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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CARM1-PLA2G4C (FusionGDB2 ID:13061)

Fusion Gene Summary for CARM1-PLA2G4C

check button Fusion gene summary
Fusion gene informationFusion gene name: CARM1-PLA2G4C
Fusion gene ID: 13061
HgeneTgene
Gene symbol

CARM1

PLA2G4C

Gene ID

10498

8605

Gene namecoactivator associated arginine methyltransferase 1phospholipase A2 group IVC
SynonymsPRMT4CPLA2-gamma
Cytomap

19p13.2

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionhistone-arginine methyltransferase CARM1protein arginine N-methyltransferase 4cytosolic phospholipase A2 gammaphospholipase A2, group IVC (cytosolic, calcium-independent)
Modification date2020031320200313
UniProtAcc

Q86X55

.
Ensembl transtripts involved in fusion geneENST00000327064, ENST00000344150, 
ENST00000354276, ENST00000413144, 
ENST00000599921, ENST00000596510, 
ENST00000599111, 
Fusion gene scores* DoF score14 X 10 X 10=14005 X 7 X 3=105
# samples 206
** MAII scorelog2(20/1400*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/105*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CARM1 [Title/Abstract] AND PLA2G4C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCARM1(10982598)-PLA2G4C(48558306), # samples:5
Anticipated loss of major functional domain due to fusion event.CARM1-PLA2G4C seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
CARM1-PLA2G4C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CARM1-PLA2G4C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
CARM1-PLA2G4C seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CARM1-PLA2G4C seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCARM1

GO:0016571

histone methylation

19405910

TgenePLA2G4C

GO:0046475

glycerophospholipid catabolic process

10085124


check buttonFusion gene breakpoints across CARM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PLA2G4C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A891-01ACARM1chr19

10982598

-PLA2G4Cchr19

48558306

-
ChimerDB4ESCATCGA-L5-A891-01ACARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
ChimerDB4ESCATCGA-L5-A891CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
ChimerDB4ESCATCGA-L5-A891CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
ChimerDB4ESCATCGA-L5-A891CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-


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Fusion Gene ORF analysis for CARM1-PLA2G4C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000327064ENST00000354276CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
5CDS-3UTRENST00000327064ENST00000413144CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
5CDS-3UTRENST00000327064ENST00000599921CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
5CDS-3UTRENST00000344150ENST00000354276CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
5CDS-3UTRENST00000344150ENST00000413144CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
5CDS-3UTRENST00000344150ENST00000599921CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
5CDS-5UTRENST00000327064ENST00000596510CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
5CDS-5UTRENST00000327064ENST00000596510CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
5CDS-5UTRENST00000344150ENST00000596510CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
5CDS-5UTRENST00000344150ENST00000596510CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
5CDS-intronENST00000327064ENST00000596510CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
5CDS-intronENST00000344150ENST00000596510CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
Frame-shiftENST00000327064ENST00000354276CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
Frame-shiftENST00000327064ENST00000354276CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
Frame-shiftENST00000327064ENST00000413144CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
Frame-shiftENST00000327064ENST00000599111CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
Frame-shiftENST00000327064ENST00000599111CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
Frame-shiftENST00000327064ENST00000599921CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
Frame-shiftENST00000344150ENST00000354276CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
Frame-shiftENST00000344150ENST00000354276CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
Frame-shiftENST00000344150ENST00000413144CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
Frame-shiftENST00000344150ENST00000599111CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
Frame-shiftENST00000344150ENST00000599111CARM1chr19

10982598

+PLA2G4Cchr19

48551645

-
Frame-shiftENST00000344150ENST00000599921CARM1chr19

10982598

+PLA2G4Cchr19

48558306

-
In-frameENST00000327064ENST00000413144CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
In-frameENST00000327064ENST00000599111CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
In-frameENST00000327064ENST00000599921CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
In-frameENST00000344150ENST00000413144CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
In-frameENST00000344150ENST00000599111CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-
In-frameENST00000344150ENST00000599921CARM1chr19

10982598

+PLA2G4Cchr19

48556404

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327064CARM1chr1910982598+ENST00000599111PLA2G4Cchr1948556404-110741046606186
ENST00000327064CARM1chr1910982598+ENST00000413144PLA2G4Cchr1948556404-60741046606187
ENST00000327064CARM1chr1910982598+ENST00000599921PLA2G4Cchr1948556404-60741046606187
ENST00000344150CARM1chr1910982598+ENST00000599111PLA2G4Cchr1948556404-9172200416138
ENST00000344150CARM1chr1910982598+ENST00000413144PLA2G4Cchr1948556404-4172200416138
ENST00000344150CARM1chr1910982598+ENST00000599921PLA2G4Cchr1948556404-4172200416138

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327064ENST00000599111CARM1chr1910982598+PLA2G4Cchr1948556404-0.0052486170.9947514
ENST00000327064ENST00000413144CARM1chr1910982598+PLA2G4Cchr1948556404-0.003590340.9964097
ENST00000327064ENST00000599921CARM1chr1910982598+PLA2G4Cchr1948556404-0.003590340.9964097
ENST00000344150ENST00000599111CARM1chr1910982598+PLA2G4Cchr1948556404-0.004120430.99587953
ENST00000344150ENST00000413144CARM1chr1910982598+PLA2G4Cchr1948556404-0.0062239990.99377596
ENST00000344150ENST00000599921CARM1chr1910982598+PLA2G4Cchr1948556404-0.0062239990.99377596

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Fusion Genomic Features for CARM1-PLA2G4C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CARM1-PLA2G4C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10982598/chr19:48558306)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CARM1

Q86X55

.
FUNCTION: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg-2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs. {ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCARM1chr19:10982598chr19:48556404ENST00000327064+116146_45373609.0DomainSAM-dependent MTase PRMT-type
HgeneCARM1chr19:10982598chr19:48556404ENST00000344150+115146_45373586.0DomainSAM-dependent MTase PRMT-type
HgeneCARM1chr19:10982598chr19:48556404ENST00000327064+116499_60873609.0RegionTransactivation domain
HgeneCARM1chr19:10982598chr19:48556404ENST00000344150+115499_60873586.0RegionTransactivation domain
TgenePLA2G4Cchr19:10982598chr19:48556404ENST0000035427614171_541476662.3333333333334DomainPLA2c
TgenePLA2G4Cchr19:10982598chr19:48556404ENST0000041314413161_541476542.0DomainPLA2c
TgenePLA2G4Cchr19:10982598chr19:48556404ENST0000059911114171_541486552.0DomainPLA2c
TgenePLA2G4Cchr19:10982598chr19:48556404ENST0000059992114171_541476542.0DomainPLA2c
TgenePLA2G4Cchr19:10982598chr19:48556404ENST000003542761417260_292476662.3333333333334RegionRequired for lipid droplet localization
TgenePLA2G4Cchr19:10982598chr19:48556404ENST000004131441316260_292476542.0RegionRequired for lipid droplet localization
TgenePLA2G4Cchr19:10982598chr19:48556404ENST000005991111417260_292486552.0RegionRequired for lipid droplet localization
TgenePLA2G4Cchr19:10982598chr19:48556404ENST000005999211417260_292476542.0RegionRequired for lipid droplet localization


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Fusion Gene Sequence for CARM1-PLA2G4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13061_13061_1_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000327064_PLA2G4C_chr19_48556404_ENST00000413144_length(transcript)=607nt_BP=410nt
AGGCGGCGCGTGGCCGGCAGGCGGCGCTGCCCGGCTCGGCCTCGGCCTGCACGGCGGCTGCGGCGGCGGTAGCGGCAGCGGCGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCCTGGGCCCGGGCGCAGCGGCGGCGGCGGCGGGGCCTGGAGC
CGGATCTAAGATGGCAGCGGCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGCGCGGGGTCGGCGGTCCCGGGCGGCGCGGGGCCCTGCGC
TACCGTGTCGGTGTTCCCCGGCGCCCGCCTCCTCACCATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGGCGCTGCG
CCTCGAGGTGCGCGCCGGCCCGGACTCGGCGGGCATCGCCCTCTACAGCCGTGATATTGAGGCATGGAGTGACACATACGACACATTCAA
GCTTGCTGACACCTACACTCTAGATGTGGTGGTGCTACTCTTGGCATTAGCCAAGAAGAATGTCAGGGAAAACAAGAAGAAGATCCTTAG

>13061_13061_1_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000327064_PLA2G4C_chr19_48556404_ENST00000413144_length(amino acids)=187AA_BP=11
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSRDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSA

--------------------------------------------------------------
>13061_13061_2_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000327064_PLA2G4C_chr19_48556404_ENST00000599111_length(transcript)=1107nt_BP=410nt
AGGCGGCGCGTGGCCGGCAGGCGGCGCTGCCCGGCTCGGCCTCGGCCTGCACGGCGGCTGCGGCGGCGGTAGCGGCAGCGGCGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCCTGGGCCCGGGCGCAGCGGCGGCGGCGGCGGGGCCTGGAGC
CGGATCTAAGATGGCAGCGGCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGCGCGGGGTCGGCGGTCCCGGGCGGCGCGGGGCCCTGCGC
TACCGTGTCGGTGTTCCCCGGCGCCCGCCTCCTCACCATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGGCGCTGCG
CCTCGAGGTGCGCGCCGGCCCGGACTCGGCGGGCATCGCCCTCTACAGCCGTGATATTGAGGCATGGAGTGACACATACGACACATTCAA
GCTTGCTGACACCTACACTCTAGATGTGGTGGTGCTACTCTTGGCATTAGCCAAGAAGAATGTCAGGGAAAACAAGAAGAAGATCCTTAG
AGAGTTGATGAACGTGGCCGGGCTCTACTACCCGAAGGATAGTGCCCGAAGTTGCTGCTTGGCATAGATGAGCCTCAGCTTCCAGGGCAC
TGTGGGCCTGTTGGTCTACTAGGGCCCTGATGTCCACCTGGCCTTCCTGTTCTTCACTCCCTTCAGCCACACGCTTCATGGCCTTGAGTT
CACCTTGGCTGTCCTAACAGGGCCAATCACCAGTGACCAGCTAGACTGTGATTTTGATAGCGTCATTCAGAAGAAGGCGTCCAAGGAGCT
GAAGGTGGTGAAATTTGTCCTGCAGGTCCCTCGGGAGATCCTGGAGCTGGAGCATGAGTGTCTGACAATCAGAAGCATCATGTCCAATGT
CCAGATGGCCAGAATGAATGTGATAGTTCAGACCAATGCCTTCCACTGCTCCTTTATGACTGCACTTCTAGCCAGTAGCTCTGCACAAGT
TAGCTCTGTAGAAGTAAGAACTTGGGCTTAAATCATGGGCTATCTCTCCACAGCCAAGTGGAGCTCTGAGAATACAACAAGTGCTCAATA

>13061_13061_2_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000327064_PLA2G4C_chr19_48556404_ENST00000599111_length(amino acids)=186AA_BP=11
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSRDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSA

--------------------------------------------------------------
>13061_13061_3_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000327064_PLA2G4C_chr19_48556404_ENST00000599921_length(transcript)=607nt_BP=410nt
AGGCGGCGCGTGGCCGGCAGGCGGCGCTGCCCGGCTCGGCCTCGGCCTGCACGGCGGCTGCGGCGGCGGTAGCGGCAGCGGCGGCGGCGG
CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGCGGCGGCCTGGGCCCGGGCGCAGCGGCGGCGGCGGCGGGGCCTGGAGC
CGGATCTAAGATGGCAGCGGCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGCGCGGGGTCGGCGGTCCCGGGCGGCGCGGGGCCCTGCGC
TACCGTGTCGGTGTTCCCCGGCGCCCGCCTCCTCACCATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGGCGCTGCG
CCTCGAGGTGCGCGCCGGCCCGGACTCGGCGGGCATCGCCCTCTACAGCCGTGATATTGAGGCATGGAGTGACACATACGACACATTCAA
GCTTGCTGACACCTACACTCTAGATGTGGTGGTGCTACTCTTGGCATTAGCCAAGAAGAATGTCAGGGAAAACAAGAAGAAGATCCTTAG

>13061_13061_3_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000327064_PLA2G4C_chr19_48556404_ENST00000599921_length(amino acids)=187AA_BP=11
MHGGCGGGSGSGGGGGGGGGGGGGGGGSGGGLGPGAAAAAAGPGAGSKMAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGD
ANGEIQRHAEQQALRLEVRAGPDSAGIALYSRDIEAWSDTYDTFKLADTYTLDVVVLLLALAKKNVRENKKKILRELMNVAGLYYPKDSA

--------------------------------------------------------------
>13061_13061_4_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000344150_PLA2G4C_chr19_48556404_ENST00000413144_length(transcript)=417nt_BP=220nt
ATGGCAGCGGCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGCGCGGGGTCGGCGGTCCCGGGCGGCGCGGGGCCCTGCGCTACCGTGTCG
GTGTTCCCCGGCGCCCGCCTCCTCACCATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGGCGCTGCGCCTCGAGGTG
CGCGCCGGCCCGGACTCGGCGGGCATCGCCCTCTACAGCCGTGATATTGAGGCATGGAGTGACACATACGACACATTCAAGCTTGCTGAC
ACCTACACTCTAGATGTGGTGGTGCTACTCTTGGCATTAGCCAAGAAGAATGTCAGGGAAAACAAGAAGAAGATCCTTAGAGAGTTGATG

>13061_13061_4_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000344150_PLA2G4C_chr19_48556404_ENST00000413144_length(amino acids)=138AA_BP=72
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSRDIEAWSDTYDTFKLAD

--------------------------------------------------------------
>13061_13061_5_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000344150_PLA2G4C_chr19_48556404_ENST00000599111_length(transcript)=917nt_BP=220nt
ATGGCAGCGGCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGCGCGGGGTCGGCGGTCCCGGGCGGCGCGGGGCCCTGCGCTACCGTGTCG
GTGTTCCCCGGCGCCCGCCTCCTCACCATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGGCGCTGCGCCTCGAGGTG
CGCGCCGGCCCGGACTCGGCGGGCATCGCCCTCTACAGCCGTGATATTGAGGCATGGAGTGACACATACGACACATTCAAGCTTGCTGAC
ACCTACACTCTAGATGTGGTGGTGCTACTCTTGGCATTAGCCAAGAAGAATGTCAGGGAAAACAAGAAGAAGATCCTTAGAGAGTTGATG
AACGTGGCCGGGCTCTACTACCCGAAGGATAGTGCCCGAAGTTGCTGCTTGGCATAGATGAGCCTCAGCTTCCAGGGCACTGTGGGCCTG
TTGGTCTACTAGGGCCCTGATGTCCACCTGGCCTTCCTGTTCTTCACTCCCTTCAGCCACACGCTTCATGGCCTTGAGTTCACCTTGGCT
GTCCTAACAGGGCCAATCACCAGTGACCAGCTAGACTGTGATTTTGATAGCGTCATTCAGAAGAAGGCGTCCAAGGAGCTGAAGGTGGTG
AAATTTGTCCTGCAGGTCCCTCGGGAGATCCTGGAGCTGGAGCATGAGTGTCTGACAATCAGAAGCATCATGTCCAATGTCCAGATGGCC
AGAATGAATGTGATAGTTCAGACCAATGCCTTCCACTGCTCCTTTATGACTGCACTTCTAGCCAGTAGCTCTGCACAAGTTAGCTCTGTA
GAAGTAAGAACTTGGGCTTAAATCATGGGCTATCTCTCCACAGCCAAGTGGAGCTCTGAGAATACAACAAGTGCTCAATAAATGCTTGCT

>13061_13061_5_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000344150_PLA2G4C_chr19_48556404_ENST00000599111_length(amino acids)=138AA_BP=72
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSRDIEAWSDTYDTFKLAD

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>13061_13061_6_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000344150_PLA2G4C_chr19_48556404_ENST00000599921_length(transcript)=417nt_BP=220nt
ATGGCAGCGGCGGCGGCGGCGGTGGGGCCGGGCGCGGGCGGCGCGGGGTCGGCGGTCCCGGGCGGCGCGGGGCCCTGCGCTACCGTGTCG
GTGTTCCCCGGCGCCCGCCTCCTCACCATCGGCGACGCGAACGGCGAGATCCAGCGGCACGCGGAGCAGCAGGCGCTGCGCCTCGAGGTG
CGCGCCGGCCCGGACTCGGCGGGCATCGCCCTCTACAGCCGTGATATTGAGGCATGGAGTGACACATACGACACATTCAAGCTTGCTGAC
ACCTACACTCTAGATGTGGTGGTGCTACTCTTGGCATTAGCCAAGAAGAATGTCAGGGAAAACAAGAAGAAGATCCTTAGAGAGTTGATG

>13061_13061_6_CARM1-PLA2G4C_CARM1_chr19_10982598_ENST00000344150_PLA2G4C_chr19_48556404_ENST00000599921_length(amino acids)=138AA_BP=72
MAAAAAAVGPGAGGAGSAVPGGAGPCATVSVFPGARLLTIGDANGEIQRHAEQQALRLEVRAGPDSAGIALYSRDIEAWSDTYDTFKLAD

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Fusion Gene PPI Analysis for CARM1-PLA2G4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CARM1-PLA2G4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CARM1-PLA2G4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource