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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACIN1-RIN3 (FusionGDB2 ID:1313)

Fusion Gene Summary for ACIN1-RIN3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACIN1-RIN3
Fusion gene ID: 1313
HgeneTgene
Gene symbol

ACIN1

RIN3

Gene ID

22985

79890

Gene nameapoptotic chromatin condensation inducer 1Ras and Rab interactor 3
SynonymsACINUS|ACN|fSAP152-
Cytomap

14q11.2

14q32.12

Type of geneprotein-codingprotein-coding
Descriptionapoptotic chromatin condensation inducer in the nucleusfunctional spliceosome-associated protein 152ras and Rab interactor 3RAB5 interacting protein 3ras interaction/interference protein 3
Modification date2020031320200320
UniProtAcc

Q9UKV3

.
Ensembl transtripts involved in fusion geneENST00000262710, ENST00000555053, 
ENST00000605057, ENST00000338631, 
ENST00000357481, ENST00000397341, 
ENST00000457657, ENST00000555352, 
ENST00000557515, 		ENST00000418924, 
ENST00000557762, ENST00000216487, 
Fusion gene scores* DoF score12 X 11 X 4=52815 X 16 X 7=1680
# samples 1318
** MAII scorelog2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACIN1 [Title/Abstract] AND RIN3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACIN1(23559191)-RIN3(93081747), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACIN1

GO:0030263

apoptotic chromosome condensation

10490026


check buttonFusion gene breakpoints across ACIN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RIN3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADA335910ACIN1chr14

23559191

-RIN3chr14

93081747

+


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Fusion Gene ORF analysis for ACIN1-RIN3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000262710ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
5CDS-3UTRENST00000555053ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
5CDS-3UTRENST00000605057ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
5CDS-intronENST00000262710ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
5CDS-intronENST00000555053ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
5CDS-intronENST00000605057ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
In-frameENST00000262710ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
In-frameENST00000555053ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
In-frameENST00000605057ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3CDSENST00000338631ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3CDSENST00000357481ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3CDSENST00000397341ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3CDSENST00000457657ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3CDSENST00000555352ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3CDSENST00000557515ENST00000216487ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3UTRENST00000338631ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3UTRENST00000357481ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3UTRENST00000397341ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3UTRENST00000457657ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3UTRENST00000555352ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-3UTRENST00000557515ENST00000418924ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-intronENST00000338631ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-intronENST00000357481ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-intronENST00000397341ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-intronENST00000457657ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-intronENST00000555352ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+
intron-intronENST00000557515ENST00000557762ACIN1chr14

23559191

-RIN3chr14

93081747

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000605057ACIN1chr1423559191-ENST00000216487RIN3chr1493081747+38104774130671008
ENST00000262710ACIN1chr1423559191-ENST00000216487RIN3chr1493081747+427193831935281069
ENST00000555053ACIN1chr1423559191-ENST00000216487RIN3chr1493081747+40407078832971069

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000605057ENST00000216487ACIN1chr1423559191-RIN3chr1493081747+0.0067360860.99326384
ENST00000262710ENST00000216487ACIN1chr1423559191-RIN3chr1493081747+0.0063472950.9936527
ENST00000555053ENST00000216487ACIN1chr1423559191-RIN3chr1493081747+0.006247130.9937529

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Fusion Genomic Features for ACIN1-RIN3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACIN1chr1423559190-RIN3chr1493081751+0.0026163240.99738365
ACIN1chr1423559190-RIN3chr1493081751+0.0026163240.99738365

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACIN1-RIN3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:23559191/chr14:93081747)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ACIN1

Q9UKV3

.
FUNCTION: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACIN1chr14:23559191chr14:93081747ENST00000262710-41972_1062031342.0DomainSAP
HgeneACIN1chr14:23559191chr14:93081747ENST00000555053-41972_1062031329.0DomainSAP
TgeneRIN3chr14:23559191chr14:93081747ENST00000216487210248_514122986.0Compositional biasNote=Pro-rich
TgeneRIN3chr14:23559191chr14:93081747ENST00000216487210722_725122986.0Compositional biasNote=Poly-Thr
TgeneRIN3chr14:23559191chr14:93081747ENST00000216487210965_972122986.0Compositional biasNote=Poly-Gly
TgeneRIN3chr14:23559191chr14:93081747ENST00000216487210703_846122986.0DomainVPS9
TgeneRIN3chr14:23559191chr14:93081747ENST00000216487210877_963122986.0DomainRas-associating

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACIN1chr14:23559191chr14:93081747ENST00000262710-4191114_11312031342.0Compositional biasNote=Pro-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000262710-4191132_13412031342.0Compositional biasNote=Arg/Asp/Glu/Lys-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000262710-419142_4422031342.0Compositional biasNote=Glu-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000262710-419573_6762031342.0Compositional biasNote=Ser-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000338631-1121114_11310615.0Compositional biasNote=Pro-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000338631-1121132_13410615.0Compositional biasNote=Arg/Asp/Glu/Lys-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000338631-112142_4420615.0Compositional biasNote=Glu-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000338631-112573_6760615.0Compositional biasNote=Ser-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000357481-1131114_11310584.0Compositional biasNote=Pro-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000357481-1131132_13410584.0Compositional biasNote=Arg/Asp/Glu/Lys-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000357481-113142_4420584.0Compositional biasNote=Glu-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000357481-113573_6760584.0Compositional biasNote=Ser-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000397341-1121114_11310584.0Compositional biasNote=Pro-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000397341-1121132_13410584.0Compositional biasNote=Arg/Asp/Glu/Lys-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000397341-112142_4420584.0Compositional biasNote=Glu-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000397341-112573_6760584.0Compositional biasNote=Ser-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000555053-4191114_11312031329.0Compositional biasNote=Pro-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000555053-4191132_13412031329.0Compositional biasNote=Arg/Asp/Glu/Lys-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000555053-419142_4422031329.0Compositional biasNote=Glu-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000555053-419573_6762031329.0Compositional biasNote=Ser-rich
HgeneACIN1chr14:23559191chr14:93081747ENST00000338631-11272_1060615.0DomainSAP
HgeneACIN1chr14:23559191chr14:93081747ENST00000357481-11372_1060584.0DomainSAP
HgeneACIN1chr14:23559191chr14:93081747ENST00000397341-11272_1060584.0DomainSAP
TgeneRIN3chr14:23559191chr14:93081747ENST0000021648721024_29122986.0Compositional biasNote=Poly-Glu
TgeneRIN3chr14:23559191chr14:93081747ENST0000021648721063_158122986.0DomainSH2


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Fusion Gene Sequence for ACIN1-RIN3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1313_1313_1_ACIN1-RIN3_ACIN1_chr14_23559191_ENST00000262710_RIN3_chr14_93081747_ENST00000216487_length(transcript)=4271nt_BP=938nt
CTTTTCTCTCGAAGGGCACCCGAAGATTGTCACGAGTCCTTAGACTCCAACTACTGCGGCAGCTTCCAAATTTCCTGAAAACCCTAAGCT
GGGCCAGCCCGGCAGCCCACGCACTTCCGGCCTCGGACCCGCCCCAAACACCCAAGCGCCCCAGCGCCTCATCTCTAGGTCCGGAAATAA
ACGAACATCTCCGATTATGGTTATACCAGGGTCGAGGGTTTCCGAATATATTCGATTCAAAGCTTCGGCAAGACGAAGAAAACCGAGCCT
GAAAGCAGGGCGAGAAAAGGGGCGCTGCAGGGCGGATGGAAAGAATTGATTGGTAACGATGTGGAGACGGAAACATCCGAGGACATCCGG
AGGAACCCGGGGAGTTCTGAGTGGTAATCGAGGGGTAGAGTATGGCAGTGGGCGGGGTCATCTCGGTACGTTCGAAGGGCGTTGGCGGAA
ATTACCGAAGATGCCCGAAGCCGTCGGGACGGACCCGAGTACCTCACGCAAGATGGCGGAGCTGGAGGAGGTGACTCTGGACGGGAAGCC
TCTTCAGGCGCTGCGGGTGACCGACCTGAAGGCCGCACTGGAGCAGCGAGGCCTAGCCAAGAGCGGGCAGAAGAGTGCCCTGGTCAAGCG
GCTCAAAGGGGCTCTAATGCTAGAAAATTTACAGAAACACTCAACACCCCATGCTGCATTCCAGCCAAATTCCCAGATTGGTGAGGAAAT
GAGCCAGAACAGTTTCATAAAACAGTATCTGGAAAAGCAGCAGGAGCTACTTAGGCAGCGTCTGGAACGTGAAGCTCGAGAAGCTGCAGA
ACTTGAAGAAGCTTCAGCTGAGTCGGAGGACGAGATGATCCATCCTGAGGGAGTGGCTTCCCTGCTGCCTCCTGACTTTCAGAGCAGCCT
GGAGAGACCAGAGCTGGAGCTCAGCAGACATTCGCCCATATTGTACCTGGAAGGCTCGGCTCTTGTGTTTGAGGACATCTTCAGATTGAT
TGCGTTCTACTGTGTCAGTAGAGACTTACTGCCCTTCACACTGCGGCTACCCCAGGCCATCCTTGAGGCCAGCAGCTTCACGGACCTTGA
GACCATCGCCAACCTGGGTCTGGGTTTCTGGGACTCCTCGCTGAATCCTCCACAAGAAAGAGGGAAGCCAGCAGAGCCCCCAAGAGACCG
GGCCCCCGGATTCCCCCTAGTCTCCAGCCTCAGGCCCACAGCCCATGACGCAAACTGTGCCTGTGAAATCGAGCTGTCGGTAGGAAATGA
CCGCCTGTGGTTTGTGAATCCTATTTTCATCGAGGACTGCAGCAGCGCCCTGCCCACCGACCAGCCACCTCTTGGAAATTGCCCTGCACG
CCCTTTGCCGCCCACCTCTGATGCCACCTCACCCACCTCCAGGTGGGCCCCACGCCGCCCACCACCCCCTCCCCCAGTGCTGCCCCTGCA
GCCCTGCAGCCCAGCCCAGCCCCCTGTGCTCCCTGCTCTTGCCCCCGCCCCTGCCTGTCCTTTGCCCACCTCTCCCCCAGTGCCTGCCCC
CCACGTCACACCCCATGCCCCAGGTCCCCCAGACCATCCGAACCAGCCGCCCATGATGACCTGCGAGAGACTCCCATGCCCCACTGCAGG
CCTGGGCCCCCTCAGGGAGGAAGCGATGAAGCCAGGGGCAGCCTCCAGTCCCTTGCAGCAGGTCCCCGCCCCGCCACTGCCTGCGAAGAA
GAACCTTCCCACTGCCCCTCCCAGACGCCGCGTTTCCGAGAGGGTGTCCTTAGAAGACCAAAGTCCGGGGATGGCGGCAGAGGGGGACCA
GCTCAGCCTGCCTCCCCAAGGGACCTCAGACGGCCCTGAGGACACGCCCCGGGAGAGCACGGAGCAAGGCCAGGACACAGAGGTGAAAGC
CAGCGATCCTCACAGCATGCCAGAGCTGCCCAGGACAGCCAAACAACCCCCAGTCCCGCCCCCCAGGAAAAAACGGATCTCTCGACAACT
GGCCTCGACCCTCCCAGCTCCCTTAGAGAACGCTGAGCTCTGCACACAGGCGATGGCCTTGGAGACACCCACGCCGGGTCCACCCAGAGA
GGGCCAAAGCCCTGCTTCTCAGGCTGGGACTCAGCACCCTCCTGCCCAGGCCACTGCCCATTCCCAGAGCTCTCCAGAGTTCAAGGGCTC
CCTGGCCTCCCTCTCAGACAGCTTGGGGGTGTCTGTCATGGCCACCGACCAGGACTCCTACTCCACCAGCAGCACGGAGGAGGAGCTGGA
GCAGTTCAGCAGCCCCAGCGTGAAGAAGAAGCCCTCCATGATCCTGGGCAAGGCTCGGCACCGGCTGAGCTTTGCCAGTTTCAGCAGCAT
GTTCCACGCTTTCCTCTCCAACAACCGCAAGCTGTACAAGAAGGTGGTGGAGCTGGCGCAGGACAAGGGCTCGTACTTTGGCAGCCTGGT
GCAGGACTACAAGGTGTACAGCCTGGAGATGATGGCGCGCCAGACCTCCAGCACGGAGATGCTGCAGGAGATTCGCACCATGATGACCCA
GCTCAAGAGCTACCTGCTGCAGAGCACCGAGCTCAAGGCCCTGGTGGACCCCGCCCTGCACTCCGAGGAGGAGCTCGAAGCAATTGTAGA
GTCTGCCTTGTACAAATGTGTCCTGAAGCCCCTGAAGGAAGCCATCAACTCATGCCTGCATCAGATCCACAGCAAGGATGGTTCGCTGCA
GCAGCTCAAGGAGAACCAGTTAGTGATCCTGGCCACCACCACCACTGACCTAGGTGTGACCACCAGCGTGCCGGAGGTGCCCATGATGGA
GAAGATCCTGCAGAAGTTCACCAGCATGCACAAGGCCTACTCACCTGAGAAGAAGATCTCCATCCTGCTCAAGACCTGCAAACTCATCTA
CGACTCCATGGCCCTCGGCAACCCAGGGAAGCCCTATGGGGCGGATGACTTCCTGCCTGTGCTCATGTATGTGCTGGCCCGCAGCAACCT
CACGGAGATGCTTCTCAATGTGGAGTACATGATGGAGCTCATGGACCCCGCCCTGCAGCTGGGGGAGGGTTCCTACTATCTGACCACCAC
CTACGGGGCCCTGGAGCACATCAAGAGCTACGACAAGATCACGGTGACCCGGCAGCTGAGTGTGGAGGTGCAGGACTCCATCCACCGCTG
GGAGCGCCGGCGTACTCTCAACAAGGCCCGGGCCTCCCGCTCCTCCGTACAGGACTTCATCTGCGTGTCGTACCTGGAGCCCGAGCAGCA
GGCGCGGACGCTGGCGTCGCGGGCGGACACCCAGGCCCAGGCGCTGTGCGCGCAGTGCGCGGAGAAGTTCGCGGTGGAGCGGCCGCAGGC
GCACCGGCTGTTCGTGCTGGTGGACGGGCGCTGCTTCCAGCTGGCGGACGACGCGCTGCCGCACTGCATCAAGGGCTACCTGCTGCGCAG
CGAGCCCAAGCGCGACTTCCACTTTGTCTACCGGCCCCTGGACGGTGGTGGCGGCGGCGGCGGCGGGAGCCCGCCCTGCCTGGTGGTGCG
GGAGCCCAACTTCCTGTGAGGCCCTCCCGGGGCGCCTCCCCTCACCCCCAGGCGCACGTCTGGCCCCGCCTCTGGCTGCGCACTCCCGAC
CGCGACGTCCACGCAGCAGAGGGACATGGGCCATTCCATGACGTGCCCAGGCCAACGTCGCAGGACAGTTGTGAAAATAACATGACGCTC
GTCCAAGGCCACTTCCTGAGGGCAAGTCCTAATAGCCCTGAGACACCGAGACGGCATGTTCTTCATTAGACGGAAAGGGAAACTGAGGCT
CAGGAGAGAGGCGCTCCAGGCCGCTGCAGCCAACAAACCGGCGCCCTCTTCACACGTAGCTCCTCAGGCCATTCCCCATGAGTCCCCCAC
ACCCACCCCATCCTCGGTCTTTGCAAAGAAGGGCCCGAGCTTAGTTTCCCCAGGACTGGCCTAGGAAGGAGCACCGGCCACAGCTGCTCC
CCGTGCCACTCAGGGTGGACCCAGCATCTCAGGAGCACCTCAGGGTGTCGGTTAAGAGACAGGCCTCCACCCCTGCACCAGAGCCTGCTC
TTAGCTCCCGGTGCCCCCAGACCCCGCAGCTCTGTGCCCGGCAAGAAGCAGCTAGACACACGCCAGGGCGCCAAGCACGGCCAGCTCCGC
GGACCCATGGACAAGCCCAGCCCCGCCTCAGGGAAAACAGGGCCTTTCCCTACAGGACACGCCCCAGAGCTGTGGCAGATTGCAGGAGCC

>1313_1313_1_ACIN1-RIN3_ACIN1_chr14_23559191_ENST00000262710_RIN3_chr14_93081747_ENST00000216487_length(amino acids)=1069AA_BP=118
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNP
PQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWA
PRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASS
PLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQP
PVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATD
QDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTS
STEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTD
LGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDP
ALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALC

--------------------------------------------------------------
>1313_1313_2_ACIN1-RIN3_ACIN1_chr14_23559191_ENST00000555053_RIN3_chr14_93081747_ENST00000216487_length(transcript)=4040nt_BP=707nt
TCGATTCAAAGCTTCGGCAAGACGAAGAAAACCGAGCCTGAAAGCAGGGCGAGAAAAGGGGCGCTGCAGGGCGGATGGAAAGAATTGATT
GGTAACGATGTGGAGACGGAAACATCCGAGGACATCCGGAGGAACCCGGGGAGTTCTGAGTGGTAATCGAGGGGTAGAGTATGGCAGTGG
GCGGGGTCATCTCGGTACGTTCGAAGGGCGTTGGCGGAAATTACCGAAGATGCCCGAAGCCGTCGGGACGGACCCGAGTACCTCACGCAA
GATGGCGGAGCTGGAGGAGGTGACTCTGGACGGGAAGCCTCTTCAGGCGCTGCGGGTGACCGACCTGAAGGCCGCACTGGAGCAGCGAGG
CCTAGCCAAGAGCGGGCAGAAGAGTGCCCTGGTCAAGCGGCTCAAAGGGGCTCTAATGCTAGAAAATTTACAGAAACACTCAACACCCCA
TGCTGCATTCCAGCCAAATTCCCAGATTGGTGAGGAAATGAGCCAGAACAGTTTCATAAAACAGTATCTGGAAAAGCAGCAGGAGCTACT
TAGGCAGCGTCTGGAACGTGAAGCTCGAGAAGCTGCAGAACTTGAAGAAGCTTCAGCTGAGTCGGAGGACGAGATGATCCATCCTGAGGG
AGTGGCTTCCCTGCTGCCTCCTGACTTTCAGAGCAGCCTGGAGAGACCAGAGCTGGAGCTCAGCAGACATTCGCCCATATTGTACCTGGA
AGGCTCGGCTCTTGTGTTTGAGGACATCTTCAGATTGATTGCGTTCTACTGTGTCAGTAGAGACTTACTGCCCTTCACACTGCGGCTACC
CCAGGCCATCCTTGAGGCCAGCAGCTTCACGGACCTTGAGACCATCGCCAACCTGGGTCTGGGTTTCTGGGACTCCTCGCTGAATCCTCC
ACAAGAAAGAGGGAAGCCAGCAGAGCCCCCAAGAGACCGGGCCCCCGGATTCCCCCTAGTCTCCAGCCTCAGGCCCACAGCCCATGACGC
AAACTGTGCCTGTGAAATCGAGCTGTCGGTAGGAAATGACCGCCTGTGGTTTGTGAATCCTATTTTCATCGAGGACTGCAGCAGCGCCCT
GCCCACCGACCAGCCACCTCTTGGAAATTGCCCTGCACGCCCTTTGCCGCCCACCTCTGATGCCACCTCACCCACCTCCAGGTGGGCCCC
ACGCCGCCCACCACCCCCTCCCCCAGTGCTGCCCCTGCAGCCCTGCAGCCCAGCCCAGCCCCCTGTGCTCCCTGCTCTTGCCCCCGCCCC
TGCCTGTCCTTTGCCCACCTCTCCCCCAGTGCCTGCCCCCCACGTCACACCCCATGCCCCAGGTCCCCCAGACCATCCGAACCAGCCGCC
CATGATGACCTGCGAGAGACTCCCATGCCCCACTGCAGGCCTGGGCCCCCTCAGGGAGGAAGCGATGAAGCCAGGGGCAGCCTCCAGTCC
CTTGCAGCAGGTCCCCGCCCCGCCACTGCCTGCGAAGAAGAACCTTCCCACTGCCCCTCCCAGACGCCGCGTTTCCGAGAGGGTGTCCTT
AGAAGACCAAAGTCCGGGGATGGCGGCAGAGGGGGACCAGCTCAGCCTGCCTCCCCAAGGGACCTCAGACGGCCCTGAGGACACGCCCCG
GGAGAGCACGGAGCAAGGCCAGGACACAGAGGTGAAAGCCAGCGATCCTCACAGCATGCCAGAGCTGCCCAGGACAGCCAAACAACCCCC
AGTCCCGCCCCCCAGGAAAAAACGGATCTCTCGACAACTGGCCTCGACCCTCCCAGCTCCCTTAGAGAACGCTGAGCTCTGCACACAGGC
GATGGCCTTGGAGACACCCACGCCGGGTCCACCCAGAGAGGGCCAAAGCCCTGCTTCTCAGGCTGGGACTCAGCACCCTCCTGCCCAGGC
CACTGCCCATTCCCAGAGCTCTCCAGAGTTCAAGGGCTCCCTGGCCTCCCTCTCAGACAGCTTGGGGGTGTCTGTCATGGCCACCGACCA
GGACTCCTACTCCACCAGCAGCACGGAGGAGGAGCTGGAGCAGTTCAGCAGCCCCAGCGTGAAGAAGAAGCCCTCCATGATCCTGGGCAA
GGCTCGGCACCGGCTGAGCTTTGCCAGTTTCAGCAGCATGTTCCACGCTTTCCTCTCCAACAACCGCAAGCTGTACAAGAAGGTGGTGGA
GCTGGCGCAGGACAAGGGCTCGTACTTTGGCAGCCTGGTGCAGGACTACAAGGTGTACAGCCTGGAGATGATGGCGCGCCAGACCTCCAG
CACGGAGATGCTGCAGGAGATTCGCACCATGATGACCCAGCTCAAGAGCTACCTGCTGCAGAGCACCGAGCTCAAGGCCCTGGTGGACCC
CGCCCTGCACTCCGAGGAGGAGCTCGAAGCAATTGTAGAGTCTGCCTTGTACAAATGTGTCCTGAAGCCCCTGAAGGAAGCCATCAACTC
ATGCCTGCATCAGATCCACAGCAAGGATGGTTCGCTGCAGCAGCTCAAGGAGAACCAGTTAGTGATCCTGGCCACCACCACCACTGACCT
AGGTGTGACCACCAGCGTGCCGGAGGTGCCCATGATGGAGAAGATCCTGCAGAAGTTCACCAGCATGCACAAGGCCTACTCACCTGAGAA
GAAGATCTCCATCCTGCTCAAGACCTGCAAACTCATCTACGACTCCATGGCCCTCGGCAACCCAGGGAAGCCCTATGGGGCGGATGACTT
CCTGCCTGTGCTCATGTATGTGCTGGCCCGCAGCAACCTCACGGAGATGCTTCTCAATGTGGAGTACATGATGGAGCTCATGGACCCCGC
CCTGCAGCTGGGGGAGGGTTCCTACTATCTGACCACCACCTACGGGGCCCTGGAGCACATCAAGAGCTACGACAAGATCACGGTGACCCG
GCAGCTGAGTGTGGAGGTGCAGGACTCCATCCACCGCTGGGAGCGCCGGCGTACTCTCAACAAGGCCCGGGCCTCCCGCTCCTCCGTACA
GGACTTCATCTGCGTGTCGTACCTGGAGCCCGAGCAGCAGGCGCGGACGCTGGCGTCGCGGGCGGACACCCAGGCCCAGGCGCTGTGCGC
GCAGTGCGCGGAGAAGTTCGCGGTGGAGCGGCCGCAGGCGCACCGGCTGTTCGTGCTGGTGGACGGGCGCTGCTTCCAGCTGGCGGACGA
CGCGCTGCCGCACTGCATCAAGGGCTACCTGCTGCGCAGCGAGCCCAAGCGCGACTTCCACTTTGTCTACCGGCCCCTGGACGGTGGTGG
CGGCGGCGGCGGCGGGAGCCCGCCCTGCCTGGTGGTGCGGGAGCCCAACTTCCTGTGAGGCCCTCCCGGGGCGCCTCCCCTCACCCCCAG
GCGCACGTCTGGCCCCGCCTCTGGCTGCGCACTCCCGACCGCGACGTCCACGCAGCAGAGGGACATGGGCCATTCCATGACGTGCCCAGG
CCAACGTCGCAGGACAGTTGTGAAAATAACATGACGCTCGTCCAAGGCCACTTCCTGAGGGCAAGTCCTAATAGCCCTGAGACACCGAGA
CGGCATGTTCTTCATTAGACGGAAAGGGAAACTGAGGCTCAGGAGAGAGGCGCTCCAGGCCGCTGCAGCCAACAAACCGGCGCCCTCTTC
ACACGTAGCTCCTCAGGCCATTCCCCATGAGTCCCCCACACCCACCCCATCCTCGGTCTTTGCAAAGAAGGGCCCGAGCTTAGTTTCCCC
AGGACTGGCCTAGGAAGGAGCACCGGCCACAGCTGCTCCCCGTGCCACTCAGGGTGGACCCAGCATCTCAGGAGCACCTCAGGGTGTCGG
TTAAGAGACAGGCCTCCACCCCTGCACCAGAGCCTGCTCTTAGCTCCCGGTGCCCCCAGACCCCGCAGCTCTGTGCCCGGCAAGAAGCAG
CTAGACACACGCCAGGGCGCCAAGCACGGCCAGCTCCGCGGACCCATGGACAAGCCCAGCCCCGCCTCAGGGAAAACAGGGCCTTTCCCT

>1313_1313_2_ACIN1-RIN3_ACIN1_chr14_23559191_ENST00000555053_RIN3_chr14_93081747_ENST00000216487_length(amino acids)=1069AA_BP=118
MVTMWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQR
GLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPE
GVASLLPPDFQSSLERPELELSRHSPILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNP
PQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWA
PRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASS
PLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQP
PVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATD
QDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTS
STEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTD
LGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDP
ALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALC

--------------------------------------------------------------
>1313_1313_3_ACIN1-RIN3_ACIN1_chr14_23559191_ENST00000605057_RIN3_chr14_93081747_ENST00000216487_length(transcript)=3810nt_BP=477nt
TGCCCGAAGCCGTCGGGACGGACCCGAGTACCTCACGCAAGATGGCGGAGCTGGAGGAGGTGACTCTGGACGGGAAGCCTCTTCAGGCGC
TGCGGGTGACCGACCTGAAGGCCGCACTGGAGCAGCGAGGCCTAGCCAAGAGCGGGCAGAAGAGTGCCCTGGTCAAGCGGCTCAAAGGGG
CTCTAATGCTAGAAAATTTACAGAAACACTCAACACCCCATGCTGCATTCCAGCCAAATTCCCAGATTGGTGAGGAAATGAGCCAGAACA
GTTTCATAAAACAGTATCTGGAAAAGCAGCAGGAGCTACTTAGGCAGCGTCTGGAACGTGAAGCTCGAGAAGCTGCAGAACTTGAAGAAG
CTTCAGCTGAGTCGGAGGACGAGATGATCCATCCTGAGGGAGTGGCTTCCCTGCTGCCTCCTGACTTTCAGAGCAGCCTGGAGAGACCAG
AGCTGGAGCTCAGCAGACATTCGCCCATATTGTACCTGGAAGGCTCGGCTCTTGTGTTTGAGGACATCTTCAGATTGATTGCGTTCTACT
GTGTCAGTAGAGACTTACTGCCCTTCACACTGCGGCTACCCCAGGCCATCCTTGAGGCCAGCAGCTTCACGGACCTTGAGACCATCGCCA
ACCTGGGTCTGGGTTTCTGGGACTCCTCGCTGAATCCTCCACAAGAAAGAGGGAAGCCAGCAGAGCCCCCAAGAGACCGGGCCCCCGGAT
TCCCCCTAGTCTCCAGCCTCAGGCCCACAGCCCATGACGCAAACTGTGCCTGTGAAATCGAGCTGTCGGTAGGAAATGACCGCCTGTGGT
TTGTGAATCCTATTTTCATCGAGGACTGCAGCAGCGCCCTGCCCACCGACCAGCCACCTCTTGGAAATTGCCCTGCACGCCCTTTGCCGC
CCACCTCTGATGCCACCTCACCCACCTCCAGGTGGGCCCCACGCCGCCCACCACCCCCTCCCCCAGTGCTGCCCCTGCAGCCCTGCAGCC
CAGCCCAGCCCCCTGTGCTCCCTGCTCTTGCCCCCGCCCCTGCCTGTCCTTTGCCCACCTCTCCCCCAGTGCCTGCCCCCCACGTCACAC
CCCATGCCCCAGGTCCCCCAGACCATCCGAACCAGCCGCCCATGATGACCTGCGAGAGACTCCCATGCCCCACTGCAGGCCTGGGCCCCC
TCAGGGAGGAAGCGATGAAGCCAGGGGCAGCCTCCAGTCCCTTGCAGCAGGTCCCCGCCCCGCCACTGCCTGCGAAGAAGAACCTTCCCA
CTGCCCCTCCCAGACGCCGCGTTTCCGAGAGGGTGTCCTTAGAAGACCAAAGTCCGGGGATGGCGGCAGAGGGGGACCAGCTCAGCCTGC
CTCCCCAAGGGACCTCAGACGGCCCTGAGGACACGCCCCGGGAGAGCACGGAGCAAGGCCAGGACACAGAGGTGAAAGCCAGCGATCCTC
ACAGCATGCCAGAGCTGCCCAGGACAGCCAAACAACCCCCAGTCCCGCCCCCCAGGAAAAAACGGATCTCTCGACAACTGGCCTCGACCC
TCCCAGCTCCCTTAGAGAACGCTGAGCTCTGCACACAGGCGATGGCCTTGGAGACACCCACGCCGGGTCCACCCAGAGAGGGCCAAAGCC
CTGCTTCTCAGGCTGGGACTCAGCACCCTCCTGCCCAGGCCACTGCCCATTCCCAGAGCTCTCCAGAGTTCAAGGGCTCCCTGGCCTCCC
TCTCAGACAGCTTGGGGGTGTCTGTCATGGCCACCGACCAGGACTCCTACTCCACCAGCAGCACGGAGGAGGAGCTGGAGCAGTTCAGCA
GCCCCAGCGTGAAGAAGAAGCCCTCCATGATCCTGGGCAAGGCTCGGCACCGGCTGAGCTTTGCCAGTTTCAGCAGCATGTTCCACGCTT
TCCTCTCCAACAACCGCAAGCTGTACAAGAAGGTGGTGGAGCTGGCGCAGGACAAGGGCTCGTACTTTGGCAGCCTGGTGCAGGACTACA
AGGTGTACAGCCTGGAGATGATGGCGCGCCAGACCTCCAGCACGGAGATGCTGCAGGAGATTCGCACCATGATGACCCAGCTCAAGAGCT
ACCTGCTGCAGAGCACCGAGCTCAAGGCCCTGGTGGACCCCGCCCTGCACTCCGAGGAGGAGCTCGAAGCAATTGTAGAGTCTGCCTTGT
ACAAATGTGTCCTGAAGCCCCTGAAGGAAGCCATCAACTCATGCCTGCATCAGATCCACAGCAAGGATGGTTCGCTGCAGCAGCTCAAGG
AGAACCAGTTAGTGATCCTGGCCACCACCACCACTGACCTAGGTGTGACCACCAGCGTGCCGGAGGTGCCCATGATGGAGAAGATCCTGC
AGAAGTTCACCAGCATGCACAAGGCCTACTCACCTGAGAAGAAGATCTCCATCCTGCTCAAGACCTGCAAACTCATCTACGACTCCATGG
CCCTCGGCAACCCAGGGAAGCCCTATGGGGCGGATGACTTCCTGCCTGTGCTCATGTATGTGCTGGCCCGCAGCAACCTCACGGAGATGC
TTCTCAATGTGGAGTACATGATGGAGCTCATGGACCCCGCCCTGCAGCTGGGGGAGGGTTCCTACTATCTGACCACCACCTACGGGGCCC
TGGAGCACATCAAGAGCTACGACAAGATCACGGTGACCCGGCAGCTGAGTGTGGAGGTGCAGGACTCCATCCACCGCTGGGAGCGCCGGC
GTACTCTCAACAAGGCCCGGGCCTCCCGCTCCTCCGTACAGGACTTCATCTGCGTGTCGTACCTGGAGCCCGAGCAGCAGGCGCGGACGC
TGGCGTCGCGGGCGGACACCCAGGCCCAGGCGCTGTGCGCGCAGTGCGCGGAGAAGTTCGCGGTGGAGCGGCCGCAGGCGCACCGGCTGT
TCGTGCTGGTGGACGGGCGCTGCTTCCAGCTGGCGGACGACGCGCTGCCGCACTGCATCAAGGGCTACCTGCTGCGCAGCGAGCCCAAGC
GCGACTTCCACTTTGTCTACCGGCCCCTGGACGGTGGTGGCGGCGGCGGCGGCGGGAGCCCGCCCTGCCTGGTGGTGCGGGAGCCCAACT
TCCTGTGAGGCCCTCCCGGGGCGCCTCCCCTCACCCCCAGGCGCACGTCTGGCCCCGCCTCTGGCTGCGCACTCCCGACCGCGACGTCCA
CGCAGCAGAGGGACATGGGCCATTCCATGACGTGCCCAGGCCAACGTCGCAGGACAGTTGTGAAAATAACATGACGCTCGTCCAAGGCCA
CTTCCTGAGGGCAAGTCCTAATAGCCCTGAGACACCGAGACGGCATGTTCTTCATTAGACGGAAAGGGAAACTGAGGCTCAGGAGAGAGG
CGCTCCAGGCCGCTGCAGCCAACAAACCGGCGCCCTCTTCACACGTAGCTCCTCAGGCCATTCCCCATGAGTCCCCCACACCCACCCCAT
CCTCGGTCTTTGCAAAGAAGGGCCCGAGCTTAGTTTCCCCAGGACTGGCCTAGGAAGGAGCACCGGCCACAGCTGCTCCCCGTGCCACTC
AGGGTGGACCCAGCATCTCAGGAGCACCTCAGGGTGTCGGTTAAGAGACAGGCCTCCACCCCTGCACCAGAGCCTGCTCTTAGCTCCCGG
TGCCCCCAGACCCCGCAGCTCTGTGCCCGGCAAGAAGCAGCTAGACACACGCCAGGGCGCCAAGCACGGCCAGCTCCGCGGACCCATGGA
CAAGCCCAGCCCCGCCTCAGGGAAAACAGGGCCTTTCCCTACAGGACACGCCCCAGAGCTGTGGCAGATTGCAGGAGCCATCGTGTGGGG

>1313_1313_3_ACIN1-RIN3_ACIN1_chr14_23559191_ENST00000605057_RIN3_chr14_93081747_ENST00000216487_length(amino acids)=1008AA_BP=57
MAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELL
RQRLEREAREAAELEEASAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLP
QAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSAL
PTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPP
MMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPR
ESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQA
TAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVE
LAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINS
CLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDF
LPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQ
DFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACIN1-RIN3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRIN3chr14:23559191chr14:93081747ENST00000216487210587_732122.33333333333333986.0RAB5B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACIN1-RIN3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACIN1-RIN3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource