Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CARD8-MYH14 (FusionGDB2 ID:13037)

Fusion Gene Summary for CARD8-MYH14

Fusion gene summary

Fusion gene information	Fusion gene name: CARD8-MYH14
	Fusion gene ID: 13037
		Hgene	Tgene
	Gene symbol	CARD8	MYH14
	Gene ID	22900	79784
	Gene name	caspase recruitment domain family member 8	myosin heavy chain 14
	Synonyms	CARDINAL\|DACAR\|DAKAR\|NDPP\|NDPP1\|TUCAN	DFNA4\|DFNA4A\|FP17425\|MHC16\|MYH17\|NMHC II-C\|NMHC-II-C\|PNMHH\|myosin
	Cytomap	19q13.33	19q13.33
	Type of gene	protein-coding	protein-coding
	Description	caspase recruitment domain-containing protein 8CARD inhibitor of NF-kappaB-activating ligandsapoptotic protein NDPP1tumor up-regulated CARD-containing antagonist of CASP9tumor up-regulated CARD-containing antagonist of caspase nine	myosin-14MYH14 variant proteinmyosin heavy chain, non-muscle IIcmyosin, heavy chain 14, non-musclemyosin, heavy polypeptide 14non-muscle myosin heavy chain IIcnonmuscle myosin heavy chain II-C
	Modification date	20200320	20200313
	UniProtAcc	Q9Y2G2	Q7Z406
	Ensembl transtripts involved in fusion gene	ENST00000519332, ENST00000519940, ENST00000520007, ENST00000520753, ENST00000521613, ENST00000357778, ENST00000359009, ENST00000391898, ENST00000447740, ENST00000520015, ENST00000520153, ENST00000522431, ENST00000600800,	ENST00000262269, ENST00000376970, ENST00000425460, ENST00000440075, ENST00000596571, ENST00000598205, ENST00000601313,
Fusion gene scores	* DoF score	12 X 16 X 6=1152	20 X 23 X 10=4600
	# samples	14	24
	** MAII score	log2(14/1152*10)=-3.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/4600*10)=-4.26052755022322 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CARD8 [Title/Abstract] AND MYH14 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CARD8(48759048)-MYH14(50752243), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CARD8	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway	11821383
Hgene	CARD8	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	11551959
Hgene	CARD8	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	11821383\|15030775
Hgene	CARD8	GO:0050713	negative regulation of interleukin-1 beta secretion	11821383
Hgene	CARD8	GO:0050718	positive regulation of interleukin-1 beta secretion	15030775
Hgene	CARD8	GO:0097340	inhibition of cysteine-type endopeptidase activity	11821383
Tgene	MYH14	GO:0031032	actomyosin structure organization	24072716

Fusion gene breakpoints across CARD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYH14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A891-01A	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
ChimerDB4	ESCA	TCGA-L5-A891	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+

Top

Fusion Gene ORF analysis for CARD8-MYH14

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-3CDS	ENST00000519332	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519332	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519332	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519332	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519332	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519332	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519332	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519332	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519332	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519332	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519332	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519332	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519332	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519332	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519940	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519940	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519940	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519940	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519940	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519940	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519940	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519940	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519940	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519940	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519940	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519940	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000519940	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000519940	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520007	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520007	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520007	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520007	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520007	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520007	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520007	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520007	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520007	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520007	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520007	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520007	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520007	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520007	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520753	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520753	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520753	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520753	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520753	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520753	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520753	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520753	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520753	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520753	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520753	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520753	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000520753	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000520753	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000521613	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000521613	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000521613	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000521613	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000521613	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000521613	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000521613	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000521613	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000521613	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000521613	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000521613	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000521613	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
5UTR-3CDS	ENST00000521613	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
5UTR-3CDS	ENST00000521613	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000357778	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000357778	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000357778	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000357778	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000357778	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000357778	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000357778	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000357778	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000357778	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000357778	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000357778	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000357778	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000357778	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000357778	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000359009	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000359009	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000359009	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000359009	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000359009	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000359009	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000359009	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000359009	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000359009	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000359009	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000359009	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000359009	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000359009	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000359009	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000391898	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000391898	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000391898	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000391898	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000391898	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000391898	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000391898	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000391898	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000391898	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000391898	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000391898	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000391898	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000391898	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000391898	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000447740	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000447740	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000447740	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000447740	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000447740	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000447740	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000447740	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000447740	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000447740	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000447740	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000447740	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000447740	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000447740	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000447740	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520015	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520015	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520015	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520015	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520015	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520015	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520015	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520015	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520015	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520015	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520015	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520015	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520015	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520015	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520153	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520153	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520153	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520153	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520153	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520153	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520153	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520153	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520153	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520153	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520153	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520153	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000520153	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000520153	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000522431	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000522431	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000522431	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000522431	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000522431	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000522431	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000522431	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000522431	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000522431	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000522431	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000522431	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000522431	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000522431	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000522431	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000600800	ENST00000262269	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000600800	ENST00000262269	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000600800	ENST00000376970	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000600800	ENST00000376970	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000600800	ENST00000425460	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000600800	ENST00000425460	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000600800	ENST00000440075	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000600800	ENST00000440075	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000600800	ENST00000596571	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000600800	ENST00000596571	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000600800	ENST00000598205	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000600800	ENST00000598205	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+
intron-3CDS	ENST00000600800	ENST00000601313	CARD8	chr19	48759049	-	MYH14	chr19	50752244	+
intron-3CDS	ENST00000600800	ENST00000601313	CARD8	chr19	48759048	-	MYH14	chr19	50752243	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for CARD8-MYH14

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CARD8	chr19	48759048	-	MYH14	chr19	50752243	+	9.51E-09	1
CARD8	chr19	48759048	-	MYH14	chr19	50752243	+	9.51E-09	1
CARD8	chr19	48759048	-	MYH14	chr19	50752243	+	9.51E-09	1
CARD8	chr19	48759048	-	MYH14	chr19	50752243	+	9.51E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CARD8-MYH14

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48759048/:50752243)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CARD8 Q9Y2G2	MYH14 Q7Z406
FUNCTION: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.	FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for CARD8-MYH14

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CARD8-MYH14

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CARD8-MYH14

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CARD8-MYH14

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source