAGAAC
ATGTATAGTTTTTGTACCCAGAGACTATGATTTATATTGATTGCACTTGCCTGCCATGATTTAGATAAGATTTTTTTTGCATGGTTTTTA
TTCTTTCCTAATGGATCCTGTTTTATAATACTTCCAAGCCTGTCCATGGATATATCAAATGTCTTCACTTGTATATTTTCATGGCTAGGT
ATTTCTAATGTTTATTCTTCCCTGTGTACTTCTACACATAGCTATGCACTATGAAAATTAAATGGAATGAATGATATGTATATTACTCAA

>12992_12992_2_CAPZA2-TES_CAPZA2_chr7_116502704_ENST00000458284_TES_chr7_115874587_ENST00000358204_length(amino acids)=438AA_BP=26
MPPPPPRFVARRKMADLEEQLSDEEKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYT
TLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSK
CHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAE
RAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMV

--------------------------------------------------------------
>12992_12992_3_CAPZA2-TES_CAPZA2_chr7_116502704_ENST00000490693_TES_chr7_115874587_ENST00000358204_length(transcript)=2591nt_BP=51nt
GCCAGAAGGAAGATGGCGGATCTGGAGGAGCAGTTGTCTGATGAAGAGAAGATGGGCTTAGGTCACGAGCAAGGATTTGGAGCCCCTTGT
TTAAAATGCAAAGAAAAATGTGAAGGATTCGAACTGCACTTCTGGAGAAAAATATGTCGTAACTGCAAGTGTGGCCAAGAAGAGCATGAT
GTCCTCTTGAGCAATGAAGAGGATCGAAAAGTGGGAAAACTTTTTGAAGACACCAAGTATACCACTCTGATTGCAAAACTAAAGTCAGAT
GGAATTCCCATGTATAAACGCAATGTTATGATATTGACGAATCCAGTTGCTGCCAAGAAGAATGTCTCCATCAATACAGTTACCTATGAG
TGGGCTCCTCCTGTCCAGAATCAAGCATTGGCCAGGCAGTACATGCAGATGCTACCCAAGGAAAAGCAGCCAGTAGCAGGCTCAGAGGGG
GCACAGTACCGGAAGAAGCAGCTGGCAAAGCAGCTCCCTGCACATGACCAGGACCCTTCAAAGTGCCATGAGTTGTCTCCCAGAGAGGTG
AAGGAGATGGAGCAGTTTGTGAAGAAATATAAGAGCGAAGCTCTGGGAGTAGGAGATGTCAAACTTCCCTGTGAGATGGATGCCCAAGGC
CCCAAACAAATGAACATTCCTGGAGGGGATAGAAGCACCCCAGCAGCAGTGGGGGCCATGGAGGACAAATCTGCTGAGCACAAAAGAACT
CAATATTCCTGCTATTGCTGCAAACTGAGTATGAAAGAAGGTGACCCAGCCATCTATGCCGAAAGGGCTGGCTATGATAAACTGTGGCAC
CCAGCTTGTTTTGTCTGCAGCACCTGCCATGAACTCCTGGTTGACATGATTTATTTTTGGAAGAATGAGAAGCTATACTGTGGCAGACAT
TACTGTGACAGCGAGAAACCCCGATGTGCTGGCTGTGACGAGCTGATATTCAGCAATGAGTATACCCAGGCAGAAAACCAGAATTGGCAC
CTGAAACACTTCTGCTGCTTTGACTGTGATAGCATTCTAGCTGGGGAGATATACGTGATGGTCAATGACAAGCCCGTGTGCAAGCCCTGC
TATGTGAAGAATCACGCTGTGGTGTGTCAAGGATGCCACAATGCCATCGACCCAGAAGTGCAGCGGGTGACCTATAACAATTTCAGCTGG
CATGCATCCACAGAGTGCTTTCTGTGCTCTTGCTGCAGCAAATGCCTCATTGGGCAGAAGTTCATGCCAGTAGAAGGGATGGTTTTCTGT
TCAGTGGAATGTAAGAAGAGGATGTCTTAGGAGGAGGGCACCCAGAAGTATCGAGCCATAGCTATCCAAAGTGGTCTGCATTTCTACTGT
AAAATGCAATTTGAAAAAAATAAAACGCAAAAAAAGAAACTGTAAAGGAAACCAAGAGATTTTGTTTAATTTTTTTGGCCATTTTTTCTT
CATCAATTTTTTTTCGGTCTCAACTTTTAAACTTGGTTTAAGCATTTGATTTGTAAAACAGTAAATAATTGTATCTTTCCATAGCTTTTC
AAATGTGAAATCATTTTTGGAAGCTTGGATCTCATTAAACTTCATGTCTCTATTCCATTTGTGCCACACACTTAAAAGTTAGTGTACTGA
ATGGAAAGATGAGCATTCCTAGTTCTACACTTCTTTTTTCCCCCTCATGTGTAAAATGAAAAGAAAACTAAATTTGCCCTAATACCAAGG
CGCTACGTTTATTGCCTCGTCTTATTCACTGACCTTTGTAATGATACACAGTGAATTCTTTTTGACAAAGAGAAATGCAGTGTAGTATGC
AGAGCTGCTGTTTTAATGCCTATGCATTTACTCTTTCCTGATTTAGGCAGAGGTGGCATTTTCTTTATTGCATTTCTCTATTTTTTTAAT
GTACCCTACCTTCAGTATTCTCTTTGTAAGTTGGTGACTTGCATCTGTGGCCTTGAATATTTTATTATCACATGTGGCATAACAGTATCC
ACACTTTTTAGTTCTTTATTTTTTTTTTTTTATTTTGAGCAATTCTCCTGCCTCAGCCTCCCAAATAGCTGGGATTACAGGTGCATGCCA
CCACACCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGTTTTCACCATGTTAGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATCC
GCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGGGAGCCACCATGCCTGACCCACACACTTTTTACTTGTATAGATGATTTTT
GGCTTGGACATAAAAGCCAAGCCACCCATTTGCTTTTAATCCAAAGAACATGTATAGTTTTTGTACCCAGAGACTATGATTTATATTGAT
TGCACTTGCCTGCCATGATTTAGATAAGATTTTTTTTGCATGGTTTTTATTCTTTCCTAATGGATCCTGTTTTATAATACTTCCAAGCCT
GTCCATGGATATATCAAATGTCTTCACTTGTATATTTTCATGGCTAGGTATTTCTAATGTTTATTCTTCCCTGTGTACTTCTACACATAG

>12992_12992_3_CAPZA2-TES_CAPZA2_chr7_116502704_ENST00000490693_TES_chr7_115874587_ENST00000358204_length(amino acids)=425AA_BP=13
MADLEEQLSDEEKMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPM
YKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEME
QFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACF
VCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CAPZA2-TES


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CAPZA2-TES


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CAPZA2-TES


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource