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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACO2-AHRR (FusionGDB2 ID:1340)

Fusion Gene Summary for ACO2-AHRR

check button Fusion gene summary
Fusion gene informationFusion gene name: ACO2-AHRR
Fusion gene ID: 1340
HgeneTgene
Gene symbol

ACO2

AHRR

Gene ID

50

57491

Gene nameaconitase 2aryl-hydrocarbon receptor repressor
SynonymsACONM|HEL-S-284|ICRD|OCA8|OPA9AHH|AHHR|bHLHe77
Cytomap

22q13.2

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionaconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitasearyl hydrocarbon receptor repressorahR repressoraryl hydrocarbon hydroxylase regulatorclass E basic helix-loop-helix protein 77dioxin receptor repressor
Modification date2020031320200322
UniProtAcc.

A9YTQ3

Ensembl transtripts involved in fusion geneENST00000216254, ENST00000396512, 
ENST00000466237, 		ENST00000512529, 
ENST00000506456, ENST00000515206, 
ENST00000316418, ENST00000505113, 
Fusion gene scores* DoF score17 X 8 X 10=13607 X 6 X 4=168
# samples 229
** MAII scorelog2(22/1360*10)=-2.62803122261304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/168*10)=-0.900464326449086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACO2 [Title/Abstract] AND AHRR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACO2(41865186)-AHRR(422844), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACO2

GO:0006099

tricarboxylic acid cycle

9630632

HgeneACO2

GO:0006101

citrate metabolic process

9630632


check buttonFusion gene breakpoints across ACO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AHRR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-EB-A5KH-06AACO2chr22

41865186

-AHRRchr5

422844

+
ChimerDB4SKCMTCGA-EB-A5KH-06AACO2chr22

41865186

+AHRRchr5

422844

+


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Fusion Gene ORF analysis for ACO2-AHRR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000216254ENST00000512529ACO2chr22

41865186

+AHRRchr5

422844

+
5CDS-5UTRENST00000396512ENST00000512529ACO2chr22

41865186

+AHRRchr5

422844

+
5CDS-intronENST00000216254ENST00000506456ACO2chr22

41865186

+AHRRchr5

422844

+
5CDS-intronENST00000216254ENST00000515206ACO2chr22

41865186

+AHRRchr5

422844

+
5CDS-intronENST00000396512ENST00000506456ACO2chr22

41865186

+AHRRchr5

422844

+
5CDS-intronENST00000396512ENST00000515206ACO2chr22

41865186

+AHRRchr5

422844

+
In-frameENST00000216254ENST00000316418ACO2chr22

41865186

+AHRRchr5

422844

+
In-frameENST00000216254ENST00000505113ACO2chr22

41865186

+AHRRchr5

422844

+
In-frameENST00000396512ENST00000316418ACO2chr22

41865186

+AHRRchr5

422844

+
In-frameENST00000396512ENST00000505113ACO2chr22

41865186

+AHRRchr5

422844

+
intron-3CDSENST00000466237ENST00000316418ACO2chr22

41865186

+AHRRchr5

422844

+
intron-3CDSENST00000466237ENST00000505113ACO2chr22

41865186

+AHRRchr5

422844

+
intron-5UTRENST00000466237ENST00000512529ACO2chr22

41865186

+AHRRchr5

422844

+
intron-intronENST00000466237ENST00000506456ACO2chr22

41865186

+AHRRchr5

422844

+
intron-intronENST00000466237ENST00000515206ACO2chr22

41865186

+AHRRchr5

422844

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216254ACO2chr2241865186+ENST00000505113AHRRchr5422844+17345871710567
ENST00000216254ACO2chr2241865186+ENST00000316418AHRRchr5422844+52225871764585
ENST00000396512ACO2chr2241865186+ENST00000505113AHRRchr5422844+17295321705567
ENST00000396512ACO2chr2241865186+ENST00000316418AHRRchr5422844+52175321759585

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216254ENST00000505113ACO2chr2241865186+AHRRchr5422844+0.16192560.83807445
ENST00000216254ENST00000316418ACO2chr2241865186+AHRRchr5422844+0.0716505050.9283495
ENST00000396512ENST00000505113ACO2chr2241865186+AHRRchr5422844+0.161397370.8386026
ENST00000396512ENST00000316418ACO2chr2241865186+AHRRchr5422844+0.071708110.92829186

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Fusion Genomic Features for ACO2-AHRR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACO2chr2241865186+AHRRchr5422843+2.88E-081
ACO2chr2241865186+AHRRchr5422843+2.88E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACO2-AHRR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41865186/chr5:422844)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AHRR

A9YTQ3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAHRRchr22:41865186chr5:422844ENST00000316418412551_701151720.0RegionNeeded for transcriptional repression
TgeneAHRRchr22:41865186chr5:422844ENST00000505113411551_701151702.0RegionNeeded for transcriptional repression

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACO2chr22:41865186chr5:422844ENST00000216254+118192_19412781.0RegionSubstrate binding
HgeneACO2chr22:41865186chr5:422844ENST00000216254+118670_67112781.0RegionSubstrate binding
TgeneAHRRchr22:41865186chr5:422844ENST00000316418412112_182151720.0DomainPAS
TgeneAHRRchr22:41865186chr5:422844ENST0000031641841228_81151720.0DomainbHLH
TgeneAHRRchr22:41865186chr5:422844ENST00000505113411112_182151702.0DomainPAS
TgeneAHRRchr22:41865186chr5:422844ENST0000050511341128_81151702.0DomainbHLH


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Fusion Gene Sequence for ACO2-AHRR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1340_1340_1_ACO2-AHRR_ACO2_chr22_41865186_ENST00000216254_AHRR_chr5_422844_ENST00000316418_length(transcript)=5222nt_BP=58nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTA
CATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTT
GGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGAC
CCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTG
CTGTCCCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCT
CCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGC
AAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAA
TTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAG
GGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGAT
GCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGA
TGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGT
CCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGA
TGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTT
TGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGA
TGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAG
GAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGG
CGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGA
GCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGA
GGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAG
TGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGT
CTACGCTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATG
CGCAGTCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCC
TTAAGTCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAG
GCAGCGAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGC
GGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCA
GCCTGTGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGGAGAAA
GGGGTCCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCG
GCAGGTGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCG
AGTTCTCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAG
TACAGAGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAA
TGAGGGTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTT
CTGAGAGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGGTGCAT
TTCAGGCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAA
GCCAGGCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCG
CCCTGACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTC
CCGTGTGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCC
TCCTGTGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAAC
GCACCTTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTT
CTTGGACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGT
CACAGATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTG
ACCTCCATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGG
GACAGAGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCAC
CTGAGGACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACACTTCT
GGCCTCTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTT
GCTGATCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGT
AGGAGGATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCAGATCT
GCTGTATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAG
CTTAGCCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAG
GGAGCTCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAG
ATCGAATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGAC
GGCAGCCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGT
GACAGGTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGT
TTTGTGGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAA
ACTCCCCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGT
ATCACTTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGT
ATTAAAGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTT
TTCAATACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGC
TTTCAAATTTTTTTGTACTGTGGTTTGTATTAAATTTGCAATATTGATGTAAAATACATGACATGCTAGTACATGTTTAACAAAAATTTA

>1340_1340_1_ACO2-AHRR_ACO2_chr22_41865186_ENST00000216254_AHRR_chr5_422844_ENST00000316418_length(amino acids)=585AA_BP=9
MSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC
FICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKP
RADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLS
RASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVG
EDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSH
PATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAA

--------------------------------------------------------------
>1340_1340_2_ACO2-AHRR_ACO2_chr22_41865186_ENST00000216254_AHRR_chr5_422844_ENST00000505113_length(transcript)=1734nt_BP=58nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTA
CATCCACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTT
GGAGACAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGAC
CCGCTGCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTT
TGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGC
AGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCAC
CAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACA
GACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGG
GGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAA
GCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCC
CATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAG
TGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCT
GCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCC
TCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTG
TGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTC
TCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCT
GACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGG
CCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCA
CAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATA

>1340_1340_2_ACO2-AHRR_ACO2_chr22_41865186_ENST00000216254_AHRR_chr5_422844_ENST00000505113_length(amino acids)=567AA_BP=9
MSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC
FICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSL
CESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPL
PWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQH
QLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQ
QVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQ

--------------------------------------------------------------
>1340_1340_3_ACO2-AHRR_ACO2_chr22_41865186_ENST00000396512_AHRR_chr5_422844_ENST00000316418_length(transcript)=5217nt_BP=53nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCC
ACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGA
CAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCT
GCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGGCCCGGGGGTCACAGGCTTGGCAGCTGCGGCTCTGCTGTC
CCGAGCCACTCATGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGACAGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGC
CGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGGAGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAAC
CCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTCTGTGCGAATCGGAACTGCATGGAAAACCCAATTACT
CAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTGACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCC
CATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCTCAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGA
GCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCCTGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTG
CCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGCCCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGG
GCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCTACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCG
GTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGCACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCA
CGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGGGGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGT
CCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGCCCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCC
ACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGCAACAGGTGTACATCTCGCACCTGGGGCACGGCGTGC
GGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCCCTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCA
CAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAGGTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCG
CCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCCAGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCT
TGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCAGTGACCACCATCCAAGCTCAGATCTGTGTGTCTACG
CTCAGATGCGTCGGTGGCTGGGCTGCCCTGCTCCTGGTCAGGCCGGAGCCCGTCCTAAGACACACGCTTTGCAGAGCTGTGCATGCGCAG
TCTGCTAGTGTGTGTGTGCAGCATACGCAGGAGCCTATCCTGAATTTTGTAAAATATCCCAACAGTTCTTAAATGAAAACTGGCCTTAAG
TCTATTCAAGCATGACAGCATTTCTCTTTGAGGAATTAAAATCTTTAGGAAAGTGATCATGGCTGGACAGCTTCATGCCCCAGAGGCAGC
GAGCACCCGTCCCATGGCTGCCAAGTCCACAGTCGGGGATGAAGCAGTCGGGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCG
GGTGATGCTCCCAAGTCCGCAGTCGGGGATGAAGCGGTCGGGTGACACACCTAGCTCAGCCCTCCCAGGCCACCTGCAGCTCCCAGCCTG
TGCTGTGCAGGCAGGGTCAGCCCATCGCCACAGTGCACTGTAGAGGCCAGCACACGGCAAATTAGAAATACAACACGCGGAGAAAGGGGT
CCGTGAGCCCACTCATAGAGGAATCTAGAACGTTCCAGGCAGCAGAGGCTGGCAGCGTGGGTCCCACACTGCCCCACACCGTGCGGCAGG
TGCTCCATGGCGCCATGACAGAGTCTGAGGCCAGACCTGGACTGGAATTGACAGCATAACCCCTGTTCCTTCTGGACATCTCCCGAGTTC
TCAGTGGGTCTCTGCGGACGGTTCTTCCTAATCTGCCTCTTGGTACATCACGTAATACAGAGTTCACAGACTCCGGGTTTGGAAGTACAG
AGAAACACACAACGTAGAGAGAAGACACAGGAAACTGCGCTGCCTGTGGGGGTTTCTCTCTGGCTGGCTGTACAGTTCACTCAAATGAGG
GTTCCCATTGCCATCCTAGGAGAATAATTAGGGACAAGACAGACAAGTATTAATAGCATTAAAACAGTTGTAAAGGCGATATTTTCTGAG
AGTAGGAAATTTGGATACAAAAGCATAAGTCAGAAAGTGAAGGTCACCAATCCACCAACCCGAGAACCTACAGCTGATGGTGCATTTCAG
GCTTCTTCCACGGTCTGGCCTGGAACCCCACCCGGCTGGTGCAGGCATCAGATCAGGGTGTAGAAGTCACCCCAAGCAAGAGGAAGCCAG
GCAGTGAGGCCCTGGGGTGTGGCTGCAGCTGGGCCCACCTGTGCGGGGGTGGGAAGGCCCCATCCTCAGGGAGAGGGCATCGGCGCCCTG
ACGTCAGCTCCACTGGGAGTGGCAGGAGCTGTGGGAGCCCATGGGTGAGGGACCCACCACCCCGCTGCACTGTGCATTGTGCCTCCCGTG
TGGACGCCCTCTCTGTTGTTGGCCCGCGGGTGAGGGACCCACCACCCCTAGGGACCCACCACCCCGCCGCACTGTGCATTCTGCCTCCTG
TGTGGACGCCCTCTCTGTTGTCAGTGGCTTTGAGGTGTCAGTGCTTACTTAGATGCTGGTTTAATGCTGGACCCATTTGTTAAACGCACC
TTCACTTTGTCAAAACCCAGGTTTGGTTGGCAGGACTGGGTCTTCTGCCCAATGCCAGGTGCCTGCGCCTCTCAGTGGCCTGGTTCTTGG
ACAGTTTGCCCCCATGTGGCAGGGATAGGGATAAGGATCTCCTCTCAGTACTGGAAGAGAACAGCCAACCATCTGAGCCCAGAGTCACAG
ATCCATCGTGGCCCCCTATGACCCCCAAGCCCTACCGAGGGGGCACTCACTCTCTGCTTAGCCAGGGGGCGTCTTTCAAAAGGTGACCTC
CATGCTGTGCTGTCGTGGGTGTGAGACGTGCTCATGGCCTTCCACTGCCATCTCTCCCTTATCTGATGCCTAAAGTCACGATGGGGACAG
AGCTACCCAGGGGCCAGCCATGGGGTGACCAGCCACCTGAGGGTCAGTCACCTGTGGAGAGCAGGCACCTGTGAAGACCAGGCACCTGAG
GACTGGCGCCTACTTCCCACTTTGGCCCTACACTGGCACAGAGCCCCTCTTTATTCATTTCTCATGCTGAGCATGGCACACTTCTGGCCT
CTGGGCATTTATGGATTTAAGACCAGGATGGTATTTCAGAAGCTTCCCACTTCCTTCCTATTCTAACCGAGTGCCCAGCTCCTTTGCTGA
TCATGGAAAGACCCTTAATAATTAGGCCTGCAGGCCAGGCGCAGTGGCTCATGCCTATAATCCCAGCACTTTAGGAGGTCAAGGTAGGAG
GATCGCTTAAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGGAAGAATGTGTCTCTACAAAAAATAATTAAAAATCAGATCTGCTGT
ATCCCTGAAAAAGTCTCAATCAACATGCATGTTCCACTCTTGGAGTTCCCTGTTCTGAGGGCCAGCCACGTCCTGTGTCCTGGAGCTTAG
CCCTCAGCAGCTCCCTTCAGCCTGGGCGCCGCCTGGGTCCCAAACGTGGCAGCTGCTCTTCCAGTCTCGGGGCCGAGGAGGGCAGGGAGC
TCAGTGACTGAGAGTCTTGTGTATCACATGTCTTGAGTGTCCTGGAGCCAACGGCTGTCACTGGGAAAAACACCAGGCCCCAAAGATCGA
ATCAGAGACGTGGCTGCGTGTTTGCGATTGTAGCCAGGCCCTTCAGTGTCATCAAAGGAGCACTGGGGCCTCCTTAAGCACAGACGGCAG
CCCCTGCCCAGGAGGCTTCTTCACCACGTCCTGCCCTGCAGCCTCCCAGACCTTTAGATGCGCCCCTGCCCAAGGCCCTCCTGGTGACAG
GTGCCAGATTGAGTGGTGGGTTGCTGCCAGGCAGGCCACGCTGTGTTGACGCTGCACTCAGCACGTGGGTGTTGGCTCTGCCGGTTTTGT
GGTGTGGGGACCCTACAGGAGGCTGCGGCCCTGAGAGCCTGGGATCAGCGAGGTGTCCGACATCCCTTCCTCAACGGCAACAAAAACTCC
CCAAGTCAGCACTTTGGTTATTTTATAGCCACAACCCTCTTGGAAAACAGTGGGGAAGACTATGGAACATAGAAAGTGTGGATGTATCAC
TTCTCTCTAAAATGTCATTGTTAGCACTAATTACAGGTTCATGTTTTTCTGTGTATGTAGCTTTTCCCTATATAGCTGAAAAAGTATTAA
AGTCAAATATAAGGTGGGAATGGGATGGAAGGGAGGAGATCAATACAACTTATATTTTTGCAGTTTCTACTGGAAGAAAAAAGTTTTCAA
TACCTAGACCAACTTGTTGAATTTTTAAAACTTATGCACTATAAATGCAACTTTCTCTACTGCTTTCTCAGTGCCTTTAGGAAGCTTTCA

>1340_1340_3_ACO2-AHRR_ACO2_chr22_41865186_ENST00000396512_AHRR_chr5_422844_ENST00000316418_length(amino acids)=585AA_BP=9
LSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC
FICRVRCLLDSTSGFLARGSQAWQLRLCCPEPLMTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKP
RADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLS
RASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVG
EDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSH
PATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAA

--------------------------------------------------------------
>1340_1340_4_ACO2-AHRR_ACO2_chr22_41865186_ENST00000396512_AHRR_chr5_422844_ENST00000505113_length(transcript)=1729nt_BP=53nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGACGGATGTAATGCACCAGAACATTTATGACTACATCC
ACGTGGACGACCGCCAGGACTTCTGCCGGCAGCTCCACTGGGCCATGGACCCTCCCCAGGTGGTGTTTGGGCAGCCCCCGCCCTTGGAGA
CAGGAGATGATGCTATCCTGGGGAGGCTGCTCAGGGCCCAGGAGTGGGGCACAGGCACGCCCACCGAGTACTCGGCCTTCCTGACCCGCT
GCTTCATCTGCCGTGTGCGCTGCCTGCTGGACAGCACCTCGGGCTTCCTGACGATGCAGTTTCAAGGAAAACTAAAATTCCTGTTTGGAC
AGAAGAAGAAGGCGCCGTCAGGAGCCATGCTCCCGCCGCGGCTGTCGCTGTTCTGCATTGCGGCACCCGTTCTCCTCCCCTCCGCAGCGG
AGATGAAAATGAGGAGCGCGCTCCTGAGGGCAAAACCCAGAGCAGACACCGCAGCCACCGCGGATGCAAAAGTAAAAGCCACCACCAGTC
TGTGCGAATCGGAACTGCATGGAAAACCCAATTACTCAGCAGGAAGGAGCAGCAGAGAGAGCGGCGTTTTGGTGCTCAGGGAACAGACTG
ACGCTGGCCGATGGGCACAGGTTCCCGCCAGGGCCCCATGCCTGTGCCTCCGGGGTGGCCCTGACCTTGTCCTTGACCCCAAGGGGGGCT
CAGGGGACAGGGAGGAGGAGCAGCACAGGATGCTGAGCAGGGCCTCTGGAGTGACAGGGCGGAGGGAGACTCCAGGACCCACAAAGCCCC
TGCCCTGGACAGCGGGAAAGCACAGTGAGGATGGTGCCAGGCCGAGGCTGCAGCCCAGCAAGAATGACCCGCCCTCCCTGCGCCCCATGC
CCCGCGGCTCCTGCCTGCCCTGCCCGTGTGTCCAGGGCACTTTCAGGAACTCGCCCATCTCTCACCCGCCGAGCCCGTCCCCCAGTGCCT
ACTCCAGCCGGACCAGCAGACCCATGCGGGATGTCGGTGAGGACCAGGTGCACCCTCCCCTCTGCCACTTTCCCCAGAGGAGCCTGCAGC
ACCAGCTCCCTCAGCCTGGAGCTCAGCGTTTTGCCACGAGGGGCTATCCCATGGAGGACATGAAGCTGCAAGGTGTACCGATGCCTCCGG
GGGACCTGTGTGGTCCGACGCTGCTGCTAGATGTGTCCATCAAGATGGAGAAGGACTCTGGGTGTGAGGGTGCTGCAGACGGCTGTGTGC
CCAGCCAGGTGTGGCTGGGGGCCAGTGACAGGAGCCACCCAGCCACCTTCCCTACCAGGATGCACCTGAAAACAGAGCCAGACTCTCGGC
AACAGGTGTACATCTCGCACCTGGGGCACGGCGTGCGGGGGGCTCAGCCCCATGGGAGGGCCACTGCTGGGCGCAGCAGGGAGCTGACCC
CTTTCCACCCTGCACACTGTGCCTGCCTGGAGCCCACAGACGGCCTTCCCCAGTCGGAGCCTCCCCACCAGCTCTGTGCACGGGGCCGAG
GTGAACAGTCCTGCACCTGCAGAGCTGCTGAGGCCGCCCCTGTGGTCAAGCGGGAGCCCTTGGACTCACCCCAGTGGGCTACTCACAGCC
AGGGAATGGTGCCCGGGATGTTGCCCAAAAGTGCCTTGGCCACGCTGGTCCCGCCCCAAGCTTCGGGGTGCACATTCCTGCCATAGCGCA

>1340_1340_4_ACO2-AHRR_ACO2_chr22_41865186_ENST00000396512_AHRR_chr5_422844_ENST00000505113_length(amino acids)=567AA_BP=9
LSVHKMAPYSLLVTRLQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRC
FICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSL
CESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPL
PWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQH
QLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQ
QVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACO2-AHRR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACO2-AHRR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACO2-AHRR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource