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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CARD8-CARD8 (FusionGDB2 ID:13034)

Fusion Gene Summary for CARD8-CARD8

Fusion gene summary

Fusion gene information	Fusion gene name: CARD8-CARD8
	Fusion gene ID: 13034
		Hgene	Tgene
	Gene symbol	CARD8	CARD8
	Gene ID	22900	22900
	Gene name	caspase recruitment domain family member 8	caspase recruitment domain family member 8
	Synonyms	CARDINAL\|DACAR\|DAKAR\|NDPP\|NDPP1\|TUCAN	CARDINAL\|DACAR\|DAKAR\|NDPP\|NDPP1\|TUCAN
	Cytomap	19q13.33	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	caspase recruitment domain-containing protein 8CARD inhibitor of NF-kappaB-activating ligandsapoptotic protein NDPP1tumor up-regulated CARD-containing antagonist of CASP9tumor up-regulated CARD-containing antagonist of caspase nine	caspase recruitment domain-containing protein 8CARD inhibitor of NF-kappaB-activating ligandsapoptotic protein NDPP1tumor up-regulated CARD-containing antagonist of CASP9tumor up-regulated CARD-containing antagonist of caspase nine
	Modification date	20200320	20200320
	UniProtAcc	Q9Y2G2	Q9Y2G2
	Ensembl transtripts involved in fusion gene	ENST00000357778, ENST00000359009, ENST00000391898, ENST00000447740, ENST00000519332, ENST00000519940, ENST00000520007, ENST00000520015, ENST00000520153, ENST00000520753, ENST00000521613, ENST00000522431, ENST00000600800,	ENST00000519940, ENST00000520015, ENST00000520753, ENST00000521613, ENST00000357778, ENST00000359009, ENST00000391898, ENST00000447740, ENST00000519332, ENST00000520007, ENST00000520153, ENST00000522431, ENST00000600800,
Fusion gene scores	* DoF score	12 X 16 X 6=1152	6 X 5 X 4=120
	# samples	14	6
	** MAII score	log2(14/1152*10)=-3.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CARD8 [Title/Abstract] AND CARD8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CARD8(48714956)-CARD8(48715133), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CARD8	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	11821383
Hgene	CARD8	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	11551959
Hgene	CARD8	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	11821383\|15030775
Hgene	CARD8	GO:0050713	negative regulation of interleukin-1 beta secretion	11821383
Hgene	CARD8	GO:0050718	positive regulation of interleukin-1 beta secretion	15030775
Hgene	CARD8	GO:0097340	inhibition of cysteine-type endopeptidase activity	11821383
Tgene	CARD8	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	11821383
Tgene	CARD8	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	11551959
Tgene	CARD8	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	11821383\|15030775
Tgene	CARD8	GO:0050713	negative regulation of interleukin-1 beta secretion	11821383
Tgene	CARD8	GO:0050718	positive regulation of interleukin-1 beta secretion	15030775
Tgene	CARD8	GO:0097340	inhibition of cysteine-type endopeptidase activity	11821383

Fusion gene breakpoints across CARD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CARD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BE086543	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+

Top

Fusion Gene ORF analysis for CARD8-CARD8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3UTR	ENST00000357778	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000357778	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000357778	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000357778	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000359009	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000359009	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000359009	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000359009	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000391898	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000391898	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000391898	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000391898	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000447740	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000447740	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000447740	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000447740	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519332	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519332	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519332	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519332	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519940	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519940	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519940	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000519940	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520007	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520007	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520007	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520007	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520015	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520015	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520015	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520015	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520153	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520153	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520153	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520153	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520753	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520753	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520753	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000520753	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000521613	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000521613	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000521613	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000521613	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000522431	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000522431	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000522431	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000522431	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000600800	ENST00000519940	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000600800	ENST00000520015	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000600800	ENST00000520753	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-3UTR	ENST00000600800	ENST00000521613	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000357778	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000359009	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000391898	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000447740	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519332	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000519940	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520007	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520015	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520153	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000520753	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000521613	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000522431	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000357778	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000359009	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000391898	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000447740	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000519332	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000520007	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000520153	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000522431	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+
intron-intron	ENST00000600800	ENST00000600800	CARD8	chr19	48714956	-	CARD8	chr19	48715133	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for CARD8-CARD8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CARD8-CARD8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48714956/:48715133)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CARD8 Q9Y2G2	CARD8 Q9Y2G2
FUNCTION: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.	FUNCTION: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for CARD8-CARD8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CARD8-CARD8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for CARD8-CARD8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CARD8-CARD8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source