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Fusion Gene Summary | |
Fusion Gene ORF analysis | |
Fusion Genomic Features | |
Fusion Protein Features | |
Fusion Gene Sequence | |
Fusion Gene PPI analysis | |
Related Drugs | |
Related Diseases |
Fusion gene:CASD1-VWC2 (FusionGDB2 ID:13185) |
Fusion Gene Summary for CASD1-VWC2 |
Fusion gene summary |
Fusion gene information | Fusion gene name: CASD1-VWC2 | Fusion gene ID: 13185 | Hgene | Tgene | Gene symbol | CASD1 | VWC2 | Gene ID | 64921 | 375567 |
Gene name | CAS1 domain containing 1 | von Willebrand factor C domain containing 2 | |
Synonyms | C7orf12|NBLA04196|SOAT | PSST739|UNQ739 | |
Cytomap | 7q21.3 | 7p12.2 | |
Type of gene | protein-coding | protein-coding | |
Description | N-acetylneuraminate 9-O-acetyltransferaseCAS1 domain-containing protein 1O-acetyltransferaseWUGSC:H_GS542D18.2sialate O-acetyltransferase | brorinbrain-specific chordin-like proteinvon Willebrand factor C domain-containing protein 2 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q96PB1 | . | |
Ensembl transtripts involved in fusion gene | ENST00000297273, | ENST00000340652, | |
Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 5 X 3 X 4=60 |
# samples | 5 | 6 | |
** MAII score | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/60*10)=0 | |
Context | PubMed: CASD1 [Title/Abstract] AND VWC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | CASD1(94147635)-VWC2(49951630), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CASD1 | GO:0005975 | carbohydrate metabolic process | 26169044 |
Fusion gene breakpoints across CASD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across VWC2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | GBM | TCGA-06-2557-01A | CASD1 | chr7 | 94147635 | - | VWC2 | chr7 | 49951630 | + |
ChimerDB4 | GBM | TCGA-06-2557-01A | CASD1 | chr7 | 94147635 | + | VWC2 | chr7 | 49951630 | + |
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Fusion Gene ORF analysis for CASD1-VWC2 |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000297273 | ENST00000340652 | CASD1 | chr7 | 94147635 | + | VWC2 | chr7 | 49951630 | + |
ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000297273 | CASD1 | chr7 | 94147635 | + | ENST00000340652 | VWC2 | chr7 | 49951630 | + | 10555 | 638 | 173 | 667 | 164 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000297273 | ENST00000340652 | CASD1 | chr7 | 94147635 | + | VWC2 | chr7 | 49951630 | + | 0.015283841 | 0.9847162 |
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Fusion Genomic Features for CASD1-VWC2 |
FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
CASD1 | chr7 | 94147635 | + | VWC2 | chr7 | 49951629 | + | 2.40E-05 | 0.9999759 |
CASD1 | chr7 | 94147635 | + | VWC2 | chr7 | 49951629 | + | 2.40E-05 | 0.9999759 |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for CASD1-VWC2 |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:94147635/chr7:49951630) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
CASD1 | . |
FUNCTION: O-acetyltransferase that catalyzes 9-O-acetylation of sialic acids (PubMed:20947662, PubMed:26169044). Sialic acids are sugars at the reducing end of glycoproteins and glycolipids, and are involved in various processes such as cell-cell interactions, host-pathogen recognition (PubMed:20947662, PubMed:26169044). {ECO:0000269|PubMed:26169044, ECO:0000305|PubMed:20947662}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 1_18 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 19_39 | 117 | 798.0 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 335_363 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 385_395 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 40_313 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 417_439 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 461_461 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 483_486 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 508_513 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 535_547 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 569_605 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 627_638 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 660_671 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 693_698 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 720_725 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 747_770 | 117 | 798.0 | Topological domain | Cytoplasmic |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 792_797 | 117 | 798.0 | Topological domain | Lumenal |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 314_334 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 364_384 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 396_416 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 440_460 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 462_482 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 487_507 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 514_534 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 548_568 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 606_626 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 639_659 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 672_692 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 699_719 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 726_746 | 117 | 798.0 | Transmembrane | Helical |
Hgene | CASD1 | chr7:94147635 | chr7:49951630 | ENST00000297273 | + | 3 | 18 | 771_791 | 117 | 798.0 | Transmembrane | Helical |
Tgene | VWC2 | chr7:94147635 | chr7:49951630 | ENST00000340652 | 2 | 4 | 120_127 | 275 | 326.0 | Compositional bias | Note=Poly-Ala | |
Tgene | VWC2 | chr7:94147635 | chr7:49951630 | ENST00000340652 | 2 | 4 | 153_212 | 275 | 326.0 | Domain | VWFC 1 | |
Tgene | VWC2 | chr7:94147635 | chr7:49951630 | ENST00000340652 | 2 | 4 | 216_274 | 275 | 326.0 | Domain | VWFC 2 | |
Tgene | VWC2 | chr7:94147635 | chr7:49951630 | ENST00000340652 | 2 | 4 | 114_116 | 275 | 326.0 | Motif | Mediates cell adhesion |
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Fusion Gene Sequence for CASD1-VWC2 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>13185_13185_1_CASD1-VWC2_CASD1_chr7_94147635_ENST00000297273_VWC2_chr7_49951630_ENST00000340652_length(transcript)=10555nt_BP=638nt AGGAAGGGGAGGAGACAGGCGTCCAGGGCGCCTGGGGAACCGGCACGGCGGAGCAGCGGCGGCGGGGCTGGGGGGAGGCCGCCGAGTCGG CCGCGGCCGAGGAGGGGCAGGCGGAGGTCGGGGGCGCCGCGGCCGCGGGGTCAGGTTCCCCGGCGGGAGGCGCAGGTGGCGGCCTGGGGA GCTGGCGGCCGCTCCTCGCCTGGCTGCAGCGGCGGCAGCCCCAGTGCTGCCCCTGTGCGGCGCCCCTTTCCCGCTCCGCCGCGCACTGTT GTCATGGAGGAACCAAGATGGCGGCTCTGGCCTACAACCTGGGCAAGCGGGAGATCAACCACTACTTCAGCGTGAGGAGCGCCAAGGTGC TGGCGCTGGTGGCCGTGCTGCTGCTCGCAGCGTGCCACCTCGCCTCCCGCCGCTACCGAGGCAATGATTCGTGTGAATACCTTCTCTCAA GTGGCAGATTTCTTGGAGAGAAAGTTTGGCAACCTCACAGTTGTATGATGCATAAATACAAAATCAGTGAAGCAAAGAACTGCCTTGTAG ATAAACATATTGCATTTATTGGAGATTCCAGAATTCGTCAATTGTTTTATTCTTTTGTAAAAATAATTAATCCCCAATTCAAAGAAGAAG GAAATAAGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCTGCTGGCAGAGAAGTGAAGACTGACGAGTGCACCATATGCCACTGTAC TTATGAGGAAGGCACATGGAGAATCGAGCGGCAGGCCATGTGCACGAGACATGAATGCAGGCAAATGTAGACGCTTCCCAGAACACAAAC TCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGATGACTCTGGGAACTATCAGTCAAAGAAGACTTTTGATGAGGAATAAT GGAAAATTGTTGGTACTTTTCCTTTTCTTGATAACAGTTACTACAACAGAAGGAAATGGATATATTTCAAAACATCAACAAGAACTTTGG GCATAAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAAGTACACAAAAGTACACTATTATATATCAAATGTATTTCTATAATCCC TCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGATTAAAAATGCTGTGTTGTCAACCGTCCTCACCGTGTACCTGCATATCTT TTTCAGTTCTGATTCCATCACCCAGGAATGTTCCCCCTGCACATTTTCACAGGGCAGAGTCACGCATGAATGGATCATAAGATATTAGGA CCAATTTCCACTGAAACCCTGTTTAAATTCTATTTAATTACAGACATATCTCTAATGTTGATGTCTACTTCACATAAATATATTTCCTTT TTATAATAATATATGGCTTTTATCTGCTTCATTCTCAGTCACTTGTGAAATGCAGGTGTAAAGATCACTAACTCACACTTTCTCAGTTCT TTCCCCTAAGCTCCTGTATTGTACACCATAGGTAAGCACATACATATATTTCATTCTTATTTACATTATTTTCTCTTCTAAGGATAACTT TAATTCATTCCCTAAACTGAGGAATAAAGTAGGCTGGAAAATTTGCATTACTGTTCCATCAAGCTGAAGCAGACAACAAAATAGGGGAGG AGTCCTTCGATTCTCCTAGGATAGTTAAGGAAAATCAAACTCCTAAACAAGTTTATATACCTGAAATCTAAATGTGCTACAGATAACTCA GCTGTCAGTTCAGTGGAATCATATTTGTCATCAGACTTGAGTCATCTATCCTCCATAAACTACACAGTAAAATCTTGACTGATAACCTTG AATTAGCCACCCTTCACAAGCAGAGTGAGGAAGCAGTTATTTTGTTAAAACAAAGCTGAAGACCAAGTGCACTCCACAACTTTCCTATAG TTATAATTCCAAACCAACTTCTTTTCTCTTCATTTGAACAGAGAACATAAAAAGCCACTGCAAAGTCCTGCTAATCTAATTAATGCATAA TAGAAAATAGTTCTACCTTTATCAATCATATCAGCATGCGGTGTGTTGATGAAAGAGGTAATTGGAGTCTTAATAGGTGTAGGATAAAAA AAGCAAAACTATAATCACTATTAATGTCTTTAAAGGATTAAAATATATATAATCATTATTTGAAGCCTCTAAAGGTATTTTTCATATTTT TGTTTATTCTGAAATTTTGCATTAAGAACCTATTAAGTACAAAGCATTGACAACAAGGGAATAAGGCTTGATTTCTTGCCTTCTTGGACT TTCGGTCTCTGGCATAAGAAGTATATGAAATCATAATGTATTGTATTAGGAGCCAAACTAGAGACCAGCAAATGGAGATTAGAAAGCCTT CCTAATGAGAAGATGGAGAACATGAAAAAATCATTATATAAAAAATAATTCAATCATTAAAGACTGAATAACATTCAAGAAAAATGGATA CATCTATCATAATTGAAAAATTAAACTATTGTGAACCTTAGTAAGTATAAAGATGCCACTGACTGAGTCATCAAAACACTACATATAGTC ATTTAATTTTTGTCTTGTTCATAAAGAACACCTTGAGCCAAAGGAACTACCAGTACATAGATTTCATGAAAATACTCAGGGGAATTATTA GCTAATTGTTCTCAGGTGTAATCAGCTTTCCAAAATTTAACCTTTGTATTAAAGACTGGTAGACATTGGCCATCCCTCCTTTATTCAAGG ATGGATTGTTTGAGACACAGTTATTTAAAGTTGTCGTTTTGCTAATAAATGGCCCTAGCCCCCATGGGTAGGTGGGCCATTAGTAACCTC TTCTCTCTCCATCAGGCATGATGCAGTTAGAGACTCAGTCCATGCAGCTCAAAGTCTTCCTGTTTCCCTTAATAATAATTCCTACCAGAA TGGATGATGAGCTCTGAAATAATTGCAATGGTGTTTTCAATGCTGTGAGAATTTCAGAAAACCTAGTATTTTGTTGCATATAGAGAGAAT GAACCCAGTATCATCTTGGGAAGTTAACTGACTCACTTGCTCTAAACTTAGTTTGACCTGCAGGGTCACCAGCACACACTCCTAAGAGCT AAAGCTCAATGGCTGTTATTACACCAAAGTAACTCCCCTCCCCATCTCTGATTTCAACCCCCTCATTCCTCTCTCCTCATAGAAATAATG CATAAACCAAACACATGGAAGAACTTGGATTTTTGACACTGTATATACTCATTAATAATAATGGCATTATTTGCATTTTTGTCCAAGATC AACTTCTTCTTGCAGTTAGACTTTCACAAATACATAGCTATCTCAGATTGACATTCTATTTTCCTCCCCTCTGTTGTCAGAGAACTCTTT GCTGAGATTGTCAACAACAAACTGTTCTATTCAATAAATAACCTGAATAACTGCCCAATAAAAAAGGAAAGTATAAGTTACTCAATTTCA AAATAATATGGTTTGGAGATAGCACAGAAAAGGGGGCCTCAGAATTCAAGTATAGAAGTTCTGGAAAAGCCATAATCACTAAAATTCAAA TAGGCCTGCTCTATAAGTACCTAATAATTGTTAAATGATTTGTTCAAGTTAATAAACTAAATCGTGCTTACAAATGTATTAATGAATTTA TTTCAAATTTTCAACCCATATTTAGATCTGAAAGTATAAAGCTACTTATGTAAGCAATAGAATGGTTCTGGAAATTATCTGATGTCTTAG AGGTTTTCAAGTTAAATTCATTCTTTCAGTGATAGGATATTTACTTGTTGGGTGGATTAACAATACTTTTTATTGACATTTCCCAGAAGT CTTGAGAAAAGTCATTTCAAAAACTTGTATTTCATCCCTGCATGCAAGAAGTATTAGATGCACTCCAGTCCAGGCAAGTCCTGCTATAAT GTTGCAGCTAGTGCAGATGGAGAGGCACAGTGTCCTTGACATCAAGGGGTCTGTAAGCCTTGAAACTAATTTAGGTTTGATTATAATACT TTTAATCTTTTGATACTTAGAATTTCATCACCTGCTTTGTGCAGTAAAACATGCTAAGAAGAATTATCATGCAGTTTTAAGTTCATAACA TCAATAATATGTTTAATAAACTTTCTTCCCTCGTTCTCCAACATAAATGTTGCATTTATATAAGGTTAAAAGTCCTAAAAAATCATAAAA TTCAGATGTTTAATTTTTGTTTTTAAGCAGTGAAATGGGTTTTTAAATGTATACATTATCTGAAACTTACAAAATATACACTGTTTCAAA CAAGCATTGTTGGAAACTAAATCCATTATTTTAAATGTGGACTATTTAAACATGTAGAAAACAAAATTATAGACATAAACTATGATTTTA AAAATATTAACAATTTGCTAAATTTGCTTCAATGGGCAAGAGATCAATCCTACTTTTCATTGTTATTTTTAATATCATATTTTTCCCCAA CATAATGTTATTATGAAGAGTATCAGATGTACAAATAAGCATCATTGGTAAAAACATACATGCTTCTTTGGCCAACATAATTTGTAACTG TCTTACTGAACCTACTTACCTACTATATTTTTTTTCCTCACTAGTAGCATCTGATGGTTGATACAGTCAGTAACTATTCTGAAGAATCAG ATTAAGAGAGAACAATTTACTTATTCAGGAATAAGTGCATTTTTACAGTACATATTTTTCACATTTCAGCTGCAACTTCCAAAGATCAGG TTCTCATTGCTCCGTAGCACAGATTAAACAGCCTACTTATGTCATATCCTCACTTCACACCAACTTCTTCAGTCTATTATTTTAGTTTTC TAAATGTAGATCTAGTTTTCAACTGAATTCTTTGAGGATCGCAATCACACACAAAATAACATCCAAACTCCTCAACATGGAAGACTGGTG TCTTCACAATTAGATCATGGACAACACCATGACCCAGGCCCCTGTGGCTGGTGAGACTTCTGGGCCCTGGGTACCACAGACTATACTCTA AACATGGTCTTTACTATCTCAGATCCTGCCCTGAGTGTCCTTTGCAGCATGTTGAGTATTAGCCATTTTCAATGTCCAGTTCAAGTGCCA TTGCTGGTAAGGCTTCTGTAGTTCTTATTGGAAGAATTGTCACTCTATGTCCCAGTAATAGTACTAATTTGGTTTCTTATTTTAACATAT CATTTAGGAATCATACCATAGTTTGCATAATGGTTAATTTTATGCCTGCTTCTTCTATTATTTACAAATCCCTTTAGTTTGGGCTGTGAA ATATTCAATTCCCAAAACATCACCCAATATCTATATGTTAAAGGCTTGTTGAATTGTATTCCATCTATTAGTTCAGAGTTATTTGCTATT CTTGTTTAAGGACAATGTATGTATTAAAGAGCAACTAAAAACTCCCATTACTGTTTGCCAACCCAGTTGTCTTTTGATTTCTCTGTCAAC TTACAAGTATCAAATATCTAAGTCACAGAACCCAGAGACACATCAAATACCCCAAATACCCCATGGTAGTTTTCGGATGAACTCTGACAG CTATTGGCCATTTCTGGTGCAAGTCAGAAAAAAATTGCTTTTAGTGTGAAATTTTTGATGCTGAAGAAAGTTGATTGTATTGAAGAGACA CTGGCCCTTTATGATAAAGGAAGTCAAGTTTACAGTTTTGATATTTGTTTACTTTCTTATTTCTAATTTTTGGAAAACAATTTTCTTAGA CTTTCATTTGTGATATTGATCATTTCTGTGTGTTTTAATCTTTCTACATAACATAATTAAACACCTCAGTAGGTATCTAGTGAACTGATA CAATAATGAGCTGAGTCATTTGTACAGAAATATAGTAGCTTCCATAATCTGAATGATAACCATTTAAAAGTGATGGTTGTTGAAATTTTA CTGTAGTGTCAAATTTCACTTTAAATTTTGCAAAGCACCTGCTATTCTAGCCTTAACACAAAGATTTGGCTAATTTTTAAATGAACAAAT CCCATTGAATATTAAGTGACACTGACAATCACCCTGAAAAGTATTCAGCCAAAGTTTCAATAGAATTAGGAAACTTAAATGAAAATGTGC TCTCAGTGCTTGGCCCATGAGCAGTTTATGATTTAAGACGTGCATACTGTTTAACTCTTTCCTTTAAAGTTCAGAAAAGTACATAAAACC TCTGGCTGACCTATTATATAGGCACAGAATTATCAAAAGCAATCAAAGTATGTACCTAAAGTCAATTTAGTATATTATGAATACAGCCTG ATGACTAAACACAATTGCAAATATTGCGACTTTAGTTTTTAATTCAATTTTCAGCAAGTAGAAATATTTCTCAATTTTATTTGGTATCTA ATTATATTAAGACCAACATATACATTAAAGTGTATTTAGATGATTAATATTTAATGATCATTATTTTATTTAATGATTAATATTTTCTAT TATTTGAATTTCTGTAATTTATGTTTTAGAAAGAACTGTTTCCAAACACATTTTATGGAAAGATTTCATTTTTCCATTCCCTTTACTTTT ATATTTACATTGTCAAATAAATACAATTCTATTTTCATTTCTATTAGTTTTCAGGGTTTATTCTTTTCCTAAGCATATAATTCTTATAAT GGAAAAAAGTGAAAAGTATCCAGTAAGTAATATACACCTATGAAACTATTAATGTTCTTTATACTACCAAGTAGTTTCATAGTTTTAAAA AGCCATTCTTAAGCAGTCGGTGAATGTATATCATCGGCCAAAAGTTATGCTAGGTTTCCTTCACTTATTATCACATTTAACCTCACAGTT CTCCCAAATTGTGGGTAATGCTATCCCCTTTGTTGCAGAAAAGTAAATATAGGCTCAGGGAAATTTAAAAACTGCCTTAAGATTCAGTCT AGTGAATGAGAGGCTGAGTTAAGAATCCAAATCTGCTTTATATCAGAGCCCGTGATTTGAAGTCTTATCATTTGTGTTTAGGTCAGGGAC CTCTAGAAAATAGACAGAAATTTCCAAAATGGTCTTTTACCCCACTCCCCATAAATAAGATAATGAATAGCAACACTGATCCCTAATTCT AGAATATCAATCTTGATACTTGTCAAAGTAAATAGTAGCTCGTCACAAAAATGTTGTAGCCTCCCTAGTCTAAATGCTTATGCTATATTT TGTTTCCTAAATCTAGAGATCTCTTTTTAAAAATAGTATTGAAGCATCAGGTTGTTCAGGTATGATTCTCATATTGAAATTTACAAAATA TAACCAAATATTGTGACCCAGTTTTTCTGGAGCCAAGAGAAGTAAACTGCCATTTATTAGGTGATGATTATAGGGCAAACACTACAATTT CAAATTTCATATTCTTTTATCTGATTTATTCATTTTATCAACTCTGCTATATTGATGAAGAAGTCAACATATGGTGGGTAACTTATCCAA ATTTCAGTGATGGGCTGGGCGTGGTGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGCAGGTGGATCAGGAGTTTGAGGCCAA CCTGACCAACATGTGAAACCCCATCTCTACTAAAAATACAAAAAAATTACCTGGGCATGGTGGCACATGCCTGTAATCTACTCGGGAGGC TGAGGCAGGAGAATCCCTTAAACCGAGGGGGTGGAGGTTGCTTGAGCCGAGATCGCGTCACTGCACTCCAGCCTGGGTAACAGAGCAAGA CTCTGTTTAAAAAAAAAAAAAAAATCAGTGATGGAACTGAGGCCAAATCTGTCTGGTTCCAAAGCTATCCTACATGGGGCACAGTCAGGA CTGGAATGGATAGCTCTACCTGCTTCCAAATATTCTTCCCTGGGGAGCAGCTGTGAGTCTTACTGAATCGATTTATTCATTGCATTCTAT GTGTCAACTGCAATTTAGACCTGGGTGATAGAGTCATATATGGTCTTTGGACCCATGAAGCTCTGAGTCAAGGATACCAGCAGATATCCT TAAACTAATAAAAAAAGCGATGGCATCACATGCCATTTTGAACTTTTGCATTAAAGTCATAAACTTACATCAGTATTATGATTTATACTT TTAAGCAAAATTTTGCCATTTTCTGATACATAGTAGCTAGCTAGTGATAAAATTATGAAGTTACCATTGTATGTTCCAATGACATAAAAA ACTAAGTGCCTGCTTGGGCTAGTTATACTCTGCAGTATACCCTGGTTTATTGTGAGGATTAAATAAAAAATCCTCACAAACCCCAATTTA ATTTAATATAGATTAATTATAAAAATAATCTACCCATGTTACATAATGTTAAATCTGTAGTTTCAAGGTGTATGCTATTTCTTAAAACAA AAACAAAGATTGTCCCCACTCCAAACAATAACAGCAATGGTGAAGGTTGTGGGTGGACAGAGGTAGTCCCACTCATCCCCAGGGGGCTCA GCTGCCACCGGCCAGGTCTATCTATTGCTCCCACCTGCTCTGACTGTTTTCTCTCAAGAAAAAGATTTTCATTTTAAGATAGGCATCAGT GCAATAAAGGAGCTTGATACAAAAATCATTATGTTCTATATATGTTTTTGTAGGTTTTAGATTAATTATGGCCAACTGATACCTTAAAAT ATTTGTTACAAATAACACTGAAGTGAGATTCAAAATTGTGCCTTCTATTGAAGCCAAGAAAGTAAATGTCTTTAAAATAAACATAATGGT GTTTTTTTTTGGTACAATAAACAGCATACCTACATTTCAGAGGACAAATCATGTTATTATAATAACCAGGAGAGAAAATAAAAGGAGACA TTAATTTGGATATGGAAGCAAAATGGAACAGAGCAATATAGAGCAAAACAGAGGTTTGTCTGAAACATTTAAAATATTAAGAAGTATGAC TAAAAAACTCAAACATTTTAATACACGATGAATCCTTTTCTTAAGGAAAAAATGAAAATAATAAAAGTGGTATTTGGATGAGATAATTTT CCTTTAAATTTATTCCTCAGAATGATGTAAATTTTCCAGCTGGAAGGTCATCTTTCTATACATGCATGCATCTATACAAATGGTTAAACA GTTACTCTCTCAATTTGCTGTGATAGGAAAGGTGGATATAAATATAAGCAAGGGTCTGATTAAAACAAAACAAAACAAACAAAAGACAAG AGAAGCACTGCATTGTTGGCAAGAAATTCCTTTTAAGTCAGACTTAAGTCCACGGAAAGCTGGACCTAAGCAGTGAAGGATGTAAGGGAA CAGAGAGAGACTCTGCTTGGCCGAGTTTGCTATTCTCATTTGTCTATGTCAATACGGCTACATAAAGTTCACAACTATTTGCACATAGCT ATAAATATAGCATGAATAAAACACATATGTATTTAATTGTGTTATTTACTATTTATAATTTGAATTGTTTAAAATAATTTTAAATACTTA TTCCATAAACTCAGTATTTGAAAACTTAAAAAAAAAGTCATTTTAAATAACATCATTTACCAAGTCTGTGTGATGCTTTACAAGGTACCT GATGAATGTAAAATTATAGCTTTTTGTCTTCATTTCTAATAGACTGTTATAGGGGAAATGTACTAAAATGTTGTACTTATTACATTTATG AATTTCTGACAGTTTCTATAGACTGAGAATAATGATATGCTTTTATAAATTATTTGGTGAAAGTTTTCCAGTAAGTGTTCATGTCCTGTA CAAATTTATTAAACAACATCAATTTTACCTAACAACTGTAACCACTAATAAATCATCAGTCACCACCTTTCCTGCATATCTGACAGATGG AGAACACTGTGCTTAGTGTTGAAGATACCAAAGGGAATTCAAGTGAGGGGAAAAGAGGAGAGCAAACTGATCAAAAGGGAATGCCCATGA TGCTTTCAGGAAACCAGGGTGAGAACATGCTGGCTGGAGGATGGGTCTGGTTTCCAGCAGAGATGATAGGAGTTAAAAGGCATAGGTGAG TTGTTCCCATCCCTGGCCTGAGCCTTACTCCATAGCTATAGAGACATAGTCTCTAGAAACAAAGGCCAGAGCATCCTTTTAACATTTATA TCATAAGTATTCTCAATAAACGTTTGCAATTTATTTGCTTTAATGTAACTTGGCAGTAAAGACTTTGGCCTTTGGAGGTCTGATTCTAAT CCCAGTTCTACCACTTACTGGTTATTTATCAGGTACACGTTACCTACCTCTCTGTAACTCAGATTGCTCATCAGTAACATGGGGAGAGTG GTATCAACCACTAAGAGGATTAAATGAGTGAATATTTGTAAAACACGTAGCCTAGAATAGATATTTATAAAGCACAAGATCTATGTAAAG TGTTTATAACATAATACATTGGAATATGAGACTTGAACATTTTGAAGATTCTAATAAATGAATAATTTAATTTAGTGCTCATTTGAAAAA TATTTTATCCTCATGTTTACATTTAACACATATAATTTATATCTTAGTTTTTATCCCATTTATATATATATTTACCAGAAAAATGTTTTG TAATACCTTAATTTTATGTGGAGTTGAATTTAAATAATTAGGCCGAATTTGTATGTATTGTTGGATGGGTATGTGTATTGACCTGATTTA >13185_13185_1_CASD1-VWC2_CASD1_chr7_94147635_ENST00000297273_VWC2_chr7_49951630_ENST00000340652_length(amino acids)=164AA_BP= MGSWRPLLAWLQRRQPQCCPCAAPLSRSAAHCCHGGTKMAALAYNLGKREINHYFSVRSAKVLALVAVLLLAACHLASRRYRGNDSCEYL -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for CASD1-VWC2 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for CASD1-VWC2 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for CASD1-VWC2 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |