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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CBFA2T2-BCL2L1 (FusionGDB2 ID:13331)

Fusion Gene Summary for CBFA2T2-BCL2L1

check button Fusion gene summary
Fusion gene informationFusion gene name: CBFA2T2-BCL2L1
Fusion gene ID: 13331
HgeneTgene
Gene symbol

CBFA2T2

BCL2L1

Gene ID

9139

598

Gene nameCBFA2/RUNX1 partner transcriptional co-repressor 2BCL2 like 1
SynonymsEHT|MTGR1|ZMYND3|p85BCL-XL/S|BCL2L|BCLX|Bcl-X|PPP1R52
Cytomap

20q11.21-q11.22

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionprotein CBFA2T2CBFA2/RUNX1 translocation partner 2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-relabcl-2-like protein 1apoptosis regulator Bcl-Xprotein phosphatase 1, regulatory subunit 52
Modification date2020031320200327
UniProtAcc

O43439

Q9BZR8

Ensembl transtripts involved in fusion geneENST00000375279, ENST00000342704, 
ENST00000344201, ENST00000346541, 
ENST00000359606, ENST00000397798, 
ENST00000397800, ENST00000491618, 
ENST00000492345, ENST00000543126, 
ENST00000307677, ENST00000376055, 
ENST00000376062, ENST00000420653, 
Fusion gene scores* DoF score26 X 9 X 12=280810 X 5 X 10=500
# samples 2711
** MAII scorelog2(27/2808*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/500*10)=-2.18442457113743
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBFA2T2 [Title/Abstract] AND BCL2L1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBFA2T2(32078107)-BCL2L1(30253889), # samples:3
Anticipated loss of major functional domain due to fusion event.CBFA2T2-BCL2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CBFA2T2-BCL2L1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

HgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453

TgeneBCL2L1

GO:0001836

release of cytochrome c from mitochondria

9843949

TgeneBCL2L1

GO:0019050

suppression by virus of host apoptotic process

15231831

TgeneBCL2L1

GO:0034097

response to cytokine

9184696

TgeneBCL2L1

GO:0043066

negative regulation of apoptotic process

7650367|9388232

TgeneBCL2L1

GO:0046902

regulation of mitochondrial membrane permeability

9843949

TgeneBCL2L1

GO:0051881

regulation of mitochondrial membrane potential

9843949

TgeneBCL2L1

GO:1900118

negative regulation of execution phase of apoptosis

20673843

TgeneBCL2L1

GO:1902042

negative regulation of extrinsic apoptotic signaling pathway via death domain receptors

26582200

TgeneBCL2L1

GO:1902230

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage

16608847

TgeneBCL2L1

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

29507230

TgeneBCL2L1

GO:1903077

negative regulation of protein localization to plasma membrane

21041309

TgeneBCL2L1

GO:2001243

negative regulation of intrinsic apoptotic signaling pathway

12011449


check buttonFusion gene breakpoints across CBFA2T2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BCL2L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HS-01ACBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
ChimerDB4SARCTCGA-DX-A8BS-01ACBFA2T2chr20

32078107

-BCL2L1chr20

30253889

-
ChimerDB4SARCTCGA-DX-A8BS-01ACBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-


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Fusion Gene ORF analysis for CBFA2T2-BCL2L1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000375279ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
5UTR-3CDSENST00000375279ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
5UTR-3CDSENST00000375279ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
5UTR-3CDSENST00000375279ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
Frame-shiftENST00000342704ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
Frame-shiftENST00000342704ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
In-frameENST00000342704ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
In-frameENST00000342704ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000344201ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000344201ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000344201ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000344201ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000346541ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000346541ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000346541ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000346541ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000359606ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000359606ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000359606ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000359606ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397798ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397798ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397798ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397798ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397800ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397800ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397800ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000397800ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000491618ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000491618ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000491618ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000491618ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000492345ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000492345ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000492345ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000492345ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000543126ENST00000307677CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000543126ENST00000376055CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000543126ENST00000376062CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-
intron-3CDSENST00000543126ENST00000420653CBFA2T2chr20

32078107

+BCL2L1chr20

30253889

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000342704CBFA2T2chr2032078107+ENST00000376055BCL2L1chr2030253889-185021510941678194
ENST00000342704CBFA2T2chr2032078107+ENST00000420653BCL2L1chr2030253889-184221510941678194

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342704ENST00000376055CBFA2T2chr2032078107+BCL2L1chr2030253889-0.298059230.7019408
ENST00000342704ENST00000420653CBFA2T2chr2032078107+BCL2L1chr2030253889-0.312357220.6876428

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Fusion Genomic Features for CBFA2T2-BCL2L1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CBFA2T2-BCL2L1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:32078107/chr20:30253889)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBFA2T2

O43439

BCL2L1

Q9BZR8

FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218). Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70374, ECO:0000269|PubMed:23251453, ECO:0000303|PubMed:12559562, ECO:0000303|PubMed:15203199}.FUNCTION: Plays a role in apoptosis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000037605513129_148125171.0MotifNote=BH1
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000037605513180_195125171.0MotifNote=BH2
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000030767713210_226188234.0TransmembraneHelical
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000037605513210_226125171.0TransmembraneHelical
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000037606202210_226188234.0TransmembraneHelical
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000042065313210_226188234.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000342704+111451_49111596.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000344201+16451_4910264.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000346541+112451_4910605.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000359606+111451_4910615.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000375279+112451_4910605.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397798+17451_4910264.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397800+111451_4910576.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000492345+113451_4910576.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000342704+11133_9711596.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000344201+1633_970264.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000346541+11233_970605.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000359606+11133_970615.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000375279+11233_970605.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397798+1733_970264.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397800+11133_970576.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000492345+11333_970576.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000342704+111113_20811596.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000344201+16113_2080264.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000346541+112113_2080605.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000359606+111113_2080615.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000375279+112113_2080605.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397798+17113_2080264.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397800+111113_2080576.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000492345+113113_2080576.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000342704+111331_37711596.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000342704+111435_48411596.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000344201+16331_3770264.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000344201+16435_4840264.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000346541+112331_3770605.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000346541+112435_4840605.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000359606+111331_3770615.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000359606+111435_4840615.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000375279+112331_3770605.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000375279+112435_4840605.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397798+17331_3770264.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397798+17435_4840264.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397800+111331_3770576.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397800+111435_4840576.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000492345+113331_3770576.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000492345+113435_4840576.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000342704+111517_55311596.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000344201+16517_5530264.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000346541+112517_5530605.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000359606+111517_5530615.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000375279+112517_5530605.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397798+17517_5530264.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397800+111517_5530576.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000492345+113517_5530576.0Zinc fingerMYND-type
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000030767713129_148188234.0MotifNote=BH1
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000030767713180_195188234.0MotifNote=BH2
TgeneBCL2L1chr20:32078107chr20:30253889ENST00000307677134_24188234.0MotifNote=BH4
TgeneBCL2L1chr20:32078107chr20:30253889ENST000003076771386_100188234.0MotifNote=BH3
TgeneBCL2L1chr20:32078107chr20:30253889ENST00000376055134_24125171.0MotifNote=BH4
TgeneBCL2L1chr20:32078107chr20:30253889ENST000003760551386_100125171.0MotifNote=BH3
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000037606202129_148188234.0MotifNote=BH1
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000037606202180_195188234.0MotifNote=BH2
TgeneBCL2L1chr20:32078107chr20:30253889ENST00000376062024_24188234.0MotifNote=BH4
TgeneBCL2L1chr20:32078107chr20:30253889ENST000003760620286_100188234.0MotifNote=BH3
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000042065313129_148188234.0MotifNote=BH1
TgeneBCL2L1chr20:32078107chr20:30253889ENST0000042065313180_195188234.0MotifNote=BH2
TgeneBCL2L1chr20:32078107chr20:30253889ENST00000420653134_24188234.0MotifNote=BH4
TgeneBCL2L1chr20:32078107chr20:30253889ENST000004206531386_100188234.0MotifNote=BH3


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Fusion Gene Sequence for CBFA2T2-BCL2L1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13331_13331_1_CBFA2T2-BCL2L1_CBFA2T2_chr20_32078107_ENST00000342704_BCL2L1_chr20_30253889_ENST00000376055_length(transcript)=1850nt_BP=215nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCC
AGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGACCAGACA
CTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCGCCATTGCCACCAGGAGAACCACTACATGC
AGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTTTCTAGAATTTATCACACTTCTGTGAGACC
CCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTGTCCAAAGGAGGCTGGCAGGTATGGAAGGGTTTGTGGC
TGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCTGAAAATGTTTTTCTGCCAGGGAGCTTGAAAGTTTTC
AGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAATTGATCATTTTCCCCCCACTCTCCCCACA
CTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGACTAGGGATTCAGGCTGCTTGGGATAAA
GATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAATGTCCTCCAGAAGCCTCTGGCTAGAG
GCCAGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGTGGCCCTTGCAGTTCAGCACCACCCTA
GTCCCTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGATGCCCCAGAGCTGTTTATGGCCTCAGCTGC
CTCACTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTTCAGGGGACTCAGCCCTGAGGTGAAAGGGA
GCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAAGGGCAGGAAGGAGAGCCTGCTGCATGGGGTGGGGTAG
GGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGTGCCCCATGCCTGTCCAGCCTGGGCAGCCAGGCTGCCAAGGCCAGAGT
GGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCCACCCTTGGCCTGTCTCATCCCCAGGGGTCCCAGCCACCCCGGGCTC
TCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTTAAGCGTGTCTGTATTTATGTGTGAGGAGC
TGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATGCTCCCTCCCCTGCCCTGGTCCAGGGAAGC
TGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTTCCAGCTCTTTGAAATAGTCTGTGTGA

>13331_13331_1_CBFA2T2-BCL2L1_CBFA2T2_chr20_32078107_ENST00000342704_BCL2L1_chr20_30253889_ENST00000376055_length(amino acids)=194AA_BP=
MAPMTILRDQLGPRQMPQSCLWPQLPHFLQEQPVASLPWAAPHGGFRGLSPEVKGSYQEQLWEPQGLPYLRQEGQEGEPAAWGGVGLTRR
ASPAWPGRSVPHACPAWAARLPRPEWPGQELFRPPSLFCSTLGLSHPQGSQPPRALCCTYLRLVFIPCEDDILFLLSVSVFMCEELLACS

--------------------------------------------------------------
>13331_13331_2_CBFA2T2-BCL2L1_CBFA2T2_chr20_32078107_ENST00000342704_BCL2L1_chr20_30253889_ENST00000420653_length(transcript)=1842nt_BP=215nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGATACTTTTGTGGAACTCTATGGGAACAATGCAGCAGCCGAGAGCCGAAAGGGCC
AGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGGCTCACTCTTCAGTCGGAAATGACCAGACA
CTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCGCCATTGCCACCAGGAGAACCACTACATGC
AGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTTTCTAGAATTTATCACACTTCTGTGAGACC
CCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTGTCCAAAGGAGGCTGGCAGGTATGGAAGGGTTTGTGGC
TGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCTGAAAATGTTTTTCTGCCAGGGAGCTTGAAAGTTTTC
AGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAATTGATCATTTTCCCCCCACTCTCCCCACA
CTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGACTAGGGATTCAGGCTGCTTGGGATAAA
GATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAATGTCCTCCAGAAGCCTCTGGCTAGAG
GCCAGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGTGGCCCTTGCAGTTCAGCACCACCCTA
GTCCCTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGATGCCCCAGAGCTGTTTATGGCCTCAGCTGC
CTCACTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTTCAGGGGACTCAGCCCTGAGGTGAAAGGGA
GCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAAGGGCAGGAAGGAGAGCCTGCTGCATGGGGTGGGGTAG
GGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGTGCCCCATGCCTGTCCAGCCTGGGCAGCCAGGCTGCCAAGGCCAGAGT
GGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCCACCCTTGGCCTGTCTCATCCCCAGGGGTCCCAGCCACCCCGGGCTC
TCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTTAAGCGTGTCTGTATTTATGTGTGAGGAGC
TGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATGCTCCCTCCCCTGCCCTGGTCCAGGGAAGC
TGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTTCCAGCTCTTTGAAATAGTCTGTGTGA

>13331_13331_2_CBFA2T2-BCL2L1_CBFA2T2_chr20_32078107_ENST00000342704_BCL2L1_chr20_30253889_ENST00000420653_length(amino acids)=194AA_BP=
MAPMTILRDQLGPRQMPQSCLWPQLPHFLQEQPVASLPWAAPHGGFRGLSPEVKGSYQEQLWEPQGLPYLRQEGQEGEPAAWGGVGLTRR
ASPAWPGRSVPHACPAWAARLPRPEWPGQELFRPPSLFCSTLGLSHPQGSQPPRALCCTYLRLVFIPCEDDILFLLSVSVFMCEELLACS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CBFA2T2-BCL2L1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000342704+111107_21511.333333333333334596.0PRDM14
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000344201+16107_2150264.0PRDM14
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000346541+112107_2150605.0PRDM14
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000359606+111107_2150615.0PRDM14
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000375279+112107_2150605.0PRDM14
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397798+17107_2150264.0PRDM14
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000397800+111107_2150576.0PRDM14
HgeneCBFA2T2chr20:32078107chr20:30253889ENST00000492345+113107_2150576.0PRDM14


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBFA2T2-BCL2L1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CBFA2T2-BCL2L1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource