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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CBFB-CHPF (FusionGDB2 ID:13365)

Fusion Gene Summary for CBFB-CHPF

Fusion gene summary

Fusion gene information	Fusion gene name: CBFB-CHPF
	Fusion gene ID: 13365
		Hgene	Tgene
	Gene symbol	CBFB	CHPF
	Gene ID	865	79586
	Gene name	core-binding factor subunit beta	chondroitin polymerizing factor
	Synonyms	PEBP2B	CHSY2\|CSS2
	Cytomap	16q22.1	2q35
	Type of gene	protein-coding	protein-coding
	Description	core-binding factor subunit betaCBF-betaPEA2-betaPEBP2-betaSL3-3 enhancer factor 1 beta subunitSL3-3 enhancer factor 1 subunit betaSL3/AKV core-binding factor beta subunitcore-binding factor beta subunitpolyomavirus enhancer binding protein 2, bet	chondroitin sulfate synthase 2N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase IIN-acetylgalactosaminyltransferase 2chondroitin glucuronyltransferase 2glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltran
	Modification date	20200320	20200313
	UniProtAcc	.	Q9P2E5
	Ensembl transtripts involved in fusion gene	ENST00000290858, ENST00000412916, ENST00000561924, ENST00000568858,	ENST00000373891, ENST00000243776, ENST00000535926,
Fusion gene scores	* DoF score	17 X 18 X 12=3672	4 X 4 X 3=48
	# samples	33	4
	** MAII score	log2(33/3672*10)=-3.47602812916799 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: CBFB [Title/Abstract] AND CHPF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CBFB(67070658)-CHPF(220405847), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CBFB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHPF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR188442	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-

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Fusion Gene ORF analysis for CBFB-CHPF

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000290858	ENST00000373891	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
5CDS-intron	ENST00000412916	ENST00000373891	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
5UTR-3CDS	ENST00000561924	ENST00000243776	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
5UTR-3CDS	ENST00000561924	ENST00000535926	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
5UTR-intron	ENST00000561924	ENST00000373891	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
In-frame	ENST00000290858	ENST00000243776	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
In-frame	ENST00000290858	ENST00000535926	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
In-frame	ENST00000412916	ENST00000243776	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
In-frame	ENST00000412916	ENST00000535926	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
intron-3CDS	ENST00000568858	ENST00000243776	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
intron-3CDS	ENST00000568858	ENST00000535926	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-
intron-intron	ENST00000568858	ENST00000373891	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000290858	CBFB	chr16	67070658	+	ENST00000243776	CHPF	chr2	220405847	-	2419	543	261	1982	573
ENST00000290858	CBFB	chr16	67070658	+	ENST00000535926	CHPF	chr2	220405847	-	1994	543	261	1982	573
ENST00000412916	CBFB	chr16	67070658	+	ENST00000243776	CHPF	chr2	220405847	-	2321	445	163	1884	573
ENST00000412916	CBFB	chr16	67070658	+	ENST00000535926	CHPF	chr2	220405847	-	1896	445	163	1884	573

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000290858	ENST00000243776	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-	0.01643012	0.9835699
ENST00000290858	ENST00000535926	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-	0.022583738	0.9774163
ENST00000412916	ENST00000243776	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-	0.015496751	0.98450327
ENST00000412916	ENST00000535926	CBFB	chr16	67070658	+	CHPF	chr2	220405847	-	0.022376278	0.97762376

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Fusion Genomic Features for CBFB-CHPF

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CBFB-CHPF

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:67070658/chr2:220405847)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CHPF Q9P2E5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transfers glucuronic acid (GlcUA) from UDP-GlcUA to N-acetylgalactosamine residues on the non-reducing end of the elongating chondroitin polymer. Has no N-acetylgalactosaminyltransferase activity. {ECO:0000269\|PubMed:12145278, ECO:0000269\|PubMed:18316376}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000243776

515_571

296

776.0

Compositional bias

Note=Ala-rich

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000535926

515_571

134

614.0

Compositional bias

Note=Ala-rich

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000243776

1_15

296

776.0

Topological domain

Cytoplasmic

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000243776

35_775

296

776.0

Topological domain

Lumenal

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000535926

1_15

134

614.0

Topological domain

Cytoplasmic

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000535926

35_775

134

614.0

Topological domain

Lumenal

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000243776

16_34

296

776.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

CHPF

chr16:67070658

chr2:220405847

ENST00000535926

16_34

134

614.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

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Fusion Gene Sequence for CBFB-CHPF

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>13365_13365_1_CBFB-CHPF_CBFB_chr16_67070658_ENST00000290858_CHPF_chr2_220405847_ENST00000243776_length(transcript)=2419nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGGGGGTGCACTATAGCCATCTGGAGCTGAGCCCTGGGGAGCCAGTGCAGGAGGGGGACCCTCATTTCCGAAGTGCCCTGACAGCCCAC
CCTGTGCGTGACCCTGTGCACATGTACCAGCTGCACAAAGCTTTCGCCCGAGCTGAACTGGAACGCACGTACCAGGAGATCCAGGAGTTA
CAGTGGGAGATCCAGAATACCAGCCATCTGGCCGTTGATGGGGACCAGGCAGCTGCTTGGCCCGTGGGTATTCCAGCACCATCCCGCCCG
GCCTCCCGCTTTGAGGTGCTGCGCTGGGACTACTTCACGGAGCAGCACGCTTTCTCCTGCGCCGATGGCTCACCCCGCTGCCCACTGCGT
GGGGCTGACCGGGCTGATGTGGCCGATGTTCTGGGGACAGCTCTAGAGGAGCTGAACCGCCGCTACCACCCGGCCTTGCGGCTCCAGAAG
CAGCAGCTGGTGAATGGCTACCGACGCTTTGATCCGGCCCGGGGTATGGAATACACGCTGGACTTGCAGCTGGAGGCACTGACCCCCCAG
GGAGGCCGCCGGCCCCTCACTCGCCGAGTGCAGCTGCTCCGGCCGCTGAGCCGCGTGGAGATCTTGCCTGTGCCCTATGTCACTGAGGCC
TCACGTCTCACTGTGCTGCTGCCTCTAGCTGCGGCTGAGCGTGACCTGGCCCCTGGCTTCTTGGAGGCCTTTGCCACTGCAGCACTGGAG
CCTGGTGATGCTGCGGCAGCCCTGACCCTGCTGCTACTGTATGAGCCGCGCCAGGCCCAGCGCGTGGCCCATGCAGATGTCTTCGCACCT
GTCAAGGCCCACGTGGCAGAGCTGGAGCGGCGTTTCCCCGGTGCCCGGGTGCCATGGCTCAGTGTGCAGACAGCCGCACCCTCACCACTG
CGCCTCATGGATCTACTCTCCAAGAAGCACCCGCTGGACACACTGTTCCTGCTGGCCGGGCCAGACACGGTGCTCACGCCTGACTTCCTG
AACCGCTGCCGCATGCATGCCATCTCCGGCTGGCAGGCCTTCTTTCCCATGCATTTCCAAGCCTTCCACCCAGCTGTGGCCCCACCACAA
GGGCCTGGGCCCCCAGAGCTGGGCCGTGACACTGGCCGCTTTGATCGCCAGGCAGCCAGCGAGGCCTGCTTCTACAACTCCGACTATGTG
GCAGCCCGTGGGCGCCTGGCGGCAGCCTCAGAACAAGAAGAGGAGCTGCTGGAGAGCCTGGATGTGTACGAGCTGTTCCTCCACTTCTCC
AGTCTGCATGTGCTGCGGGCGGTGGAGCCGGCGCTGCTGCAGCGCTACCGGGCCCAGACGTGCAGCGCGAGGCTCAGTGAGGACCTGTAC
CACCGCTGCCTCCAGAGCGTGCTTGAGGGCCTCGGCTCCCGAACCCAGCTGGCCATGCTACTCTTTGAACAGGAGCAGGGCAACAGCACC
TGACCCCACCCTGTCCCCGTGGGCCGTGGCATGGCCACACCCCACCCCACTTCTCCCCCAAAACCAGAGCCACCTGCCAGCCTCGCTGGG
CAGGGCTGGCCGTAGCCAGACCCCAAGCTGGCCCACTGGTCCCCTCTCTGGCTCTGTGGGTCCCTGGGCTCTGGACAAGCACTGGGGGAC
GTGCCCCCAGAGCCACCCACTTCTCATCCCAAACCCAGTTTCCCTGCCCCCTGACGCTGCTGATTCGGGCTGTGGCCTCCACGTATTTAT
GCAGTACAGTCTGCCTGACGCCAGCCCTGCCTCTGGGCCCTGGGGGCTGGGCTGTAGAAGAGTTGTTGGGGAAGGAGGGAGCTGAGGAGG

>13365_13365_1_CBFB-CHPF_CBFB_chr16_67070658_ENST00000290858_CHPF_chr2_220405847_ENST00000243776_length(amino acids)=573AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKGVHYSHLELSPGEPVQEGDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQELQWEIQNTSHLAVDGDQAAAWPVGIPAP
SRPASRFEVLRWDYFTEQHAFSCADGSPRCPLRGADRADVADVLGTALEELNRRYHPALRLQKQQLVNGYRRFDPARGMEYTLDLQLEAL
TPQGGRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFATAALEPGDAAAALTLLLLYEPRQAQRVAHADV
FAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVA
PPQGPGPPELGRDTGRFDRQAASEACFYNSDYVAARGRLAAASEQEEELLESLDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSARLSE

--------------------------------------------------------------
>13365_13365_2_CBFB-CHPF_CBFB_chr16_67070658_ENST00000290858_CHPF_chr2_220405847_ENST00000535926_length(transcript)=1994nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGGGGGTGCACTATAGCCATCTGGAGCTGAGCCCTGGGGAGCCAGTGCAGGAGGGGGACCCTCATTTCCGAAGTGCCCTGACAGCCCAC
CCTGTGCGTGACCCTGTGCACATGTACCAGCTGCACAAAGCTTTCGCCCGAGCTGAACTGGAACGCACGTACCAGGAGATCCAGGAGTTA
CAGTGGGAGATCCAGAATACCAGCCATCTGGCCGTTGATGGGGACCAGGCAGCTGCTTGGCCCGTGGGTATTCCAGCACCATCCCGCCCG
GCCTCCCGCTTTGAGGTGCTGCGCTGGGACTACTTCACGGAGCAGCACGCTTTCTCCTGCGCCGATGGCTCACCCCGCTGCCCACTGCGT
GGGGCTGACCGGGCTGATGTGGCCGATGTTCTGGGGACAGCTCTAGAGGAGCTGAACCGCCGCTACCACCCGGCCTTGCGGCTCCAGAAG
CAGCAGCTGGTGAATGGCTACCGACGCTTTGATCCGGCCCGGGGTATGGAATACACGCTGGACTTGCAGCTGGAGGCACTGACCCCCCAG
GGAGGCCGCCGGCCCCTCACTCGCCGAGTGCAGCTGCTCCGGCCGCTGAGCCGCGTGGAGATCTTGCCTGTGCCCTATGTCACTGAGGCC
TCACGTCTCACTGTGCTGCTGCCTCTAGCTGCGGCTGAGCGTGACCTGGCCCCTGGCTTCTTGGAGGCCTTTGCCACTGCAGCACTGGAG
CCTGGTGATGCTGCGGCAGCCCTGACCCTGCTGCTACTGTATGAGCCGCGCCAGGCCCAGCGCGTGGCCCATGCAGATGTCTTCGCACCT
GTCAAGGCCCACGTGGCAGAGCTGGAGCGGCGTTTCCCCGGTGCCCGGGTGCCATGGCTCAGTGTGCAGACAGCCGCACCCTCACCACTG
CGCCTCATGGATCTACTCTCCAAGAAGCACCCGCTGGACACACTGTTCCTGCTGGCCGGGCCAGACACGGTGCTCACGCCTGACTTCCTG
AACCGCTGCCGCATGCATGCCATCTCCGGCTGGCAGGCCTTCTTTCCCATGCATTTCCAAGCCTTCCACCCAGCTGTGGCCCCACCACAA
GGGCCTGGGCCCCCAGAGCTGGGCCGTGACACTGGCCGCTTTGATCGCCAGGCAGCCAGCGAGGCCTGCTTCTACAACTCCGACTATGTG
GCAGCCCGTGGGCGCCTGGCGGCAGCCTCAGAACAAGAAGAGGAGCTGCTGGAGAGCCTGGATGTGTACGAGCTGTTCCTCCACTTCTCC
AGTCTGCATGTGCTGCGGGCGGTGGAGCCGGCGCTGCTGCAGCGCTACCGGGCCCAGACGTGCAGCGCGAGGCTCAGTGAGGACCTGTAC
CACCGCTGCCTCCAGAGCGTGCTTGAGGGCCTCGGCTCCCGAACCCAGCTGGCCATGCTACTCTTTGAACAGGAGCAGGGCAACAGCACC

>13365_13365_2_CBFB-CHPF_CBFB_chr16_67070658_ENST00000290858_CHPF_chr2_220405847_ENST00000535926_length(amino acids)=573AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKGVHYSHLELSPGEPVQEGDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQELQWEIQNTSHLAVDGDQAAAWPVGIPAP
SRPASRFEVLRWDYFTEQHAFSCADGSPRCPLRGADRADVADVLGTALEELNRRYHPALRLQKQQLVNGYRRFDPARGMEYTLDLQLEAL
TPQGGRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFATAALEPGDAAAALTLLLLYEPRQAQRVAHADV
FAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVA
PPQGPGPPELGRDTGRFDRQAASEACFYNSDYVAARGRLAAASEQEEELLESLDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSARLSE

--------------------------------------------------------------
>13365_13365_3_CBFB-CHPF_CBFB_chr16_67070658_ENST00000412916_CHPF_chr2_220405847_ENST00000243776_length(transcript)=2321nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGGGGGT
GCACTATAGCCATCTGGAGCTGAGCCCTGGGGAGCCAGTGCAGGAGGGGGACCCTCATTTCCGAAGTGCCCTGACAGCCCACCCTGTGCG
TGACCCTGTGCACATGTACCAGCTGCACAAAGCTTTCGCCCGAGCTGAACTGGAACGCACGTACCAGGAGATCCAGGAGTTACAGTGGGA
GATCCAGAATACCAGCCATCTGGCCGTTGATGGGGACCAGGCAGCTGCTTGGCCCGTGGGTATTCCAGCACCATCCCGCCCGGCCTCCCG
CTTTGAGGTGCTGCGCTGGGACTACTTCACGGAGCAGCACGCTTTCTCCTGCGCCGATGGCTCACCCCGCTGCCCACTGCGTGGGGCTGA
CCGGGCTGATGTGGCCGATGTTCTGGGGACAGCTCTAGAGGAGCTGAACCGCCGCTACCACCCGGCCTTGCGGCTCCAGAAGCAGCAGCT
GGTGAATGGCTACCGACGCTTTGATCCGGCCCGGGGTATGGAATACACGCTGGACTTGCAGCTGGAGGCACTGACCCCCCAGGGAGGCCG
CCGGCCCCTCACTCGCCGAGTGCAGCTGCTCCGGCCGCTGAGCCGCGTGGAGATCTTGCCTGTGCCCTATGTCACTGAGGCCTCACGTCT
CACTGTGCTGCTGCCTCTAGCTGCGGCTGAGCGTGACCTGGCCCCTGGCTTCTTGGAGGCCTTTGCCACTGCAGCACTGGAGCCTGGTGA
TGCTGCGGCAGCCCTGACCCTGCTGCTACTGTATGAGCCGCGCCAGGCCCAGCGCGTGGCCCATGCAGATGTCTTCGCACCTGTCAAGGC
CCACGTGGCAGAGCTGGAGCGGCGTTTCCCCGGTGCCCGGGTGCCATGGCTCAGTGTGCAGACAGCCGCACCCTCACCACTGCGCCTCAT
GGATCTACTCTCCAAGAAGCACCCGCTGGACACACTGTTCCTGCTGGCCGGGCCAGACACGGTGCTCACGCCTGACTTCCTGAACCGCTG
CCGCATGCATGCCATCTCCGGCTGGCAGGCCTTCTTTCCCATGCATTTCCAAGCCTTCCACCCAGCTGTGGCCCCACCACAAGGGCCTGG
GCCCCCAGAGCTGGGCCGTGACACTGGCCGCTTTGATCGCCAGGCAGCCAGCGAGGCCTGCTTCTACAACTCCGACTATGTGGCAGCCCG
TGGGCGCCTGGCGGCAGCCTCAGAACAAGAAGAGGAGCTGCTGGAGAGCCTGGATGTGTACGAGCTGTTCCTCCACTTCTCCAGTCTGCA
TGTGCTGCGGGCGGTGGAGCCGGCGCTGCTGCAGCGCTACCGGGCCCAGACGTGCAGCGCGAGGCTCAGTGAGGACCTGTACCACCGCTG
CCTCCAGAGCGTGCTTGAGGGCCTCGGCTCCCGAACCCAGCTGGCCATGCTACTCTTTGAACAGGAGCAGGGCAACAGCACCTGACCCCA
CCCTGTCCCCGTGGGCCGTGGCATGGCCACACCCCACCCCACTTCTCCCCCAAAACCAGAGCCACCTGCCAGCCTCGCTGGGCAGGGCTG
GCCGTAGCCAGACCCCAAGCTGGCCCACTGGTCCCCTCTCTGGCTCTGTGGGTCCCTGGGCTCTGGACAAGCACTGGGGGACGTGCCCCC
AGAGCCACCCACTTCTCATCCCAAACCCAGTTTCCCTGCCCCCTGACGCTGCTGATTCGGGCTGTGGCCTCCACGTATTTATGCAGTACA
GTCTGCCTGACGCCAGCCCTGCCTCTGGGCCCTGGGGGCTGGGCTGTAGAAGAGTTGTTGGGGAAGGAGGGAGCTGAGGAGGGGGCATCT

>13365_13365_3_CBFB-CHPF_CBFB_chr16_67070658_ENST00000412916_CHPF_chr2_220405847_ENST00000243776_length(amino acids)=573AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKGVHYSHLELSPGEPVQEGDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQELQWEIQNTSHLAVDGDQAAAWPVGIPAP
SRPASRFEVLRWDYFTEQHAFSCADGSPRCPLRGADRADVADVLGTALEELNRRYHPALRLQKQQLVNGYRRFDPARGMEYTLDLQLEAL
TPQGGRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFATAALEPGDAAAALTLLLLYEPRQAQRVAHADV
FAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVA
PPQGPGPPELGRDTGRFDRQAASEACFYNSDYVAARGRLAAASEQEEELLESLDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSARLSE

--------------------------------------------------------------
>13365_13365_4_CBFB-CHPF_CBFB_chr16_67070658_ENST00000412916_CHPF_chr2_220405847_ENST00000535926_length(transcript)=1896nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGGGGGT
GCACTATAGCCATCTGGAGCTGAGCCCTGGGGAGCCAGTGCAGGAGGGGGACCCTCATTTCCGAAGTGCCCTGACAGCCCACCCTGTGCG
TGACCCTGTGCACATGTACCAGCTGCACAAAGCTTTCGCCCGAGCTGAACTGGAACGCACGTACCAGGAGATCCAGGAGTTACAGTGGGA
GATCCAGAATACCAGCCATCTGGCCGTTGATGGGGACCAGGCAGCTGCTTGGCCCGTGGGTATTCCAGCACCATCCCGCCCGGCCTCCCG
CTTTGAGGTGCTGCGCTGGGACTACTTCACGGAGCAGCACGCTTTCTCCTGCGCCGATGGCTCACCCCGCTGCCCACTGCGTGGGGCTGA
CCGGGCTGATGTGGCCGATGTTCTGGGGACAGCTCTAGAGGAGCTGAACCGCCGCTACCACCCGGCCTTGCGGCTCCAGAAGCAGCAGCT
GGTGAATGGCTACCGACGCTTTGATCCGGCCCGGGGTATGGAATACACGCTGGACTTGCAGCTGGAGGCACTGACCCCCCAGGGAGGCCG
CCGGCCCCTCACTCGCCGAGTGCAGCTGCTCCGGCCGCTGAGCCGCGTGGAGATCTTGCCTGTGCCCTATGTCACTGAGGCCTCACGTCT
CACTGTGCTGCTGCCTCTAGCTGCGGCTGAGCGTGACCTGGCCCCTGGCTTCTTGGAGGCCTTTGCCACTGCAGCACTGGAGCCTGGTGA
TGCTGCGGCAGCCCTGACCCTGCTGCTACTGTATGAGCCGCGCCAGGCCCAGCGCGTGGCCCATGCAGATGTCTTCGCACCTGTCAAGGC
CCACGTGGCAGAGCTGGAGCGGCGTTTCCCCGGTGCCCGGGTGCCATGGCTCAGTGTGCAGACAGCCGCACCCTCACCACTGCGCCTCAT
GGATCTACTCTCCAAGAAGCACCCGCTGGACACACTGTTCCTGCTGGCCGGGCCAGACACGGTGCTCACGCCTGACTTCCTGAACCGCTG
CCGCATGCATGCCATCTCCGGCTGGCAGGCCTTCTTTCCCATGCATTTCCAAGCCTTCCACCCAGCTGTGGCCCCACCACAAGGGCCTGG
GCCCCCAGAGCTGGGCCGTGACACTGGCCGCTTTGATCGCCAGGCAGCCAGCGAGGCCTGCTTCTACAACTCCGACTATGTGGCAGCCCG
TGGGCGCCTGGCGGCAGCCTCAGAACAAGAAGAGGAGCTGCTGGAGAGCCTGGATGTGTACGAGCTGTTCCTCCACTTCTCCAGTCTGCA
TGTGCTGCGGGCGGTGGAGCCGGCGCTGCTGCAGCGCTACCGGGCCCAGACGTGCAGCGCGAGGCTCAGTGAGGACCTGTACCACCGCTG
CCTCCAGAGCGTGCTTGAGGGCCTCGGCTCCCGAACCCAGCTGGCCATGCTACTCTTTGAACAGGAGCAGGGCAACAGCACCTGACCCCA

>13365_13365_4_CBFB-CHPF_CBFB_chr16_67070658_ENST00000412916_CHPF_chr2_220405847_ENST00000535926_length(amino acids)=573AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKGVHYSHLELSPGEPVQEGDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQELQWEIQNTSHLAVDGDQAAAWPVGIPAP
SRPASRFEVLRWDYFTEQHAFSCADGSPRCPLRGADRADVADVLGTALEELNRRYHPALRLQKQQLVNGYRRFDPARGMEYTLDLQLEAL
TPQGGRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFATAALEPGDAAAALTLLLLYEPRQAQRVAHADV
FAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVA
PPQGPGPPELGRDTGRFDRQAASEACFYNSDYVAARGRLAAASEQEEELLESLDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSARLSE

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CBFB-CHPF

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CBFB-CHPF

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for CBFB-CHPF

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source