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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CARD8-RPA1 (FusionGDB2 ID:13040)

Fusion Gene Summary for CARD8-RPA1

check button Fusion gene summary
Fusion gene informationFusion gene name: CARD8-RPA1
Fusion gene ID: 13040
HgeneTgene
Gene symbol

CARD8

RPA1

Gene ID

22900

25885

Gene namecaspase recruitment domain family member 8RNA polymerase I subunit A
SynonymsCARDINAL|DACAR|DAKAR|NDPP|NDPP1|TUCANA190|AFDCIN|RPA1|RPA194|RPO1-4|RPO14
Cytomap

19q13.33

2p11.2

Type of geneprotein-codingprotein-coding
Descriptioncaspase recruitment domain-containing protein 8CARD inhibitor of NF-kappaB-activating ligandsapoptotic protein NDPP1tumor up-regulated CARD-containing antagonist of CASP9tumor up-regulated CARD-containing antagonist of caspase nineDNA-directed RNA polymerase I subunit RPA1DNA-directed RNA polymerase I largest subunitDNA-directed RNA polymerase I subunit ADNA-directed RNA polymerase I subunit A1RNA polymerase I 194 kDa subunitpolymerase (RNA) I polypeptide A, 194kDapolymerase
Modification date2020032020200313
UniProtAcc

Q9Y2G2

.
Ensembl transtripts involved in fusion geneENST00000391898, ENST00000447740, 
ENST00000519332, ENST00000519940, 
ENST00000520007, ENST00000520015, 
ENST00000520153, ENST00000520753, 
ENST00000521613, ENST00000522431, 
ENST00000357778, ENST00000359009, 
ENST00000600800, 		ENST00000573924, 
ENST00000254719, 
Fusion gene scores* DoF score12 X 16 X 6=11529 X 8 X 3=216
# samples 149
** MAII scorelog2(14/1152*10)=-3.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CARD8 [Title/Abstract] AND RPA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCARD8(48744218)-RPA1(1746096), # samples:1
Anticipated loss of major functional domain due to fusion event.CARD8-RPA1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCARD8

GO:0031665

negative regulation of lipopolysaccharide-mediated signaling pathway

11821383

HgeneCARD8

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

11551959

HgeneCARD8

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

11821383|15030775

HgeneCARD8

GO:0050713

negative regulation of interleukin-1 beta secretion

11821383

HgeneCARD8

GO:0050718

positive regulation of interleukin-1 beta secretion

15030775

HgeneCARD8

GO:0097340

inhibition of cysteine-type endopeptidase activity

11821383


check buttonFusion gene breakpoints across CARD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA884322CARD8chr19

48744218

-RPA1chr17

1746096

+


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Fusion Gene ORF analysis for CARD8-RPA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000391898ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000447740ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000519332ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000519940ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000520007ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000520015ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000520153ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000520753ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000521613ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5CDS-intronENST00000522431ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5UTR-3CDSENST00000357778ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
5UTR-3CDSENST00000359009ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
5UTR-intronENST00000357778ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
5UTR-intronENST00000359009ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+
Frame-shiftENST00000519332ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
Frame-shiftENST00000519940ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
Frame-shiftENST00000520007ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
Frame-shiftENST00000520753ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
Frame-shiftENST00000521613ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
In-frameENST00000391898ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
In-frameENST00000447740ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
In-frameENST00000520015ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
In-frameENST00000520153ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
In-frameENST00000522431ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
intron-3CDSENST00000600800ENST00000254719CARD8chr19

48744218

-RPA1chr17

1746096

+
intron-intronENST00000600800ENST00000573924CARD8chr19

48744218

-RPA1chr17

1746096

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391898CARD8chr1948744218-ENST00000254719RPA1chr171746096+42991021081919603
ENST00000447740CARD8chr1948744218-ENST00000254719RPA1chr171746096+43961992052016603
ENST00000520153CARD8chr1948744218-ENST00000254719RPA1chr171746096+44862892952106603
ENST00000520015CARD8chr1948744218-ENST00000254719RPA1chr171746096+43821851912002603
ENST00000522431CARD8chr1948744218-ENST00000254719RPA1chr171746096+45483513572168603

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391898ENST00000254719CARD8chr1948744218-RPA1chr171746096+0.0018590830.99814093
ENST00000447740ENST00000254719CARD8chr1948744218-RPA1chr171746096+0.0022038410.9977962
ENST00000520153ENST00000254719CARD8chr1948744218-RPA1chr171746096+0.0021277250.99787223
ENST00000520015ENST00000254719CARD8chr1948744218-RPA1chr171746096+0.0021929390.9978071
ENST00000522431ENST00000254719CARD8chr1948744218-RPA1chr171746096+0.0018329010.99816704

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Fusion Genomic Features for CARD8-RPA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CARD8chr1948744218-RPA1chr171746096+0.0004365730.9995634
CARD8chr1948744218-RPA1chr171746096+0.0004365730.9995634

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CARD8-RPA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:48744218/chr17:1746096)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CARD8

Q9Y2G2

.
FUNCTION: Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPA1chr19:48744218chr17:1746096ENST00000254719017197_28111617.0DNA bindingNote=OB
TgeneRPA1chr19:48744218chr17:1746096ENST00000254719017481_50311617.0Zinc fingerC4-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCARD8chr19:48744218chr17:1746096ENST00000359009-210340_4300432.0DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000359009-21056_3400432.0DomainFIIND
HgeneCARD8chr19:48744218chr17:1746096ENST00000391898-111340_43019538.0DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000391898-11156_34019538.0DomainFIIND
HgeneCARD8chr19:48744218chr17:1746096ENST00000447740-211340_43019488.0DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000447740-21156_34019488.0DomainFIIND
HgeneCARD8chr19:48744218chr17:1746096ENST00000519940-414340_43019538.0DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000519940-41456_34019538.0DomainFIIND
HgeneCARD8chr19:48744218chr17:1746096ENST00000520015-211340_43019546.0DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000520015-21156_34019546.0DomainFIIND
HgeneCARD8chr19:48744218chr17:1746096ENST00000520153-312340_43019488.0DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000520153-31256_34019488.0DomainFIIND
HgeneCARD8chr19:48744218chr17:1746096ENST00000520753-413340_43019840.3333333333334DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000520753-41356_34019840.3333333333334DomainFIIND
HgeneCARD8chr19:48744218chr17:1746096ENST00000521613-312340_43019488.0DomainCARD
HgeneCARD8chr19:48744218chr17:1746096ENST00000521613-31256_34019488.0DomainFIIND


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Fusion Gene Sequence for CARD8-RPA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13040_13040_1_CARD8-RPA1_CARD8_chr19_48744218_ENST00000391898_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4299nt_BP=102nt
GGTAAAAAAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTGAGGAAGA
GCTGCCGAGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAAT
AGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAG
GAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATG
GAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCCGCAAGTA
GCTCCTCCAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGTTTCTAAG
GCTTATGGTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGTGCCCATT
GCCAGCCTCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTCCCGAGGG
GAAGGGAAGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTTCTTTCCT
CTTATTGAAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGACTACGAG
ATGACCTTCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGATTGATGAC
CTCGAGAACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAGGTCTAAC
AACAGAGAAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGCTGATAAA
TTTGATGGTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTCTTCAAGC
ACTATCATTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGTTTCCATC
TCTGATCTAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCAAGGCGAC
AAGCCGGACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGACTGCAAT
AAGAAAGTGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGATCCTGTCA
GTAAATATTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGCTTATCTT
GGGGAATTAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAGGGTCAAA
GTGGAGACCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAGGCTGGTC
ATGAGCATCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGATTTCCTCC
CACCTCCGTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCATCTCAGA
ACCCATCGGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGCGCAAGAC
CAGTCACTCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTGCAGACCA
TGAAGTAAATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTCAGCGGGG
CGAGCTGAGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGTGCTACAT
AGTTGGTAATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCAGGGTTTA
ATAGACTGAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTAAGGAAAT
CCGAGCGGCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTGTACACAT
TCCTGCATTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTTGTTTTAA
TAAACAGTATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTTCATAATA
AATGTTCACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGCAGCCCTG
AAATGCATCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTTTATTGAT
GTTTACGCAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTGGGCCTTT
CAGTCAGCAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATTGGCCGCA
CATCTCGCCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCGGAGGCTT
TTGGATATGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGGGATGACT
TCCGTTCCTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGTCTCAGGA
GATGGTAACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTATAAAGCAT
CGACGAGAAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTAACCAGTC
TTTCATGCCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACCAGGACAG
GACGTGTCCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTGATTGGGA
ACCCAGGGGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGCAGAGGAG
CATCAGAAACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTACCTCGAA
AGGCTGTTGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGCAATTAGG
AGAAAAAAATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAAAATAAAA

>13040_13040_1_CARD8-RPA1_CARD8_chr19_48744218_ENST00000391898_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0
MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK
SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY
QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE
TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ
PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS
SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK

--------------------------------------------------------------
>13040_13040_2_CARD8-RPA1_CARD8_chr19_48744218_ENST00000447740_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4396nt_BP=199nt
TGACCAAGAGGAACAGAACACAGAGCAGCCTGGCAGTGTCCAAGCAACAAGCCTCCGCTCCTCCTTCCTGCACCCTGGGGCTCCTGAAAC
TCACATGGGTAAAAAAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTG
AGGAAGAGCTGCCGAGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTAC
GGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCT
CGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTAT
CTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCC
GCAAGTAGCTCCTCCAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGT
TTCTAAGGCTTATGGTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGT
GCCCATTGCCAGCCTCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTC
CCGAGGGGAAGGGAAGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTT
CTTTCCTCTTATTGAAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGA
CTACGAGATGACCTTCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGAT
TGATGACCTCGAGAACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAG
GTCTAACAACAGAGAAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGC
TGATAAATTTGATGGTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTC
TTCAAGCACTATCATTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGT
TTCCATCTCTGATCTAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCA
AGGCGACAAGCCGGACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGA
CTGCAATAAGAAAGTGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGAT
CCTGTCAGTAAATATTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGC
TTATCTTGGGGAATTAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAG
GGTCAAAGTGGAGACCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAG
GCTGGTCATGAGCATCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGAT
TTCCTCCCACCTCCGTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCA
TCTCAGAACCCATCGGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGC
GCAAGACCAGTCACTCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTG
CAGACCATGAAGTAAATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTC
AGCGGGGCGAGCTGAGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGT
GCTACATAGTTGGTAATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCA
GGGTTTAATAGACTGAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTA
AGGAAATCCGAGCGGCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTG
TACACATTCCTGCATTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTT
GTTTTAATAAACAGTATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTT
CATAATAAATGTTCACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGC
AGCCCTGAAATGCATCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTT
TATTGATGTTTACGCAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTG
GGCCTTTCAGTCAGCAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATT
GGCCGCACATCTCGCCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCG
GAGGCTTTTGGATATGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGG
GATGACTTCCGTTCCTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGT
CTCAGGAGATGGTAACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTAT
AAAGCATCGACGAGAAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTA
ACCAGTCTTTCATGCCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACC
AGGACAGGACGTGTCCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTG
ATTGGGAACCCAGGGGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGC
AGAGGAGCATCAGAAACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTA
CCTCGAAAGGCTGTTGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGC
AATTAGGAGAAAAAAATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAA

>13040_13040_2_CARD8-RPA1_CARD8_chr19_48744218_ENST00000447740_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0
MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK
SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY
QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE
TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ
PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS
SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK

--------------------------------------------------------------
>13040_13040_3_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520015_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4382nt_BP=185nt
AGAACACAGAGCAGCCTGGCAGTGTCCAAGCAACAAGCCTCCGCTCCTCCTTCCTGCACCCTGGGGCTCCTGAAACTCACATGGGTAAAA
AAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTGAGGAAGAGCTGCCG
AGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAATAGTCCGC
CGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAGGAAGAAC
AATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATGGAATTAG
AAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCCGCAAGTAGCTCCTC
CAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGTTTCTAAGGCTTATG
GTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGTGCCCATTGCCAGCC
TCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTCCCGAGGGGAAGGGA
AGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTTCTTTCCTCTTATTG
AAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGACTACGAGATGACCT
TCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGATTGATGACCTCGAGA
ACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAGGTCTAACAACAGAG
AAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGCTGATAAATTTGATG
GTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTCTTCAAGCACTATCA
TTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGTTTCCATCTCTGATC
TAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCAAGGCGACAAGCCGG
ACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGACTGCAATAAGAAAG
TGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGATCCTGTCAGTAAATA
TTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGCTTATCTTGGGGAAT
TAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAGGGTCAAAGTGGAGA
CCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAGGCTGGTCATGAGCA
TCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGATTTCCTCCCACCTCC
GTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCATCTCAGAACCCATC
GGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGCGCAAGACCAGTCAC
TCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTGCAGACCATGAAGTA
AATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTCAGCGGGGCGAGCTG
AGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGTGCTACATAGTTGGT
AATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCAGGGTTTAATAGACT
GAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTAAGGAAATCCGAGCG
GCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTGTACACATTCCTGCA
TTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTTGTTTTAATAAACAG
TATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTTCATAATAAATGTTC
ACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGCAGCCCTGAAATGCA
TCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTTTATTGATGTTTACG
CAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTGGGCCTTTCAGTCAG
CAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATTGGCCGCACATCTCG
CCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCGGAGGCTTTTGGATA
TGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGGGATGACTTCCGTTC
CTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGTCTCAGGAGATGGTA
ACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTATAAAGCATCGACGAG
AAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTAACCAGTCTTTCATG
CCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACCAGGACAGGACGTGT
CCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTGATTGGGAACCCAGG
GGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGCAGAGGAGCATCAGA
AACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTACCTCGAAAGGCTGT
TGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGCAATTAGGAGAAAAA
AATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAAAATAAAAGGGTAAT

>13040_13040_3_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520015_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0
MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK
SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY
QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE
TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ
PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS
SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK

--------------------------------------------------------------
>13040_13040_4_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520153_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4486nt_BP=289nt
AGAGCAGCCTGGCAGTGTCCAAGCAACAAGCCTCCGCTCCTCCTTCCTGCACCCTGGGGCTCCTGAAACTCACATGAGAAGGAGGGCTGT
CTGAGATTCGAGGGAAACAAGCTCTCAGGACTTCCGGTCGCCATGATGGCTGTGGGCGGTAAACGCGGTTAGTGCAAGCATCTGGGCCAT
CTTCAATGGTAAAAAAGATACAGTAAAGACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTG
AGGAAGAGCTGCCGAGACGGCCATCATGCAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTAC
GGGGAATAGTCCGCCGCGTTATCGACTGCTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCT
CGTGGAGGAAGAACAATTGTCCAGCAACTGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTAT
CTTGATGGAATTAGAAGTTTTGAAGTCAGCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCC
GCAAGTAGCTCCTCCAGCGCCAGCAGCCAGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGT
TTCTAAGGCTTATGGTGCTTCAAAGACATTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGT
GCCCATTGCCAGCCTCACTCCTTACCAGTCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTC
CCGAGGGGAAGGGAAGCTTTTCTCCCTAGAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTT
CTTTCCTCTTATTGAAGTGAACAAGGTGTATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGA
CTACGAGATGACCTTCAATAACGAGACTTCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGAT
TGATGACCTCGAGAACAAGTCGAAAGACTCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAG
GTCTAACAACAGAGAAGTTGCCAAGAGGAATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGC
TGATAAATTTGATGGTTCTAGACAGCCCGTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTC
TTCAAGCACTATCATTGCGAATCCTGACATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGT
TTCCATCTCTGATCTAAAGAGCGGCGGAGTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCA
AGGCGACAAGCCGGACTACTTTAGTTCTGTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGA
CTGCAATAAGAAAGTGATTGATCAACAGAATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGAT
CCTGTCAGTAAATATTGCAGATTTTCAAGAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGC
TTATCTTGGGGAATTAAAAGACAAGAATGAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAG
GGTCAAAGTGGAGACCTACAACGACGAGTCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAG
GCTGGTCATGAGCATCAGGAGAAGTGCATTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGAT
TTCCTCCCACCTCCGTGTGACGATCCCATGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCA
TCTCAGAACCCATCGGTAGGCAAAGGAAAATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGC
GCAAGACCAGTCACTCCCTCTGCCTTCAGGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTG
CAGACCATGAAGTAAATTATGTAACTAGGTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTC
AGCGGGGCGAGCTGAGAAGCGGTCATGAGCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGT
GCTACATAGTTGGTAATGCTTGGAATGGCAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCA
GGGTTTAATAGACTGAGTCAGATGGGTCTGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTA
AGGAAATCCGAGCGGCTACAAAGCGTTTCTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTG
TACACATTCCTGCATTCATGTATTTTGTTTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTT
GTTTTAATAAACAGTATATTCTTTGGTTGTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTT
CATAATAAATGTTCACTTGGGGGGGATGTTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGC
AGCCCTGAAATGCATCTTTCAAAGCATGAAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTT
TATTGATGTTTACGCAGCAGTCTAACACCAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTG
GGCCTTTCAGTCAGCAAAAGCATGCTCGCTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATT
GGCCGCACATCTCGCCGTCGTACCCCGGCAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCG
GAGGCTTTTGGATATGGGGAGTGATGGTGTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGG
GATGACTTCCGTTCCTGAGGACAGACACAGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGT
CTCAGGAGATGGTAACTGGGTCGCATTTCAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTAT
AAAGCATCGACGAGAAAATTACAGTCTTCAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTA
ACCAGTCTTTCATGCCTACTACTCCCAGCATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACC
AGGACAGGACGTGTCCAGGGAACGCTGACACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTG
ATTGGGAACCCAGGGGCAGTGCCAGGGGGAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGC
AGAGGAGCATCAGAAACTGGCTCCACTGTTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTA
CCTCGAAAGGCTGTTGATGTTGTTCTGTTTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGC
AATTAGGAGAAAAAAATCTAATCATTTCGCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAA

>13040_13040_4_CARD8-RPA1_CARD8_chr19_48744218_ENST00000520153_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0
MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK
SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY
QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE
TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ
PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS
SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK

--------------------------------------------------------------
>13040_13040_5_CARD8-RPA1_CARD8_chr19_48744218_ENST00000522431_RPA1_chr17_1746096_ENST00000254719_length(transcript)=4548nt_BP=351nt
GGGGCTCCTGAAACTCACATGGTAAGCGCTGCAGAAACGCAGCAGGTGGTGACTTTAGGGGAGGACAGGCCAAATGGGAGAATCCCCTTA
AGCTTCGGTTTCTCTAGTTCTCAACTTCTTTTGAAATAATGTTCATAGAGAAGGAGGGCTGTCTGAGATTCGAGGGAAACAAGCTCTCAG
GACTTCCGGTCGCCATGATGGCTGTGGGCGGTAAACGCGGTTAGTGCAAGCATCTGGGCCATCTTCAATGGTAAAAAAGATACAGTAAAG
ACATAAATACCACATTTGACAAATGGAAAAAAAGGAGTGTCCAGAAAAGAGTAGCAGCAGTGAGGAAGAGCTGCCGAGACGGCCATCATG
CAGAAGGGGGATACAAACATAAAGCCCATCCTCCAAGTCATCAACATCCGTCCCATTACTACGGGGAATAGTCCGCCGCGTTATCGACTG
CTCATGAGTGATGGATTGAACACTCTATCCTCTTTCATGTTGGCGACACAGTTGAACCCTCTCGTGGAGGAAGAACAATTGTCCAGCAAC
TGTGTATGCCAGATTCACAGATTTATTGTGAACACTCTGAAAGACGGAAGGAGAGTAGTTATCTTGATGGAATTAGAAGTTTTGAAGTCA
GCTGAAGCAGTTGGAGTGAAGATTGGCAATCCAGTGCCCTATAATGAAGGACTCGGGCAGCCGCAAGTAGCTCCTCCAGCGCCAGCAGCC
AGCCCAGCAGCAAGCAGCAGGCCCCAGCCGCAGAATGGAAGCTCGGGAATGGGTTCTACTGTTTCTAAGGCTTATGGTGCTTCAAAGACA
TTTGGAAAAGCTGCAGGTCCCAGCCTGTCACACACTTCTGGGGGAACACAGTCCAAAGTGGTGCCCATTGCCAGCCTCACTCCTTACCAG
TCCAAGTGGACCATTTGTGCTCGTGTTACCAACAAAAGTCAGATCCGTACCTGGAGCAACTCCCGAGGGGAAGGGAAGCTTTTCTCCCTA
GAACTGGTTGACGAAAGTGGTGAAATCCGAGCTACAGCTTTCAATGAGCAAGTGGACAAGTTCTTTCCTCTTATTGAAGTGAACAAGGTG
TATTATTTCTCGAAAGGCACCCTGAAGATTGCTAACAAGCAGTTCACAGCTGTTAAAAATGACTACGAGATGACCTTCAATAACGAGACT
TCCGTCATGCCCTGTGAGGACGACCATCATTTACCTACGGTTCAGTTTGATTTCACGGGGATTGATGACCTCGAGAACAAGTCGAAAGAC
TCACTTGTAGACATCATCGGGATCTGCAAGAGCTATGAAGACGCCACTAAAATCACAGTGAGGTCTAACAACAGAGAAGTTGCCAAGAGG
AATATCTACTTGATGGACACATCCGGGAAGGTGGTGACTGCTACACTGTGGGGGGAAGATGCTGATAAATTTGATGGTTCTAGACAGCCC
GTGTTGGCTATCAAAGGAGCCCGAGTCTCTGATTTCGGTGGACGGAGCCTCTCCGTGCTGTCTTCAAGCACTATCATTGCGAATCCTGAC
ATCCCAGAGGCCTATAAGCTTCGTGGATGGTTTGACGCAGAAGGACAAGCCTTAGATGGTGTTTCCATCTCTGATCTAAAGAGCGGCGGA
GTCGGAGGGAGTAACACCAACTGGAAAACCTTGTATGAGGTCAAATCCGAGAACCTGGGCCAAGGCGACAAGCCGGACTACTTTAGTTCT
GTGGCCACAGTGGTGTATCTTCGCAAAGAGAACTGCATGTACCAAGCCTGCCCGACTCAGGACTGCAATAAGAAAGTGATTGATCAACAG
AATGGATTGTACCGCTGTGAGAAGTGCGACACCGAATTTCCCAATTTCAAGTACCGCATGATCCTGTCAGTAAATATTGCAGATTTTCAA
GAGAATCAGTGGGTGACTTGTTTCCAGGAGTCTGCTGAAGCTATCCTTGGACAAAATGCTGCTTATCTTGGGGAATTAAAAGACAAGAAT
GAACAGGCATTTGAAGAAGTTTTCCAGAATGCCAACTTCCGATCTTTCATATTCAGAGTCAGGGTCAAAGTGGAGACCTACAACGACGAG
TCTCGAATTAAGGCCACTGTGATGGACGTGAAGCCCGTGGACTACAGAGAGTATGGCCGAAGGCTGGTCATGAGCATCAGGAGAAGTGCA
TTGATGTGAGAGGAGCAGTGCCAATCGGGCAGAAGTTTGCAAATAGGCAGAATGGAATCGATTTCCTCCCACCTCCGTGTGACGATCCCA
TGTTAGCTACACAGTGCAGAGGCTCTTGATGGTGGACTAAGCAATTTCCCCCCTCGTGCGCATCTCAGAACCCATCGGTAGGCAAAGGAA
AATACGCTCAGGTGGTTGTGGTGTAGACTGTGTCAGGCCTACGGAGTCAGCCAGTGGCTAGCGCAAGACCAGTCACTCCCTCTGCCTTCA
GGCTTCTGTCAATTTCATTATCATCAAGCAGGAATTATGTCGTAAGTCACTGACCCTAACTGCAGACCATGAAGTAAATTATGTAACTAG
GTTTTTGCTTCTCCAGTGGTGACCACCCCCCCCCATCCCCGCTCACAACTTGGGTTCTTCTCAGCGGGGCGAGCTGAGAAGCGGTCATGA
GCACCTGGGGATTTTAGTAAGTGTGTCTTCCTAGAATTCGAAGGCTCTCTCTTTCTAGAGGTGCTACATAGTTGGTAATGCTTGGAATGG
CAATAGGGTAGAATGATTAATCAAAGGCATATCTTCTATATCTGAAGAGTATCCTTCCTTCAGGGTTTAATAGACTGAGTCAGATGGGTC
TGATATTAATCAAAATTGTCTCTTCTGAGGACCGCTGATAAGCATTGACTTGCCGTCCCCTAAGGAAATCCGAGCGGCTACAAAGCGTTT
CTTTACTTCTCACTTCAATTAATGCTGCGCTTCGCTTGGTGAGTGCGTACTTTTTCTACCTGTACACATTCCTGCATTCATGTATTTTGT
TTTTTTTGACTAAAGCTATGTTACATGGAAAGGATTTTGAAGCCTTTTGTTTCCCTTGCTTTGTTTTAATAAACAGTATATTCTTTGGTT
GTGAATCCTACTTTCTTTGAATGCAAAGAGTTCCTATAACTGGAAAGCAATTAATTAGCCTTCATAATAAATGTTCACTTGGGGGGGATG
TTAACTCATTATAAACCCGAAGATTAGTCCAAGGCATGGAGATCCTTCTTCCTAGTGTTTGCAGCCCTGAAATGCATCTTTCAAAGCATG
AAAACACTAAAAACAAAAAGCCATTTTGCCTGAGGATGCTGATGATCTGGCACTTGGGATTTTATTGATGTTTACGCAGCAGTCTAACAC
CAACCACGCTTTGAAATGTGTACAGACAGTGAGCTGGTAAGAAAACAGTAATTATGCTAGTGGGCCTTTCAGTCAGCAAAAGCATGCTCG
CTCTGTGTGTTCCTAATCATATTAATTATCTATCCGGTGGCTGCAACACACCGCCTGCCATTGGCCGCACATCTCGCCGTCGTACCCCGG
CAGTGCGGCGGTCACTCTGCAGCCAGAGGACCTGCTGTTCATCACTGCACATGCCGCCTGCGGAGGCTTTTGGATATGGGGAGTGATGGT
GTCCTGTCTGTCTCCCCCCTCGGTGTCTGCCGTTGACATAGGGGCCAGCCAGCCCTAGACGGGATGACTTCCGTTCCTGAGGACAGACAC
AGAGGGACTCCTGCTCAGCCTCACTAATTGTTTAGACACATTCCTTCCTACCCTTCTCTAGTCTCAGGAGATGGTAACTGGGTCGCATTT
CAGTCTCTGACTGAGGCCTCAGCCATTTTTACGGAAGTTCTTTTCTGTCTGACCTTGCTTATAAAGCATCGACGAGAAAATTACAGTCTT
CAACCCTCTTCTGGATTGACAAATTGTGGCTGGGAAGTGGCGATCTAGCTTTCAGCCCAGTAACCAGTCTTTCATGCCTACTACTCCCAG
CATTCCCTCCTCTCCCCACGTGTCTGTCCACACAGTGAAGAGGCCTGACCAGCCGTGGTACCAGGACAGGACGTGTCCAGGGAACGCTGA
CACCTGTCCTCGCGCCTTCTCAGTGGCCAGCGTGATGAAACCAGCACGTCTCCGTGGATGTGATTGGGAACCCAGGGGCAGTGCCAGGGG
GAGGGCTCCCTCGAGGAGGCTGTTTCTAACAGATTTCCCCACTCAAAGATCAGATCACCAGCAGAGGAGCATCAGAAACTGGCTCCACTG
TTGGGCTTTTCAGAGATTTTGGTCCCTGCGGGTTGCCTAAATAGATTCTGGCCCACAGTTTACCTCGAAAGGCTGTTGATGTTGTTCTGT
TTCTCCTCTTTCACTTAGAGATCAATGTTGATTTTGCGTACACCATGACATCAGCGTTAGGCAATTAGGAGAAAAAAATCTAATCATTTC
GCCTTTATTTCAAGTGGTTCTTGAATTCCCTCCAGTCTCATTGTGAAAGGGGCAGGGAAAAAAATAAAAGGGTAATAATCTGATTTCTGT

>13040_13040_5_CARD8-RPA1_CARD8_chr19_48744218_ENST00000522431_RPA1_chr17_1746096_ENST00000254719_length(amino acids)=603AA_BP=0
MQKGDTNIKPILQVINIRPITTGNSPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQIHRFIVNTLKDGRRVVILMELEVLK
SAEAVGVKIGNPVPYNEGLGQPQVAPPAPAASPAASSRPQPQNGSSGMGSTVSKAYGASKTFGKAAGPSLSHTSGGTQSKVVPIASLTPY
QSKWTICARVTNKSQIRTWSNSRGEGKLFSLELVDESGEIRATAFNEQVDKFFPLIEVNKVYYFSKGTLKIANKQFTAVKNDYEMTFNNE
TSVMPCEDDHHLPTVQFDFTGIDDLENKSKDSLVDIIGICKSYEDATKITVRSNNREVAKRNIYLMDTSGKVVTATLWGEDADKFDGSRQ
PVLAIKGARVSDFGGRSLSVLSSSTIIANPDIPEAYKLRGWFDAEGQALDGVSISDLKSGGVGGSNTNWKTLYEVKSENLGQGDKPDYFS
SVATVVYLRKENCMYQACPTQDCNKKVIDQQNGLYRCEKCDTEFPNFKYRMILSVNIADFQENQWVTCFQESAEAILGQNAAYLGELKDK

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Fusion Gene PPI Analysis for CARD8-RPA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CARD8-RPA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CARD8-RPA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource