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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CASZ1-EXOSC10 (FusionGDB2 ID:13282)

Fusion Gene Summary for CASZ1-EXOSC10

check button Fusion gene summary
Fusion gene informationFusion gene name: CASZ1-EXOSC10
Fusion gene ID: 13282
HgeneTgene
Gene symbol

CASZ1

EXOSC10

Gene ID

54897

5394

Gene namecastor zinc finger 1exosome component 10
SynonymsCAS11|CST|SRG|ZNF693|dJ734G22.1PM-Scl|PM/Scl-100|PMSCL|PMSCL2|RRP6|Rrp6p|p2|p3|p4
Cytomap

1p36.22

1p36.22

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein castor homolog 1castor homolog 1, zinc fingercastor-related proteinsurvival-relatedzinc finger protein 693exosome component 10P100 polymyositis-scleroderma overlap syndrome-associated autoantigenautoantigen PM-SCLpolymyositis/scleroderma autoantigen 100 kDapolymyositis/scleroderma autoantigen 2
Modification date2020031320200313
UniProtAcc

Q86V15

Q01780

Ensembl transtripts involved in fusion geneENST00000344008, ENST00000377022, 
ENST00000478728, 		ENST00000544779, 
ENST00000485606, ENST00000304457, 
ENST00000376936, 
Fusion gene scores* DoF score23 X 19 X 12=524410 X 11 X 7=770
# samples 3016
** MAII scorelog2(30/5244*10)=-4.12763327972587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/770*10)=-2.2667865406949
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CASZ1 [Title/Abstract] AND EXOSC10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCASZ1(10856621)-EXOSC10(11131030), # samples:2
Anticipated loss of major functional domain due to fusion event.CASZ1-EXOSC10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CASZ1-EXOSC10 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
CASZ1-EXOSC10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASZ1

GO:0045893

positive regulation of transcription, DNA-templated

27693370


check buttonFusion gene breakpoints across CASZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EXOSC10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1846CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
ChimerDB4UCECTCGA-AX-A3G6-01ACASZ1chr1

10856621

-EXOSC10chr1

11131030

-
ChimerDB4UCECTCGA-AX-A3G6CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
ChimerDB4UCECTCGA-D1-A16I-01ACASZ1chr1

10702916

-EXOSC10chr1

11126805

-


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Fusion Gene ORF analysis for CASZ1-EXOSC10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000344008ENST00000544779CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
5CDS-3UTRENST00000377022ENST00000544779CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
5CDS-3UTRENST00000377022ENST00000544779CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
5CDS-intronENST00000344008ENST00000485606CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
5CDS-intronENST00000377022ENST00000485606CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
5CDS-intronENST00000377022ENST00000485606CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
5UTR-3CDSENST00000344008ENST00000304457CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000344008ENST00000304457CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000344008ENST00000376936CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000344008ENST00000376936CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000377022ENST00000304457CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000377022ENST00000304457CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000377022ENST00000376936CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000377022ENST00000376936CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-3CDSENST00000478728ENST00000304457CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
5UTR-3CDSENST00000478728ENST00000376936CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
5UTR-3UTRENST00000344008ENST00000544779CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-3UTRENST00000344008ENST00000544779CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-3UTRENST00000377022ENST00000544779CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-3UTRENST00000377022ENST00000544779CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-3UTRENST00000478728ENST00000544779CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
5UTR-intronENST00000344008ENST00000485606CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-intronENST00000344008ENST00000485606CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-intronENST00000377022ENST00000485606CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
5UTR-intronENST00000377022ENST00000485606CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
5UTR-intronENST00000478728ENST00000485606CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
Frame-shiftENST00000344008ENST00000304457CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
Frame-shiftENST00000344008ENST00000376936CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
Frame-shiftENST00000377022ENST00000304457CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
Frame-shiftENST00000377022ENST00000376936CASZ1chr1

10725139

-EXOSC10chr1

11134383

-
In-frameENST00000377022ENST00000304457CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
In-frameENST00000377022ENST00000376936CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-3CDSENST00000344008ENST00000304457CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-3CDSENST00000344008ENST00000376936CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-3CDSENST00000478728ENST00000304457CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
intron-3CDSENST00000478728ENST00000304457CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
intron-3CDSENST00000478728ENST00000304457CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-3CDSENST00000478728ENST00000376936CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
intron-3CDSENST00000478728ENST00000376936CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
intron-3CDSENST00000478728ENST00000376936CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-3UTRENST00000344008ENST00000544779CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-3UTRENST00000478728ENST00000544779CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
intron-3UTRENST00000478728ENST00000544779CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
intron-3UTRENST00000478728ENST00000544779CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-intronENST00000344008ENST00000485606CASZ1chr1

10702916

-EXOSC10chr1

11126805

-
intron-intronENST00000478728ENST00000485606CASZ1chr1

10856621

-EXOSC10chr1

11131030

-
intron-intronENST00000478728ENST00000485606CASZ1chr1

10856620

-EXOSC10chr1

11131030

-
intron-intronENST00000478728ENST00000485606CASZ1chr1

10702916

-EXOSC10chr1

11126805

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377022CASZ1chr110702916-ENST00000304457EXOSC10chr111126805-4611448028546101442
ENST00000377022CASZ1chr110702916-ENST00000376936EXOSC10chr111126805-4611448028546101442

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377022ENST00000304457CASZ1chr110702916-EXOSC10chr111126805-0.159222290.8407777
ENST00000377022ENST00000376936CASZ1chr110702916-EXOSC10chr111126805-0.159222290.8407777

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Fusion Genomic Features for CASZ1-EXOSC10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CASZ1-EXOSC10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:10856621/chr1:11131030)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASZ1

Q86V15

EXOSC10

Q01780

FUNCTION: Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}.FUNCTION: Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3'-5' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of MTREX, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA. {ECO:0000250, ECO:0000269|PubMed:14527413, ECO:0000269|PubMed:16455498, ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:17545563, ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:19056938, ECO:0000269|PubMed:20368444, ECO:0000269|PubMed:20699273}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211080_114313871760.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-2021384_41713871760.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211031_105513871760.0Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211300_132413871760.0Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-2021551_57513871760.0Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-2021610_63413871760.0Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-2021668_69213871760.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161080_114301167.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161635_167001167.0Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161672_172901167.0Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161691_171801167.0Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-116384_41701167.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211635_167013871760.0Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211672_172913871760.0Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211691_171813871760.0Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161031_105501167.0Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161300_132401167.0Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161457_148101167.0Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161515_153701167.0Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-1161571_159501167.0Zinc fingerC2H2-type 8
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-116551_57501167.0Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-116610_63401167.0Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10702916chr1:11126805ENST00000344008-116668_69201167.0Zinc fingerC2H2-type 3
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211457_148113871760.0Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211515_153713871760.0Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10702916chr1:11126805ENST00000377022-20211571_159513871760.0Zinc fingerC2H2-type 8
TgeneEXOSC10chr1:10702916chr1:11126805ENST000003044572224503_583850861.0DomainHRDC
TgeneEXOSC10chr1:10702916chr1:11126805ENST000003769362325503_583875886.0DomainHRDC


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Fusion Gene Sequence for CASZ1-EXOSC10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13282_13282_1_CASZ1-EXOSC10_CASZ1_chr1_10702916_ENST00000377022_EXOSC10_chr1_11126805_ENST00000304457_length(transcript)=4611nt_BP=4480nt
ATGCGCGCCCGCGGCGCTCCATCCCAAACACACACACATTTTTCCCCCGGACTTGGAAAGTCACCCAAAGCCGCCCCAAGTGCAGGCAAA
CAGACCTTGCTGACTGAAGGCAAAGACTCCTCCATCCCACCTGCCCTCCCAGCTGCCACGGCCATCGACCCCTCCTTTACAAGGGGCTCC
TGCAACTCCCCAGCAGCACGTGTTGGAATGGACTTCGGACCCTGGCCTCTTGGGATGCAAAGGATGAAGTGACACCCCCAGCTACATCCG
AGGAGGTTCTAGGACCTGCTACGAGAGTTTGGGACCAAGGAGAAGAGAATGGATCTTGGAACAGCTGAGGGCACCCGGTGCACGGACCCG
CCTGCAGGCAAGCCCGCCATGGCGCCCAAACGCAAGGGTGGCCTGAAGCTGAACGCCATCTGCGCCAAGCTGAGCCGCCAGGTGGTGGTG
GAGAAGCGAGCTGACGCCGGCTCCCACACGGAGGGCAGCCCATCGCAGCCCCGGGACCAAGAGCGCAGTGGCCCTGAGTCTGGGGCAGCC
CGGGCCCCCCGCAGCGAGGAAGACAAGAGACGGGCAGTGATCGAGAAGTGGGTGAACGGGGAGTACAGCGAGGAGCCGGCACCCACACCC
GTGTTGGGGCGGATTGCCCGCGAGGGCCTGGAGCTGCCTCCCGAGGGTGTCTACATGGTGCAGCCCCAGGGGTGCAGCGATGAGGAAGAC
CACGCGGAGGAGCCCTCCAAGGACGGCGGTGCCCTGGAGGAGAAGGATTCGGACGGGGCAGCCTCCAAGGAGGACAGCGGCCCCAGCACC
AGGCAGGCTTCAGGAGAGGCCTCCTCGCTGCGGGACTACGCGGCCTCCACCATGACCGAGTTCCTCGGCATGTTTGGCTATGATGACCAG
AACACGCGGGACGAGCTGGCCAGGAAGATCAGCTTTGAGAAGCTGCACGCGGGCTCCACCCCGGAGGCAGCCACCTCCTCCATGCTGCCC
ACCTCCGAGGATACCCTCAGCAAGCGGGCGCGGTTCTCTAAGTATGAGGAGTACATCCGCAAGCTCAAGGCTGGCGAGCAGCTCTCCTGG
CCGGCCCCCAGCACCAAGACCGAGGAGCGGGTGGGCAAGGAGGTGGTGGGCACCCTGCCCGGCCTGCGGCTGCCCAGCAGCACGGCCCAC
CTGGAGACCAAGGCCACCATCCTGCCCCTGCCGTCGCACAGCAGTGTCCAGATGCAGAACCTGGTAGCCCGGGCCTCCAAGTACGACTTC
TTCATCCAAAAACTGAAGACCGGCGAGAATCTGCGGCCCCAGAACGGGAGCACCTACAAGAAGCCATCCAAGTACGACCTGGAGAATGTC
AAGTACCTGCACCTCTTCAAACCCGGGGAGGGCAGCCCCGACATGGGCGGGGCCATCGCCTTCAAGACAGGCAAGGTGGGGCGCCCTTCC
AAGTACGACGTCCGGGGCATCCAGAAGCCAGGCCCCGCCAAGGTTCCGCCCACCCCCAGCCTGGCTCCCGCACCCCTCGCCAGCGTGCCC
AGTGCCCCCAGCGCCCCCGGGCCAGGGCCAGAGCCTCCTGCCTCCCTGTCCTTCAACACTCCCGAGTACCTGAAGTCAACCTTCTCCAAA
ACAGACTCCATCACCACGGGGACCGTCTCCACTGTCAAGAACGGACTGCCCACAGATAAACCAGCCGTCACTGAAGATGTAAACATTTAC
CAGAAATATATTGCCAGGTTCTCGGGCAGCCAGCACTGTGGCCACATCCACTGTGCCTACCAGTACCGCGAGCACTACCACTGCCTTGAC
CCTGAGTGTAACTACCAGAGGTTCACGAGTAAGCAGGACGTGATCCGCCACTACAACATGCACAAGAAGCGCGACAACTCCCTGCAGCAC
GGCTTCATGCGTTTCAGCCCGCTGGACGACTGCAGCGTCTACTACCACGGCTGCCACCTCAATGGGAAGAGCACCCACTATCACTGCATG
CAGGTGGGCTGTAACAAGGTGTACACGAGCACGTCTGACGTGATGACCCACGAGAACTTCCACAAGAAGAATACCCAGCTCATTAACGAC
GGCTTCCAGCGCTTCCGAGCCACCGAAGACTGTGGCACAGCCGACTGCCAGTTCTACGGACAGAAGACCACGCACTTCCACTGCAGGCGC
CCCGGCTGCACATTCACTTTCAAGAACAAGTGTGACATCGAGAAGCACAAGAGCTACCACATCAAGGACGATGCCTACGCCAAGGACGGC
TTCAAGAAGTTCTACAAGTACGAGGAGTGCAAGTACGAGGGCTGCGTGTACAGCAAGGCTACCAACCACTTCCACTGCATCCGCGCCGGC
TGCGGCTTCACCTTCACCTCCACCAGCCAGATGACCTCTCACAAGCGCAAGCATGAGCGCCGGCACATCCGCTCCTCGGGCGCGCTGGGG
CTGCCGCCCTCGCTGCTGGGCGCCAAGGACACGGAGCACGAGGAGTCCAGCAACGACGACCTTGTTGACTTCTCCGCCCTGAGCAGCAAG
AACTCCAGCCTGAGCGCCTCCCCTACCAGCCAGCAGTCCTCTGCGTCCCTGGCTGCCGCCACTGCCGCCACCGAGGCTGGGCCCAGTGCC
ACCAAACCTCCCAACAGCAAGATCTCGGGGCTGCTGCCCCAGGGCCTGCCTGGCTCAATCCCCCTGGCCCTGGCCCTCTCCAACTCGGGC
CTGCCCACCCCCACGCCCTACTTCCCCATACTGGCTGGCCGTGGGAGCACCTCCCTGCCTGTGGGCACCCCCAGCCTCCTGGGTGCCGTG
TCGTCTGGGTCAGCAGCCTCAGCCACCCCTGACACACCCACGCTGGTCGCCTCGGGAGCTGGAGACTCAGCCCCCGTGGCTGCCGCCTCT
GTCCCGGCACCACCCGCCTCCATCATGGAGAGGATCTCTGCAAGCAAGGGCCTCATCTCGCCCATGATGGCCAGGCTGGCTGCAGCTGCC
CTCAAGCCCTCTGCCACCTTTGACCCAGGAAGCGGGCAGCAGGTCACCCCAGCCAGGTTCCCCCCGGCCCAAGTGAAGCCGGAACCCGGT
GAGAGCACCGGCGCCCCAGGCCCCCACGAAGCCTCCCAGGACCGCAGTCTAGACCTGACTGTGAAGGAGCCCAGCAACGAATCAAATGGC
CACGCAGTCCCGGCAAATTCATCTCTTTTATCCTCGCTTATGAATAAGATGTCTCAGGGCAACCCTGGCCTGGGCAGCCTGCTGAACATC
AAGGCGGAAGCGGAGGGGAGCCCCGCTGCGGAGCCCTCGCCCTTCCTAGGCAAGGCCGTGAAGGCGCTGGTTCAGGAGAAGTTGGCAGAG
CCCTGGAAGGTGTACCTGCGCAGGTTTGGTACAAAGGACTTCTGTGACGGCCAGTGTGACTTCCTCCACAAGGCCCACTTCCACTGCGTG
GTGGAGGAATGCGGCGCGCTCTTCAGCACCTTGGACGGGGCCATCAAGCACGCAAACTTCCACTTCCGGACAGAGGGAGGAGCAGCAAAA
GGAAACACAGAGGCTGCCTTTCCGGCCTCGGCCGCCGAGACCAAACCTCCCATGGCCCCCTCGTCCCCTCCGGTCCCTCCTGTCACCACG
GCCACGGTGTCCTCTCTGGAGGGGCCCGCTCCCAGCCCGGCCTCCGTGCCCTCCACCCCCACCCTGCTCGCCTGGAAGCAGCTGGCTTCC
ACCATACCCCAGATGCCTCAGATCCCAGCGTCAGTGCCTCACCTGCCCGCCTCGCCCTTGGCAACGACTTCTCTAGAGAACGCCAAGCCC
CAGGTCAAACCCGGATTCCTCCAGTTCCAGGAGAACGATCCTTGCCTCGCCACGGACTGCAAGTACGCCAACAAGTTCCACTTCCACTGT
CTCTTTGGGAACTGCAAGTACGTCTGCAAAACGTCTGGCAAGGCCGAATCCCACTGCCTGGACCACATCAACCCCAACAACAACCTGGTG
AACGTGCGAGACCAGTTTGCATACTACTCTCTGCAGTGTCTCTGTCCCAACCAGCACTGCGAGTTCCGAATGCGTGGGCACTACCACTGC
CTCCGCACCGGCTGCTATTTTGTGACCAACATCACCACCAAGCTCCCCTGGCACATCAAGAAGCATGAGAAGGCGGAGCGGCGGGCAGCC
AATGGCTTCAAATACTTCACCAAGCGCGAGGAGTGTGGCAGGCTAGGTTGCAAGTACAACCAGGTGAACAGCCACTTCCACTGCATCCGG
GAGGGCTGCCAGTTCTCCTTCCTCCTCAAGCACCAGATGACCTCCCACGCGCGGAAGCACATGCGGAGGATGCTGGGGAAGAACTTCGAC
CGCGTGCCCCCCTCCCAGGGCCCCCCAGGCCTGATGGATGCTGAGACAGATGAGTGCATGGACTACACTGGCTGCAGCCCAGGCGCCATG
TCCTCTGAGTCATCCACCATGGACCGGAGCTGCTCCAGCACCCCCGTGGGTAACGAGAGCACCGCGGCAGAGGCTTCAGGTACAACTGGC
CACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAACCA

>13282_13282_1_CASZ1-EXOSC10_CASZ1_chr1_10702916_ENST00000377022_EXOSC10_chr1_11126805_ENST00000304457_length(amino acids)=1442AA_BP=1397
MLREFGTKEKRMDLGTAEGTRCTDPPAGKPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRS
EEDKRRAVIEKWVNGEYSEEPAPTPVLGRIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASG
EASSLRDYAASTMTEFLGMFGYDDQNTRDELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPST
KTEERVGKEVVGTLPGLRLPSSTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHL
FKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSIT
TGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRF
SPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTF
TFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSL
LGAKDTEHEESSNDDLVDFSALSSKNSSLSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPT
PYFPILAGRGSTSLPVGTPSLLGAVSSGSAASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSA
TFDPGSGQQVTPARFPPAQVKPEPGESTGAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAE
GSPAAEPSPFLGKAVKALVQEKLAEPWKVYLRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEA
AFPASAAETKPPMAPSSPPVPPVTTATVSSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPG
FLQFQENDPCLATDCKYANKFHFHCLFGNCKYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGC
YFVTNITTKLPWHIKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPS
QGPPGLMDAETDECMDYTGCSPGAMSSESSTMDRSCSSTPVGNESTAAEASGTTGHRDSPGRHVAPVDRKHQMLVLLLYIHIFKPLKFFL

--------------------------------------------------------------
>13282_13282_2_CASZ1-EXOSC10_CASZ1_chr1_10702916_ENST00000377022_EXOSC10_chr1_11126805_ENST00000376936_length(transcript)=4611nt_BP=4480nt
ATGCGCGCCCGCGGCGCTCCATCCCAAACACACACACATTTTTCCCCCGGACTTGGAAAGTCACCCAAAGCCGCCCCAAGTGCAGGCAAA
CAGACCTTGCTGACTGAAGGCAAAGACTCCTCCATCCCACCTGCCCTCCCAGCTGCCACGGCCATCGACCCCTCCTTTACAAGGGGCTCC
TGCAACTCCCCAGCAGCACGTGTTGGAATGGACTTCGGACCCTGGCCTCTTGGGATGCAAAGGATGAAGTGACACCCCCAGCTACATCCG
AGGAGGTTCTAGGACCTGCTACGAGAGTTTGGGACCAAGGAGAAGAGAATGGATCTTGGAACAGCTGAGGGCACCCGGTGCACGGACCCG
CCTGCAGGCAAGCCCGCCATGGCGCCCAAACGCAAGGGTGGCCTGAAGCTGAACGCCATCTGCGCCAAGCTGAGCCGCCAGGTGGTGGTG
GAGAAGCGAGCTGACGCCGGCTCCCACACGGAGGGCAGCCCATCGCAGCCCCGGGACCAAGAGCGCAGTGGCCCTGAGTCTGGGGCAGCC
CGGGCCCCCCGCAGCGAGGAAGACAAGAGACGGGCAGTGATCGAGAAGTGGGTGAACGGGGAGTACAGCGAGGAGCCGGCACCCACACCC
GTGTTGGGGCGGATTGCCCGCGAGGGCCTGGAGCTGCCTCCCGAGGGTGTCTACATGGTGCAGCCCCAGGGGTGCAGCGATGAGGAAGAC
CACGCGGAGGAGCCCTCCAAGGACGGCGGTGCCCTGGAGGAGAAGGATTCGGACGGGGCAGCCTCCAAGGAGGACAGCGGCCCCAGCACC
AGGCAGGCTTCAGGAGAGGCCTCCTCGCTGCGGGACTACGCGGCCTCCACCATGACCGAGTTCCTCGGCATGTTTGGCTATGATGACCAG
AACACGCGGGACGAGCTGGCCAGGAAGATCAGCTTTGAGAAGCTGCACGCGGGCTCCACCCCGGAGGCAGCCACCTCCTCCATGCTGCCC
ACCTCCGAGGATACCCTCAGCAAGCGGGCGCGGTTCTCTAAGTATGAGGAGTACATCCGCAAGCTCAAGGCTGGCGAGCAGCTCTCCTGG
CCGGCCCCCAGCACCAAGACCGAGGAGCGGGTGGGCAAGGAGGTGGTGGGCACCCTGCCCGGCCTGCGGCTGCCCAGCAGCACGGCCCAC
CTGGAGACCAAGGCCACCATCCTGCCCCTGCCGTCGCACAGCAGTGTCCAGATGCAGAACCTGGTAGCCCGGGCCTCCAAGTACGACTTC
TTCATCCAAAAACTGAAGACCGGCGAGAATCTGCGGCCCCAGAACGGGAGCACCTACAAGAAGCCATCCAAGTACGACCTGGAGAATGTC
AAGTACCTGCACCTCTTCAAACCCGGGGAGGGCAGCCCCGACATGGGCGGGGCCATCGCCTTCAAGACAGGCAAGGTGGGGCGCCCTTCC
AAGTACGACGTCCGGGGCATCCAGAAGCCAGGCCCCGCCAAGGTTCCGCCCACCCCCAGCCTGGCTCCCGCACCCCTCGCCAGCGTGCCC
AGTGCCCCCAGCGCCCCCGGGCCAGGGCCAGAGCCTCCTGCCTCCCTGTCCTTCAACACTCCCGAGTACCTGAAGTCAACCTTCTCCAAA
ACAGACTCCATCACCACGGGGACCGTCTCCACTGTCAAGAACGGACTGCCCACAGATAAACCAGCCGTCACTGAAGATGTAAACATTTAC
CAGAAATATATTGCCAGGTTCTCGGGCAGCCAGCACTGTGGCCACATCCACTGTGCCTACCAGTACCGCGAGCACTACCACTGCCTTGAC
CCTGAGTGTAACTACCAGAGGTTCACGAGTAAGCAGGACGTGATCCGCCACTACAACATGCACAAGAAGCGCGACAACTCCCTGCAGCAC
GGCTTCATGCGTTTCAGCCCGCTGGACGACTGCAGCGTCTACTACCACGGCTGCCACCTCAATGGGAAGAGCACCCACTATCACTGCATG
CAGGTGGGCTGTAACAAGGTGTACACGAGCACGTCTGACGTGATGACCCACGAGAACTTCCACAAGAAGAATACCCAGCTCATTAACGAC
GGCTTCCAGCGCTTCCGAGCCACCGAAGACTGTGGCACAGCCGACTGCCAGTTCTACGGACAGAAGACCACGCACTTCCACTGCAGGCGC
CCCGGCTGCACATTCACTTTCAAGAACAAGTGTGACATCGAGAAGCACAAGAGCTACCACATCAAGGACGATGCCTACGCCAAGGACGGC
TTCAAGAAGTTCTACAAGTACGAGGAGTGCAAGTACGAGGGCTGCGTGTACAGCAAGGCTACCAACCACTTCCACTGCATCCGCGCCGGC
TGCGGCTTCACCTTCACCTCCACCAGCCAGATGACCTCTCACAAGCGCAAGCATGAGCGCCGGCACATCCGCTCCTCGGGCGCGCTGGGG
CTGCCGCCCTCGCTGCTGGGCGCCAAGGACACGGAGCACGAGGAGTCCAGCAACGACGACCTTGTTGACTTCTCCGCCCTGAGCAGCAAG
AACTCCAGCCTGAGCGCCTCCCCTACCAGCCAGCAGTCCTCTGCGTCCCTGGCTGCCGCCACTGCCGCCACCGAGGCTGGGCCCAGTGCC
ACCAAACCTCCCAACAGCAAGATCTCGGGGCTGCTGCCCCAGGGCCTGCCTGGCTCAATCCCCCTGGCCCTGGCCCTCTCCAACTCGGGC
CTGCCCACCCCCACGCCCTACTTCCCCATACTGGCTGGCCGTGGGAGCACCTCCCTGCCTGTGGGCACCCCCAGCCTCCTGGGTGCCGTG
TCGTCTGGGTCAGCAGCCTCAGCCACCCCTGACACACCCACGCTGGTCGCCTCGGGAGCTGGAGACTCAGCCCCCGTGGCTGCCGCCTCT
GTCCCGGCACCACCCGCCTCCATCATGGAGAGGATCTCTGCAAGCAAGGGCCTCATCTCGCCCATGATGGCCAGGCTGGCTGCAGCTGCC
CTCAAGCCCTCTGCCACCTTTGACCCAGGAAGCGGGCAGCAGGTCACCCCAGCCAGGTTCCCCCCGGCCCAAGTGAAGCCGGAACCCGGT
GAGAGCACCGGCGCCCCAGGCCCCCACGAAGCCTCCCAGGACCGCAGTCTAGACCTGACTGTGAAGGAGCCCAGCAACGAATCAAATGGC
CACGCAGTCCCGGCAAATTCATCTCTTTTATCCTCGCTTATGAATAAGATGTCTCAGGGCAACCCTGGCCTGGGCAGCCTGCTGAACATC
AAGGCGGAAGCGGAGGGGAGCCCCGCTGCGGAGCCCTCGCCCTTCCTAGGCAAGGCCGTGAAGGCGCTGGTTCAGGAGAAGTTGGCAGAG
CCCTGGAAGGTGTACCTGCGCAGGTTTGGTACAAAGGACTTCTGTGACGGCCAGTGTGACTTCCTCCACAAGGCCCACTTCCACTGCGTG
GTGGAGGAATGCGGCGCGCTCTTCAGCACCTTGGACGGGGCCATCAAGCACGCAAACTTCCACTTCCGGACAGAGGGAGGAGCAGCAAAA
GGAAACACAGAGGCTGCCTTTCCGGCCTCGGCCGCCGAGACCAAACCTCCCATGGCCCCCTCGTCCCCTCCGGTCCCTCCTGTCACCACG
GCCACGGTGTCCTCTCTGGAGGGGCCCGCTCCCAGCCCGGCCTCCGTGCCCTCCACCCCCACCCTGCTCGCCTGGAAGCAGCTGGCTTCC
ACCATACCCCAGATGCCTCAGATCCCAGCGTCAGTGCCTCACCTGCCCGCCTCGCCCTTGGCAACGACTTCTCTAGAGAACGCCAAGCCC
CAGGTCAAACCCGGATTCCTCCAGTTCCAGGAGAACGATCCTTGCCTCGCCACGGACTGCAAGTACGCCAACAAGTTCCACTTCCACTGT
CTCTTTGGGAACTGCAAGTACGTCTGCAAAACGTCTGGCAAGGCCGAATCCCACTGCCTGGACCACATCAACCCCAACAACAACCTGGTG
AACGTGCGAGACCAGTTTGCATACTACTCTCTGCAGTGTCTCTGTCCCAACCAGCACTGCGAGTTCCGAATGCGTGGGCACTACCACTGC
CTCCGCACCGGCTGCTATTTTGTGACCAACATCACCACCAAGCTCCCCTGGCACATCAAGAAGCATGAGAAGGCGGAGCGGCGGGCAGCC
AATGGCTTCAAATACTTCACCAAGCGCGAGGAGTGTGGCAGGCTAGGTTGCAAGTACAACCAGGTGAACAGCCACTTCCACTGCATCCGG
GAGGGCTGCCAGTTCTCCTTCCTCCTCAAGCACCAGATGACCTCCCACGCGCGGAAGCACATGCGGAGGATGCTGGGGAAGAACTTCGAC
CGCGTGCCCCCCTCCCAGGGCCCCCCAGGCCTGATGGATGCTGAGACAGATGAGTGCATGGACTACACTGGCTGCAGCCCAGGCGCCATG
TCCTCTGAGTCATCCACCATGGACCGGAGCTGCTCCAGCACCCCCGTGGGTAACGAGAGCACCGCGGCAGAGGCTTCAGGTACAACTGGC
CACAGAGATAGTCCTGGAAGACACGTGGCGCCTGTGGACCGGAAGCACCAAATGCTGGTGCTGCTTTTGTACATACATATTTTTAAACCA

>13282_13282_2_CASZ1-EXOSC10_CASZ1_chr1_10702916_ENST00000377022_EXOSC10_chr1_11126805_ENST00000376936_length(amino acids)=1442AA_BP=1397
MLREFGTKEKRMDLGTAEGTRCTDPPAGKPAMAPKRKGGLKLNAICAKLSRQVVVEKRADAGSHTEGSPSQPRDQERSGPESGAARAPRS
EEDKRRAVIEKWVNGEYSEEPAPTPVLGRIAREGLELPPEGVYMVQPQGCSDEEDHAEEPSKDGGALEEKDSDGAASKEDSGPSTRQASG
EASSLRDYAASTMTEFLGMFGYDDQNTRDELARKISFEKLHAGSTPEAATSSMLPTSEDTLSKRARFSKYEEYIRKLKAGEQLSWPAPST
KTEERVGKEVVGTLPGLRLPSSTAHLETKATILPLPSHSSVQMQNLVARASKYDFFIQKLKTGENLRPQNGSTYKKPSKYDLENVKYLHL
FKPGEGSPDMGGAIAFKTGKVGRPSKYDVRGIQKPGPAKVPPTPSLAPAPLASVPSAPSAPGPGPEPPASLSFNTPEYLKSTFSKTDSIT
TGTVSTVKNGLPTDKPAVTEDVNIYQKYIARFSGSQHCGHIHCAYQYREHYHCLDPECNYQRFTSKQDVIRHYNMHKKRDNSLQHGFMRF
SPLDDCSVYYHGCHLNGKSTHYHCMQVGCNKVYTSTSDVMTHENFHKKNTQLINDGFQRFRATEDCGTADCQFYGQKTTHFHCRRPGCTF
TFKNKCDIEKHKSYHIKDDAYAKDGFKKFYKYEECKYEGCVYSKATNHFHCIRAGCGFTFTSTSQMTSHKRKHERRHIRSSGALGLPPSL
LGAKDTEHEESSNDDLVDFSALSSKNSSLSASPTSQQSSASLAAATAATEAGPSATKPPNSKISGLLPQGLPGSIPLALALSNSGLPTPT
PYFPILAGRGSTSLPVGTPSLLGAVSSGSAASATPDTPTLVASGAGDSAPVAAASVPAPPASIMERISASKGLISPMMARLAAAALKPSA
TFDPGSGQQVTPARFPPAQVKPEPGESTGAPGPHEASQDRSLDLTVKEPSNESNGHAVPANSSLLSSLMNKMSQGNPGLGSLLNIKAEAE
GSPAAEPSPFLGKAVKALVQEKLAEPWKVYLRRFGTKDFCDGQCDFLHKAHFHCVVEECGALFSTLDGAIKHANFHFRTEGGAAKGNTEA
AFPASAAETKPPMAPSSPPVPPVTTATVSSLEGPAPSPASVPSTPTLLAWKQLASTIPQMPQIPASVPHLPASPLATTSLENAKPQVKPG
FLQFQENDPCLATDCKYANKFHFHCLFGNCKYVCKTSGKAESHCLDHINPNNNLVNVRDQFAYYSLQCLCPNQHCEFRMRGHYHCLRTGC
YFVTNITTKLPWHIKKHEKAERRAANGFKYFTKREECGRLGCKYNQVNSHFHCIREGCQFSFLLKHQMTSHARKHMRRMLGKNFDRVPPS
QGPPGLMDAETDECMDYTGCSPGAMSSESSTMDRSCSSTPVGNESTAAEASGTTGHRDSPGRHVAPVDRKHQMLVLLLYIHIFKPLKFFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CASZ1-EXOSC10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CASZ1-EXOSC10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CASZ1-EXOSC10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource