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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ACO1-ARL3 (FusionGDB2 ID:1336) |
Fusion Gene Summary for ACO1-ARL3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ACO1-ARL3 | Fusion gene ID: 1336 | Hgene | Tgene | Gene symbol | ACO1 | ARL3 | Gene ID | 48 | 403 |
| Gene name | aconitase 1 | ADP ribosylation factor like GTPase 3 | |
| Synonyms | ACONS|HEL60|IREB1|IREBP|IREBP1|IRP1 | ARFL3|JBTS35|RP83 | |
| Cytomap | 9p21.1 | 10q24.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytoplasmic aconitate hydrataseaconitase 1, solubleaconitate hydratase, cytoplasmiccitrate hydro-lyasecytoplasmic aconitasecytosplasmic aconitaseepididymis luminal protein 60epididymis secretory sperm binding proteinferritin repressor proteiniron | ADP-ribosylation factor-like protein 3ADP-ribosylation factor-like 3ARF-like 3 | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | P21399 | P36405 | |
| Ensembl transtripts involved in fusion gene | ENST00000309951, ENST00000379923, ENST00000541043, | ENST00000260746, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 7 X 5 X 5=175 |
| # samples | 6 | 7 | |
| ** MAII score | log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ACO1 [Title/Abstract] AND ARL3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ACO1(32436395)-ARL3(104445758), # samples:2 ARL3(104445573)-ACO1(32440463), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ACO1 | GO:0006101 | citrate metabolic process | 8041788|16527810 |
| Hgene | ACO1 | GO:0010040 | response to iron(II) ion | 8041788 |
| Tgene | ARL3 | GO:0007264 | small GTPase mediated signal transduction | 22085962 |
| Fusion gene breakpoints across ACO1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ARL3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-D1-A175-01A | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - |
| ChimerDB4 | UCEC | TCGA-D1-A175 | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - |
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Fusion Gene ORF analysis for ACO1-ARL3 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000309951 | ENST00000260746 | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - |
| In-frame | ENST00000379923 | ENST00000260746 | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - |
| In-frame | ENST00000541043 | ENST00000260746 | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000541043 | ACO1 | chr9 | 32436395 | + | ENST00000260746 | ARL3 | chr10 | 104445758 | - | 5850 | 2453 | 149 | 2686 | 845 |
| ENST00000379923 | ACO1 | chr9 | 32436395 | + | ENST00000260746 | ARL3 | chr10 | 104445758 | - | 5850 | 2453 | 149 | 2686 | 845 |
| ENST00000309951 | ACO1 | chr9 | 32436395 | + | ENST00000260746 | ARL3 | chr10 | 104445758 | - | 5782 | 2385 | 33 | 2618 | 861 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000541043 | ENST00000260746 | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - | 0.001178504 | 0.99882144 |
| ENST00000379923 | ENST00000260746 | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - | 0.001178504 | 0.99882144 |
| ENST00000309951 | ENST00000260746 | ACO1 | chr9 | 32436395 | + | ARL3 | chr10 | 104445758 | - | 0.001239516 | 0.99876046 |
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Fusion Genomic Features for ACO1-ARL3 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for ACO1-ARL3 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32436395/chr10:104445758) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ACO1 | ARL3 |
| FUNCTION: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. {ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250}. | FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:16525022, PubMed:18588884). Required for normal cytokinesis and cilia signaling (PubMed:22085962). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E (PubMed:30269812). Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (PubMed:22085962). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity). {ECO:0000250|UniProtKB:Q9WUL7, ECO:0000269|PubMed:16525022, ECO:0000269|PubMed:18588884, ECO:0000269|PubMed:22085962}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACO1 | chr9:32436395 | chr10:104445758 | ENST00000309951 | + | 18 | 21 | 205_207 | 749 | 890.0 | Region | Substrate binding |
| Hgene | ACO1 | chr9:32436395 | chr10:104445758 | ENST00000379923 | + | 19 | 22 | 205_207 | 749 | 890.0 | Region | Substrate binding |
| Tgene | ARL3 | chr9:32436395 | chr10:104445758 | ENST00000260746 | 3 | 6 | 126_129 | 105 | 183.0 | Nucleotide binding | GTP | |
| Tgene | ARL3 | chr9:32436395 | chr10:104445758 | ENST00000260746 | 3 | 6 | 159_161 | 105 | 183.0 | Nucleotide binding | GTP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ACO1 | chr9:32436395 | chr10:104445758 | ENST00000309951 | + | 18 | 21 | 779_780 | 749 | 890.0 | Region | Substrate binding |
| Hgene | ACO1 | chr9:32436395 | chr10:104445758 | ENST00000379923 | + | 19 | 22 | 779_780 | 749 | 890.0 | Region | Substrate binding |
| Tgene | ARL3 | chr9:32436395 | chr10:104445758 | ENST00000260746 | 3 | 6 | 24_31 | 105 | 183.0 | Nucleotide binding | GTP | |
| Tgene | ARL3 | chr9:32436395 | chr10:104445758 | ENST00000260746 | 3 | 6 | 67_71 | 105 | 183.0 | Nucleotide binding | GTP |
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Fusion Gene Sequence for ACO1-ARL3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >1336_1336_1_ACO1-ARL3_ACO1_chr9_32436395_ENST00000309951_ARL3_chr10_104445758_ENST00000260746_length(transcript)=5782nt_BP=2385nt GGGGCGAGAGGGGGCGGAGCGTGGAGGCGGCAGCTGGAACCGCGCAGCGCACGGGAACGCGTCCCGCTGCTTGGGTCAGGTTCGCCGGTC GCGGGAGCCCCGCCGTGCAGTCGGAGGAACACGTGGCCATCAGTAATCATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCT GTACAACCAGGAAAGAAATTCTTCAATTTGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCAGAGTTCTTCTGGAA GCAGCCATTCGGAATTGTGATGAGTTTTTGGTGAAGAAACAGGATATTGAAAATATTCTACATTGGAATGTCACGCAGCACAAGAACATA GAAGTGCCATTTAAGCCTGCTCGTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTGTGGTTGACTTTGCTGCAATGCGTGATGCTGTG AAAAAGTTAGGAGGAGATCCAGAGAAAATAAACCCTGTCTGCCCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGA AGGGCAGACAGTTTACAGAAGAATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAAGTGGGGTTCCCAGGCTTTT CACAACATGCGGATTATTCCCCCTGGCTCAGGAATCATCCACCAGGTGAATTTGGAATATTTGGCAAGAGTGGTATTTGATCAGGATGGA TATTATTACCCAGACAGCCTCGTGGGCACAGACTCGCACACTACCATGATTGATGGCTTGGGCATTCTTGGTTGGGGTGTCGGTGGTATT GAAGCAGAAGCTGTCATGCTGGGTCAGCCAATCAGTATGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTG GTAACATCCACTGACATCGTGCTCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAATTTGTCGAGTTCTTCGGGCCTGGA GTAGCCCAGTTGTCCATTGCTGACCGAGCTACGATTGCTAACATGTGTCCAGAGTACGGAGCAACTGCTGCCTTTTTCCCAGTTGATGAA GTTAGTATCACGTACCTGGTGCAAACAGGTCGTGATGAAGAAAAATTAAAGTATATTAAAAAATATCTTCAGGCTGTAGGAATGTTTCGA GATTTCAATGACCCTTCTCAAGACCCAGACTTCACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCAAA AGGCCTCAGGACAAAGTTGCTGTGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAGCCAAGCAAGGATTTAAAGGATTCCAAGTT GCTCCTGAACATCATAATGACCATAAGACCTTTATCTATGATAACACTGAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCATT ACTAGCTGCACAAACACCAGTAATCCGTCTGTGATGTTAGGGGCAGGATTGTTAGCAAAGAAAGCTGTGGATGCTGGCCTGAACGTGATG CCTTACATCAAAACTAGCCTGTCTCCTGGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTATCTGTCTCAGCTT GGGTTTGACGTGGTGGGCTATGGCTGCATGACCTGCATTGGCAACAGTGGGCCTTTACCTGAACCTGTGGTAGAAGCCATCACACAGGGA GACCTTGTAGCTGTTGGAGTACTATCTGGAAACAGGAATTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCCTCTCCC CCCTTAGTAATAGCATATGCAATTGCTGGAACCATCAGAATCGACTTTGAGAAAGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGGTA TTTCTGAAAGATATCTGGCCGACTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGGGATGTTTAAGGAAGTCTATCAG AAAATAGAGACTGTGAATGAAAGCTGGAATGCCTTAGCAACCCCATCAGATAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAA TCACCACCATTCTTTGAAAACCTGACTTTGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATTTGGGAGATTCG GTAACAACTGACCACATCTCCCCAGCTGGAAATATTGCAAGAAACAGTCCTGCTGCTCGCTACTTAACTAACAGAGGCCTAACTCCACGA GAATTCAACTCCTATGGCTCCCGCCGAGGTAATGACGCCGTCATGGCACGGGGAACATTTGCCAACATTCGCTTGTTAAACAGATTTTTG AACAAGCAGGCACCACAGACTATCCATCTGCCTTCTGGGGAAATCGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCA GTGCTCATCTTTGCTAATAAGCAGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGAC CGAGTCTGGCAGATCCAGTCTTGCTCAGCTCTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAG AAGAAATAAAATCTAGACGAATGGAGATGCAGGAGCTGCGGGAGCCGAATTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAA TGTTTTTCCATCTGTGTACAGCTCCAGCTGTTTGAAGAGAGGGAACAACACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACT GATCTCTGAGGTTCAGTATCATTTTTCAAATAAAGGAATTATATTATTTCCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACA TGATTAGAAAATGAGATCTTTTAAATGAGCAAGAGATTGCATTGCAGTTTAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAA AAAAGAAAAAGAAAAAGAGGAAGAAGCAGCTTTGCTGAGTTCATTTATTTACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACC ACAGACAGTGTTTGCTGGTGCTGTCAGTGATTTTTACCGTCACTAGCCCAGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGG GGTGGGGGGAGAAAAGGCAGATAATTAAACCATCTCATCGTCTTGCAGGTCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAA AAAAAAAAAAGTCTTTCTTGCAGACAAGTCACTACAGAAACATACCCCATCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAG AAGCAAATTCTTATGACTTTTGACTGTAATGACATCTGGAATGTAAGGAGAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTA AAAAGCTCTCACATCGAGGGCTCAGGCTAGCGTAAACAGGCTTTCTCCAGCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGG CTTCTCCACGGCCGTCCTATAGACAGGATTTCTAAAGCTCAAAGAATTCTGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTT AGAAATAAATGCAGCTTTACCATGAACCTGCTCCACTGAGAAAAGCCAGGCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACT TGGTGGTGTGGGATGCTCCTGGATGGAGAGGGTTTGCTGCTGGGGAGGACATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAAT CAAGAGTCACCCCAGCTGCTGGGCTCCTCTGCCTCTCTGCAGCAGAATGTCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACAT TTCTCCTGCCCCTCGTTGCAAAACGAGCTTGTTTCCCTGAACCTCAGAAATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGC CCGGCTCCTGAATTAAACTCTGTTCTGGTGCCTGAGCTCAGGGGTTTTCAGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCT GGGGGCCAGCTGCCTTCTCATCCTGGGAGGTGGCCCTTCCCAAGCCCATCAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTG GCCCTCAATACCCAGCTGCTTCTGGCTAAGAGTGCAGCAGAGACTGAGGCATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAA CAAAGCCAGCCGTGAAAAGGTGCCCCAGAGTTGCTGTGGACAGACCTGTAAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAAC CTCAGAGCTAGCTGCTCTCTGCAGCCTCCTCCACTGGCTTCTCTGGCTCACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGG AATCAGAAATCCCCCTTCTACCAGGCTGCAAATGTGGCTCTAGCACTTGCAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTT ATCTGAGGGGCAAAATGCCTGCTTGGAGGTCTGCAATTTTGGAACACTGCAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTT TGTTCTTTTACCACCAACTTAGGGGACTGTTTTAAAGAGCCATCCCAAGGCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCC TCTGTAAATGTTCTGATTTGCTCTCAGCTGCAGAGACACAGAGACACTGCAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGA ACCCTCCTGGGGCTCTGGGGTAGATGAGAGAAGCCTGAAAAAGGCAGAGTTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCC CTCTTGCCTCTTCCCTGCCCACTCCTGCCCCCTGACCAGAAGACAGAATTTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGT CCCCAGTGAGTCTTAGCGAGACTTTTGCCCTGCGCACAATTGCATCTGAATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGG CCTGGGGGGTGCTCGTGATATGTGCTCAAGCCAGTTGTGGGAAAAACTCGAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTT TGGCTGGATTCCCTGCACCCAGTGCAACACACCCTTTCCCCTTCACTCTCCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGC TGAGCTGGGGAACATGTCGGTGCACAGCTGAAAGTCAGCGATTATGCCGGCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCC CACGGCTGCTGGGAGGACATGGTCCTGCCCCCTTCCTTCCTCCCTCCCTCCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTT ATTCCCCTCTGGACTAAAGTAGTGGCTATTTTTGTGCCACTCTGCGCCCCACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGA GGGTGACACCATGTCACCCTCACCAGGACTCGTCTCTCCATTCCCGTCAGAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACC AGTTCTTACTTCCTTTTATTTTTAGCTCTGCACTCCATGTGGTTTCAGGGTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCC TTTTGAAAATGATAATCAAAGGAAGAGATGTGGTGTTTGGTCATGTGGAAAACTCAATGTATAATTTAGACGTCTGTCAAAAATCCGACA >1336_1336_1_ACO1-ARL3_ACO1_chr9_32436395_ENST00000309951_ARL3_chr10_104445758_ENST00000260746_length(amino acids)=861AA_BP=784 MEPRSARERVPLLGSGSPVAGAPPCSRRNTWPSVIMSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLV KKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDL EFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPI SMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGR DEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTF IYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMT CIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDE IQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGN IARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEIELAELLEEEKLSCVPVLIFANKQDLL -------------------------------------------------------------- >1336_1336_2_ACO1-ARL3_ACO1_chr9_32436395_ENST00000379923_ARL3_chr10_104445758_ENST00000260746_length(transcript)=5850nt_BP=2453nt GGGGCGAGAGGGGGCGGAGCGTGGAGGCGGCAGCTGGAACCGCGCAGCGCACGGGAACGCGTCCCGCTGCTTGGGTCAGGTTCGCCGGTC GCGGGAGCCCCGCCGTGCAGTCGGAGAGGGTGTCACTCTGAGTGGTGCTTCCTCAGCCCCTGTCAAAAAGCAGTTTCCACCATCCTGGAG TGTGGAACACGTGGCCATCAGTAATCATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAAATTCT TCAATTTGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCAGAGTTCTTCTGGAAGCAGCCATTCGGAATTGTGATG AGTTTTTGGTGAAGAAACAGGATATTGAAAATATTCTACATTGGAATGTCACGCAGCACAAGAACATAGAAGTGCCATTTAAGCCTGCTC GTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTGTGGTTGACTTTGCTGCAATGCGTGATGCTGTGAAAAAGTTAGGAGGAGATCCAG AGAAAATAAACCCTGTCTGCCCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGTTTACAGAAGA ATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAAGTGGGGTTCCCAGGCTTTTCACAACATGCGGATTATTCCCC CTGGCTCAGGAATCATCCACCAGGTGAATTTGGAATATTTGGCAAGAGTGGTATTTGATCAGGATGGATATTATTACCCAGACAGCCTCG TGGGCACAGACTCGCACACTACCATGATTGATGGCTTGGGCATTCTTGGTTGGGGTGTCGGTGGTATTGAAGCAGAAGCTGTCATGCTGG GTCAGCCAATCAGTATGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTGGTAACATCCACTGACATCGTGC TCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAATTTGTCGAGTTCTTCGGGCCTGGAGTAGCCCAGTTGTCCATTGCTG ACCGAGCTACGATTGCTAACATGTGTCCAGAGTACGGAGCAACTGCTGCCTTTTTCCCAGTTGATGAAGTTAGTATCACGTACCTGGTGC AAACAGGTCGTGATGAAGAAAAATTAAAGTATATTAAAAAATATCTTCAGGCTGTAGGAATGTTTCGAGATTTCAATGACCCTTCTCAAG ACCCAGACTTCACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCAAAAGGCCTCAGGACAAAGTTGCTG TGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAGCCAAGCAAGGATTTAAAGGATTCCAAGTTGCTCCTGAACATCATAATGACC ATAAGACCTTTATCTATGATAACACTGAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCATTACTAGCTGCACAAACACCAGTA ATCCGTCTGTGATGTTAGGGGCAGGATTGTTAGCAAAGAAAGCTGTGGATGCTGGCCTGAACGTGATGCCTTACATCAAAACTAGCCTGT CTCCTGGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTATCTGTCTCAGCTTGGGTTTGACGTGGTGGGCTATG GCTGCATGACCTGCATTGGCAACAGTGGGCCTTTACCTGAACCTGTGGTAGAAGCCATCACACAGGGAGACCTTGTAGCTGTTGGAGTAC TATCTGGAAACAGGAATTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCCTCTCCCCCCTTAGTAATAGCATATGCAA TTGCTGGAACCATCAGAATCGACTTTGAGAAAGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGGTATTTCTGAAAGATATCTGGCCGA CTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGGGATGTTTAAGGAAGTCTATCAGAAAATAGAGACTGTGAATGAAA GCTGGAATGCCTTAGCAACCCCATCAGATAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAATCACCACCATTCTTTGAAAACC TGACTTTGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATTTGGGAGATTCGGTAACAACTGACCACATCTCCC CAGCTGGAAATATTGCAAGAAACAGTCCTGCTGCTCGCTACTTAACTAACAGAGGCCTAACTCCACGAGAATTCAACTCCTATGGCTCCC GCCGAGGTAATGACGCCGTCATGGCACGGGGAACATTTGCCAACATTCGCTTGTTAAACAGATTTTTGAACAAGCAGGCACCACAGACTA TCCATCTGCCTTCTGGGGAAATCGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGC AGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTT GCTCAGCTCTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAGAAGAAATAAAATCTAGACGAAT GGAGATGCAGGAGCTGCGGGAGCCGAATTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAATGTTTTTCCATCTGTGTACAGC TCCAGCTGTTTGAAGAGAGGGAACAACACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACTGATCTCTGAGGTTCAGTATCAT TTTTCAAATAAAGGAATTATATTATTTCCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACATGATTAGAAAATGAGATCTTTT AAATGAGCAAGAGATTGCATTGCAGTTTAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAAAAAAGAAAAAGAAAAAGAGGAA GAAGCAGCTTTGCTGAGTTCATTTATTTACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACCACAGACAGTGTTTGCTGGTGCT GTCAGTGATTTTTACCGTCACTAGCCCAGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGGGGTGGGGGGAGAAAAGGCAGAT AATTAAACCATCTCATCGTCTTGCAGGTCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAAAAAAAAAAAAGTCTTTCTTGCA GACAAGTCACTACAGAAACATACCCCATCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAGAAGCAAATTCTTATGACTTTTG ACTGTAATGACATCTGGAATGTAAGGAGAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTAAAAAGCTCTCACATCGAGGGCT CAGGCTAGCGTAAACAGGCTTTCTCCAGCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGGCTTCTCCACGGCCGTCCTATAG ACAGGATTTCTAAAGCTCAAAGAATTCTGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTTAGAAATAAATGCAGCTTTACCA TGAACCTGCTCCACTGAGAAAAGCCAGGCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACTTGGTGGTGTGGGATGCTCCTGG ATGGAGAGGGTTTGCTGCTGGGGAGGACATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAATCAAGAGTCACCCCAGCTGCTGG GCTCCTCTGCCTCTCTGCAGCAGAATGTCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACATTTCTCCTGCCCCTCGTTGCAAA ACGAGCTTGTTTCCCTGAACCTCAGAAATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGCCCGGCTCCTGAATTAAACTCTG TTCTGGTGCCTGAGCTCAGGGGTTTTCAGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCTGGGGGCCAGCTGCCTTCTCATC CTGGGAGGTGGCCCTTCCCAAGCCCATCAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTGGCCCTCAATACCCAGCTGCTTC TGGCTAAGAGTGCAGCAGAGACTGAGGCATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAACAAAGCCAGCCGTGAAAAGGTG CCCCAGAGTTGCTGTGGACAGACCTGTAAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAACCTCAGAGCTAGCTGCTCTCTGC AGCCTCCTCCACTGGCTTCTCTGGCTCACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGGAATCAGAAATCCCCCTTCTACC AGGCTGCAAATGTGGCTCTAGCACTTGCAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTTATCTGAGGGGCAAAATGCCTGC TTGGAGGTCTGCAATTTTGGAACACTGCAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTTTGTTCTTTTACCACCAACTTAG GGGACTGTTTTAAAGAGCCATCCCAAGGCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCCTCTGTAAATGTTCTGATTTGCT CTCAGCTGCAGAGACACAGAGACACTGCAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGAACCCTCCTGGGGCTCTGGGGTA GATGAGAGAAGCCTGAAAAAGGCAGAGTTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCCCTCTTGCCTCTTCCCTGCCCAC TCCTGCCCCCTGACCAGAAGACAGAATTTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGTCCCCAGTGAGTCTTAGCGAGAC TTTTGCCCTGCGCACAATTGCATCTGAATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGGCCTGGGGGGTGCTCGTGATATG TGCTCAAGCCAGTTGTGGGAAAAACTCGAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTTTGGCTGGATTCCCTGCACCCAG TGCAACACACCCTTTCCCCTTCACTCTCCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGCTGAGCTGGGGAACATGTCGGTG CACAGCTGAAAGTCAGCGATTATGCCGGCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCCCACGGCTGCTGGGAGGACATGG TCCTGCCCCCTTCCTTCCTCCCTCCCTCCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTTATTCCCCTCTGGACTAAAGTAG TGGCTATTTTTGTGCCACTCTGCGCCCCACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGAGGGTGACACCATGTCACCCTCA CCAGGACTCGTCTCTCCATTCCCGTCAGAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACCAGTTCTTACTTCCTTTTATTTT TAGCTCTGCACTCCATGTGGTTTCAGGGTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCCTTTTGAAAATGATAATCAAAGG AAGAGATGTGGTGTTTGGTCATGTGGAAAACTCAATGTATAATTTAGACGTCTGTCAAAAATCCGACAAATAAAATTTAGCTGGAACGAA >1336_1336_2_ACO1-ARL3_ACO1_chr9_32436395_ENST00000379923_ARL3_chr10_104445758_ENST00000260746_length(amino acids)=845AA_BP=768 MSKSSFHHPGVWNTWPSVIMSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQH KNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGS QAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKP HPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVG MFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVI AAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAI TQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKE VYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGL TPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEIELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHT -------------------------------------------------------------- >1336_1336_3_ACO1-ARL3_ACO1_chr9_32436395_ENST00000541043_ARL3_chr10_104445758_ENST00000260746_length(transcript)=5850nt_BP=2453nt GGGGCGAGAGGGGGCGGAGCGTGGAGGCGGCAGCTGGAACCGCGCAGCGCACGGGAACGCGTCCCGCTGCTTGGGTCAGGTTCGCCGGTC GCGGGAGCCCCGCCGTGCAGTCGGAGAGGGTGTCACTCTGAGTGGTGCTTCCTCAGCCCCTGTCAAAAAGCAGTTTCCACCATCCTGGAG TGTGGAACACGTGGCCATCAGTAATCATGAGCAACCCATTCGCACACCTTGCTGAGCCATTGGATCCTGTACAACCAGGAAAGAAATTCT TCAATTTGAATAAATTGGAGGATTCAAGATATGGGCGCTTACCATTTTCGATCAGAGTTCTTCTGGAAGCAGCCATTCGGAATTGTGATG AGTTTTTGGTGAAGAAACAGGATATTGAAAATATTCTACATTGGAATGTCACGCAGCACAAGAACATAGAAGTGCCATTTAAGCCTGCTC GTGTCATCCTGCAGGACTTTACGGGTGTGCCCGCTGTGGTTGACTTTGCTGCAATGCGTGATGCTGTGAAAAAGTTAGGAGGAGATCCAG AGAAAATAAACCCTGTCTGCCCTGCTGATCTTGTAATAGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGTTTACAGAAGA ATCAAGACCTGGAATTTGAAAGAAATAGAGAGCGATTTGAATTTTTAAAGTGGGGTTCCCAGGCTTTTCACAACATGCGGATTATTCCCC CTGGCTCAGGAATCATCCACCAGGTGAATTTGGAATATTTGGCAAGAGTGGTATTTGATCAGGATGGATATTATTACCCAGACAGCCTCG TGGGCACAGACTCGCACACTACCATGATTGATGGCTTGGGCATTCTTGGTTGGGGTGTCGGTGGTATTGAAGCAGAAGCTGTCATGCTGG GTCAGCCAATCAGTATGGTGCTTCCTCAGGTGATTGGCTACAGGCTGATGGGGAAGCCCCACCCTCTGGTAACATCCACTGACATCGTGC TCACCATTACCAAGCACCTCCGCCAGGTTGGGGTAGTGGGCAAATTTGTCGAGTTCTTCGGGCCTGGAGTAGCCCAGTTGTCCATTGCTG ACCGAGCTACGATTGCTAACATGTGTCCAGAGTACGGAGCAACTGCTGCCTTTTTCCCAGTTGATGAAGTTAGTATCACGTACCTGGTGC AAACAGGTCGTGATGAAGAAAAATTAAAGTATATTAAAAAATATCTTCAGGCTGTAGGAATGTTTCGAGATTTCAATGACCCTTCTCAAG ACCCAGACTTCACCCAGGTTGTGGAATTAGATTTGAAAACAGTAGTGCCTTGCTGTAGTGGACCCAAAAGGCCTCAGGACAAAGTTGCTG TGTCCGACATGAAAAAGGACTTTGAGAGCTGCCTTGGAGCCAAGCAAGGATTTAAAGGATTCCAAGTTGCTCCTGAACATCATAATGACC ATAAGACCTTTATCTATGATAACACTGAATTCACCCTTGCTCATGGTTCTGTGGTCATTGCTGCCATTACTAGCTGCACAAACACCAGTA ATCCGTCTGTGATGTTAGGGGCAGGATTGTTAGCAAAGAAAGCTGTGGATGCTGGCCTGAACGTGATGCCTTACATCAAAACTAGCCTGT CTCCTGGGAGTGGCGTGGTCACCTACTACCTACAAGAAAGCGGAGTCATGCCTTATCTGTCTCAGCTTGGGTTTGACGTGGTGGGCTATG GCTGCATGACCTGCATTGGCAACAGTGGGCCTTTACCTGAACCTGTGGTAGAAGCCATCACACAGGGAGACCTTGTAGCTGTTGGAGTAC TATCTGGAAACAGGAATTTTGAAGGTCGAGTTCACCCCAACACCCGGGCCAACTATTTAGCCTCTCCCCCCTTAGTAATAGCATATGCAA TTGCTGGAACCATCAGAATCGACTTTGAGAAAGAGCCATTGGGAGTAAATGCAAAGGGACAGCAGGTATTTCTGAAAGATATCTGGCCGA CTAGAGACGAGATCCAGGCAGTGGAGCGTCAGTATGTCATCCCGGGGATGTTTAAGGAAGTCTATCAGAAAATAGAGACTGTGAATGAAA GCTGGAATGCCTTAGCAACCCCATCAGATAAGCTGTTTTTCTGGAATTCCAAATCTACGTATATCAAATCACCACCATTCTTTGAAAACC TGACTTTGGATCTTCAGCCCCCTAAATCTATAGTGGATGCCTATGTGCTGCTAAATTTGGGAGATTCGGTAACAACTGACCACATCTCCC CAGCTGGAAATATTGCAAGAAACAGTCCTGCTGCTCGCTACTTAACTAACAGAGGCCTAACTCCACGAGAATTCAACTCCTATGGCTCCC GCCGAGGTAATGACGCCGTCATGGCACGGGGAACATTTGCCAACATTCGCTTGTTAAACAGATTTTTGAACAAGCAGGCACCACAGACTA TCCATCTGCCTTCTGGGGAAATCGAACTAGCGGAATTACTGGAGGAAGAAAAACTAAGTTGTGTGCCAGTGCTCATCTTTGCTAATAAGC AGGATTTGCTCACAGCAGCCCCTGCCTCTGAAATTGCAGAAGGACTGAACCTGCATACCATCCGCGACCGAGTCTGGCAGATCCAGTCTT GCTCAGCTCTCACAGGAGAGGGCGTTCAGGATGGCATGAACTGGGTCTGCAAAAATGTCAATGCAAAGAAGAAATAAAATCTAGACGAAT GGAGATGCAGGAGCTGCGGGAGCCGAATTCGGTCCTGAAAAACACTAATTTGCTGCTTTCTGACCAAATGTTTTTCCATCTGTGTACAGC TCCAGCTGTTTGAAGAGAGGGAACAACACGGTTTAGAAAGAATCCCCATTCCAGCAGTAGATTTAACTGATCTCTGAGGTTCAGTATCAT TTTTCAAATAAAGGAATTATATTATTTCCTCTGCATAATTGAAATAGTATTAAATGTCTCAAAGCACATGATTAGAAAATGAGATCTTTT AAATGAGCAAGAGATTGCATTGCAGTTTAGACAATTCCAGTGGGCTTTTTTTTCCTCTCAAAAAAAAAAAAAGAAAAAGAAAAAGAGGAA GAAGCAGCTTTGCTGAGTTCATTTATTTACTGACCCGTCCCTTGCATTCCCTCCATGGTTTTGAAACCACAGACAGTGTTTGCTGGTGCT GTCAGTGATTTTTACCGTCACTAGCCCAGCCAGGCTTCAGTCTGTCCGACAGGAAGCTGCTGGGTGGGGGTGGGGGGAGAAAAGGCAGAT AATTAAACCATCTCATCGTCTTGCAGGTCGGAGACTACGTATGTAATCCTCACTCTTTGGACAGAAAAAAAAAAAAAAGTCTTTCTTGCA GACAAGTCACTACAGAAACATACCCCATCCCACCCACCCCTGCCTCTGCCCCAGCCAGCCACACAGAGAAGCAAATTCTTATGACTTTTG ACTGTAATGACATCTGGAATGTAAGGAGAGGTGGGAGGTTTAATTCCAGAAAAATTACAAGGTCCTTAAAAAGCTCTCACATCGAGGGCT CAGGCTAGCGTAAACAGGCTTTCTCCAGCTCAGTGGAGCAGTGAGCAGCCGACTCTGAGATTAGCTGGCTTCTCCACGGCCGTCCTATAG ACAGGATTTCTAAAGCTCAAAGAATTCTGTGTTTAAACGATCACAATAGGCCGCTGCTATCAGATTTTAGAAATAAATGCAGCTTTACCA TGAACCTGCTCCACTGAGAAAAGCCAGGCAGATCGATTTTTAGATCAATTTTTACAGTGCTGGCAACTTGGTGGTGTGGGATGCTCCTGG ATGGAGAGGGTTTGCTGCTGGGGAGGACATGGGTGTGTGTGTGACTGCAGGGGTCGTGTCCAAGGAATCAAGAGTCACCCCAGCTGCTGG GCTCCTCTGCCTCTCTGCAGCAGAATGTCCGTCCTCTGTTGATTGATTGGAGAGGAATAGCAGAACATTTCTCCTGCCCCTCGTTGCAAA ACGAGCTTGTTTCCCTGAACCTCAGAAATCCTCAGCTTCAAACATGGGGAAACAGGCCAGAGCATTGCCCGGCTCCTGAATTAAACTCTG TTCTGGTGCCTGAGCTCAGGGGTTTTCAGAGAATGAATAAGAGACTGTCCAGTGACTGGTGGGTCCCTGGGGGCCAGCTGCCTTCTCATC CTGGGAGGTGGCCCTTCCCAAGCCCATCAGGGCGTGTGAGCAGACTGAAGGGGCCGCTGCAGCCCCTGGCCCTCAATACCCAGCTGCTTC TGGCTAAGAGTGCAGCAGAGACTGAGGCATAGCCAGCTTCAAAAGCGATCTGACATGAAAGTCATTAACAAAGCCAGCCGTGAAAAGGTG CCCCAGAGTTGCTGTGGACAGACCTGTAAGGACTTGCAAAACAAAAGAAAGTGAGGGGTTTTTTTAACCTCAGAGCTAGCTGCTCTCTGC AGCCTCCTCCACTGGCTTCTCTGGCTCACCCAAGCTCTCCCTTACAGAGGCAACACAGAATTATAAGGAATCAGAAATCCCCCTTCTACC AGGCTGCAAATGTGGCTCTAGCACTTGCAAATTGTTTTTTCTTCCGAATAGTTCAGCAGGGACAAGTTATCTGAGGGGCAAAATGCCTGC TTGGAGGTCTGCAATTTTGGAACACTGCAGTATGGAACTTTGGCATTGGAGGGTCTGTAAAATATTTTTGTTCTTTTACCACCAACTTAG GGGACTGTTTTAAAGAGCCATCCCAAGGCCTCTCCTAGCAGGCAGAAGCCACTCCTCTGATAACGGCCTCTGTAAATGTTCTGATTTGCT CTCAGCTGCAGAGACACAGAGACACTGCAGATGTCACACGCTTTCATCTTCCCTTTGAGCCCTTTTGAACCCTCCTGGGGCTCTGGGGTA GATGAGAGAAGCCTGAAAAAGGCAGAGTTTGAAAGCTCCCATTTAAAAACAAAATACTTTTTAAAGCCCTCTTGCCTCTTCCCTGCCCAC TCCTGCCCCCTGACCAGAAGACAGAATTTGAAGCTGGAAAGGGAAGACCCCTTTTCCCCTCCTCCTGTCCCCAGTGAGTCTTAGCGAGAC TTTTGCCCTGCGCACAATTGCATCTGAATGTGCGGGGGAGAGGGCTGGGGGCCGGAGGGCAGGCAAGGCCTGGGGGGTGCTCGTGATATG TGCTCAAGCCAGTTGTGGGAAAAACTCGAGTCCTCCCCTCCTCCCGACCTACCCCGTGTGGCTGCTTTTGGCTGGATTCCCTGCACCCAG TGCAACACACCCTTTCCCCTTCACTCTCCCTTGGTTACTATGGAAACAAGGGTGTCATTGATGTGGGCTGAGCTGGGGAACATGTCGGTG CACAGCTGAAAGTCAGCGATTATGCCGGCGGTTAGAAATGTGCCAGGGTTAAAGGAGTCCGCAGCTCCCACGGCTGCTGGGAGGACATGG TCCTGCCCCCTTCCTTCCTCCCTCCCTCCGTCTCCACTTCTCTCTCCTTGCTTTTGACAAATTTCTTTATTCCCCTCTGGACTAAAGTAG TGGCTATTTTTGTGCCACTCTGCGCCCCACCCTCACTGTTGGCCGCTCCTTATCCGGCCTGGCCTGGAGGGTGACACCATGTCACCCTCA CCAGGACTCGTCTCTCCATTCCCGTCAGAGTTTGCTTTGATTTCCCTTTCCTTTCCTTCTCGGGGACCAGTTCTTACTTCCTTTTATTTT TAGCTCTGCACTCCATGTGGTTTCAGGGTTCAGTCTGATCCATCAAAAGGTTCTTTTTTTATAATCCCTTTTGAAAATGATAATCAAAGG AAGAGATGTGGTGTTTGGTCATGTGGAAAACTCAATGTATAATTTAGACGTCTGTCAAAAATCCGACAAATAAAATTTAGCTGGAACGAA >1336_1336_3_ACO1-ARL3_ACO1_chr9_32436395_ENST00000541043_ARL3_chr10_104445758_ENST00000260746_length(amino acids)=845AA_BP=768 MSKSSFHHPGVWNTWPSVIMSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQH KNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGS QAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKP HPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVG MFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVI AAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAI TQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKE VYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGL TPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEIELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ACO1-ARL3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ACO1-ARL3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ACO1-ARL3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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