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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACIN1-HAUS4 (FusionGDB2 ID:1306)

Fusion Gene Summary for ACIN1-HAUS4

check button Fusion gene summary
Fusion gene informationFusion gene name: ACIN1-HAUS4
Fusion gene ID: 1306
HgeneTgene
Gene symbol

ACIN1

HAUS4

Gene ID

22985

54930

Gene nameapoptotic chromatin condensation inducer 1HAUS augmin like complex subunit 4
SynonymsACINUS|ACN|fSAP152C14orf94
Cytomap

14q11.2

14q11.2

Type of geneprotein-codingprotein-coding
Descriptionapoptotic chromatin condensation inducer in the nucleusfunctional spliceosome-associated protein 152HAUS augmin-like complex subunit 4homologous to Augmin subunits
Modification date2020031320200313
UniProtAcc

Q9UKV3

Q9H6D7

Ensembl transtripts involved in fusion geneENST00000262710, ENST00000457657, 
ENST00000555053, ENST00000605057, 
ENST00000555352, ENST00000338631, 
ENST00000357481, ENST00000397341, 
ENST00000557515, 		ENST00000206474, 
ENST00000342454, ENST00000347758, 
ENST00000397409, ENST00000490506, 
ENST00000541587, ENST00000554446, 
ENST00000555367, ENST00000555986, 
Fusion gene scores* DoF score12 X 11 X 4=5281 X 1 X 1=1
# samples 132
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/1*10)=4.32192809488736
Context

PubMed: ACIN1 [Title/Abstract] AND HAUS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACIN1(23547360)-HAUS4(23424385), # samples:2
ACIN1(23547359)-HAUS4(23424385), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACIN1

GO:0030263

apoptotic chromosome condensation

10490026


check buttonFusion gene breakpoints across ACIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HAUS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-18-4721-01AACIN1chr14

23547360

-HAUS4chr14

23424385

-
ChimerDB4LUSCTCGA-18-4721ACIN1chr14

23547359

-HAUS4chr14

23424385

-
ChimerDB4LUSCTCGA-18-4721ACIN1chr14

23547360

-HAUS4chr14

23424385

-
ChimerDB4STADTCGA-D7-A6EVACIN1chr14

23547359

-HAUS4chr14

23424385

-


Top

Fusion Gene ORF analysis for ACIN1-HAUS4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262710ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000262710ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000457657ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000555053ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5CDS-5UTRENST00000605057ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
5UTR-5UTRENST00000555352ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000338631ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000357481ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000397341ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000206474ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000206474ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000342454ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000342454ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000347758ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000347758ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000397409ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000397409ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000490506ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000490506ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000541587ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000541587ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000554446ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000554446ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000555367ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000555367ACIN1chr14

23547359

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000555986ACIN1chr14

23547360

-HAUS4chr14

23424385

-
intron-5UTRENST00000557515ENST00000555986ACIN1chr14

23547359

-HAUS4chr14

23424385

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ACIN1-HAUS4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ACIN1-HAUS4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:23547360/:23424385)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACIN1

Q9UKV3

HAUS4

Q9H6D7

FUNCTION: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. {ECO:0000269|PubMed:19369198, ECO:0000269|PubMed:19427217}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ACIN1-HAUS4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ACIN1-HAUS4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACIN1-HAUS4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACIN1-HAUS4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource