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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CASC3-ACLY (FusionGDB2 ID:13141)

Fusion Gene Summary for CASC3-ACLY

check button Fusion gene summary
Fusion gene informationFusion gene name: CASC3-ACLY
Fusion gene ID: 13141
HgeneTgene
Gene symbol

CASC3

ACLY

Gene ID

22794

47

Gene nameCASC3 exon junction complex subunitATP citrate lyase
SynonymsBTZ|MLN51ACL|ATPCL|CLATP
Cytomap

17q21.1

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionprotein CASC3MLN 51barentszcancer susceptibility 3cancer susceptibility candidate 3cancer susceptibility candidate gene 3 proteinmetastatic lymph node 51metastatic lymph node gene 51 proteinprotein barentszATP-citrate synthaseATP-citrate (pro-S-)-lyasecitrate cleavage enzyme
Modification date2020031320200313
UniProtAcc

O15234

P53396

Ensembl transtripts involved in fusion geneENST00000264645, ENST00000588779, 
ENST00000352035, ENST00000353196, 
ENST00000393896, ENST00000537919, 
ENST00000590151, 
Fusion gene scores* DoF score21 X 10 X 10=210013 X 13 X 6=1014
# samples 2815
** MAII scorelog2(28/2100*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(15/1014*10)=-2.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASC3 [Title/Abstract] AND ACLY [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCASC3(38324670)-ACLY(40024157), # samples:3
Anticipated loss of major functional domain due to fusion event.CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CASC3-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CASC3-ACLY seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASC3

GO:0000398

mRNA splicing, via spliceosome

29301961

TgeneACLY

GO:0006085

acetyl-CoA biosynthetic process

1371749

TgeneACLY

GO:0006101

citrate metabolic process

1371749

TgeneACLY

GO:0006107

oxaloacetate metabolic process

1371749

TgeneACLY

GO:0008610

lipid biosynthetic process

23932781


check buttonFusion gene breakpoints across CASC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACLY (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-R5-A7ZE-01BCASC3chr17

38324670

+ACLYchr17

40024157

-
ChimerDB4STADTCGA-R5-A7ZECASC3chr17

38324670

+ACLYchr17

40024157

-


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Fusion Gene ORF analysis for CASC3-ACLY

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264645ENST00000588779CASC3chr17

38324670

+ACLYchr17

40024157

-
Frame-shiftENST00000264645ENST00000352035CASC3chr17

38324670

+ACLYchr17

40024157

-
In-frameENST00000264645ENST00000353196CASC3chr17

38324670

+ACLYchr17

40024157

-
In-frameENST00000264645ENST00000393896CASC3chr17

38324670

+ACLYchr17

40024157

-
In-frameENST00000264645ENST00000537919CASC3chr17

38324670

+ACLYchr17

40024157

-
In-frameENST00000264645ENST00000590151CASC3chr17

38324670

+ACLYchr17

40024157

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000264645CASC3chr1738324670+ENST00000590151ACLYchr1740024157-317921911722217681
ENST00000264645CASC3chr1738324670+ENST00000353196ACLYchr1740024157-316521911722217681
ENST00000264645CASC3chr1738324670+ENST00000537919ACLYchr1740024157-264021911722217681
ENST00000264645CASC3chr1738324670+ENST00000393896ACLYchr1740024157-252221911722217681

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264645ENST00000590151CASC3chr1738324670+ACLYchr1740024157-0.0016803430.9983197
ENST00000264645ENST00000353196CASC3chr1738324670+ACLYchr1740024157-0.0016103570.9983897
ENST00000264645ENST00000537919CASC3chr1738324670+ACLYchr1740024157-0.0067465970.9932534
ENST00000264645ENST00000393896CASC3chr1738324670+ACLYchr1740024157-0.0081440060.991856

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Fusion Genomic Features for CASC3-ACLY


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CASC3-ACLY


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38324670/chr17:40024157)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASC3

O15234

ACLY

P53396

FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer. {ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961}.FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:9116495}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+111495_1316551130.6666666666667Coiled coilOntology_term=ECO:0000255
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114392_3956551130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+111441_466551130.6666666666667Compositional biasNote=Poly-Gly
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114425_4286551130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114643_6486551130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114204_2106551130.6666666666667MotifNuclear localization signal 1
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114254_2626551130.6666666666667MotifNuclear localization signal 2
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114462_4666551130.6666666666667MotifNote=Nuclear export signal
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114137_2836551130.6666666666667RegionNote=Sufficient to form the EJC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114692_6956551130.6666666666667Compositional biasNote=Poly-Pro
HgeneCASC3chr17:38324670chr17:40024157ENST00000264645+1114377_7036551130.6666666666667RegionNote=Necessary for localization in cytoplasmic stress granules
TgeneACLYchr17:38324670chr17:40024157ENST0000035203527294_26510701102.0DomainNote=ATP-grasp
TgeneACLYchr17:38324670chr17:40024157ENST0000035319626284_26510601092.0DomainNote=ATP-grasp
TgeneACLYchr17:38324670chr17:40024157ENST0000039389626284_26510601092.0DomainNote=ATP-grasp
TgeneACLYchr17:38324670chr17:40024157ENST0000059015127294_26510701102.0DomainNote=ATP-grasp
TgeneACLYchr17:38324670chr17:40024157ENST000003520352729109_11110701102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST00000352035272966_6710701102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST000003520352729701_72110701102.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000003520352729752_77810701102.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000003531962628109_11110601092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST00000353196262866_6710601092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST000003531962628701_72110601092.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000003531962628752_77810601092.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000003938962628109_11110601092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST00000393896262866_6710601092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST000003938962628701_72110601092.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000003938962628752_77810601092.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000005901512729109_11110701102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST00000590151272966_6710701102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:38324670chr17:40024157ENST000005901512729701_72110701102.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000005901512729752_77810701102.0Nucleotide bindingATP
TgeneACLYchr17:38324670chr17:40024157ENST000003520352729779_78910701102.0RegionCoA-binding
TgeneACLYchr17:38324670chr17:40024157ENST000003531962628779_78910601092.0RegionCoA-binding
TgeneACLYchr17:38324670chr17:40024157ENST000003938962628779_78910601092.0RegionCoA-binding
TgeneACLYchr17:38324670chr17:40024157ENST000005901512729779_78910701102.0RegionCoA-binding


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Fusion Gene Sequence for CASC3-ACLY


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13141_13141_1_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000353196_length(transcript)=3165nt_BP=2191nt
CACACACACACACACACACACACACACCCCAACACACACACACACACCCCAACACACACACACACACACACACACACACACACACACACA
CACACACACACACACACAGCGGGATGGCCGAGCGCCGCACGCGTAGCACGCCGGGACTAGCTATCCAGCCTCCCAGCAGCCTCTGCGACG
GGCGCGGTGCGTAAGTACCTCGCCGGTGGTGGCCGTTCTCCGTAAGATGGCGGACCGGCGGCGGCAGCGCGCTTCGCAAGACACCGAGGA
CGAGGAATCTGGTGCTTCGGGCTCCGACAGCGGCGGCTCCCCGTTGCGGGGAGGCGGGAGCTGCAGCGGTAGCGCCGGAGGCGGCGGCAG
CGGCTCTCTGCCTTCACAGCGCGGAGGCCGAACCGGGGCCCTTCATCTGCGGCGGGTGGAGAGCGGGGGCGCCAAGAGTGCTGAGGAGTC
GGAGTGTGAGAGTGAAGATGGCATTGAAGGTGATGCTGTTCTCTCGGATTATGAAAGTGCAGAAGACTCGGAAGGTGAAGAAGGTGAATA
CAGTGAAGAGGAAAACTCCAAAGTGGAGCTGAAATCAGAAGCTAATGATGCTGTTAATTCTTCAACAAAAGAAGAGAAGGGAGAAGAAAA
GCCTGACACCAAAAGCACTGTGACTGGAGAGAGGCAAAGTGGGGACGGACAGGAGAGCACAGAGCCTGTGGAGAACAAAGTGGGTAAAAA
GGGCCCTAAGCATTTGGATGATGATGAAGATCGGAAGAATCCAGCATACATACCTCGGAAAGGGCTCTTCTTTGAGCATGATCTTCGAGG
GCAAACTCAGGAGGAGGAAGTCAGACCCAAGGGGCGTCAGCGAAAGCTATGGAAGGATGAGGGTCGCTGGGAGCATGACAAGTTCCGGGA
AGATGAGCAGGCCCCAAAGTCCCGACAGGAGCTCATTGCTCTTTATGGTTATGACATTCGCTCAGCTCATAATCCTGATGACATCAAACC
TCGAAGAATCCGGAAACCCCGATATGGGAGTCCTCCACAAAGAGATCCAAACTGGAACGGTGAGCGGCTAAACAAGTCTCATCGCCACCA
GGGTCTTGGGGGCACCCTACCACCAAGGACATTTATTAACAGGAATGCTGCAGGTACCGGCCGTATGTCTGCACCCAGGAATTATTCTCG
ATCTGGGGGCTTCAAGGAAGGTCGTGCTGGTTTTAGGCCTGTGGAAGCTGGTGGGCAGCATGGTGGCCGGTCTGGTGAGACTGTTAAGCA
TGAGATTAGTTACCGGTCACGGCGCCTAGAGCAGACTTCTGTGAGGGATCCATCTCCAGAAGCAGATGCTCCAGTGCTTGGCAGTCCTGA
GAAGGAAGAGGCAGCCTCAGAGCCACCAGCTGCTGCTCCTGATGCTGCACCACCACCCCCTGATAGGCCCATTGAGAAGAAATCCTATTC
CCGGGCAAGAAGAACTCGAACCAAAGTTGGAGATGCAGTCAAGCTTGCAGAGGAGGTGCCCCCTCCTCCTGAAGGACTGATTCCAGCACC
TCCAGTCCCAGAAACCACCCCAACTCCACCTACTAAGACTGGGACCTGGGAAGCTCCGGTGGATTCTAGTACAAGTGGACTTGAGCAAGA
TGTGGCACAACTAAATATAGCAGAACAGAATTGGAGTCCGGGGCAGCCTTCTTTCCTGCAACCACGGGAACTTCGAGGTATGCCCAACCA
TATACACATGGGAGCAGGACCTCCACCTCAGTTTAACCGGATGGAAGAAATGGGTGTCCAGGGTGGTCGAGCCAAACGCTATTCATCCCA
GCGGCAAAGACCTGTGCCAGAGCCCCCCGCCCCTCCAGTGCATATCAGTATCATGGAGGGACATTACTATGATCCACTGCAGTTCCAGGG
ACCAATCTATACCCATGGTGACAGCCCTGCCCCGCTGCCTCCACAGGGCATGCTTGTGCAGCCAGGAATGAACCTTCCCCACCCAGGTTT
ACATCCCCACCAGACACCAGCTCCTCTGCCCAATCCAGGCCTCTATCCCCCACCAGTGTCCATGTCTCCAGGACAGCCACCACCTCAGCA
GTTGCTTGCTCCTACTTACTTTTCTGCTCCAGGCGTCATGAACTTTGGTAATCCCAGTTACCCTTATGCTCCAGGGGCACTGCCTCCCCC
ACCACCGCCTCATCTGTATCCTAATACACAGGACACTATCTTGATCAGAAGAGGCTGAAGCAGGGGCTGTATCGTCATCCGTGGGATGAT
ATTTCATATGTTCTTCCGGAACACATGAGCATGTAACAGAGCCAGGAACCCTACTGCAGTAAACTGAAGACAAGATCTCTTCCCCCAAGA
AAAAGTGTACAGACAGCTGGCAGTGGAGCCTGCTTTATTTAGCAGGGGCCTGGAATGTAAACAGCCACTGGGGTACAGGCACCGAAGACC
AACATCCACAGGCTAACACCCCTTCAGTCCACACAAAGAAGCTTCATATTTTTTTTATAAGCATAGAAATAAAAACCAAGCCAATATTTG
TGACTTTGCTCTGCTACCTGCTGTATTTATTATATGGAAGCATCTAAGTACTGTCAGGATGGGGTCTTCCTCATTGTAGGGCGTTAGGAT
GTTGCTTTCTTTTTCCATTAGTTAAACATTTTTTTCTCCTTTGGAGGAAGGGAATGAAACATTTATGGCCTCAAGATACTATACATTTAA
AGCACCCCAATGTCTCTCTTTTTTTTTTTTTACTTCCCTTTCTTCTTCCTTATATAACATGAAGAACATTGTATTAATCTGATTTTTAAA
GATCTTTTTGTATGTTACGTGTTAAGGGCTTGTTTGGTATCCCACTGAAATGTTCTGTGTTGCAGACCAGAGTCTGTTTATGTCAGGGGG
ATGGGGCCATTGCATCCTTAGCCATTGTCACAAAATATGTGGAGTAGTAACTTAATATGTAAAGTTGTAACATACATACATTTAAAATGG
AAATGCAGAAAGCTGTGAAATGTCTTGTGTCTTATGTTCTCTGTATTTATGCAGCTGATTTGTCTGTCTGTAACTGAAGTGTGGGTCCAA
GGACTCCTAACTACTTTGCATCTGTAATCCACAAAGATTCTGGGCAGCTGCCACCTCAGTCTCTTCTCTGTATTATCATAGTCTGGTTTA

>13141_13141_1_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000353196_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------
>13141_13141_2_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000393896_length(transcript)=2522nt_BP=2191nt
CACACACACACACACACACACACACACCCCAACACACACACACACACCCCAACACACACACACACACACACACACACACACACACACACA
CACACACACACACACACAGCGGGATGGCCGAGCGCCGCACGCGTAGCACGCCGGGACTAGCTATCCAGCCTCCCAGCAGCCTCTGCGACG
GGCGCGGTGCGTAAGTACCTCGCCGGTGGTGGCCGTTCTCCGTAAGATGGCGGACCGGCGGCGGCAGCGCGCTTCGCAAGACACCGAGGA
CGAGGAATCTGGTGCTTCGGGCTCCGACAGCGGCGGCTCCCCGTTGCGGGGAGGCGGGAGCTGCAGCGGTAGCGCCGGAGGCGGCGGCAG
CGGCTCTCTGCCTTCACAGCGCGGAGGCCGAACCGGGGCCCTTCATCTGCGGCGGGTGGAGAGCGGGGGCGCCAAGAGTGCTGAGGAGTC
GGAGTGTGAGAGTGAAGATGGCATTGAAGGTGATGCTGTTCTCTCGGATTATGAAAGTGCAGAAGACTCGGAAGGTGAAGAAGGTGAATA
CAGTGAAGAGGAAAACTCCAAAGTGGAGCTGAAATCAGAAGCTAATGATGCTGTTAATTCTTCAACAAAAGAAGAGAAGGGAGAAGAAAA
GCCTGACACCAAAAGCACTGTGACTGGAGAGAGGCAAAGTGGGGACGGACAGGAGAGCACAGAGCCTGTGGAGAACAAAGTGGGTAAAAA
GGGCCCTAAGCATTTGGATGATGATGAAGATCGGAAGAATCCAGCATACATACCTCGGAAAGGGCTCTTCTTTGAGCATGATCTTCGAGG
GCAAACTCAGGAGGAGGAAGTCAGACCCAAGGGGCGTCAGCGAAAGCTATGGAAGGATGAGGGTCGCTGGGAGCATGACAAGTTCCGGGA
AGATGAGCAGGCCCCAAAGTCCCGACAGGAGCTCATTGCTCTTTATGGTTATGACATTCGCTCAGCTCATAATCCTGATGACATCAAACC
TCGAAGAATCCGGAAACCCCGATATGGGAGTCCTCCACAAAGAGATCCAAACTGGAACGGTGAGCGGCTAAACAAGTCTCATCGCCACCA
GGGTCTTGGGGGCACCCTACCACCAAGGACATTTATTAACAGGAATGCTGCAGGTACCGGCCGTATGTCTGCACCCAGGAATTATTCTCG
ATCTGGGGGCTTCAAGGAAGGTCGTGCTGGTTTTAGGCCTGTGGAAGCTGGTGGGCAGCATGGTGGCCGGTCTGGTGAGACTGTTAAGCA
TGAGATTAGTTACCGGTCACGGCGCCTAGAGCAGACTTCTGTGAGGGATCCATCTCCAGAAGCAGATGCTCCAGTGCTTGGCAGTCCTGA
GAAGGAAGAGGCAGCCTCAGAGCCACCAGCTGCTGCTCCTGATGCTGCACCACCACCCCCTGATAGGCCCATTGAGAAGAAATCCTATTC
CCGGGCAAGAAGAACTCGAACCAAAGTTGGAGATGCAGTCAAGCTTGCAGAGGAGGTGCCCCCTCCTCCTGAAGGACTGATTCCAGCACC
TCCAGTCCCAGAAACCACCCCAACTCCACCTACTAAGACTGGGACCTGGGAAGCTCCGGTGGATTCTAGTACAAGTGGACTTGAGCAAGA
TGTGGCACAACTAAATATAGCAGAACAGAATTGGAGTCCGGGGCAGCCTTCTTTCCTGCAACCACGGGAACTTCGAGGTATGCCCAACCA
TATACACATGGGAGCAGGACCTCCACCTCAGTTTAACCGGATGGAAGAAATGGGTGTCCAGGGTGGTCGAGCCAAACGCTATTCATCCCA
GCGGCAAAGACCTGTGCCAGAGCCCCCCGCCCCTCCAGTGCATATCAGTATCATGGAGGGACATTACTATGATCCACTGCAGTTCCAGGG
ACCAATCTATACCCATGGTGACAGCCCTGCCCCGCTGCCTCCACAGGGCATGCTTGTGCAGCCAGGAATGAACCTTCCCCACCCAGGTTT
ACATCCCCACCAGACACCAGCTCCTCTGCCCAATCCAGGCCTCTATCCCCCACCAGTGTCCATGTCTCCAGGACAGCCACCACCTCAGCA
GTTGCTTGCTCCTACTTACTTTTCTGCTCCAGGCGTCATGAACTTTGGTAATCCCAGTTACCCTTATGCTCCAGGGGCACTGCCTCCCCC
ACCACCGCCTCATCTGTATCCTAATACACAGGACACTATCTTGATCAGAAGAGGCTGAAGCAGGGGCTGTATCGTCATCCGTGGGATGAT
ATTTCATATGTTCTTCCGGAACACATGAGCATGTAACAGAGCCAGGAACCCTACTGCAGTAAACTGAAGACAAGATCTCTTCCCCCAAGA
AAAAGTGTACAGACAGCTGGCAGTGGAGCCTGCTTTATTTAGCAGGGGCCTGGAATGTAAACAGCCACTGGGGTACAGGCACCGAAGACC
AACATCCACAGGCTAACACCCCTTCAGTCCACACAAAGAAGCTTCATATTTTTTTTATAAGCATAGAAATAAAAACCAAGCCAATATTTG

>13141_13141_2_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000393896_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------
>13141_13141_3_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000537919_length(transcript)=2640nt_BP=2191nt
CACACACACACACACACACACACACACCCCAACACACACACACACACCCCAACACACACACACACACACACACACACACACACACACACA
CACACACACACACACACAGCGGGATGGCCGAGCGCCGCACGCGTAGCACGCCGGGACTAGCTATCCAGCCTCCCAGCAGCCTCTGCGACG
GGCGCGGTGCGTAAGTACCTCGCCGGTGGTGGCCGTTCTCCGTAAGATGGCGGACCGGCGGCGGCAGCGCGCTTCGCAAGACACCGAGGA
CGAGGAATCTGGTGCTTCGGGCTCCGACAGCGGCGGCTCCCCGTTGCGGGGAGGCGGGAGCTGCAGCGGTAGCGCCGGAGGCGGCGGCAG
CGGCTCTCTGCCTTCACAGCGCGGAGGCCGAACCGGGGCCCTTCATCTGCGGCGGGTGGAGAGCGGGGGCGCCAAGAGTGCTGAGGAGTC
GGAGTGTGAGAGTGAAGATGGCATTGAAGGTGATGCTGTTCTCTCGGATTATGAAAGTGCAGAAGACTCGGAAGGTGAAGAAGGTGAATA
CAGTGAAGAGGAAAACTCCAAAGTGGAGCTGAAATCAGAAGCTAATGATGCTGTTAATTCTTCAACAAAAGAAGAGAAGGGAGAAGAAAA
GCCTGACACCAAAAGCACTGTGACTGGAGAGAGGCAAAGTGGGGACGGACAGGAGAGCACAGAGCCTGTGGAGAACAAAGTGGGTAAAAA
GGGCCCTAAGCATTTGGATGATGATGAAGATCGGAAGAATCCAGCATACATACCTCGGAAAGGGCTCTTCTTTGAGCATGATCTTCGAGG
GCAAACTCAGGAGGAGGAAGTCAGACCCAAGGGGCGTCAGCGAAAGCTATGGAAGGATGAGGGTCGCTGGGAGCATGACAAGTTCCGGGA
AGATGAGCAGGCCCCAAAGTCCCGACAGGAGCTCATTGCTCTTTATGGTTATGACATTCGCTCAGCTCATAATCCTGATGACATCAAACC
TCGAAGAATCCGGAAACCCCGATATGGGAGTCCTCCACAAAGAGATCCAAACTGGAACGGTGAGCGGCTAAACAAGTCTCATCGCCACCA
GGGTCTTGGGGGCACCCTACCACCAAGGACATTTATTAACAGGAATGCTGCAGGTACCGGCCGTATGTCTGCACCCAGGAATTATTCTCG
ATCTGGGGGCTTCAAGGAAGGTCGTGCTGGTTTTAGGCCTGTGGAAGCTGGTGGGCAGCATGGTGGCCGGTCTGGTGAGACTGTTAAGCA
TGAGATTAGTTACCGGTCACGGCGCCTAGAGCAGACTTCTGTGAGGGATCCATCTCCAGAAGCAGATGCTCCAGTGCTTGGCAGTCCTGA
GAAGGAAGAGGCAGCCTCAGAGCCACCAGCTGCTGCTCCTGATGCTGCACCACCACCCCCTGATAGGCCCATTGAGAAGAAATCCTATTC
CCGGGCAAGAAGAACTCGAACCAAAGTTGGAGATGCAGTCAAGCTTGCAGAGGAGGTGCCCCCTCCTCCTGAAGGACTGATTCCAGCACC
TCCAGTCCCAGAAACCACCCCAACTCCACCTACTAAGACTGGGACCTGGGAAGCTCCGGTGGATTCTAGTACAAGTGGACTTGAGCAAGA
TGTGGCACAACTAAATATAGCAGAACAGAATTGGAGTCCGGGGCAGCCTTCTTTCCTGCAACCACGGGAACTTCGAGGTATGCCCAACCA
TATACACATGGGAGCAGGACCTCCACCTCAGTTTAACCGGATGGAAGAAATGGGTGTCCAGGGTGGTCGAGCCAAACGCTATTCATCCCA
GCGGCAAAGACCTGTGCCAGAGCCCCCCGCCCCTCCAGTGCATATCAGTATCATGGAGGGACATTACTATGATCCACTGCAGTTCCAGGG
ACCAATCTATACCCATGGTGACAGCCCTGCCCCGCTGCCTCCACAGGGCATGCTTGTGCAGCCAGGAATGAACCTTCCCCACCCAGGTTT
ACATCCCCACCAGACACCAGCTCCTCTGCCCAATCCAGGCCTCTATCCCCCACCAGTGTCCATGTCTCCAGGACAGCCACCACCTCAGCA
GTTGCTTGCTCCTACTTACTTTTCTGCTCCAGGCGTCATGAACTTTGGTAATCCCAGTTACCCTTATGCTCCAGGGGCACTGCCTCCCCC
ACCACCGCCTCATCTGTATCCTAATACACAGGACACTATCTTGATCAGAAGAGGCTGAAGCAGGGGCTGTATCGTCATCCGTGGGATGAT
ATTTCATATGTTCTTCCGGAACACATGAGCATGTAACAGAGCCAGGAACCCTACTGCAGTAAACTGAAGACAAGATCTCTTCCCCCAAGA
AAAAGTGTACAGACAGCTGGCAGTGGAGCCTGCTTTATTTAGCAGGGGCCTGGAATGTAAACAGCCACTGGGGTACAGGCACCGAAGACC
AACATCCACAGGCTAACACCCCTTCAGTCCACACAAAGAAGCTTCATATTTTTTTTATAAGCATAGAAATAAAAACCAAGCCAATATTTG
TGACTTTGCTCTGCTACCTGCTGTATTTATTATATGGAAGCATCTAAGTACTGTCAGGATGGGGTCTTCCTCATTGTAGGGCGTTAGGAT

>13141_13141_3_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000537919_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------
>13141_13141_4_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000590151_length(transcript)=3179nt_BP=2191nt
CACACACACACACACACACACACACACCCCAACACACACACACACACCCCAACACACACACACACACACACACACACACACACACACACA
CACACACACACACACACAGCGGGATGGCCGAGCGCCGCACGCGTAGCACGCCGGGACTAGCTATCCAGCCTCCCAGCAGCCTCTGCGACG
GGCGCGGTGCGTAAGTACCTCGCCGGTGGTGGCCGTTCTCCGTAAGATGGCGGACCGGCGGCGGCAGCGCGCTTCGCAAGACACCGAGGA
CGAGGAATCTGGTGCTTCGGGCTCCGACAGCGGCGGCTCCCCGTTGCGGGGAGGCGGGAGCTGCAGCGGTAGCGCCGGAGGCGGCGGCAG
CGGCTCTCTGCCTTCACAGCGCGGAGGCCGAACCGGGGCCCTTCATCTGCGGCGGGTGGAGAGCGGGGGCGCCAAGAGTGCTGAGGAGTC
GGAGTGTGAGAGTGAAGATGGCATTGAAGGTGATGCTGTTCTCTCGGATTATGAAAGTGCAGAAGACTCGGAAGGTGAAGAAGGTGAATA
CAGTGAAGAGGAAAACTCCAAAGTGGAGCTGAAATCAGAAGCTAATGATGCTGTTAATTCTTCAACAAAAGAAGAGAAGGGAGAAGAAAA
GCCTGACACCAAAAGCACTGTGACTGGAGAGAGGCAAAGTGGGGACGGACAGGAGAGCACAGAGCCTGTGGAGAACAAAGTGGGTAAAAA
GGGCCCTAAGCATTTGGATGATGATGAAGATCGGAAGAATCCAGCATACATACCTCGGAAAGGGCTCTTCTTTGAGCATGATCTTCGAGG
GCAAACTCAGGAGGAGGAAGTCAGACCCAAGGGGCGTCAGCGAAAGCTATGGAAGGATGAGGGTCGCTGGGAGCATGACAAGTTCCGGGA
AGATGAGCAGGCCCCAAAGTCCCGACAGGAGCTCATTGCTCTTTATGGTTATGACATTCGCTCAGCTCATAATCCTGATGACATCAAACC
TCGAAGAATCCGGAAACCCCGATATGGGAGTCCTCCACAAAGAGATCCAAACTGGAACGGTGAGCGGCTAAACAAGTCTCATCGCCACCA
GGGTCTTGGGGGCACCCTACCACCAAGGACATTTATTAACAGGAATGCTGCAGGTACCGGCCGTATGTCTGCACCCAGGAATTATTCTCG
ATCTGGGGGCTTCAAGGAAGGTCGTGCTGGTTTTAGGCCTGTGGAAGCTGGTGGGCAGCATGGTGGCCGGTCTGGTGAGACTGTTAAGCA
TGAGATTAGTTACCGGTCACGGCGCCTAGAGCAGACTTCTGTGAGGGATCCATCTCCAGAAGCAGATGCTCCAGTGCTTGGCAGTCCTGA
GAAGGAAGAGGCAGCCTCAGAGCCACCAGCTGCTGCTCCTGATGCTGCACCACCACCCCCTGATAGGCCCATTGAGAAGAAATCCTATTC
CCGGGCAAGAAGAACTCGAACCAAAGTTGGAGATGCAGTCAAGCTTGCAGAGGAGGTGCCCCCTCCTCCTGAAGGACTGATTCCAGCACC
TCCAGTCCCAGAAACCACCCCAACTCCACCTACTAAGACTGGGACCTGGGAAGCTCCGGTGGATTCTAGTACAAGTGGACTTGAGCAAGA
TGTGGCACAACTAAATATAGCAGAACAGAATTGGAGTCCGGGGCAGCCTTCTTTCCTGCAACCACGGGAACTTCGAGGTATGCCCAACCA
TATACACATGGGAGCAGGACCTCCACCTCAGTTTAACCGGATGGAAGAAATGGGTGTCCAGGGTGGTCGAGCCAAACGCTATTCATCCCA
GCGGCAAAGACCTGTGCCAGAGCCCCCCGCCCCTCCAGTGCATATCAGTATCATGGAGGGACATTACTATGATCCACTGCAGTTCCAGGG
ACCAATCTATACCCATGGTGACAGCCCTGCCCCGCTGCCTCCACAGGGCATGCTTGTGCAGCCAGGAATGAACCTTCCCCACCCAGGTTT
ACATCCCCACCAGACACCAGCTCCTCTGCCCAATCCAGGCCTCTATCCCCCACCAGTGTCCATGTCTCCAGGACAGCCACCACCTCAGCA
GTTGCTTGCTCCTACTTACTTTTCTGCTCCAGGCGTCATGAACTTTGGTAATCCCAGTTACCCTTATGCTCCAGGGGCACTGCCTCCCCC
ACCACCGCCTCATCTGTATCCTAATACACAGGACACTATCTTGATCAGAAGAGGCTGAAGCAGGGGCTGTATCGTCATCCGTGGGATGAT
ATTTCATATGTTCTTCCGGAACACATGAGCATGTAACAGAGCCAGGAACCCTACTGCAGTAAACTGAAGACAAGATCTCTTCCCCCAAGA
AAAAGTGTACAGACAGCTGGCAGTGGAGCCTGCTTTATTTAGCAGGGGCCTGGAATGTAAACAGCCACTGGGGTACAGGCACCGAAGACC
AACATCCACAGGCTAACACCCCTTCAGTCCACACAAAGAAGCTTCATATTTTTTTTATAAGCATAGAAATAAAAACCAAGCCAATATTTG
TGACTTTGCTCTGCTACCTGCTGTATTTATTATATGGAAGCATCTAAGTACTGTCAGGATGGGGTCTTCCTCATTGTAGGGCGTTAGGAT
GTTGCTTTCTTTTTCCATTAGTTAAACATTTTTTTCTCCTTTGGAGGAAGGGAATGAAACATTTATGGCCTCAAGATACTATACATTTAA
AGCACCCCAATGTCTCTCTTTTTTTTTTTTTACTTCCCTTTCTTCTTCCTTATATAACATGAAGAACATTGTATTAATCTGATTTTTAAA
GATCTTTTTGTATGTTACGTGTTAAGGGCTTGTTTGGTATCCCACTGAAATGTTCTGTGTTGCAGACCAGAGTCTGTTTATGTCAGGGGG
ATGGGGCCATTGCATCCTTAGCCATTGTCACAAAATATGTGGAGTAGTAACTTAATATGTAAAGTTGTAACATACATACATTTAAAATGG
AAATGCAGAAAGCTGTGAAATGTCTTGTGTCTTATGTTCTCTGTATTTATGCAGCTGATTTGTCTGTCTGTAACTGAAGTGTGGGTCCAA
GGACTCCTAACTACTTTGCATCTGTAATCCACAAAGATTCTGGGCAGCTGCCACCTCAGTCTCTTCTCTGTATTATCATAGTCTGGTTTA

>13141_13141_4_CASC3-ACLY_CASC3_chr17_38324670_ENST00000264645_ACLY_chr17_40024157_ENST00000590151_length(amino acids)=681AA_BP=
MRRARCVSTSPVVAVLRKMADRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSA
EESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKV
GKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDD
IKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGRAGFRPVEAGGQHGGRSGET
VKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTKVGDAVKLAEEVPPPPEGLI
PAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQGGRAKRY
SSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAPLPNPGLYPPPVSMSPGQPP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CASC3-ACLY


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CASC3-ACLY


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CASC3-ACLY


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource