FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CAV2-FAM189B (FusionGDB2 ID:13327)

Fusion Gene Summary for CAV2-FAM189B

check button Fusion gene summary
Fusion gene informationFusion gene name: CAV2-FAM189B
Fusion gene ID: 13327
HgeneTgene
Gene symbol

CAV2

FAM189B

Gene ID

858

10712

Gene namecaveolin 2family with sequence similarity 189 member B
SynonymsCAVC1orf2|COTE1
Cytomap

7q31.2

1q22

Type of geneprotein-codingprotein-coding
Descriptioncaveolin-2caveolae protein, 20-kDcaveolin 2 isoform a and bprotein FAM189B
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000462876, ENST00000222693, 
ENST00000343213, ENST00000393480, 
ENST00000350210, ENST00000361361, 
ENST00000368368, ENST00000472550, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 2 X 2=8
# samples 32
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/8*10)=1.32192809488736
Context

PubMed: CAV2 [Title/Abstract] AND FAM189B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCAV2(116139901)-FAM189B(155221669), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCAV2

GO:0006906

vesicle fusion

12743374

HgeneCAV2

GO:0008286

insulin receptor signaling pathway

20455999

HgeneCAV2

GO:0016050

vesicle organization

12743374

HgeneCAV2

GO:0043410

positive regulation of MAPK cascade

20455999

HgeneCAV2

GO:0043547

positive regulation of GTPase activity

8552590

HgeneCAV2

GO:0048278

vesicle docking

12743374

HgeneCAV2

GO:0070836

caveola assembly

12743374


check buttonFusion gene breakpoints across CAV2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM189B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAI091384CAV2chr7

116139901

+FAM189Bchr1

155221669

-


Top

Fusion Gene ORF analysis for CAV2-FAM189B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000462876ENST00000350210CAV2chr7

116139901

+FAM189Bchr1

155221669

-
3UTR-3CDSENST00000462876ENST00000361361CAV2chr7

116139901

+FAM189Bchr1

155221669

-
3UTR-3CDSENST00000462876ENST00000368368CAV2chr7

116139901

+FAM189Bchr1

155221669

-
3UTR-5UTRENST00000462876ENST00000472550CAV2chr7

116139901

+FAM189Bchr1

155221669

-
5CDS-5UTRENST00000222693ENST00000472550CAV2chr7

116139901

+FAM189Bchr1

155221669

-
5CDS-5UTRENST00000343213ENST00000472550CAV2chr7

116139901

+FAM189Bchr1

155221669

-
5CDS-5UTRENST00000393480ENST00000472550CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000222693ENST00000350210CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000222693ENST00000361361CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000222693ENST00000368368CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000343213ENST00000350210CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000343213ENST00000361361CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000343213ENST00000368368CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000393480ENST00000350210CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000393480ENST00000361361CAV2chr7

116139901

+FAM189Bchr1

155221669

-
In-frameENST00000393480ENST00000368368CAV2chr7

116139901

+FAM189Bchr1

155221669

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222693CAV2chr7116139901+ENST00000350210FAM189Bchr1155221669-2020847651511248
ENST00000222693CAV2chr7116139901+ENST00000368368FAM189Bchr1155221669-2008847651499244
ENST00000222693CAV2chr7116139901+ENST00000361361FAM189Bchr1155221669-2008847651499244
ENST00000343213CAV2chr7116139901+ENST00000350210FAM189Bchr1155221669-2020847651511248
ENST00000343213CAV2chr7116139901+ENST00000368368FAM189Bchr1155221669-2008847651499244
ENST00000343213CAV2chr7116139901+ENST00000361361FAM189Bchr1155221669-2008847651499244
ENST00000393480CAV2chr7116139901+ENST00000350210FAM189Bchr1155221669-2020847651511248
ENST00000393480CAV2chr7116139901+ENST00000368368FAM189Bchr1155221669-2008847651499244
ENST00000393480CAV2chr7116139901+ENST00000361361FAM189Bchr1155221669-2008847651499244

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222693ENST00000350210CAV2chr7116139901+FAM189Bchr1155221669-0.903868730.096131235
ENST00000222693ENST00000368368CAV2chr7116139901+FAM189Bchr1155221669-0.88373110.11626894
ENST00000222693ENST00000361361CAV2chr7116139901+FAM189Bchr1155221669-0.88373110.11626894
ENST00000343213ENST00000350210CAV2chr7116139901+FAM189Bchr1155221669-0.903868730.096131235
ENST00000343213ENST00000368368CAV2chr7116139901+FAM189Bchr1155221669-0.88373110.11626894
ENST00000343213ENST00000361361CAV2chr7116139901+FAM189Bchr1155221669-0.88373110.11626894
ENST00000393480ENST00000350210CAV2chr7116139901+FAM189Bchr1155221669-0.903868730.096131235
ENST00000393480ENST00000368368CAV2chr7116139901+FAM189Bchr1155221669-0.88373110.11626894
ENST00000393480ENST00000361361CAV2chr7116139901+FAM189Bchr1155221669-0.88373110.11626894

Top

Fusion Genomic Features for CAV2-FAM189B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for CAV2-FAM189B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116139901/chr1:155221669)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000035021009243_2490573.0Compositional biasNote=Poly-Pro
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000035021009634_6380573.0Compositional biasNote=Poly-Ser
TgeneFAM189Bchr7:116139901chr1:155221669ENST00000361361012243_2490669.0Compositional biasNote=Poly-Pro
TgeneFAM189Bchr7:116139901chr1:155221669ENST00000361361012634_6380669.0Compositional biasNote=Poly-Ser
TgeneFAM189Bchr7:116139901chr1:155221669ENST00000368368011243_2490651.0Compositional biasNote=Poly-Pro
TgeneFAM189Bchr7:116139901chr1:155221669ENST00000368368011634_6380651.0Compositional biasNote=Poly-Ser
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000035021009174_1940573.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST000003502100934_540573.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST000003502100967_870573.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST000003502100991_1110573.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST00000361361012174_1940669.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000036136101234_540669.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000036136101267_870669.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000036136101291_1110669.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST00000368368011174_1940651.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000036836801134_540651.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000036836801167_870651.0TransmembraneHelical
TgeneFAM189Bchr7:116139901chr1:155221669ENST0000036836801191_1110651.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCAV2chr7:116139901chr1:155221669ENST00000222693+1387_1070163.0IntramembraneHelical
HgeneCAV2chr7:116139901chr1:155221669ENST00000343213+1287_1070113.0IntramembraneHelical
HgeneCAV2chr7:116139901chr1:155221669ENST00000222693+13108_1620163.0Topological domainCytoplasmic
HgeneCAV2chr7:116139901chr1:155221669ENST00000222693+131_860163.0Topological domainCytoplasmic
HgeneCAV2chr7:116139901chr1:155221669ENST00000343213+12108_1620113.0Topological domainCytoplasmic
HgeneCAV2chr7:116139901chr1:155221669ENST00000343213+121_860113.0Topological domainCytoplasmic


Top

Fusion Gene Sequence for CAV2-FAM189B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13327_13327_1_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000222693_FAM189B_chr1_155221669_ENST00000350210_length(transcript)=2020nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGTTTTCTTGATCAGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCC
CGGTCAGCCGAGAAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTA
AAGGGCAGCTGGCCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGA
CATAAGCAGCTGACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACA
GCGGGTCTCTGGTGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCG
TGCGCTCCGTGGACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCT
TCGAGGAAAGCCCCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCC
CCACAGCTGCCCGCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGG
GAGGGGGCCGCCCAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACC
GGCCTCCTCATCCGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACT
CTCTTTGACCCTCAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACA
GCCCAGTGCCCTTGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGG
GCTGCACGTCCCCGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATC

>13327_13327_1_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000222693_FAM189B_chr1_155221669_ENST00000350210_length(amino acids)=248AA_BP=
MFVKLLTVCKPSINFSFPLVFLIRLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQ
ISRKAPDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAA

--------------------------------------------------------------
>13327_13327_2_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000222693_FAM189B_chr1_155221669_ENST00000361361_length(transcript)=2008nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCCCGGTCAGCCGAG
AAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTAAAGGGCAGCTGG
CCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGACATAAGCAGCTG
ACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACAGCGGGTCTCTGG
TGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCGTGCGCTCCGTGG
ACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCTTCGAGGAAAGCC
CCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCCCCACAGCTGCCC
GCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGGGAGGGGGCCGCC
CAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACCGGCCTCCTCATC
CGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACTCTCTTTGACCCT
CAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACAGCCCAGTGCCCT
TGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGGGCTGCACGTCCC
CGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATCCCCCAGAGTATA

>13327_13327_2_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000222693_FAM189B_chr1_155221669_ENST00000361361_length(amino acids)=244AA_BP=
MFVKLLTVCKPSINFSFPLGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRK
APDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAAVPAT

--------------------------------------------------------------
>13327_13327_3_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000222693_FAM189B_chr1_155221669_ENST00000368368_length(transcript)=2008nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCCCGGTCAGCCGAG
AAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTAAAGGGCAGCTGG
CCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGACATAAGCAGCTG
ACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACAGCGGGTCTCTGG
TGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCGTGCGCTCCGTGG
ACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCTTCGAGGAAAGCC
CCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCCCCACAGCTGCCC
GCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGGGAGGGGGCCGCC
CAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACCGGCCTCCTCATC
CGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACTCTCTTTGACCCT
CAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACAGCCCAGTGCCCT
TGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGGGCTGCACGTCCC
CGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATCCCCCAGAGTATA

>13327_13327_3_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000222693_FAM189B_chr1_155221669_ENST00000368368_length(amino acids)=244AA_BP=
MFVKLLTVCKPSINFSFPLGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRK
APDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAAVPAT

--------------------------------------------------------------
>13327_13327_4_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000343213_FAM189B_chr1_155221669_ENST00000350210_length(transcript)=2020nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGTTTTCTTGATCAGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCC
CGGTCAGCCGAGAAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTA
AAGGGCAGCTGGCCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGA
CATAAGCAGCTGACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACA
GCGGGTCTCTGGTGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCG
TGCGCTCCGTGGACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCT
TCGAGGAAAGCCCCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCC
CCACAGCTGCCCGCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGG
GAGGGGGCCGCCCAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACC
GGCCTCCTCATCCGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACT
CTCTTTGACCCTCAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACA
GCCCAGTGCCCTTGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGG
GCTGCACGTCCCCGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATC

>13327_13327_4_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000343213_FAM189B_chr1_155221669_ENST00000350210_length(amino acids)=248AA_BP=
MFVKLLTVCKPSINFSFPLVFLIRLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQ
ISRKAPDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAA

--------------------------------------------------------------
>13327_13327_5_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000343213_FAM189B_chr1_155221669_ENST00000361361_length(transcript)=2008nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCCCGGTCAGCCGAG
AAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTAAAGGGCAGCTGG
CCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGACATAAGCAGCTG
ACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACAGCGGGTCTCTGG
TGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCGTGCGCTCCGTGG
ACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCTTCGAGGAAAGCC
CCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCCCCACAGCTGCCC
GCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGGGAGGGGGCCGCC
CAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACCGGCCTCCTCATC
CGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACTCTCTTTGACCCT
CAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACAGCCCAGTGCCCT
TGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGGGCTGCACGTCCC
CGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATCCCCCAGAGTATA

>13327_13327_5_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000343213_FAM189B_chr1_155221669_ENST00000361361_length(amino acids)=244AA_BP=
MFVKLLTVCKPSINFSFPLGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRK
APDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAAVPAT

--------------------------------------------------------------
>13327_13327_6_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000343213_FAM189B_chr1_155221669_ENST00000368368_length(transcript)=2008nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCCCGGTCAGCCGAG
AAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTAAAGGGCAGCTGG
CCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGACATAAGCAGCTG
ACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACAGCGGGTCTCTGG
TGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCGTGCGCTCCGTGG
ACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCTTCGAGGAAAGCC
CCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCCCCACAGCTGCCC
GCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGGGAGGGGGCCGCC
CAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACCGGCCTCCTCATC
CGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACTCTCTTTGACCCT
CAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACAGCCCAGTGCCCT
TGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGGGCTGCACGTCCC
CGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATCCCCCAGAGTATA

>13327_13327_6_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000343213_FAM189B_chr1_155221669_ENST00000368368_length(amino acids)=244AA_BP=
MFVKLLTVCKPSINFSFPLGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRK
APDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAAVPAT

--------------------------------------------------------------
>13327_13327_7_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000393480_FAM189B_chr1_155221669_ENST00000350210_length(transcript)=2020nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGTTTTCTTGATCAGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCC
CGGTCAGCCGAGAAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTA
AAGGGCAGCTGGCCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGA
CATAAGCAGCTGACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACA
GCGGGTCTCTGGTGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCG
TGCGCTCCGTGGACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCT
TCGAGGAAAGCCCCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCC
CCACAGCTGCCCGCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGG
GAGGGGGCCGCCCAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACC
GGCCTCCTCATCCGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACT
CTCTTTGACCCTCAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACA
GCCCAGTGCCCTTGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGG
GCTGCACGTCCCCGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATC

>13327_13327_7_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000393480_FAM189B_chr1_155221669_ENST00000350210_length(amino acids)=248AA_BP=
MFVKLLTVCKPSINFSFPLVFLIRLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQ
ISRKAPDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAA

--------------------------------------------------------------
>13327_13327_8_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000393480_FAM189B_chr1_155221669_ENST00000361361_length(transcript)=2008nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCCCGGTCAGCCGAG
AAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTAAAGGGCAGCTGG
CCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGACATAAGCAGCTG
ACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACAGCGGGTCTCTGG
TGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCGTGCGCTCCGTGG
ACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCTTCGAGGAAAGCC
CCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCCCCACAGCTGCCC
GCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGGGAGGGGGCCGCC
CAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACCGGCCTCCTCATC
CGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACTCTCTTTGACCCT
CAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACAGCCCAGTGCCCT
TGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGGGCTGCACGTCCC
CGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATCCCCCAGAGTATA

>13327_13327_8_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000393480_FAM189B_chr1_155221669_ENST00000361361_length(amino acids)=244AA_BP=
MFVKLLTVCKPSINFSFPLGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRK
APDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAAVPAT

--------------------------------------------------------------
>13327_13327_9_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000393480_FAM189B_chr1_155221669_ENST00000368368_length(transcript)=2008nt_BP=84nt
AGCGGCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGCATCTCAAGGTGCCC
CGGAGCCTGTGGGGCCGGCCTGGCCGAGAGAGCCTCCACCTTCGCAGCTGCGGAGATCTGAGCTCTAGCTCTTCCCTGCGGCGTCTCCTG
TCTGGCCGCAGGCTGGAGCGTGGTACCCGCCCCCACAGCCTCAGCCTCAACGGGGGCAGCCGGGAGACTGGGCTCTGACCTAGGCTTCTT
GTCACACTGAACACATCCAGCCACAGGCACCAGCTGGTTGGGACCAGCAGCCCCCAGCATCCTCTTGCACTGGCTGGCACAAAAAGAAAC
CTGCTGTATACCCCCCAAAGTGTCCCTTTCCCTCCTACCTCTGGGGTCTCTTGCTGCTTGCCTCTGCTGCTCTGGACTGGGAGAGCTTCT
GTCCTGTGCTGCATGGGTATTTAGACTGTGGGGGAGATGCCCCTTCTTATAGCACTGGAGGAGGAAAACAAATTCTTGTCCCCCTCAGAA
TGAGAGTGGCTCTTTCTGATTTGCAAGGGCACTATGGTCAGGGCAAAGGCATGGCCCAGGTGTTTAAGTACAGGGTGACGTGTGCCTATG
CAATGGGGTGGTAAGGCAGGCACGAAGAGTCCAAAAAATCTAGGTGGCCTCTCAGCTCTGCCACCTCTAGCTGCATGACCTTGGGCAAGC
TATGTAACCCCAATTGCCTGCTCCATTAAAGACTGTGAAGGTAGAATGTTTGTAAAGCTCTTAACAGTATGTAAGCCTTCAATAAATTTC
AGTTTTCCCCTTGGGCTCTGCTCTGAAGCCTGCCTCTTCCGCCTAGCCCGCTGCCCTTCCCCCAAGTTGCTACGTGCCCGGTCAGCCGAG
AAACGGCGCCCTGTGCCCACCTTCCAAAAAGTTCCCCTGCCCTCGGGCCCTGCACCTGCCCACTCCCTGGGGGACCTAAAGGGCAGCTGG
CCAGGTCGGGGCCTGGTCACTCGTTTCCTCCAGATATCCAGGAAAGCCCCAGACCCCAGTGGGACTGGAGCTCATGGACATAAGCAGCTG
ACTTCAGGGACCTTTATACCAAAGTGCTTGAGGAAGAAGCTGCTTCTGTTTCCTCTGCAGATACAGTGTCCATGGACAGCGGGTCTCTGG
TGCTGTCAGCCATTGGTGACCTCCCTGGGGGCTCTAGCCCGTCGGAGGACTCGTGCCTGCTGGAGCTGCAGGGCTCCGTGCGCTCCGTGG
ACTACGTTCTCTTTCGCTCCATCCAGCGCAGCCGTGCCGGCTACTGCCTCAGCCTGGACTGTGGCCTGCGGGGCCCCTTCGAGGAAAGCC
CCCTGCCACGGCGCCCCCCACGGGCTGCCCGCTCCTATTCCTGCTCTGCCCCTGAAGCTCCACCCCCACTGGGTGCCCCCACAGCTGCCC
GCAGCTGCCACCGGTTGGAGGGCTGGCCGCCCTGGGTGGGACCCTGCTTCCCCGAGCTGAGGCGGCGGGTCCCCCGGGGAGGGGGCCGCC
CAGCCGCAGCCCCGCCCACCCGAGCCCCGACTCGTCGCTTCAGCGATAGCTCAGGTTCCCTCACCCCACCGGGGCACCGGCCTCCTCATC
CGGCATCCCCACCACCGCTGCTGCTGCCACGGTCCCACAGCGACCCAGGCATCACGACCTCCAGTGACACTGGCCACTCTCTTTGACCCT
CAGCTTCACGATGGCTCGTGCATCTGTGAACGAGTGGCCTCCATTGTAGACGCATCACGTACAATGGCTCCATGGACAGCCCAGTGCCCT
TGTACCCTACCGATTGCCCCCCTTCTTATGAGGCAGTCATGGGACTACGAGGAGACAGCCAGCCACTGGGACCTCTGGGCTGCACGTCCC
CGCCCCCAGCCCCTCTCCTACACACCATGCTGGACCTGGAGGAATTTGTCCCGCCTGTGCCCCCACCGCCCTACTATCCCCCAGAGTATA

>13327_13327_9_CAV2-FAM189B_CAV2_chr7_116139901_ENST00000393480_FAM189B_chr1_155221669_ENST00000368368_length(amino acids)=244AA_BP=
MFVKLLTVCKPSINFSFPLGLCSEACLFRLARCPSPKLLRARSAEKRRPVPTFQKVPLPSGPAPAHSLGDLKGSWPGRGLVTRFLQISRK
APDPSGTGAHGHKQLTSGTFIPKCLRKKLLLFPLQIQCPWTAGLWCCQPLVTSLGALARRRTRACWSCRAPCAPWTTFSFAPSSAAVPAT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CAV2-FAM189B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CAV2-FAM189B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CAV2-FAM189B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource