Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CASP8-CFLAR (FusionGDB2 ID:13243)

Fusion Gene Summary for CASP8-CFLAR

Fusion gene summary

Fusion gene information	Fusion gene name: CASP8-CFLAR
	Fusion gene ID: 13243
		Hgene	Tgene
	Gene symbol	CASP8	CFLAR
	Gene ID	841	8837
	Gene name	caspase 8	CASP8 and FADD like apoptosis regulator
	Synonyms	ALPS2B\|CAP4\|Casp-8\|FLICE\|MACH\|MCH5	CASH\|CASP8AP1\|CLARP\|Casper\|FLAME\|FLAME-1\|FLAME1\|FLIP\|I-FLICE\|MRIT\|c-FLIP\|c-FLIPL\|c-FLIPR\|c-FLIPS\|cFLIP
	Cytomap	2q33.1	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	caspase-8FADD-homologous ICE/CED-3-like proteaseFADD-like ICEICE-like apoptotic protease 5MACH-alpha-1/2/3 proteinMACH-beta-1/2/3/4 proteinMORT1-associated ced-3 homologapoptotic cysteine proteaseapoptotic protease Mch-5caspase 8, apoptosis-relat	CASP8 and FADD-like apoptosis regulatorFADD-like antiapoptotic molecule 1MACH-related inducer of toxicitycaspase homologcaspase-eight-related proteincaspase-like apoptosis regulatory proteincaspase-related inducer of apoptosiscellular FLICE-like in
	Modification date	20200322	20200322
	UniProtAcc	Q14790	O15519
	Ensembl transtripts involved in fusion gene	ENST00000490682, ENST00000264274, ENST00000264275, ENST00000392258, ENST00000392259, ENST00000392266, ENST00000432109, ENST00000323492, ENST00000358485,	ENST00000309955, ENST00000340870, ENST00000341222, ENST00000341582, ENST00000342795, ENST00000355558, ENST00000395148, ENST00000423241, ENST00000440180, ENST00000443227, ENST00000457277, ENST00000479953, ENST00000490965, ENST00000494258,
Fusion gene scores	* DoF score	10 X 7 X 10=700	10 X 11 X 6=660
	# samples	12	14
	** MAII score	log2(12/700*10)=-2.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/660*10)=-2.23703919730085 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CASP8 [Title/Abstract] AND CFLAR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CASP8(202098835)-CFLAR(201994452), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CASP8	GO:0006508	proteolysis	12888622
Hgene	CASP8	GO:0036462	TRAIL-activated apoptotic signaling pathway	21785459
Hgene	CASP8	GO:0045862	positive regulation of proteolysis	18387192
Hgene	CASP8	GO:0097191	extrinsic apoptotic signaling pathway	21785459
Hgene	CASP8	GO:0097202	activation of cysteine-type endopeptidase activity	18387192
Tgene	CFLAR	GO:0060544	regulation of necroptotic process	21737330
Tgene	CFLAR	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Tgene	CFLAR	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	9208847

Fusion gene breakpoints across CASP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CFLAR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A18T-01A	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
ChimerDB4	SKCM	TCGA-WE-A8K4-01A	CASP8	chr2	202098835	-	CFLAR	chr2	201994452	+
ChimerDB4	SKCM	TCGA-WE-A8K4-01A	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
ChimerDB4	STAD	TCGA-BR-8361-01A	CASP8	chr2	202098835	-	CFLAR	chr2	201994452	+

Top

Fusion Gene ORF analysis for CASP8-CFLAR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-5UTR	ENST00000490682	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-5UTR	ENST00000490682	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
3UTR-intron	ENST00000490682	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264274	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000264275	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392258	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392259	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000392266	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-5UTR	ENST00000432109	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264274	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000264275	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392258	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392259	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000392266	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
5UTR-intron	ENST00000432109	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000323492	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000309955	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000340870	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000341222	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000341582	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000342795	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000355558	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000395148	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000423241	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-5UTR	ENST00000358485	ENST00000440180	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000323492	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000443227	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000457277	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000479953	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000490965	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+
intron-intron	ENST00000358485	ENST00000494258	CASP8	chr2	202098835	+	CFLAR	chr2	201994452	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Genomic Features for CASP8-CFLAR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CASP8	chr2	202098835	+	CFLAR	chr2	201994451	+	5.08E-07	0.9999995
CASP8	chr2	202098835	+	CFLAR	chr2	201994451	+	5.08E-07	0.9999995

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CASP8-CFLAR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:202098835/:201994452)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CASP8 Q14790	CFLAR O15519
FUNCTION: Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood (By similarity). Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death (PubMed:23516580, PubMed:8681376, PubMed:8681377, PubMed:9006941, PubMed:9184224, PubMed:8962078). Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 (PubMed:8962078, PubMed:9006941). Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A (PubMed:8681376, PubMed:8681377). The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation (PubMed:9184224). The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases (PubMed:9184224). Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC (PubMed:9184224). In addition to extrinsic apoptosis, also acts as a negative regulator of necroptosis: acts by cleaving RIPK1 at 'Asp-324', which is crucial to inhibit RIPK1 kinase activity, limiting TNF-induced apoptosis, necroptosis and inflammatory response (PubMed:31827280, PubMed:31827281). Also able to initiate pyroptosis by mediating cleavage and activation of gasdermin-D (GSDMD): GSDMD cleavage promoting release of the N-terminal moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (By similarity). Initiates pyroptosis following inactivation of MAP3K7/TAK1 (By similarity). Also acts as a regulator of innate immunity by mediating cleavage and inactivation of N4BP1 downstream of TLR3 or TLR4, thereby promoting cytokine production (By similarity). May participate in the Granzyme B (GZMB) cell death pathways (PubMed:8755496). Cleaves PARP1 (PubMed:8681376). {ECO:0000250\|UniProtKB:O89110, ECO:0000269\|PubMed:23516580, ECO:0000269\|PubMed:31827280, ECO:0000269\|PubMed:31827281, ECO:0000269\|PubMed:8681376, ECO:0000269\|PubMed:8681377, ECO:0000269\|PubMed:8755496, ECO:0000269\|PubMed:8962078, ECO:0000269\|PubMed:9006941, ECO:0000269\|PubMed:9184224}.; FUNCTION: [Isoform 5]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305\|PubMed:8681376}.; FUNCTION: [Isoform 6]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305\|PubMed:8681376}.; FUNCTION: [Isoform 7]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex (Probable). Acts as an inhibitor of the caspase cascade (PubMed:12010809). {ECO:0000269\|PubMed:12010809, ECO:0000305\|PubMed:8681376}.; FUNCTION: [Isoform 8]: Lacks the catalytic site and may interfere with the pro-apoptotic activity of the complex. {ECO:0000305\|PubMed:8681376}.	FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269\|PubMed:9880531}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Gene Sequence for CASP8-CFLAR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for CASP8-CFLAR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CASP8-CFLAR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CASP8-CFLAR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source