FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CASK-FHL2 (FusionGDB2 ID:13193)

Fusion Gene Summary for CASK-FHL2

check button Fusion gene summary
Fusion gene informationFusion gene name: CASK-FHL2
Fusion gene ID: 13193
HgeneTgene
Gene symbol

CASK

FHL2

Gene ID

8573

2274

Gene namecalcium/calmodulin dependent serine protein kinasefour and a half LIM domains 2
SynonymsCAGH39|CAMGUK|CMG|FGS4|LIN2|MICPCH|MRXSNA|TNRC8|hCASKAAG11|DRAL|FHL-2|SLIM-3|SLIM3
Cytomap

Xp11.4

2q12.2

Type of geneprotein-codingprotein-coding
Descriptionperipheral plasma membrane protein CASKcalcium/calmodulin-dependent serin protein kinasecalcium/calmodulin-dependent serine protein kinase (MAGUK family)calcium/calmodulin-dependent serine protein kinase membrane-associated guanylate kinaseprotein linfour and a half LIM domains protein 2LIM domain protein DRALaging-associated gene 11down-regulated in rhabdomyosarcoma LIM proteinskeletal muscle LIM-protein 3
Modification date2020032720200327
UniProtAcc

O14936

Q14192

Ensembl transtripts involved in fusion geneENST00000318588, ENST00000361962, 
ENST00000378154, ENST00000378158, 
ENST00000378163, ENST00000378166, 
ENST00000421587, ENST00000442742, 
ENST00000472704, 		ENST00000322142, 
ENST00000336660, ENST00000344213, 
ENST00000358129, ENST00000393353, 
ENST00000408995, ENST00000409177, 
ENST00000409807, ENST00000607522, 
ENST00000393352, 
Fusion gene scores* DoF score13 X 12 X 5=7807 X 3 X 5=105
# samples 149
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/105*10)=-0.222392421336448
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASK [Title/Abstract] AND FHL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCASK(41598636)-FHL2(105990190), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASK

GO:0010839

negative regulation of keratinocyte proliferation

18664494

TgeneFHL2

GO:0000122

negative regulation of transcription by RNA polymerase II

15692560

TgeneFHL2

GO:0043066

negative regulation of apoptotic process

15692560


check buttonFusion gene breakpoints across CASK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FHL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8532CASKchrX

41598636

-FHL2chr2

105990190

-


Top

Fusion Gene ORF analysis for CASK-FHL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000318588ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000318588ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000361962ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378154ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378158ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378163ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000378166ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000421587ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
5CDS-intronENST00000442742ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000318588ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000361962ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000378154ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000378158ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000378163ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000378166ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000421587ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
In-frameENST00000442742ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
intron-3CDSENST00000472704ENST00000393352CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000322142CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000336660CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000344213CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000358129CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000393353CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000408995CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000409177CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000409807CASKchrX

41598636

-FHL2chr2

105990190

-
intron-intronENST00000472704ENST00000607522CASKchrX

41598636

-FHL2chr2

105990190

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000421587CASKchrX41598636-ENST00000393352FHL2chr2105990190-1594453241136370
ENST00000318588CASKchrX41598636-ENST00000393352FHL2chr2105990190-1616475461158370
ENST00000361962CASKchrX41598636-ENST00000393352FHL2chr2105990190-1616475461158370
ENST00000378163CASKchrX41598636-ENST00000393352FHL2chr2105990190-20459044751587370
ENST00000378158CASKchrX41598636-ENST00000393352FHL2chr2105990190-19217803511463370
ENST00000378166CASKchrX41598636-ENST00000393352FHL2chr2105990190-1597456271139370
ENST00000442742CASKchrX41598636-ENST00000393352FHL2chr2105990190-1589448191131370
ENST00000378154CASKchrX41598636-ENST00000393352FHL2chr2105990190-20459044751587370

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000421587ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010360170.99896395
ENST00000318588ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010568980.99894315
ENST00000361962ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010568980.99894315
ENST00000378163ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0034282970.99657166
ENST00000378158ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0025443330.99745566
ENST00000378166ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010582410.9989417
ENST00000442742ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0010210320.998979
ENST00000378154ENST00000393352CASKchrX41598636-FHL2chr2105990190-0.0034282970.99657166

Top

Fusion Genomic Features for CASK-FHL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CASK-FHL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:41598636/chr2:105990190)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASK

O14936

FHL2

Q14192

FUNCTION: Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O70589}.FUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-52618_26143910.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-52718_26143927.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-52718_26143922.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-52518_26143898.0Nucleotide bindingATP
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-52618_26143899.0Nucleotide bindingATP
TgeneFHL2chrX:41598636chr2:105990190ENST0000032214227101_15352280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000032214227162_21252280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000032214227221_27552280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000035812938101_15352280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000035812938162_21252280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000035812938221_27552280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335216101_15352280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335216162_21252280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335216221_27552280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335316101_15352280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335316162_21252280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000039335316221_27552280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000040899516101_15352280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000040899516162_21252280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000040899516221_27552280.0DomainLIM zinc-binding 4
TgeneFHL2chrX:41598636chr2:105990190ENST0000040980716101_15352280.0DomainLIM zinc-binding 2
TgeneFHL2chrX:41598636chr2:105990190ENST0000040980716162_21252280.0DomainLIM zinc-binding 3
TgeneFHL2chrX:41598636chr2:105990190ENST0000040980716221_27552280.0DomainLIM zinc-binding 4

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-52612_276143910.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526343_398143910.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526402_455143910.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526489_564143910.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526612_682143910.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526739_911143910.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-52712_276143927.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527343_398143927.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527402_455143927.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527489_564143927.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527612_682143927.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527739_911143927.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-52712_276143922.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527343_398143922.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527402_455143922.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527489_564143922.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527612_682143922.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527739_911143922.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-52512_276143898.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525343_398143898.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525402_455143898.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525489_564143898.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525612_682143898.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525739_911143898.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-52612_276143899.0DomainProtein kinase
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526343_398143899.0DomainL27 1
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526402_455143899.0DomainL27 2
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526489_564143899.0DomainPDZ
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526612_682143899.0DomainSH3
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526739_911143899.0DomainGuanylate kinase-like
HgeneCASKchrX:41598636chr2:105990190ENST00000378158-526305_315143910.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000378163-527305_315143927.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000378166-527305_315143922.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000421587-525305_315143898.0RegionNote=Calmodulin-binding
HgeneCASKchrX:41598636chr2:105990190ENST00000442742-526305_315143899.0RegionNote=Calmodulin-binding
TgeneFHL2chrX:41598636chr2:105990190ENST000003221422740_9252280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000003581293840_9252280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000003933521640_9252280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000003933531640_9252280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000004089951640_9252280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST000004098071640_9252280.0DomainLIM zinc-binding 1
TgeneFHL2chrX:41598636chr2:105990190ENST00000322142277_3152280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000358129387_3152280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000393352167_3152280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000393353167_3152280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000408995167_3152280.0Zinc fingerC4-type
TgeneFHL2chrX:41598636chr2:105990190ENST00000409807167_3152280.0Zinc fingerC4-type


Top

Fusion Gene Sequence for CASK-FHL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13193_13193_1_CASK-FHL2_CASK_chrX_41598636_ENST00000318588_FHL2_chr2_105990190_ENST00000393352_length(transcript)=1616nt_BP=475nt
CCGTTTTCGAAGCCCTCCACGCTGCGGCCGCTATCCCCTCCGGACCATGGCCGACGACGACGTGCTGTTCGAGGATGTGTACGAGCTGTG
CGAGGTGATCGGAAAGGGTCCCTTCAGTGTTGTACGACGATGTATCAACAGAGAAACTGGGCAACAATTTGCTGTAAAAATTGTTGATGT
AGCCAAGTTCACATCAAGTCCAGGGTTAAGTACAGAAGATCTAAAGCGGGAAGCCAGTATCTGTCATATGCTGAAACATCCACACATTGT
AGAGTTATTGGAGACATATAGCTCAGATGGAATGCTTTACATGGTTTTCGAATTTATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAA
GCGAGCTGACGCTGGTTTTGTGTACAGTGAAGCTGTAGCCAGCCATTATATGAGACAGATACTGGAAGCTCTACGCTACTGCCATGATAA
TAACATAATTCACAGGGATGTGAAGGACTTGTCTTACAAGGACCGGCACTGGCATGAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTC
ACTGGTGGACAAGCCCTTTGCTGCCAAGGAGGACCAGCTGCTCTGTACAGACTGCTATTCCAACGAGTACTCATCCAAGTGCCAGGAATG
CAAGAAGACCATCATGCCAGGTACCCGCAAGATGGAGTACAAGGGCAGCAGCTGGCATGAGACCTGCTTCATCTGCCACCGCTGCCAGCA
GCCAATTGGAACCAAGAGTTTCATCCCCAAAGACAATCAGAATTTCTGTGTGCCCTGCTATGAGAAACAACATGCCATGCAGTGCGTTCA
GTGCAAAAAGCCCATCACCACGGGAGGGGTCACTTACCGGGAGCAGCCCTGGCACAAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCA
GCTGTCTGGGCAGCGCTTCACAGCTCGCGATGACTTTGCCTACTGCCTGAACTGCTTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTG
CACCAACCCCATCAGCGGACTTGGTGGCACAAAATACATCTCCTTTGAGGAACGGCAGTGGCATAACGACTGCTTTAACTGTAAGAAGTG
CTCCCTCTCACTGGTGGGGCGTGGCTTCCTCACAGAGAGGGACGACATCCTGTGCCCCGACTGTGGGAAAGACATCTGAATTCAACACAG
AGAAGTTGCTGCTTGTGATCTCACACACAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATT
GAGACTTTCTTCTAGTGCTTTTCAGTGATACTCACGTTTGCTTAAACCCTTTAGTGCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAA
CTCGCCCTAGGCCCTAGGTGGGAAGATGGTTTGAAATTTTTGTAATCGAGTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCC
TTTATAAATCTTTCTCTCACTGTCTATTTAAGTGCAATTAACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCA

>13193_13193_1_CASK-FHL2_CASK_chrX_41598636_ENST00000318588_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------
>13193_13193_2_CASK-FHL2_CASK_chrX_41598636_ENST00000361962_FHL2_chr2_105990190_ENST00000393352_length(transcript)=1616nt_BP=475nt
CCGTTTTCGAAGCCCTCCACGCTGCGGCCGCTATCCCCTCCGGACCATGGCCGACGACGACGTGCTGTTCGAGGATGTGTACGAGCTGTG
CGAGGTGATCGGAAAGGGTCCCTTCAGTGTTGTACGACGATGTATCAACAGAGAAACTGGGCAACAATTTGCTGTAAAAATTGTTGATGT
AGCCAAGTTCACATCAAGTCCAGGGTTAAGTACAGAAGATCTAAAGCGGGAAGCCAGTATCTGTCATATGCTGAAACATCCACACATTGT
AGAGTTATTGGAGACATATAGCTCAGATGGAATGCTTTACATGGTTTTCGAATTTATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAA
GCGAGCTGACGCTGGTTTTGTGTACAGTGAAGCTGTAGCCAGCCATTATATGAGACAGATACTGGAAGCTCTACGCTACTGCCATGATAA
TAACATAATTCACAGGGATGTGAAGGACTTGTCTTACAAGGACCGGCACTGGCATGAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTC
ACTGGTGGACAAGCCCTTTGCTGCCAAGGAGGACCAGCTGCTCTGTACAGACTGCTATTCCAACGAGTACTCATCCAAGTGCCAGGAATG
CAAGAAGACCATCATGCCAGGTACCCGCAAGATGGAGTACAAGGGCAGCAGCTGGCATGAGACCTGCTTCATCTGCCACCGCTGCCAGCA
GCCAATTGGAACCAAGAGTTTCATCCCCAAAGACAATCAGAATTTCTGTGTGCCCTGCTATGAGAAACAACATGCCATGCAGTGCGTTCA
GTGCAAAAAGCCCATCACCACGGGAGGGGTCACTTACCGGGAGCAGCCCTGGCACAAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCA
GCTGTCTGGGCAGCGCTTCACAGCTCGCGATGACTTTGCCTACTGCCTGAACTGCTTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTG
CACCAACCCCATCAGCGGACTTGGTGGCACAAAATACATCTCCTTTGAGGAACGGCAGTGGCATAACGACTGCTTTAACTGTAAGAAGTG
CTCCCTCTCACTGGTGGGGCGTGGCTTCCTCACAGAGAGGGACGACATCCTGTGCCCCGACTGTGGGAAAGACATCTGAATTCAACACAG
AGAAGTTGCTGCTTGTGATCTCACACACAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATT
GAGACTTTCTTCTAGTGCTTTTCAGTGATACTCACGTTTGCTTAAACCCTTTAGTGCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAA
CTCGCCCTAGGCCCTAGGTGGGAAGATGGTTTGAAATTTTTGTAATCGAGTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCC
TTTATAAATCTTTCTCTCACTGTCTATTTAAGTGCAATTAACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCA

>13193_13193_2_CASK-FHL2_CASK_chrX_41598636_ENST00000361962_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------
>13193_13193_3_CASK-FHL2_CASK_chrX_41598636_ENST00000378154_FHL2_chr2_105990190_ENST00000393352_length(transcript)=2045nt_BP=904nt
GCCGCCGCCACCTCCCTCCGCGGCGATCCTCGCTCCATGGTCCTGCCGCGGCCCCCTCTGTAGCCCGAGCTGCTCCGCGACGCGACGGAG
CCGGCCTCGGACAGAGGGAGCGGTCGCGGCCTCGCGGCCCGCGCGGGCTGACGAGCGGAGAGCGCGACGCCGCGCGGTCCCCGAGGATCC
GCACGCCGGGCAGCGCGGCCCGAGCAGCGCGAGAAGCAGCGGGCGGGCGGGCGGCGCCGGGCCCGGGCCGCCCTCGCTCCCGCGCCCCGG
CCCCGCCGCCCGCGCCGGGGCGGTCGCCTGCAGAGGAAGGCGCCGCAGTCTCTGGGCCTCGCGGCCCCACTCGAGCGTCCTCGGCACCGA
GGGCTCGCGGGTCCTGAGGGGAGGAGGCGATCCCGGGGCTGGGCACTGAGCTCTTGGGCGCCCCCACCCCCGTTTTCGAAGCCCTCCACG
CTGCGGCCGCTATCCCCTCCGGACCATGGCCGACGACGACGTGCTGTTCGAGGATGTGTACGAGCTGTGCGAGGTGATCGGAAAGGGTCC
CTTCAGTGTTGTACGACGATGTATCAACAGAGAAACTGGGCAACAATTTGCTGTAAAAATTGTTGATGTAGCCAAGTTCACATCAAGTCC
AGGGTTAAGTACAGAAGATCTAAAGCGGGAAGCCAGTATCTGTCATATGCTGAAACATCCACACATTGTAGAGTTATTGGAGACATATAG
CTCAGATGGAATGCTTTACATGGTTTTCGAATTTATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAAGCGAGCTGACGCTGGTTTTGT
GTACAGTGAAGCTGTAGCCAGCCATTATATGAGACAGATACTGGAAGCTCTACGCTACTGCCATGATAATAACATAATTCACAGGGATGT
GAAGGACTTGTCTTACAAGGACCGGCACTGGCATGAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTCACTGGTGGACAAGCCCTTTGC
TGCCAAGGAGGACCAGCTGCTCTGTACAGACTGCTATTCCAACGAGTACTCATCCAAGTGCCAGGAATGCAAGAAGACCATCATGCCAGG
TACCCGCAAGATGGAGTACAAGGGCAGCAGCTGGCATGAGACCTGCTTCATCTGCCACCGCTGCCAGCAGCCAATTGGAACCAAGAGTTT
CATCCCCAAAGACAATCAGAATTTCTGTGTGCCCTGCTATGAGAAACAACATGCCATGCAGTGCGTTCAGTGCAAAAAGCCCATCACCAC
GGGAGGGGTCACTTACCGGGAGCAGCCCTGGCACAAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCAGCTGTCTGGGCAGCGCTTCAC
AGCTCGCGATGACTTTGCCTACTGCCTGAACTGCTTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTGCACCAACCCCATCAGCGGACT
TGGTGGCACAAAATACATCTCCTTTGAGGAACGGCAGTGGCATAACGACTGCTTTAACTGTAAGAAGTGCTCCCTCTCACTGGTGGGGCG
TGGCTTCCTCACAGAGAGGGACGACATCCTGTGCCCCGACTGTGGGAAAGACATCTGAATTCAACACAGAGAAGTTGCTGCTTGTGATCT
CACACACAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATTGAGACTTTCTTCTAGTGCTTT
TCAGTGATACTCACGTTTGCTTAAACCCTTTAGTGCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAACTCGCCCTAGGCCCTAGGTGG
GAAGATGGTTTGAAATTTTTGTAATCGAGTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCCTTTATAAATCTTTCTCTCACT
GTCTATTTAAGTGCAATTAACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCAGTTGTTATTTACAGCTCTGTA

>13193_13193_3_CASK-FHL2_CASK_chrX_41598636_ENST00000378154_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------
>13193_13193_4_CASK-FHL2_CASK_chrX_41598636_ENST00000378158_FHL2_chr2_105990190_ENST00000393352_length(transcript)=1921nt_BP=780nt
CGGCCCGCGCGGGCTGACGAGCGGAGAGCGCGACGCCGCGCGGTCCCCGAGGATCCGCACGCCGGGCAGCGCGGCCCGAGCAGCGCGAGA
AGCAGCGGGCGGGCGGGCGGCGCCGGGCCCGGGCCGCCCTCGCTCCCGCGCCCCGGCCCCGCCGCCCGCGCCGGGGCGGTCGCCTGCAGA
GGAAGGCGCCGCAGTCTCTGGGCCTCGCGGCCCCACTCGAGCGTCCTCGGCACCGAGGGCTCGCGGGTCCTGAGGGGAGGAGGCGATCCC
GGGGCTGGGCACTGAGCTCTTGGGCGCCCCCACCCCCGTTTTCGAAGCCCTCCACGCTGCGGCCGCTATCCCCTCCGGACCATGGCCGAC
GACGACGTGCTGTTCGAGGATGTGTACGAGCTGTGCGAGGTGATCGGAAAGGGTCCCTTCAGTGTTGTACGACGATGTATCAACAGAGAA
ACTGGGCAACAATTTGCTGTAAAAATTGTTGATGTAGCCAAGTTCACATCAAGTCCAGGGTTAAGTACAGAAGATCTAAAGCGGGAAGCC
AGTATCTGTCATATGCTGAAACATCCACACATTGTAGAGTTATTGGAGACATATAGCTCAGATGGAATGCTTTACATGGTTTTCGAATTT
ATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAAGCGAGCTGACGCTGGTTTTGTGTACAGTGAAGCTGTAGCCAGCCATTATATGAGA
CAGATACTGGAAGCTCTACGCTACTGCCATGATAATAACATAATTCACAGGGATGTGAAGGACTTGTCTTACAAGGACCGGCACTGGCAT
GAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTCACTGGTGGACAAGCCCTTTGCTGCCAAGGAGGACCAGCTGCTCTGTACAGACTGC
TATTCCAACGAGTACTCATCCAAGTGCCAGGAATGCAAGAAGACCATCATGCCAGGTACCCGCAAGATGGAGTACAAGGGCAGCAGCTGG
CATGAGACCTGCTTCATCTGCCACCGCTGCCAGCAGCCAATTGGAACCAAGAGTTTCATCCCCAAAGACAATCAGAATTTCTGTGTGCCC
TGCTATGAGAAACAACATGCCATGCAGTGCGTTCAGTGCAAAAAGCCCATCACCACGGGAGGGGTCACTTACCGGGAGCAGCCCTGGCAC
AAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCAGCTGTCTGGGCAGCGCTTCACAGCTCGCGATGACTTTGCCTACTGCCTGAACTGC
TTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTGCACCAACCCCATCAGCGGACTTGGTGGCACAAAATACATCTCCTTTGAGGAACGG
CAGTGGCATAACGACTGCTTTAACTGTAAGAAGTGCTCCCTCTCACTGGTGGGGCGTGGCTTCCTCACAGAGAGGGACGACATCCTGTGC
CCCGACTGTGGGAAAGACATCTGAATTCAACACAGAGAAGTTGCTGCTTGTGATCTCACACACAGATTTTTATGTTTTCTTTCTCACCCA
GGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATTGAGACTTTCTTCTAGTGCTTTTCAGTGATACTCACGTTTGCTTAAACCCTTTAGT
GCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAACTCGCCCTAGGCCCTAGGTGGGAAGATGGTTTGAAATTTTTGTAATCGAGTAAGG
CACACCCAAATGTAAAAATCCTTTTGAATGATGCCTTTATAAATCTTTCTCTCACTGTCTATTTAAGTGCAATTAACATATGTCACGAAC
TTGAAAGTTTTCTAAACTCAATAAGGTAATGACCAGTTGTTATTTACAGCTCTGTAACCTCCCGTTGCGTCAAGTCTAAACCAAGATTAT

>13193_13193_4_CASK-FHL2_CASK_chrX_41598636_ENST00000378158_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------
>13193_13193_5_CASK-FHL2_CASK_chrX_41598636_ENST00000378163_FHL2_chr2_105990190_ENST00000393352_length(transcript)=2045nt_BP=904nt
GCCGCCGCCACCTCCCTCCGCGGCGATCCTCGCTCCATGGTCCTGCCGCGGCCCCCTCTGTAGCCCGAGCTGCTCCGCGACGCGACGGAG
CCGGCCTCGGACAGAGGGAGCGGTCGCGGCCTCGCGGCCCGCGCGGGCTGACGAGCGGAGAGCGCGACGCCGCGCGGTCCCCGAGGATCC
GCACGCCGGGCAGCGCGGCCCGAGCAGCGCGAGAAGCAGCGGGCGGGCGGGCGGCGCCGGGCCCGGGCCGCCCTCGCTCCCGCGCCCCGG
CCCCGCCGCCCGCGCCGGGGCGGTCGCCTGCAGAGGAAGGCGCCGCAGTCTCTGGGCCTCGCGGCCCCACTCGAGCGTCCTCGGCACCGA
GGGCTCGCGGGTCCTGAGGGGAGGAGGCGATCCCGGGGCTGGGCACTGAGCTCTTGGGCGCCCCCACCCCCGTTTTCGAAGCCCTCCACG
CTGCGGCCGCTATCCCCTCCGGACCATGGCCGACGACGACGTGCTGTTCGAGGATGTGTACGAGCTGTGCGAGGTGATCGGAAAGGGTCC
CTTCAGTGTTGTACGACGATGTATCAACAGAGAAACTGGGCAACAATTTGCTGTAAAAATTGTTGATGTAGCCAAGTTCACATCAAGTCC
AGGGTTAAGTACAGAAGATCTAAAGCGGGAAGCCAGTATCTGTCATATGCTGAAACATCCACACATTGTAGAGTTATTGGAGACATATAG
CTCAGATGGAATGCTTTACATGGTTTTCGAATTTATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAAGCGAGCTGACGCTGGTTTTGT
GTACAGTGAAGCTGTAGCCAGCCATTATATGAGACAGATACTGGAAGCTCTACGCTACTGCCATGATAATAACATAATTCACAGGGATGT
GAAGGACTTGTCTTACAAGGACCGGCACTGGCATGAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTCACTGGTGGACAAGCCCTTTGC
TGCCAAGGAGGACCAGCTGCTCTGTACAGACTGCTATTCCAACGAGTACTCATCCAAGTGCCAGGAATGCAAGAAGACCATCATGCCAGG
TACCCGCAAGATGGAGTACAAGGGCAGCAGCTGGCATGAGACCTGCTTCATCTGCCACCGCTGCCAGCAGCCAATTGGAACCAAGAGTTT
CATCCCCAAAGACAATCAGAATTTCTGTGTGCCCTGCTATGAGAAACAACATGCCATGCAGTGCGTTCAGTGCAAAAAGCCCATCACCAC
GGGAGGGGTCACTTACCGGGAGCAGCCCTGGCACAAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCAGCTGTCTGGGCAGCGCTTCAC
AGCTCGCGATGACTTTGCCTACTGCCTGAACTGCTTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTGCACCAACCCCATCAGCGGACT
TGGTGGCACAAAATACATCTCCTTTGAGGAACGGCAGTGGCATAACGACTGCTTTAACTGTAAGAAGTGCTCCCTCTCACTGGTGGGGCG
TGGCTTCCTCACAGAGAGGGACGACATCCTGTGCCCCGACTGTGGGAAAGACATCTGAATTCAACACAGAGAAGTTGCTGCTTGTGATCT
CACACACAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATTGAGACTTTCTTCTAGTGCTTT
TCAGTGATACTCACGTTTGCTTAAACCCTTTAGTGCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAACTCGCCCTAGGCCCTAGGTGG
GAAGATGGTTTGAAATTTTTGTAATCGAGTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCCTTTATAAATCTTTCTCTCACT
GTCTATTTAAGTGCAATTAACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCAGTTGTTATTTACAGCTCTGTA

>13193_13193_5_CASK-FHL2_CASK_chrX_41598636_ENST00000378163_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------
>13193_13193_6_CASK-FHL2_CASK_chrX_41598636_ENST00000378166_FHL2_chr2_105990190_ENST00000393352_length(transcript)=1597nt_BP=456nt
CGCTGCGGCCGCTATCCCCTCCGGACCATGGCCGACGACGACGTGCTGTTCGAGGATGTGTACGAGCTGTGCGAGGTGATCGGAAAGGGT
CCCTTCAGTGTTGTACGACGATGTATCAACAGAGAAACTGGGCAACAATTTGCTGTAAAAATTGTTGATGTAGCCAAGTTCACATCAAGT
CCAGGGTTAAGTACAGAAGATCTAAAGCGGGAAGCCAGTATCTGTCATATGCTGAAACATCCACACATTGTAGAGTTATTGGAGACATAT
AGCTCAGATGGAATGCTTTACATGGTTTTCGAATTTATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAAGCGAGCTGACGCTGGTTTT
GTGTACAGTGAAGCTGTAGCCAGCCATTATATGAGACAGATACTGGAAGCTCTACGCTACTGCCATGATAATAACATAATTCACAGGGAT
GTGAAGGACTTGTCTTACAAGGACCGGCACTGGCATGAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTCACTGGTGGACAAGCCCTTT
GCTGCCAAGGAGGACCAGCTGCTCTGTACAGACTGCTATTCCAACGAGTACTCATCCAAGTGCCAGGAATGCAAGAAGACCATCATGCCA
GGTACCCGCAAGATGGAGTACAAGGGCAGCAGCTGGCATGAGACCTGCTTCATCTGCCACCGCTGCCAGCAGCCAATTGGAACCAAGAGT
TTCATCCCCAAAGACAATCAGAATTTCTGTGTGCCCTGCTATGAGAAACAACATGCCATGCAGTGCGTTCAGTGCAAAAAGCCCATCACC
ACGGGAGGGGTCACTTACCGGGAGCAGCCCTGGCACAAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCAGCTGTCTGGGCAGCGCTTC
ACAGCTCGCGATGACTTTGCCTACTGCCTGAACTGCTTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTGCACCAACCCCATCAGCGGA
CTTGGTGGCACAAAATACATCTCCTTTGAGGAACGGCAGTGGCATAACGACTGCTTTAACTGTAAGAAGTGCTCCCTCTCACTGGTGGGG
CGTGGCTTCCTCACAGAGAGGGACGACATCCTGTGCCCCGACTGTGGGAAAGACATCTGAATTCAACACAGAGAAGTTGCTGCTTGTGAT
CTCACACACAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATTGAGACTTTCTTCTAGTGCT
TTTCAGTGATACTCACGTTTGCTTAAACCCTTTAGTGCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAACTCGCCCTAGGCCCTAGGT
GGGAAGATGGTTTGAAATTTTTGTAATCGAGTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCCTTTATAAATCTTTCTCTCA
CTGTCTATTTAAGTGCAATTAACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCAGTTGTTATTTACAGCTCTG

>13193_13193_6_CASK-FHL2_CASK_chrX_41598636_ENST00000378166_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------
>13193_13193_7_CASK-FHL2_CASK_chrX_41598636_ENST00000421587_FHL2_chr2_105990190_ENST00000393352_length(transcript)=1594nt_BP=453nt
TGCGGCCGCTATCCCCTCCGGACCATGGCCGACGACGACGTGCTGTTCGAGGATGTGTACGAGCTGTGCGAGGTGATCGGAAAGGGTCCC
TTCAGTGTTGTACGACGATGTATCAACAGAGAAACTGGGCAACAATTTGCTGTAAAAATTGTTGATGTAGCCAAGTTCACATCAAGTCCA
GGGTTAAGTACAGAAGATCTAAAGCGGGAAGCCAGTATCTGTCATATGCTGAAACATCCACACATTGTAGAGTTATTGGAGACATATAGC
TCAGATGGAATGCTTTACATGGTTTTCGAATTTATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAAGCGAGCTGACGCTGGTTTTGTG
TACAGTGAAGCTGTAGCCAGCCATTATATGAGACAGATACTGGAAGCTCTACGCTACTGCCATGATAATAACATAATTCACAGGGATGTG
AAGGACTTGTCTTACAAGGACCGGCACTGGCATGAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTCACTGGTGGACAAGCCCTTTGCT
GCCAAGGAGGACCAGCTGCTCTGTACAGACTGCTATTCCAACGAGTACTCATCCAAGTGCCAGGAATGCAAGAAGACCATCATGCCAGGT
ACCCGCAAGATGGAGTACAAGGGCAGCAGCTGGCATGAGACCTGCTTCATCTGCCACCGCTGCCAGCAGCCAATTGGAACCAAGAGTTTC
ATCCCCAAAGACAATCAGAATTTCTGTGTGCCCTGCTATGAGAAACAACATGCCATGCAGTGCGTTCAGTGCAAAAAGCCCATCACCACG
GGAGGGGTCACTTACCGGGAGCAGCCCTGGCACAAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCAGCTGTCTGGGCAGCGCTTCACA
GCTCGCGATGACTTTGCCTACTGCCTGAACTGCTTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTGCACCAACCCCATCAGCGGACTT
GGTGGCACAAAATACATCTCCTTTGAGGAACGGCAGTGGCATAACGACTGCTTTAACTGTAAGAAGTGCTCCCTCTCACTGGTGGGGCGT
GGCTTCCTCACAGAGAGGGACGACATCCTGTGCCCCGACTGTGGGAAAGACATCTGAATTCAACACAGAGAAGTTGCTGCTTGTGATCTC
ACACACAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATTGAGACTTTCTTCTAGTGCTTTT
CAGTGATACTCACGTTTGCTTAAACCCTTTAGTGCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAACTCGCCCTAGGCCCTAGGTGGG
AAGATGGTTTGAAATTTTTGTAATCGAGTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCCTTTATAAATCTTTCTCTCACTG
TCTATTTAAGTGCAATTAACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCAGTTGTTATTTACAGCTCTGTAA

>13193_13193_7_CASK-FHL2_CASK_chrX_41598636_ENST00000421587_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------
>13193_13193_8_CASK-FHL2_CASK_chrX_41598636_ENST00000442742_FHL2_chr2_105990190_ENST00000393352_length(transcript)=1589nt_BP=448nt
CCGCTATCCCCTCCGGACCATGGCCGACGACGACGTGCTGTTCGAGGATGTGTACGAGCTGTGCGAGGTGATCGGAAAGGGTCCCTTCAG
TGTTGTACGACGATGTATCAACAGAGAAACTGGGCAACAATTTGCTGTAAAAATTGTTGATGTAGCCAAGTTCACATCAAGTCCAGGGTT
AAGTACAGAAGATCTAAAGCGGGAAGCCAGTATCTGTCATATGCTGAAACATCCACACATTGTAGAGTTATTGGAGACATATAGCTCAGA
TGGAATGCTTTACATGGTTTTCGAATTTATGGATGGAGCAGATCTGTGTTTTGAAATCGTAAAGCGAGCTGACGCTGGTTTTGTGTACAG
TGAAGCTGTAGCCAGCCATTATATGAGACAGATACTGGAAGCTCTACGCTACTGCCATGATAATAACATAATTCACAGGGATGTGAAGGA
CTTGTCTTACAAGGACCGGCACTGGCATGAAGCCTGTTTCCACTGCTCGCAGTGCAGAAACTCACTGGTGGACAAGCCCTTTGCTGCCAA
GGAGGACCAGCTGCTCTGTACAGACTGCTATTCCAACGAGTACTCATCCAAGTGCCAGGAATGCAAGAAGACCATCATGCCAGGTACCCG
CAAGATGGAGTACAAGGGCAGCAGCTGGCATGAGACCTGCTTCATCTGCCACCGCTGCCAGCAGCCAATTGGAACCAAGAGTTTCATCCC
CAAAGACAATCAGAATTTCTGTGTGCCCTGCTATGAGAAACAACATGCCATGCAGTGCGTTCAGTGCAAAAAGCCCATCACCACGGGAGG
GGTCACTTACCGGGAGCAGCCCTGGCACAAGGAGTGCTTCGTGTGCACCGCCTGCAGGAAGCAGCTGTCTGGGCAGCGCTTCACAGCTCG
CGATGACTTTGCCTACTGCCTGAACTGCTTCTGTGACTTGTATGCCAAGAAGTGTGCTGGGTGCACCAACCCCATCAGCGGACTTGGTGG
CACAAAATACATCTCCTTTGAGGAACGGCAGTGGCATAACGACTGCTTTAACTGTAAGAAGTGCTCCCTCTCACTGGTGGGGCGTGGCTT
CCTCACAGAGAGGGACGACATCCTGTGCCCCGACTGTGGGAAAGACATCTGAATTCAACACAGAGAAGTTGCTGCTTGTGATCTCACACA
CAGATTTTTATGTTTTCTTTCTCACCCAGGCAATCTTGCCTTCTGGTTTCTTCCAGCCACATTGAGACTTTCTTCTAGTGCTTTTCAGTG
ATACTCACGTTTGCTTAAACCCTTTAGTGCTTTGTGATAGTTCAGTCCCAGGGAAAGAGAAAACTCGCCCTAGGCCCTAGGTGGGAAGAT
GGTTTGAAATTTTTGTAATCGAGTAAGGCACACCCAAATGTAAAAATCCTTTTGAATGATGCCTTTATAAATCTTTCTCTCACTGTCTAT
TTAAGTGCAATTAACATATGTCACGAACTTGAAAGTTTTCTAAACTCAATAAGGTAATGACCAGTTGTTATTTACAGCTCTGTAACCTCC

>13193_13193_8_CASK-FHL2_CASK_chrX_41598636_ENST00000442742_FHL2_chr2_105990190_ENST00000393352_length(amino acids)=370AA_BP=143
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMV
FEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLC
TDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ
PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDD

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CASK-FHL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CASK-FHL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CASK-FHL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource