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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CBLB-ALCAM (FusionGDB2 ID:13380)

Fusion Gene Summary for CBLB-ALCAM

check button Fusion gene summary
Fusion gene informationFusion gene name: CBLB-ALCAM
Fusion gene ID: 13380
HgeneTgene
Gene symbol

CBLB

ALCAM

Gene ID

868

214

Gene nameCbl proto-oncogene Bactivated leukocyte cell adhesion molecule
SynonymsCbl-b|Nbla00127|RNF56CD166|MEMD
Cytomap

3q13.11

3q13.11

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase CBL-BCas-Br-M (murine) ecotropic retroviral transforming sequence bCbl proto-oncogene B, E3 ubiquitin protein ligaseCbl proto-oncogene, E3 ubiquitin protein ligase BRING finger protein 56RING-type E3 ubiquitin transferase CD166 antigen
Modification date2020032720200320
UniProtAcc

Q13191

Q13740

Ensembl transtripts involved in fusion geneENST00000264122, ENST00000394027, 
ENST00000403724, ENST00000405772, 
ENST00000545639, ENST00000407712, 
ENST00000389927, ENST00000481337, 
ENST00000486979, ENST00000306107, 
ENST00000472644, 
Fusion gene scores* DoF score10 X 12 X 3=36011 X 11 X 6=726
# samples 1312
** MAII scorelog2(13/360*10)=-1.46948528330122
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/726*10)=-2.59693514238723
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBLB [Title/Abstract] AND ALCAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBLB(105572257)-ALCAM(105290695), # samples:2
ALCAM(105271429)-CBLB(105495386), # samples:1
Anticipated loss of major functional domain due to fusion event.CBLB-ALCAM seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
CBLB-ALCAM seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CBLB-ALCAM seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CBLB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALCAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-7075CBLBchr3

105572257

-ALCAMchr3

105290695

+


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Fusion Gene ORF analysis for CBLB-ALCAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264122ENST00000389927CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000264122ENST00000481337CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000264122ENST00000486979CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000394027ENST00000389927CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000394027ENST00000481337CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000394027ENST00000486979CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000403724ENST00000389927CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000403724ENST00000481337CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000403724ENST00000486979CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000405772ENST00000389927CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000405772ENST00000481337CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000405772ENST00000486979CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000545639ENST00000389927CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000545639ENST00000481337CBLBchr3

105572257

-ALCAMchr3

105290695

+
5CDS-intronENST00000545639ENST00000486979CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000264122ENST00000306107CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000264122ENST00000472644CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000403724ENST00000306107CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000403724ENST00000472644CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000405772ENST00000306107CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000405772ENST00000472644CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000545639ENST00000306107CBLBchr3

105572257

-ALCAMchr3

105290695

+
Frame-shiftENST00000545639ENST00000472644CBLBchr3

105572257

-ALCAMchr3

105290695

+
In-frameENST00000394027ENST00000306107CBLBchr3

105572257

-ALCAMchr3

105290695

+
In-frameENST00000394027ENST00000472644CBLBchr3

105572257

-ALCAMchr3

105290695

+
intron-3CDSENST00000407712ENST00000306107CBLBchr3

105572257

-ALCAMchr3

105290695

+
intron-3CDSENST00000407712ENST00000472644CBLBchr3

105572257

-ALCAMchr3

105290695

+
intron-intronENST00000407712ENST00000389927CBLBchr3

105572257

-ALCAMchr3

105290695

+
intron-intronENST00000407712ENST00000481337CBLBchr3

105572257

-ALCAMchr3

105290695

+
intron-intronENST00000407712ENST00000486979CBLBchr3

105572257

-ALCAMchr3

105290695

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394027CBLBchr3105572257-ENST00000306107ALCAMchr3105290695+303649914586190
ENST00000394027CBLBchr3105572257-ENST00000472644ALCAMchr3105290695+299749914586190

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394027ENST00000306107CBLBchr3105572257-ALCAMchr3105290695+0.0004590790.9995409
ENST00000394027ENST00000472644CBLBchr3105572257-ALCAMchr3105290695+0.0005889850.999411

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Fusion Genomic Features for CBLB-ALCAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CBLBchr3105572257-ALCAMchr3105290695+0.0002800080.9997199
CBLBchr3105572257-ALCAMchr3105290695+0.0002800080.9997199

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CBLB-ALCAM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:105572257/chr3:105290695)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CBLB

Q13191

ALCAM

Q13740

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). {ECO:0000250|UniProtKB:Q3TTA7, ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:10086340, ECO:0000269|PubMed:11087752, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:14661060, ECO:0000269|PubMed:20525694}.FUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO:0000250|UniProtKB:P42292, ECO:0000269|PubMed:15048703, ECO:0000269|PubMed:15294938, ECO:0000269|PubMed:15496415, ECO:0000269|PubMed:16352806, ECO:0000269|PubMed:24945728, ECO:0000269|PubMed:7760007}.; FUNCTION: [Isoform 3]: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. {ECO:0000269|PubMed:15496415}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALCAMchr3:105572257chr3:105290695ENST000004726441215550_5835411319.6666666666667Topological domainCytoplasmic

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319219_232139983.0Calcium bindingOntology_term=ECO:0000255
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315219_232139771.0Calcium bindingOntology_term=ECO:0000255
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319477_925139983.0Compositional biasNote=Pro-rich
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315477_925139771.0Compositional biasNote=Pro-rich
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-31935_343139983.0DomainCbl-PTB
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319931_970139983.0DomainUBA
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-31535_343139771.0DomainCbl-PTB
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315931_970139771.0DomainUBA
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319168_240139983.0RegionNote=EF-hand-like
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319241_343139983.0RegionNote=SH2-like
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319344_372139983.0RegionNote=Linker
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-31935_167139983.0RegionNote=4H
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315168_240139771.0RegionNote=EF-hand-like
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315241_343139771.0RegionNote=SH2-like
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315344_372139771.0RegionNote=Linker
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-31535_167139771.0RegionNote=4H
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319373_412139983.0Zinc fingerRING-type
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315373_412139771.0Zinc fingerRING-type
TgeneALCAMchr3:105572257chr3:105290695ENST000003061071316125_2345541201.0DomainNote=Ig-like V-type 2
TgeneALCAMchr3:105572257chr3:105290695ENST000003061071316245_3285541201.0DomainNote=Ig-like C2-type 1
TgeneALCAMchr3:105572257chr3:105290695ENST00000306107131628_1205541201.0DomainNote=Ig-like V-type 1
TgeneALCAMchr3:105572257chr3:105290695ENST000003061071316333_4095541201.0DomainNote=Ig-like C2-type 2
TgeneALCAMchr3:105572257chr3:105290695ENST000003061071316416_5015541201.0DomainNote=Ig-like C2-type 3
TgeneALCAMchr3:105572257chr3:105290695ENST000004726441215125_2345411319.6666666666667DomainNote=Ig-like V-type 2
TgeneALCAMchr3:105572257chr3:105290695ENST000004726441215245_3285411319.6666666666667DomainNote=Ig-like C2-type 1
TgeneALCAMchr3:105572257chr3:105290695ENST00000472644121528_1205411319.6666666666667DomainNote=Ig-like V-type 1
TgeneALCAMchr3:105572257chr3:105290695ENST000004726441215333_4095411319.6666666666667DomainNote=Ig-like C2-type 2
TgeneALCAMchr3:105572257chr3:105290695ENST000004726441215416_5015411319.6666666666667DomainNote=Ig-like C2-type 3
TgeneALCAMchr3:105572257chr3:105290695ENST00000306107131628_5275541201.0Topological domainExtracellular
TgeneALCAMchr3:105572257chr3:105290695ENST000003061071316550_5835541201.0Topological domainCytoplasmic
TgeneALCAMchr3:105572257chr3:105290695ENST00000472644121528_5275411319.6666666666667Topological domainExtracellular
TgeneALCAMchr3:105572257chr3:105290695ENST000003061071316528_5495541201.0TransmembraneHelical
TgeneALCAMchr3:105572257chr3:105290695ENST000004726441215528_5495411319.6666666666667TransmembraneHelical


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Fusion Gene Sequence for CBLB-ALCAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13380_13380_1_CBLB-ALCAM_CBLB_chr3_105572257_ENST00000394027_ALCAM_chr3_105290695_ENST00000306107_length(transcript)=3036nt_BP=499nt
CCTTTCAGCCCCAGATGGCTTTGGCTCCCGGTCCCGACGCTCACGCCCACCTGCCACCCCTTATTGAACTAAAATTCCAGATGGCAAACT
CAATGAATGGCAGAAACCCTGGTGGTCGAGGAGGAAATCCCCGAAAAGGTCGAATTTTGGGTATTATTGATGCTATTCAGGATGCAGTTG
GACCCCCTAAGCAAGCTGCCGCAGATCGCAGGACCGTGGAGAAGACTTGGAAGCTCATGGACAAAGTGGTAAGACTGTGCCAAAATCCCA
AACTTCAGTTGAAAAATAGCCCACCATATATACTTGATATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGATG
ACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCTACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGAC
TCTTTAAAGAAGGCAAGGAGAGAATGTATGAAGAACAGTCACAGGACAGGACTGCATCAAAACATGTAAACAAGGACCTCGGTAATATGG
AAGAAAACAAAAAGTTAGAAGAAAACAATCACAAAACTGAAGCCTAAGAGAGAAACTGTCCTAGTTGTCCAGAGATAAAAATCATATAGA
CCAATTGAAGCATGAACGTGGATTGTATTTAAGACATAAACAAAGACATTGACAGCAATTCATGGTTCAAGTATTAAGCAGTTCATTCTA
CCAAGCTGTCACAGGTTTTCAGAGAATTATCTCAAGTAAAACAAATGAAATTTAATTACAAACAATAAGAACAAGTTTTGGCAGCCATGA
TAATAGGTCATATGTTGTGTTTGGTTCAATTTTTTTTCCGTAAATGTCTGCACTGAGGATTTCTTTTTGGTTTGCCTTTTATGTAAATTT
TTTACGTAGCTATTTTTATACACTGTAAGCTTTGTTCTGGGAGTTGCTGTTAATCTGATGTATAATGTAATGTTTTTATTTCAATTGTTT
ATATGGATAATCTGAGCAGGTACATTTCTGATTCTGATTGCTATCAGCAATGCCCCAAACTTTCTCATAAGCACCTAAAACCCAAAGGTG
GCAGCTTGTGAAGATTGGGGACACTCATATTGCCCTAATTAAAAACTGTGATTTTTATCACAAGGGAGGGGAGGCCGAGAGTCAGACTGA
TAGACACCATAGGAGCCGACTCTTTGATATGCCACCAGCGAACTCTCAGAAATAAATCACAGATGCATATAGACACACATACATAATGGT
ACTCCCAAACTGACAATTTTACCTATTCTGAAAAAGACATAAAACAGAATTTGGTAGCACTTACCTCTACAGACACCTGCTAATAAATTA
TTTTCTGTCAAAAGAAAAAACACAAGCATGTGTGAGAGACAGTTTGGAAAAATCATGGTCAACATTCCCATTTTCATAGATCACAATGTA
AATCACTATAATTACAAATTGGTGTTAAATCCTTTGGGTTATCCACTGCCTTAAAATTATACCTATTTCATGTTTAAAAAGATATCAATC
AGAATTGGAGTTTTTAACAGTGGTCATTATCAAAGCTGTGTTATTTTCCACAGAATATAGAATATATATTTTTTTCGTGTGTGTTTTTGT
TAACTACCCTACAGATATTGAATGCACCTTGAGATAATTTAGTGTTTTTAACTGATACATAATTTATCAAGCAGTACATGAAAGTGTAAT
AATAAAATGTCTATGTATCTTTAGTTACATTCAAATTTGTAACTTTATAAACATGTTTTATGCTTGAGGAAATTTTTAAGGTGGTAGTAT
AAATGGAAACTTTTTGAAGTAGACCAGATATGGGCTACTTGTGACTAGACTTTTAAACTTTGCTCTTTCAAGCAGAAGCCTGGTTTCTGG
GAGAACACTGCACAGCGATTTCTTTCCCAGGATTTACACAACTTTAAAGGGAAGATAAATGAACATCAGATTTCTAGGTATAGAACTATG
TTATTGAAAGGAAAAGGAAAACTGGTGTTTGTTTCTTAGACTCATGAAATAAAAAATTATGAAGGCAATGAAAAATAAATTGAAAATTAA
AGTCAGATGAGAATAGGAATAATACTTTGCCACTTCTGCATTATTTAGAAACATACGTTATTGTACATTTGTAAACCATTTACTGTCTGG
GCAATAGTGACTCCGTTTAATAAAAGCTTCCGTAGTGCATTGGTATGGATTAAATGCATAAAATATTCTTAGACTCGATGCTGTATAAAA
TATTATGGGAAAAAAAGAAAATACGTTATTTTGCCTCTAAACTTTTATTGAAGTTTTATTTGGCAGGAAAAAAAATTGAATCTTGGTCAA
CATTTAAACCAAAGTAAAAGGGGAAAAACCAAAGTTATTTGTTTTGCATGGCTAAGCCATTCTGTTATCTCTGTAAATACTGTGATTTCT
TTTTTATTTTCTCTTTAGAATTTTGTTAAAGAAATTCTAAAATTTTTAAACACCTGCTCTCCACAATAAATCACAAACACTAAAATAAAA
TTACTTCCATATAAATATTATTTTCTCTTTTGGTGTGGGAGATCAAAGGTTTAAAGTCTAACTTCTAAGATATATTTGCAGAAAGAAGCA
ACATGACAATAGAGAGAGTTATGCTACAATTATTTCTTGGTTTCCACTTGCAATGGTTAATTAAGTCCAAAAACAGCTGTCAGAACCTCG
AGAGCAGAACATGAGAAACTCAGAGCTCTGGACCGAAAGCAGAAAGTTTGCCGGGAAAAAAAAAGACAACATTATTACCATCGATTCAGT
GCCTGGATAAAGAGGAAAGCTTACTTGTTTAATGGCAGCCACATGCACGAAGATGCTAAGAAGAAAAAGAATTCCAAATCCTCAACTTTT
GAGGTTTCGGCTCTCCAATTTAACTCTTTGGCAACAGGAAACAGGTTTTGCAAGTTCAAGGTTCACTCCCTATATGTGATTATAGGAATT

>13380_13380_1_CBLB-ALCAM_CBLB_chr3_105572257_ENST00000394027_ALCAM_chr3_105290695_ENST00000306107_length(amino acids)=190AA_BP=161
MALAPGPDAHAHLPPLIELKFQMANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLK
NSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRTASKHVNKDLGNMEENKK

--------------------------------------------------------------
>13380_13380_2_CBLB-ALCAM_CBLB_chr3_105572257_ENST00000394027_ALCAM_chr3_105290695_ENST00000472644_length(transcript)=2997nt_BP=499nt
CCTTTCAGCCCCAGATGGCTTTGGCTCCCGGTCCCGACGCTCACGCCCACCTGCCACCCCTTATTGAACTAAAATTCCAGATGGCAAACT
CAATGAATGGCAGAAACCCTGGTGGTCGAGGAGGAAATCCCCGAAAAGGTCGAATTTTGGGTATTATTGATGCTATTCAGGATGCAGTTG
GACCCCCTAAGCAAGCTGCCGCAGATCGCAGGACCGTGGAGAAGACTTGGAAGCTCATGGACAAAGTGGTAAGACTGTGCCAAAATCCCA
AACTTCAGTTGAAAAATAGCCCACCATATATACTTGATATTTTGCCTGATACATATCAGCATTTACGACTTATATTGAGTAAATATGATG
ACAACCAGAAACTTGCCCAACTCAGTGAGAATGAGTACTTTAAAATCTACATTGATAGCCTTATGAAAAAGTCAAAACGGGCAATAAGAC
TCTTTAAAGAAGGCAAGGAGAGAATGTATGAAGAACAGTCACAGGACAGGACTGCATCAAAACATGTAAACAAGGACCTCGGTAATATGG
AAGAAAACAAAAAGTTAGAAGAAAACAATCACAAAACTGAAGCCTAAGAGAGAAACTGTCCTAGTTGTCCAGAGATAAAAATCATATAGA
CCAATTGAAGCATGAACGTGGATTGTATTTAAGACATAAACAAAGACATTGACAGCAATTCATGGTTCAAGTATTAAGCAGTTCATTCTA
CCAAGCTGTCACAGGTTTTCAGAGAATTATCTCAAGTAAAACAAATGAAATTTAATTACAAACAATAAGAACAAGTTTTGGCAGCCATGA
TAATAGGTCATATGTTGTGTTTGGTTCAATTTTTTTTCCGTAAATGTCTGCACTGAGGATTTCTTTTTGGTTTGCCTTTTATGTAAATTT
TTTACGTAGCTATTTTTATACACTGTAAGCTTTGTTCTGGGAGTTGCTGTTAATCTGATGTATAATGTAATGTTTTTATTTCAATTGTTT
ATATGGATAATCTGAGCAGGTACATTTCTGATTCTGATTGCTATCAGCAATGCCCCAAACTTTCTCATAAGCACCTAAAACCCAAAGGTG
GCAGCTTGTGAAGATTGGGGACACTCATATTGCCCTAATTAAAAACTGTGATTTTTATCACAAGGGAGGGGAGGCCGAGAGTCAGACTGA
TAGACACCATAGGAGCCGACTCTTTGATATGCCACCAGCGAACTCTCAGAAATAAATCACAGATGCATATAGACACACATACATAATGGT
ACTCCCAAACTGACAATTTTACCTATTCTGAAAAAGACATAAAACAGAATTTGGTAGCACTTACCTCTACAGACACCTGCTAATAAATTA
TTTTCTGTCAAAAGAAAAAACACAAGCATGTGTGAGAGACAGTTTGGAAAAATCATGGTCAACATTCCCATTTTCATAGATCACAATGTA
AATCACTATAATTACAAATTGGTGTTAAATCCTTTGGGTTATCCACTGCCTTAAAATTATACCTATTTCATGTTTAAAAAGATATCAATC
AGAATTGGAGTTTTTAACAGTGGTCATTATCAAAGCTGTGTTATTTTCCACAGAATATAGAATATATATTTTTTTCGTGTGTGTTTTTGT
TAACTACCCTACAGATATTGAATGCACCTTGAGATAATTTAGTGTTTTTAACTGATACATAATTTATCAAGCAGTACATGAAAGTGTAAT
AATAAAATGTCTATGTATCTTTAGTTACATTCAAATTTGTAACTTTATAAACATGTTTTATGCTTGAGGAAATTTTTAAGGTGGTAGTAT
AAATGGAAACTTTTTGAAGTAGACCAGATATGGGCTACTTGTGACTAGACTTTTAAACTTTGCTCTTTCAAGCAGAAGCCTGGTTTCTGG
GAGAACACTGCACAGCGATTTCTTTCCCAGGATTTACACAACTTTAAAGGGAAGATAAATGAACATCAGATTTCTAGGTATAGAACTATG
TTATTGAAAGGAAAAGGAAAACTGGTGTTTGTTTCTTAGACTCATGAAATAAAAAATTATGAAGGCAATGAAAAATAAATTGAAAATTAA
AGTCAGATGAGAATAGGAATAATACTTTGCCACTTCTGCATTATTTAGAAACATACGTTATTGTACATTTGTAAACCATTTACTGTCTGG
GCAATAGTGACTCCGTTTAATAAAAGCTTCCGTAGTGCATTGGTATGGATTAAATGCATAAAATATTCTTAGACTCGATGCTGTATAAAA
TATTATGGGAAAAAAAGAAAATACGTTATTTTGCCTCTAAACTTTTATTGAAGTTTTATTTGGCAGGAAAAAAAATTGAATCTTGGTCAA
CATTTAAACCAAAGTAAAAGGGGAAAAACCAAAGTTATTTGTTTTGCATGGCTAAGCCATTCTGTTATCTCTGTAAATACTGTGATTTCT
TTTTTATTTTCTCTTTAGAATTTTGTTAAAGAAATTCTAAAATTTTTAAACACCTGCTCTCCACAATAAATCACAAACACTAAAATAAAA
TTACTTCCATATAAATATTATTTTCTCTTTTGGTGTGGGAGATCAAAGGTTTAAAGTCTAACTTCTAAGATATATTTGCAGAAAGAAGCA
ACATGACAATAGAGAGAGTTATGCTACAATTATTTCTTGGTTTCCACTTGCAATGGTTAATTAAGTCCAAAAACAGCTGTCAGAACCTCG
AGAGCAGAACATGAGAAACTCAGAGCTCTGGACCGAAAGCAGAAAGTTTGCCGGGAAAAAAAAAGACAACATTATTACCATCGATTCAGT
GCCTGGATAAAGAGGAAAGCTTACTTGTTTAATGGCAGCCACATGCACGAAGATGCTAAGAAGAAAAAGAATTCCAAATCCTCAACTTTT
GAGGTTTCGGCTCTCCAATTTAACTCTTTGGCAACAGGAAACAGGTTTTGCAAGTTCAAGGTTCACTCCCTATATGTGATTATAGGAATT

>13380_13380_2_CBLB-ALCAM_CBLB_chr3_105572257_ENST00000394027_ALCAM_chr3_105290695_ENST00000472644_length(amino acids)=190AA_BP=161
MALAPGPDAHAHLPPLIELKFQMANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLK
NSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRTASKHVNKDLGNMEENKK

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Fusion Gene PPI Analysis for CBLB-ALCAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319891_927139.66666666666666983.0SH3KBP1
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315891_927139.66666666666666771.0SH3KBP1
HgeneCBLBchr3:105572257chr3:105290695ENST00000264122-319543_568139.66666666666666983.0VAV1
HgeneCBLBchr3:105572257chr3:105290695ENST00000403724-315543_568139.66666666666666771.0VAV1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBLB-ALCAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CBLB-ALCAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource