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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACO2-ARHGAP8 (FusionGDB2 ID:1341)

Fusion Gene Summary for ACO2-ARHGAP8

check button Fusion gene summary
Fusion gene informationFusion gene name: ACO2-ARHGAP8
Fusion gene ID: 1341
HgeneTgene
Gene symbol

ACO2

ARHGAP8

Gene ID

50

23779

Gene nameaconitase 2Rho GTPase activating protein 8
SynonymsACONM|HEL-S-284|ICRD|OCA8|OPA9BPGAP1|PP610
Cytomap

22q13.2

22q13.31

Type of geneprotein-codingprotein-coding
Descriptionaconitate hydratase, mitochondrialaconitase 2, mitochondrialcitrate hydro-lyaseepididymis secretory sperm binding protein Li 284mitochondrial aconitaserho GTPase-activating protein 8BCH domain-containing Cdc42GAP-like proteinBNIP-2 and Cdc42GAP homology domain-containing, proline-rich and Cdc42GAP-like protein subtype-1rho-type GTPase-activating protein 8
Modification date2020031320200313
UniProtAcc.

P85298

Ensembl transtripts involved in fusion geneENST00000216254, ENST00000396512, 
ENST00000466237, 		ENST00000336963, 
ENST00000356099, ENST00000389773, 
ENST00000389774, ENST00000469872, 
ENST00000517296, 
Fusion gene scores* DoF score17 X 8 X 10=13606 X 9 X 5=270
# samples 227
** MAII scorelog2(22/1360*10)=-2.62803122261304
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/270*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACO2 [Title/Abstract] AND ARHGAP8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACO2(41895866)-ARHGAP8(45110471), # samples:2
Anticipated loss of major functional domain due to fusion event.ACO2-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ACO2-ARHGAP8 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACO2

GO:0006099

tricarboxylic acid cycle

9630632

HgeneACO2

GO:0006101

citrate metabolic process

9630632

TgeneARHGAP8

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20179103


check buttonFusion gene breakpoints across ACO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+ARHGAP8chr22

45098372

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

-ARHGAP8chr22

45110471

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+ARHGAP8chr22

45110471

+
ChimerDB4UCECTCGA-AJ-A3EM-01AACO2chr22

41895866

+ARHGAP8chr22

45121124

+


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Fusion Gene ORF analysis for ACO2-ARHGAP8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000216254ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000216254ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000216254ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
5CDS-intronENST00000216254ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000216254ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000216254ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
5CDS-intronENST00000216254ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000216254ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000216254ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000216254ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
5CDS-intronENST00000216254ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000216254ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000216254ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
5CDS-intronENST00000396512ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000396512ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000396512ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
5CDS-intronENST00000396512ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000396512ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000396512ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
5CDS-intronENST00000396512ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000396512ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000396512ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000396512ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
5CDS-intronENST00000396512ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
5CDS-intronENST00000396512ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
5CDS-intronENST00000396512ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
Frame-shiftENST00000216254ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
Frame-shiftENST00000396512ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
In-frameENST00000216254ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
In-frameENST00000216254ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
In-frameENST00000216254ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
In-frameENST00000216254ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
In-frameENST00000396512ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
In-frameENST00000396512ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
In-frameENST00000396512ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
In-frameENST00000396512ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
intron-3CDSENST00000466237ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
intron-3CDSENST00000466237ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
intron-3CDSENST00000466237ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
intron-3CDSENST00000466237ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
intron-3CDSENST00000466237ENST00000517296ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
intron-intronENST00000466237ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
intron-intronENST00000466237ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
intron-intronENST00000466237ENST00000336963ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
intron-intronENST00000466237ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
intron-intronENST00000466237ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
intron-intronENST00000466237ENST00000356099ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
intron-intronENST00000466237ENST00000389773ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
intron-intronENST00000466237ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
intron-intronENST00000466237ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
intron-intronENST00000466237ENST00000389774ACO2chr22

41895866

+ARHGAP8chr22

45121124

+
intron-intronENST00000466237ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45098372

+
intron-intronENST00000466237ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45110471

+
intron-intronENST00000466237ENST00000469872ACO2chr22

41895866

+ARHGAP8chr22

45121124

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000216254ACO2chr2241895866+ENST00000517296ARHGAP8chr2245110471+210419571992661
ENST00000216254ACO2chr2241895866+ENST00000389773ARHGAP8chr2245110471+194519571755582
ENST00000396512ACO2chr2241895866+ENST00000517296ARHGAP8chr2245110471+209919021987661
ENST00000396512ACO2chr2241895866+ENST00000389773ARHGAP8chr2245110471+194019021750582
ENST00000216254ACO2chr2241895866+ENST00000517296ARHGAP8chr2245121124+202319571911634
ENST00000216254ACO2chr2241895866+ENST00000389773ARHGAP8chr2245121124+186419571674555
ENST00000396512ACO2chr2241895866+ENST00000517296ARHGAP8chr2245121124+201819021906634
ENST00000396512ACO2chr2241895866+ENST00000389773ARHGAP8chr2245121124+185919021669555

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000216254ENST00000517296ACO2chr2241895866+ARHGAP8chr2245110471+0.0173173060.9826827
ENST00000216254ENST00000389773ACO2chr2241895866+ARHGAP8chr2245110471+0.0178844670.9821155
ENST00000396512ENST00000517296ACO2chr2241895866+ARHGAP8chr2245110471+0.0171122030.98288774
ENST00000396512ENST00000389773ACO2chr2241895866+ARHGAP8chr2245110471+0.0177100260.98228997
ENST00000216254ENST00000517296ACO2chr2241895866+ARHGAP8chr2245121124+0.0241454490.9758546
ENST00000216254ENST00000389773ACO2chr2241895866+ARHGAP8chr2245121124+0.0104318850.98956805
ENST00000396512ENST00000517296ACO2chr2241895866+ARHGAP8chr2245121124+0.0238712910.9761287
ENST00000396512ENST00000389773ACO2chr2241895866+ARHGAP8chr2245121124+0.0101970550.98980296

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Fusion Genomic Features for ACO2-ARHGAP8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACO2chr2241895866+ARHGAP8chr2245110470+1.64E-111
ACO2chr2241895866+ARHGAP8chr2245121123+5.16E-081
ACO2chr2241895866+ARHGAP8chr2245110470+1.64E-111
ACO2chr2241895866+ARHGAP8chr2245121123+5.16E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACO2-ARHGAP8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:41895866/chr22:45110471)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARHGAP8

P85298

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP8chr22:41895866chr22:45110471ENST0000035609901213_1990434.0DomainCRAL-TRIO
TgeneARHGAP8chr22:41895866chr22:45110471ENST00000356099012226_4120434.0DomainRho-GAP
TgeneARHGAP8chr22:41895866chr22:45110471ENST0000038977401313_1990465.0DomainCRAL-TRIO
TgeneARHGAP8chr22:41895866chr22:45110471ENST00000389774013226_4120465.0DomainRho-GAP
TgeneARHGAP8chr22:41895866chr22:45121124ENST0000035609901213_1990434.0DomainCRAL-TRIO
TgeneARHGAP8chr22:41895866chr22:45121124ENST00000356099012226_4120434.0DomainRho-GAP
TgeneARHGAP8chr22:41895866chr22:45121124ENST0000038977401313_1990465.0DomainCRAL-TRIO
TgeneARHGAP8chr22:41895866chr22:45121124ENST00000389774013226_4120465.0DomainRho-GAP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACO2chr22:41895866chr22:45110471ENST00000216254+218192_19457781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45110471ENST00000216254+218670_67157781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121124ENST00000216254+218192_19457781.0RegionSubstrate binding
HgeneACO2chr22:41895866chr22:45121124ENST00000216254+218670_67157781.0RegionSubstrate binding


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Fusion Gene Sequence for ACO2-ARHGAP8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1341_1341_1_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45110471_ENST00000389773_length(transcript)=1945nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGT
GCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGGATGA
CCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTATTTGAA
GTACACACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTCCCTGGGCTG
GCTCCAGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGT
CCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCT
TAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCAC
CAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCAT
CCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGAC
CGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAA
GACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCG
TGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTC
CCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTC
CCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGA
GCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCC
TACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGT
CTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCC

>1341_1341_1_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45110471_ENST00000389773_length(amino acids)=582AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRF
GRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLW
NILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPP
VLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVT
GCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHG

--------------------------------------------------------------
>1341_1341_2_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45110471_ENST00000517296_length(transcript)=2104nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGG
CGTCCGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCG
GGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCT
GCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGT
GAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTC
CAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAG
CGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCC
CTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGC
AGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGA
GTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCA
CAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAATACGACCAGCTGGTCATCCCTCCCGAAGT
TTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGACACCACCGCCGCGGCCCCCGCTGCCCAC
ACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCT
GAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGG
GAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCT
GACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCT
CCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTC
TAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCAC
TGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAG
GGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAG
AAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATC

>1341_1341_2_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45110471_ENST00000517296_length(amino acids)=661AA_BP=63
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSV
VPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYKKNLKALYVVHPTSFIKVLWNILKPLISHKF
GKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLRE
KGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPE
HNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAA

--------------------------------------------------------------
>1341_1341_3_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45121124_ENST00000389773_length(transcript)=1864nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCC
CTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGC
AGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGA
GTATTTGAAGTACACACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTC
CCTGGGCTGGCTCCAGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTT
CATCAAGGTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCA
CGAACACCTTAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCC
GCCTCCCACCAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGG
CGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAG
CGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGT
GATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAG
CAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCA
TGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGG
GGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGC
ACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCT
CACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCC
CACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAA

>1341_1341_3_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45121124_ENST00000389773_length(amino acids)=555AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYL
KYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEH
LKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQ
TVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV
SRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTK

--------------------------------------------------------------
>1341_1341_4_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45121124_ENST00000517296_length(transcript)=2023nt_BP=195nt
CTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGC
CTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAA
CATTGTTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGT
GATCCTTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCT
GCCCATGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCAC
CCTCAGTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGT
ACATGAGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCT
CCACTCCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAG
GAAGAGGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCT
GCAGGTGGCAGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCG
GCTGCTGGAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGTGGAACATCTTGAAGCCCCT
CATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAATACGACCAGCTGGTCATCCC
TCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGACACCACCGCCGCGGCCCCC
GCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGT
GACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTA
CAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCA
GCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTT
ACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAAT
GAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAA
CATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACA
GGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGAT
GGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAA

>1341_1341_4_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000216254_ARHGAP8_chr22_45121124_ENST00000517296_length(amino acids)=634AA_BP=62
MSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQV
AGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPE
VLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQ
GKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNS
SNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAA

--------------------------------------------------------------
>1341_1341_5_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45110471_ENST00000389773_length(transcript)=1940nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGGTGGTGCCCA
TGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGGATGACCGCT
TTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTATTTGAAGTACA
CACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTCCCTGGGCTGGCTCC
AGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGT
GGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAAT
ACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGA
CACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCCC
CTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCC
GCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCT
TCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCA
CTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGG
AGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGA
GTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACG
GCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCC
TACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTG
CACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCATGCCTCTGG

>1341_1341_5_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45110471_ENST00000389773_length(amino acids)=582AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRF
GRRVVTFSCCRMPPSHELDHQRLLEYLKYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLW
NILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPP
VLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVT
GCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHG

--------------------------------------------------------------
>1341_1341_6_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45110471_ENST00000517296_length(transcript)=2099nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGCATCCACAACGGGGTGATCGCCGTCTTCCAGCGCAAGGGGCTGCCCGACCAGGAGCTCTTCAGCCTCAACGAGGGCGTCC
GGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCCTTCGGGACA
AGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCATGCTGCAGG
CCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCAGTGTGAAGC
TAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATGAGTCCAGGG
GCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACTCCAGCGAGG
GGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGG
TGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGG
ATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTACA
AGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGT
TTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGC
GGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGC
AGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAG
AGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGC
CCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCT
TCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAG
AGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACC
TGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAAC
TGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAG
CCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGAC
GTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAA

>1341_1341_6_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45110471_ENST00000517296_length(amino acids)=661AA_BP=63
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRIHNGVIAVFQRKGLPDQELFSLNEGVR
QLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKL
EDALARAHARVPPAIVQMLLVLQGVHESRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSV
VPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYKKNLKALYVVHPTSFIKVLWNILKPLISHKF
GKKVIYFNYLSELHEHLKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLRE
KGLRTEGLFRRSASVQTVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPE
HNYVVLRYLMGFLHAVSRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAA

--------------------------------------------------------------
>1341_1341_7_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45121124_ENST00000389773_length(transcript)=1859nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGAGGCCCTCGG
TGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGGTGGCAGGGG
ATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGCTGGAGTATT
TGAAGTACACACTGGACCAATACGTTGAGAACGATTATACCATCGTCTATTTCCACTACGGGCTGAACAGCCGGAACAAGCCTTCCCTGG
GCTGGCTCCAGAGCGCATACAAGGAGTTCGATAGGAAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCA
AGGTCCTGTGGAACATCTTGAAGCCCCTCATCAGTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAAC
ACCTTAAATACGACCAGCTGGTCATCCCTCCCGAAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTC
CCACCAAGACACCACCGCCGCGGCCCCCGCTGCCCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAAC
TCATCCCCCCTGTGCTGAGGTTCACAGTGACGTACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGC
AGACCGTCCGCGAGATCCAGAGGCTCTACAACCAAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCC
TGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGCTTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCC
TGCGTGTCACTGGCTGCCGCCAGATCTTACGGAGCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGG
TGTCCCGGGAGAGCATCTTCAACAAAATGAACAGCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCT
CCTCCCTGAGTGCCCTTGTGCCCCTGAACATGTTCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTG
GGGAGCACGGCCTGGCACCATGGGAACAGGGGAGCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCA
AGCCTACCCTACCTCCGAGTCCCCTGATGGCAGCCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACAC
CTGTCTGTGCACTTGTATGTTTTGTAAACTTGGCATCTGTAAAAATAACCAGCCATTAGATGAATTCAGAACCTTCTAATGAAAACTCCA

>1341_1341_7_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45121124_ENST00000389773_length(amino acids)=555AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQVAGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYL
KYTLDQYVENDYTIVYFHYGLNSRNKPSLGWLQSAYKEFDRKYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEH
LKYDQLVIPPEVLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQ
TVREIQRLYNQGKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAV
SRESIFNKMNSSNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTK

--------------------------------------------------------------
>1341_1341_8_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45121124_ENST00000517296_length(transcript)=2018nt_BP=190nt
CTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAG
TCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTG
TTCGCAAACGGCAGCTGTTGAAGACAGAGCTGGGGTCCTTCTTCACGGAGTACCTGCAGAACCAGCTGCTGACAAAAGGCATGGTGATCC
TTCGGGACAAGATTCGCTTCTATGAGGGACAGAAGCTGCTGGACTCACTGGCAGAGACCTGGGACTTCTTCTTCAGTGACGTGCTGCCCA
TGCTGCAGGCCATCTTCTACCCGGTGCAGGGCAAGGAGCCATCGGTGCGCCAGCTGGCCCTGCTGCACTTCCGGAATGCCATCACCCTCA
GTGTGAAGCTAGAGGATGCGCTGGCCCGGGCCCATGCCCGTGTGCCCCCTGCCATCGTGCAGATGCTGCTGGTGCTGCAGGGGGTACATG
AGTCCAGGGGCGTGACTGAGGACTACCTGCGCCTGGAGACGCTGGTCCAGAAGGTGGTGTCGCCATACCTGGGCACCTACGGCCTCCACT
CCAGCGAGGGGCCCTTCACCCATTCCTGCATCCTGGAGCTGCAGAGAGACAAGGCGGCGGCGGCTGCTGTGCTGGGTGCAGTGAGGAAGA
GGCCCTCGGTGGTGCCCATGGCTGGCCAGGATCCTGCGCTGAGCACGAGTCACCCGTTCTACGACGTGGCCAGACATGGCATTCTGCAGG
TGGCAGGGGATGACCGCTTTGGAAGACGTGTTGTCACGTTCAGCTGCTGCCGGATGCCACCCTCCCACGAGCTGGACCACCAGCGGCTGC
TGGAGTACAAGAAGAACTTGAAGGCCCTCTACGTGGTGCACCCCACCAGCTTCATCAAGGTCCTGTGGAACATCTTGAAGCCCCTCATCA
GTCACAAGTTTGGGAAGAAAGTCATCTATTTCAACTACCTGAGTGAGCTCCACGAACACCTTAAATACGACCAGCTGGTCATCCCTCCCG
AAGTTTTGCGGTACGATGAGAAGCTCCAGAGCCTGCACGAGGGCCGGACGCCGCCTCCCACCAAGACACCACCGCCGCGGCCCCCGCTGC
CCACACAGCAGTTTGGCGTCAGTCTGCAATACCTCAAAGACAAAAATCAAGGCGAACTCATCCCCCCTGTGCTGAGGTTCACAGTGACGT
ACCTGAGAGAGAAAGGCCTGCGCACCGAGGGCCTGTTCCGGAGATCCGCCAGCGTGCAGACCGTCCGCGAGATCCAGAGGCTCTACAACC
AAGGGAAGCCCGTGAACTTTGACGACTACGGGGACATTCACATCCCTGCCGTGATCCTGAAGACCTTCCTGCGAGAGCTGCCCCAGCCGC
TTCTGACCTTCCAGGCCTACGAGCAGATTCTCGGGATCACCTGTGTGGAGAGCAGCCTGCGTGTCACTGGCTGCCGCCAGATCTTACGGA
GCCTCCCAGAGCACAACTACGTCGTCCTCCGCTACCTCATGGGCTTCCTGCATGCGGTGTCCCGGGAGAGCATCTTCAACAAAATGAACA
GCTCTAACCTGGCCTGTGTCTTCGGGCTGAATTTGATCTGGCCATCCCAGGGGGTCTCCTCCCTGAGTGCCCTTGTGCCCCTGAACATGT
TCACTGAACTGCTGATCGAGTACTATGAAAAGATCTTCAGCACCCCGGAGGCACCTGGGGAGCACGGCCTGGCACCATGGGAACAGGGGA
GCAGGGCAGCCCCTTTGCAGGAGGCTGTGCCACGGACACAAGCCACGGGCCTCACCAAGCCTACCCTACCTCCGAGTCCCCTGATGGCAG
CCAGAAGACGTCTCTAGTGTTGCGAACACTCTGTATATTTCGAGCTACCTCCCACACCTGTCTGTGCACTTGTATGTTTTGTAAACTTGG

>1341_1341_8_ACO2-ARHGAP8_ACO2_chr22_41895866_ENST00000396512_ARHGAP8_chr22_45121124_ENST00000517296_length(amino acids)=634AA_BP=62
LSVHKMAPYSLLVTRLQKALGVRQYHVASVLCQRAKVAMSHFEPNEYIHYDLLEKNINIVRKRQLLKTELGSFFTEYLQNQLLTKGMVIL
RDKIRFYEGQKLLDSLAETWDFFFSDVLPMLQAIFYPVQGKEPSVRQLALLHFRNAITLSVKLEDALARAHARVPPAIVQMLLVLQGVHE
SRGVTEDYLRLETLVQKVVSPYLGTYGLHSSEGPFTHSCILELQRDKAAAAAVLGAVRKRPSVVPMAGQDPALSTSHPFYDVARHGILQV
AGDDRFGRRVVTFSCCRMPPSHELDHQRLLEYKKNLKALYVVHPTSFIKVLWNILKPLISHKFGKKVIYFNYLSELHEHLKYDQLVIPPE
VLRYDEKLQSLHEGRTPPPTKTPPPRPPLPTQQFGVSLQYLKDKNQGELIPPVLRFTVTYLREKGLRTEGLFRRSASVQTVREIQRLYNQ
GKPVNFDDYGDIHIPAVILKTFLRELPQPLLTFQAYEQILGITCVESSLRVTGCRQILRSLPEHNYVVLRYLMGFLHAVSRESIFNKMNS
SNLACVFGLNLIWPSQGVSSLSALVPLNMFTELLIEYYEKIFSTPEAPGEHGLAPWEQGSRAAPLQEAVPRTQATGLTKPTLPPSPLMAA

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Fusion Gene PPI Analysis for ACO2-ARHGAP8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACO2-ARHGAP8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACO2-ARHGAP8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource