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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CBFB-NUTF2 (FusionGDB2 ID:13375)

Fusion Gene Summary for CBFB-NUTF2

check button Fusion gene summary
Fusion gene informationFusion gene name: CBFB-NUTF2
Fusion gene ID: 13375
HgeneTgene
Gene symbol

CBFB

NUTF2

Gene ID

865

10204

Gene namecore-binding factor subunit betanuclear transport factor 2
SynonymsPEBP2BNTF-2|NTF2|PP15
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
Descriptioncore-binding factor subunit betaCBF-betaPEA2-betaPEBP2-betaSL3-3 enhancer factor 1 beta subunitSL3-3 enhancer factor 1 subunit betaSL3/AKV core-binding factor beta subunitcore-binding factor beta subunitpolyomavirus enhancer binding protein 2, betnuclear transport factor 2placental protein 15
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000561924, ENST00000290858, 
ENST00000412916, ENST00000568858, 
ENST00000219169, ENST00000568396, 
ENST00000569436, 
Fusion gene scores* DoF score17 X 18 X 12=367212 X 9 X 6=648
# samples 3315
** MAII scorelog2(33/3672*10)=-3.47602812916799
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/648*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBFB [Title/Abstract] AND NUTF2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBFB(67070658)-NUTF2(67902243), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUTF2

GO:0006606

protein import into nucleus

7744965|10679025

TgeneNUTF2

GO:0006611

protein export from nucleus

16449645


check buttonFusion gene breakpoints across CBFB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUTF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-78-8660-01ACBFBchr16

67070658

+NUTF2chr16

67902243

+
ChimerDB4LUADTCGA-78-8660CBFBchr16

67070658

+NUTF2chr16

67902242

+


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Fusion Gene ORF analysis for CBFB-NUTF2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000561924ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902243

+
5UTR-3CDSENST00000561924ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902242

+
5UTR-3CDSENST00000561924ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902243

+
5UTR-3CDSENST00000561924ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902242

+
5UTR-3CDSENST00000561924ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902243

+
5UTR-3CDSENST00000561924ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902242

+
In-frameENST00000290858ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902243

+
In-frameENST00000290858ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902242

+
In-frameENST00000290858ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902243

+
In-frameENST00000290858ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902242

+
In-frameENST00000290858ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902243

+
In-frameENST00000290858ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902242

+
In-frameENST00000412916ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902243

+
In-frameENST00000412916ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902242

+
In-frameENST00000412916ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902243

+
In-frameENST00000412916ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902242

+
In-frameENST00000412916ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902243

+
In-frameENST00000412916ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902242

+
intron-3CDSENST00000568858ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902243

+
intron-3CDSENST00000568858ENST00000219169CBFBchr16

67070658

+NUTF2chr16

67902242

+
intron-3CDSENST00000568858ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902243

+
intron-3CDSENST00000568858ENST00000568396CBFBchr16

67070658

+NUTF2chr16

67902242

+
intron-3CDSENST00000568858ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902243

+
intron-3CDSENST00000568858ENST00000569436CBFBchr16

67070658

+NUTF2chr16

67902242

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290858CBFBchr1667070658+ENST00000219169NUTF2chr1667902243+2482543261827188
ENST00000290858CBFBchr1667070658+ENST00000569436NUTF2chr1667902243+1238543261827188
ENST00000290858CBFBchr1667070658+ENST00000568396NUTF2chr1667902243+1238543261827188
ENST00000412916CBFBchr1667070658+ENST00000219169NUTF2chr1667902243+2384445163729188
ENST00000412916CBFBchr1667070658+ENST00000569436NUTF2chr1667902243+1140445163729188
ENST00000412916CBFBchr1667070658+ENST00000568396NUTF2chr1667902243+1140445163729188
ENST00000290858CBFBchr1667070658+ENST00000219169NUTF2chr1667902242+2482543261827188
ENST00000290858CBFBchr1667070658+ENST00000569436NUTF2chr1667902242+1238543261827188
ENST00000290858CBFBchr1667070658+ENST00000568396NUTF2chr1667902242+1238543261827188
ENST00000412916CBFBchr1667070658+ENST00000219169NUTF2chr1667902242+2384445163729188
ENST00000412916CBFBchr1667070658+ENST00000569436NUTF2chr1667902242+1140445163729188
ENST00000412916CBFBchr1667070658+ENST00000568396NUTF2chr1667902242+1140445163729188

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290858ENST00000219169CBFBchr1667070658+NUTF2chr1667902243+0.0042578290.99574214
ENST00000290858ENST00000569436CBFBchr1667070658+NUTF2chr1667902243+0.0054759710.994524
ENST00000290858ENST00000568396CBFBchr1667070658+NUTF2chr1667902243+0.0054759710.994524
ENST00000412916ENST00000219169CBFBchr1667070658+NUTF2chr1667902243+0.0050389080.99496114
ENST00000412916ENST00000569436CBFBchr1667070658+NUTF2chr1667902243+0.0045474070.9954526
ENST00000412916ENST00000568396CBFBchr1667070658+NUTF2chr1667902243+0.0045474070.9954526
ENST00000290858ENST00000219169CBFBchr1667070658+NUTF2chr1667902242+0.0042578290.99574214
ENST00000290858ENST00000569436CBFBchr1667070658+NUTF2chr1667902242+0.0054759710.994524
ENST00000290858ENST00000568396CBFBchr1667070658+NUTF2chr1667902242+0.0054759710.994524
ENST00000412916ENST00000219169CBFBchr1667070658+NUTF2chr1667902242+0.0050389080.99496114
ENST00000412916ENST00000569436CBFBchr1667070658+NUTF2chr1667902242+0.0045474070.9954526
ENST00000412916ENST00000568396CBFBchr1667070658+NUTF2chr1667902242+0.0045474070.9954526

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Fusion Genomic Features for CBFB-NUTF2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CBFBchr1667070658+NUTF2chr1667902242+2.62E-111
CBFBchr1667070658+NUTF2chr1667902242+2.62E-111
CBFBchr1667070658+NUTF2chr1667902242+2.62E-111
CBFBchr1667070658+NUTF2chr1667902242+2.62E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CBFB-NUTF2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:67070658/chr16:67902243)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNUTF2chr16:67070658chr16:67902242ENST000002191691510_12133128.0DomainNTF2
TgeneNUTF2chr16:67070658chr16:67902242ENST000005683961510_12133128.0DomainNTF2
TgeneNUTF2chr16:67070658chr16:67902242ENST000005694361510_12133128.0DomainNTF2
TgeneNUTF2chr16:67070658chr16:67902243ENST000002191691510_12133128.0DomainNTF2
TgeneNUTF2chr16:67070658chr16:67902243ENST000005683961510_12133128.0DomainNTF2
TgeneNUTF2chr16:67070658chr16:67902243ENST000005694361510_12133128.0DomainNTF2


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Fusion Gene Sequence for CBFB-NUTF2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13375_13375_1_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902242_ENST00000219169_length(transcript)=2482nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGATTGACGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAG
AAAATTCAGCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGAT
GAAGACCCCATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCC
CTGCACAACTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGA
TGCTCCAAATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGG
ATGCTAGACTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTT
TTTTTTTTTTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACAT
TGATTTGTTCAGATGTTTCAATGCCTCATGATACAATAAAACCACAAAAATTTTCTTAACAGTTTAAATTGTTTTAATTAGTTTACTAGT
TGGCTGGGCATCAGAAGCTACCCAGACCCGTTGTCTCTCTCATGTTTCACCCTCCCACTTCTGCCCCAACTCTGAATACCTGTTGCAGGG
AGAAACTGCTGAAGCAGCACTCCCAGCTAGCCTCTCAGAAGCCGTGTAGGGCAGTTCTCTCCCACTCCACAGGGCGACTGGTCTTTGGAA
AGCAGGCAGGAAGAGCTCAGGTCTGGCCTGAAGCTTCTCTCACTGAAGCCTGTGCAGTCAGTTCTGATACCTCCTGTGACTTCTGCTCTG
GGTAGGTTCAGGGCCCTAGTAGCAGGAGAGATGATCCTGAATCCTGTTGAAGCTGGAGAGGCCTTGGCAAAATGGCTCATCACGTTCAGG
CCCTCCGGGCTGAGTTGTCAGCAGTATCAAGGGAGGGGCCTGCTCTATCCCCAGAAGGATCAGGATCATATCCAGGATGCCCCACATACA
CCAAGCCAGGCAGAGGGCAGCTCAGCTCCTGTCCCATCTGCTTTGGATATCTTTACCCAAAGGCAGGTAACCCGAAGAGCCAGCCTCCAC
TGCCCACAGAGCCAGGCCCAGTTGTGTTGGAGTATAGGTCAGGAGCTGTGGAAGGAGGCAGTCTGTGAGGGACTCATGCTTTAGGAGTCC
TCACCCCTCAGACTGCTGCAGGACATTGCCAGGCCTCTCTCCACTTCCTTCCTCAGCATACAGACTTCATGCTATCTTCCAATTCCGGGG
AGTCTTAGCTATTAGGGCAGTTTCTGCTTCTCCATTTTGGGGACAAAGGCCTTGCCCAGTACAAATCTAGCCCCTTGTCCCACAGACTTC
TGGATGGTATAAACCTAGTGGCAATGTAGCAACCATAGGCTAGAACCAAACCCAAGATTTGGGTCAGTGCCCTGTTAAGGGTTTTAGGAT
TGGTAAGGACACCACAGCTAAATCTGACATGTAAAAGGATACCCTTCCCCTGTCCCACTACGGGTGGAGGCTAAGGACCTCCTCAGATCC
CACAGATTGCCTGGTGACATTGGGCACAGGGCTGGATGGTGTGCTGTTTGAGAGGACAGCATGCTCAGGAGATTTCAGTGGGAATGATCT
CTAGGCTGATGTGTATTTGGGGAAGTGGGGGTGGGGAAGAGGTAGGTGCCTGCTGCCTCAAACCACCTTGTGTAAAATCTGCAATACGGC

>13375_13375_1_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902242_ENST00000219169_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_2_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902242_ENST00000568396_length(transcript)=1238nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGATTGACGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAG
AAAATTCAGCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGAT
GAAGACCCCATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCC
CTGCACAACTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGA
TGCTCCAAATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGG
ATGCTAGACTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTT
TTTTTTTTTTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACAT

>13375_13375_2_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902242_ENST00000568396_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_3_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902242_ENST00000569436_length(transcript)=1238nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGATTGACGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAG
AAAATTCAGCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGAT
GAAGACCCCATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCC
CTGCACAACTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGA
TGCTCCAAATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGG
ATGCTAGACTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTT
TTTTTTTTTTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACAT

>13375_13375_3_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902242_ENST00000569436_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_4_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902243_ENST00000219169_length(transcript)=2482nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGATTGACGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAG
AAAATTCAGCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGAT
GAAGACCCCATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCC
CTGCACAACTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGA
TGCTCCAAATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGG
ATGCTAGACTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTT
TTTTTTTTTTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACAT
TGATTTGTTCAGATGTTTCAATGCCTCATGATACAATAAAACCACAAAAATTTTCTTAACAGTTTAAATTGTTTTAATTAGTTTACTAGT
TGGCTGGGCATCAGAAGCTACCCAGACCCGTTGTCTCTCTCATGTTTCACCCTCCCACTTCTGCCCCAACTCTGAATACCTGTTGCAGGG
AGAAACTGCTGAAGCAGCACTCCCAGCTAGCCTCTCAGAAGCCGTGTAGGGCAGTTCTCTCCCACTCCACAGGGCGACTGGTCTTTGGAA
AGCAGGCAGGAAGAGCTCAGGTCTGGCCTGAAGCTTCTCTCACTGAAGCCTGTGCAGTCAGTTCTGATACCTCCTGTGACTTCTGCTCTG
GGTAGGTTCAGGGCCCTAGTAGCAGGAGAGATGATCCTGAATCCTGTTGAAGCTGGAGAGGCCTTGGCAAAATGGCTCATCACGTTCAGG
CCCTCCGGGCTGAGTTGTCAGCAGTATCAAGGGAGGGGCCTGCTCTATCCCCAGAAGGATCAGGATCATATCCAGGATGCCCCACATACA
CCAAGCCAGGCAGAGGGCAGCTCAGCTCCTGTCCCATCTGCTTTGGATATCTTTACCCAAAGGCAGGTAACCCGAAGAGCCAGCCTCCAC
TGCCCACAGAGCCAGGCCCAGTTGTGTTGGAGTATAGGTCAGGAGCTGTGGAAGGAGGCAGTCTGTGAGGGACTCATGCTTTAGGAGTCC
TCACCCCTCAGACTGCTGCAGGACATTGCCAGGCCTCTCTCCACTTCCTTCCTCAGCATACAGACTTCATGCTATCTTCCAATTCCGGGG
AGTCTTAGCTATTAGGGCAGTTTCTGCTTCTCCATTTTGGGGACAAAGGCCTTGCCCAGTACAAATCTAGCCCCTTGTCCCACAGACTTC
TGGATGGTATAAACCTAGTGGCAATGTAGCAACCATAGGCTAGAACCAAACCCAAGATTTGGGTCAGTGCCCTGTTAAGGGTTTTAGGAT
TGGTAAGGACACCACAGCTAAATCTGACATGTAAAAGGATACCCTTCCCCTGTCCCACTACGGGTGGAGGCTAAGGACCTCCTCAGATCC
CACAGATTGCCTGGTGACATTGGGCACAGGGCTGGATGGTGTGCTGTTTGAGAGGACAGCATGCTCAGGAGATTTCAGTGGGAATGATCT
CTAGGCTGATGTGTATTTGGGGAAGTGGGGGTGGGGAAGAGGTAGGTGCCTGCTGCCTCAAACCACCTTGTGTAAAATCTGCAATACGGC

>13375_13375_4_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902243_ENST00000219169_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_5_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902243_ENST00000568396_length(transcript)=1238nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGATTGACGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAG
AAAATTCAGCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGAT
GAAGACCCCATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCC
CTGCACAACTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGA
TGCTCCAAATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGG
ATGCTAGACTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTT
TTTTTTTTTTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACAT

>13375_13375_5_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902243_ENST00000568396_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_6_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902243_ENST00000569436_length(transcript)=1238nt_BP=543nt
GCGGTGAGCGCTGGGGCTGCGCGGGCGGCAGGCAACGGCTGAGGCGGCGGCGGCGGCGGCGGCGGCGTGGGTTGGGCTCGAGCGGGCGGC
GGCGCCTCAGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTC
AGTCGGTCAGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGC
GTCGTGCCCGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGG
GACCGGCCCCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAAT
CTGTCTCTCCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGC
AAGATTGACGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAG
AAAATTCAGCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGAT
GAAGACCCCATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCC
CTGCACAACTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGA
TGCTCCAAATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGG
ATGCTAGACTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTT
TTTTTTTTTTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACAT

>13375_13375_6_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000290858_NUTF2_chr16_67902243_ENST00000569436_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_7_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902242_ENST00000219169_length(transcript)=2384nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGATTGA
CGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAGAAAATTCA
GCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGATGAAGACCC
CATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCCCTGCACAA
CTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGATGCTCCAA
ATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGGATGCTAGA
CTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTTTTTTTTTT
TTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACATTGATTTGT
TCAGATGTTTCAATGCCTCATGATACAATAAAACCACAAAAATTTTCTTAACAGTTTAAATTGTTTTAATTAGTTTACTAGTTGGCTGGG
CATCAGAAGCTACCCAGACCCGTTGTCTCTCTCATGTTTCACCCTCCCACTTCTGCCCCAACTCTGAATACCTGTTGCAGGGAGAAACTG
CTGAAGCAGCACTCCCAGCTAGCCTCTCAGAAGCCGTGTAGGGCAGTTCTCTCCCACTCCACAGGGCGACTGGTCTTTGGAAAGCAGGCA
GGAAGAGCTCAGGTCTGGCCTGAAGCTTCTCTCACTGAAGCCTGTGCAGTCAGTTCTGATACCTCCTGTGACTTCTGCTCTGGGTAGGTT
CAGGGCCCTAGTAGCAGGAGAGATGATCCTGAATCCTGTTGAAGCTGGAGAGGCCTTGGCAAAATGGCTCATCACGTTCAGGCCCTCCGG
GCTGAGTTGTCAGCAGTATCAAGGGAGGGGCCTGCTCTATCCCCAGAAGGATCAGGATCATATCCAGGATGCCCCACATACACCAAGCCA
GGCAGAGGGCAGCTCAGCTCCTGTCCCATCTGCTTTGGATATCTTTACCCAAAGGCAGGTAACCCGAAGAGCCAGCCTCCACTGCCCACA
GAGCCAGGCCCAGTTGTGTTGGAGTATAGGTCAGGAGCTGTGGAAGGAGGCAGTCTGTGAGGGACTCATGCTTTAGGAGTCCTCACCCCT
CAGACTGCTGCAGGACATTGCCAGGCCTCTCTCCACTTCCTTCCTCAGCATACAGACTTCATGCTATCTTCCAATTCCGGGGAGTCTTAG
CTATTAGGGCAGTTTCTGCTTCTCCATTTTGGGGACAAAGGCCTTGCCCAGTACAAATCTAGCCCCTTGTCCCACAGACTTCTGGATGGT
ATAAACCTAGTGGCAATGTAGCAACCATAGGCTAGAACCAAACCCAAGATTTGGGTCAGTGCCCTGTTAAGGGTTTTAGGATTGGTAAGG
ACACCACAGCTAAATCTGACATGTAAAAGGATACCCTTCCCCTGTCCCACTACGGGTGGAGGCTAAGGACCTCCTCAGATCCCACAGATT
GCCTGGTGACATTGGGCACAGGGCTGGATGGTGTGCTGTTTGAGAGGACAGCATGCTCAGGAGATTTCAGTGGGAATGATCTCTAGGCTG
ATGTGTATTTGGGGAAGTGGGGGTGGGGAAGAGGTAGGTGCCTGCTGCCTCAAACCACCTTGTGTAAAATCTGCAATACGGCTTCTTCCA

>13375_13375_7_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902242_ENST00000219169_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_8_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902242_ENST00000568396_length(transcript)=1140nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGATTGA
CGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAGAAAATTCA
GCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGATGAAGACCC
CATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCCCTGCACAA
CTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGATGCTCCAA
ATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGGATGCTAGA
CTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTTTTTTTTTT
TTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACATTGATTTGT

>13375_13375_8_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902242_ENST00000568396_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_9_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902242_ENST00000569436_length(transcript)=1140nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGATTGA
CGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAGAAAATTCA
GCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGATGAAGACCC
CATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCCCTGCACAA
CTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGATGCTCCAA
ATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGGATGCTAGA
CTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTTTTTTTTTT
TTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACATTGATTTGT

>13375_13375_9_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902242_ENST00000569436_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_10_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902243_ENST00000219169_length(transcript)=2384nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGATTGA
CGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAGAAAATTCA
GCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGATGAAGACCC
CATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCCCTGCACAA
CTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGATGCTCCAA
ATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGGATGCTAGA
CTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTTTTTTTTTT
TTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACATTGATTTGT
TCAGATGTTTCAATGCCTCATGATACAATAAAACCACAAAAATTTTCTTAACAGTTTAAATTGTTTTAATTAGTTTACTAGTTGGCTGGG
CATCAGAAGCTACCCAGACCCGTTGTCTCTCTCATGTTTCACCCTCCCACTTCTGCCCCAACTCTGAATACCTGTTGCAGGGAGAAACTG
CTGAAGCAGCACTCCCAGCTAGCCTCTCAGAAGCCGTGTAGGGCAGTTCTCTCCCACTCCACAGGGCGACTGGTCTTTGGAAAGCAGGCA
GGAAGAGCTCAGGTCTGGCCTGAAGCTTCTCTCACTGAAGCCTGTGCAGTCAGTTCTGATACCTCCTGTGACTTCTGCTCTGGGTAGGTT
CAGGGCCCTAGTAGCAGGAGAGATGATCCTGAATCCTGTTGAAGCTGGAGAGGCCTTGGCAAAATGGCTCATCACGTTCAGGCCCTCCGG
GCTGAGTTGTCAGCAGTATCAAGGGAGGGGCCTGCTCTATCCCCAGAAGGATCAGGATCATATCCAGGATGCCCCACATACACCAAGCCA
GGCAGAGGGCAGCTCAGCTCCTGTCCCATCTGCTTTGGATATCTTTACCCAAAGGCAGGTAACCCGAAGAGCCAGCCTCCACTGCCCACA
GAGCCAGGCCCAGTTGTGTTGGAGTATAGGTCAGGAGCTGTGGAAGGAGGCAGTCTGTGAGGGACTCATGCTTTAGGAGTCCTCACCCCT
CAGACTGCTGCAGGACATTGCCAGGCCTCTCTCCACTTCCTTCCTCAGCATACAGACTTCATGCTATCTTCCAATTCCGGGGAGTCTTAG
CTATTAGGGCAGTTTCTGCTTCTCCATTTTGGGGACAAAGGCCTTGCCCAGTACAAATCTAGCCCCTTGTCCCACAGACTTCTGGATGGT
ATAAACCTAGTGGCAATGTAGCAACCATAGGCTAGAACCAAACCCAAGATTTGGGTCAGTGCCCTGTTAAGGGTTTTAGGATTGGTAAGG
ACACCACAGCTAAATCTGACATGTAAAAGGATACCCTTCCCCTGTCCCACTACGGGTGGAGGCTAAGGACCTCCTCAGATCCCACAGATT
GCCTGGTGACATTGGGCACAGGGCTGGATGGTGTGCTGTTTGAGAGGACAGCATGCTCAGGAGATTTCAGTGGGAATGATCTCTAGGCTG
ATGTGTATTTGGGGAAGTGGGGGTGGGGAAGAGGTAGGTGCCTGCTGCCTCAAACCACCTTGTGTAAAATCTGCAATACGGCTTCTTCCA

>13375_13375_10_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902243_ENST00000219169_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_11_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902243_ENST00000568396_length(transcript)=1140nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGATTGA
CGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAGAAAATTCA
GCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGATGAAGACCC
CATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCCCTGCACAA
CTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGATGCTCCAA
ATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGGATGCTAGA
CTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTTTTTTTTTT
TTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACATTGATTTGT

>13375_13375_11_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902243_ENST00000568396_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

--------------------------------------------------------------
>13375_13375_12_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902243_ENST00000569436_length(transcript)=1140nt_BP=445nt
AGACTCCCCGGAACGGGAGCCCACGCGGGCGGGCGCCTGAAACAAAGGGAAGCGGGCGTCCGGGCGCCGCGGGTGGGCGGTCAGTCGGTC
AGCGCGGAGCCAGCCAGCGGGTGCCCGCGCAAGCCCCGAGCGCGGCCGGCCGGCGCGGCCTCAGGGCGGGAAGATGCCGCGCGTCGTGCC
CGACCAGAGAAGCAAGTTCGAGAACGAGGAGTTTTTTAGGAAGCTGAGCCGCGAGTGTGAGATTAAGTACACGGGCTTCAGGGACCGGCC
CCACGAGGAACGCCAGGCACGCTTCCAGAACGCCTGCCGCGACGGCCGCTCGGAAATCGCTTTTGTGGCCACAGGAACCAATCTGTCTCT
CCAGTTTTTTCCGGCCAGCTGGCAGGGAGAACAGCGACAAACACCTAGCCGAGAGTATGTCGACTTAGAAAGAGAAGCAGGCAAGATTGA
CGCGTCATGCCTTACGTGGGAAGGACAACAGTTCCAGGGGAAAGCTGCCATTGTGGAGAAGTTGTCTAGCCTTCCGTTCCAGAAAATTCA
GCACAGCATCACCGCGCAGGACCATCAGCCCACTCCAGATAGCTGCATCATCAGCATGGTTGTGGGCCAGCTTAAGGCGGATGAAGACCC
CATCATGGGGTTCCACCAGATGTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGCCCTGCACAA
CTTTGGCTGACCTCCTCTCAGCTAGGCACTCACGCTGTTTCCTCCTCCCTCCTCTTCCCAATACTATTCCCACTCCTCCAGATGCTCCAA
ATATCATGCACAAATGAGCAGGGCCGCGGTGGGAGTGGGCGCAGTGCGCTGCTGCCACTGAGGTGTTGTGCATGATGTTTGGATGCTAGA
CTAGTTGCATCTGACGGGAGAAGTTTGTGTTGTACCAGCGCATGCCTTGGAAAGACTTAAGTAATGCAAAAGGTTGTCCTTTTTTTTTTT
TTTTTTTTTTTAATCTACTGACAAGTTGCTCTAGTAACCCAAAGAAGTGAAGGAGAAAGCAGCTGCCTCACCGCCCAGACATTGATTTGT

>13375_13375_12_CBFB-NUTF2_CBFB_chr16_67070658_ENST00000412916_NUTF2_chr16_67902243_ENST00000569436_length(amino acids)=188AA_BP=94
MPRVVPDQRSKFENEEFFRKLSRECEIKYTGFRDRPHEERQARFQNACRDGRSEIAFVATGTNLSLQFFPASWQGEQRQTPSREYVDLER
EAGKIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMF

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Fusion Gene PPI Analysis for CBFB-NUTF2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBFB-NUTF2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CBFB-NUTF2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource